{ "uniprot_canonical_ac": "A2AU72-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AU72-1|ARMC3_MOUSE Isoform 1 of Armadillo repeat-containing protein 3 OS=Mus musculus OX=10090 GN=Armc3 PE=1 SV=1 CANONICAL=A2AU72-1", "length": 881, "sequence": "MGKKIKKEVEPPPKDVFDPITIESKKAATVVLMLKSPEEDILAKACEAIYKFALKGEENKATLLELGAVEPLTKLLTHEDKTVRRNAMMIFGILASNSDVKKLLRELEVMNSVIAQLSPEEEVVIHEFASLCLANMSVEYTGKVQIFEHGGLEPLIRLLSSSDPDVKKNSIECIYNLVQDFQCRTTLQELNAIPPILELLRSEYPIIQLLALKTLGVITCDKEARTMLKENQGLDHLTKILETKELNDLHVEALSVIANCLEDMDTMVLMQQTGSLKKVLSFAESSTIPDIQKNAAKAIAKAAYDPENRKVFHEQEVEKCLVTLLGSDSDGTKIAASQAISALCENLSCKEFFNTQGIPQIVQLLRSDNEEVREAAALALANLTTSSPANANAAAEADAIDPLINILSSKRDGAIANAATVLTNMATQEPLRAIIQNHEIMHALLGPLHSTNTLVQSTAALTVAATACDVEARTQLRNCGGLVPLVGLLHSKNDEVRRHASWAVMVCAGDEPMAVELCRLGALNILEEINRSLSRKNKFSEAAYNKLLNNNLSLKYSQTGYLSSSNIISDGFYDYGRINPGTKLLSLKELCLQELNDQRAILLVNNKSDTSPPPSMEDKSSDVGYGRSISSSSSLRRGSKEKANAIFGSPTEEKSEPASVRNTILSRAFTKEKGVSKKKSRLQLICSSYLLWKGKGKKEEEKVKEEEEILALPKFTEGSPEKEWNPPPDPEFCVYVLEVTKSILPIVNLKEQIEVLAKYVADKMGGKIPKEKLADFSWELHISELKFQLKSNVVPIGYIKKGIFYHRALLFKALADKIGVGCSLVRGEYSRGWNEVKLVNEARKGMIGNLPPPEEYIVDLMFHPGNLLKLRSKEADLYRFL" }, "uniprot_id": "ARMC3_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AU72", "id": "A2AU72", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17971504", "type": [ "PubMed" ], "id": "17971504" } ], "title": "Tissue expression patterns identify mouse cilia genes.", "journal": "Physiological genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074552.1", "id": "NP_001074552.1", "database": "RefSeq" } ], "authors": "McClintock TS, Glasser CE, Bose SC, Bergman DA", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23437000", "type": [ "PubMed" ], "id": "23437000" } ], "title": "Next-generation sequencing identifies the Danforth's short tail mouse mutation as a retrotransposon insertion affecting Ptf1a expression.", "journal": "PLoS genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074552.1", "id": "NP_001074552.1", "database": "RefSeq" } ], "authors": "Vlangos CN, Siuniak AN, Robinson D, Chinnaiyan AM, Lyons RH Jr, Cavalcoli JD, Keegan CE", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23437001", "type": [ "PubMed" ], "id": "23437001" } ], "title": "A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse.", "journal": "PLoS genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074552.1", "id": "NP_001074552.1", "database": "RefSeq" } ], "authors": "Lugani F, Arora R, Papeta N, Patel A, Zheng Z, Sterken R, Singer RA, Caridi G, Mendelsohn C, Sussel L, Papaioannou VE, Gharavi AG", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26449520", "type": [ "PubMed" ], "id": "26449520" } ], "title": "Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice.", "journal": "Genes, brain, and behavior", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074552.1", "id": "NP_001074552.1", "database": "RefSeq" } ], "authors": "Delprato A, Bonheur B, Algeo MP, Rosay P, Lu L, Williams RW, Crusio WE", "date": "2015" } ], "uniprot_ac": "A2AU72", "site_annotation": [ { "end_pos": 137, "annotation": "n_glycosylation_sequon", "start_pos": 135 }, { "end_pos": 348, "annotation": "n_glycosylation_sequon", "start_pos": 346 }, { "end_pos": 384, "annotation": "n_glycosylation_sequon", "start_pos": 382 }, { "end_pos": 532, "annotation": "n_glycosylation_sequon", "start_pos": 530 }, { "end_pos": 553, "annotation": "n_glycosylation_sequon", "start_pos": 551 }, { "end_pos": 608, "annotation": "n_glycosylation_sequon", "start_pos": 606 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AU72#A2AU71-1", "isoform_ac": "A2AU71-1", "locus": { "end_pos": 19201768, "strand": "-", "start_pos": 19310123, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000049255", "id": "ENSMUST00000049255", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000048784", "id": "ENSMUSP00000048784", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AU71-1|ARMC3_MOUSE Computationally mapped isoform of Armadillo repeat-containing protein 3 OS=Mus musculus OX=10090 GN=Armc3 PE=1 SV=1 CANONICAL=A2AU72-1", "length": 869, "sequence": "MGKKIKKEVEPPPKDVFDPITIESKKAATVVLMLKSPEEDILAKACEAIYKFALKGEENKATLLELGAVEPLTKLLTHEDKTVRRNAMMIFGILASNSDVKKLLRELEVMNSVIAQLSPEEEVVIHEFASLCLANMSVEYTGKVQIFEHGGLEPLIRLLSSSDPDVKKNSIECIYNLVQDFQCRTTLQELNAIPPILELLRSEYPIIQLLALKTLGVITCDKEARTMLKENQGLDHLTKILETKELNDLHVEALSVIANCLEDMDTMVLMQQTGSLKKVLSFAESSTIPDIQKNAAKAIAKAAYDPENRKVFHEQEVEKCLVTLLGSDSDGTKIAASQAISALCENLSCKEFFNTQGIPQIVQLLRSDNEEVREAAALALANLTTSSPANANAAAEADAIDPLINILSSKRDGAIANAATVLTNMATQEPLRAIIQNHEIMHALLGPLHSTNTLVQSTAALTVAATACDVEARTQLRNCGGLVPLVGLLHSKNDEVRRHASWAVMVCAGDEPMAVELCRLGALNILEEINRSLSRKNKFSEAAYNKLLNNNLSLKYSQTGYLSSSNIISDGFYDYGRINPGTKLLSLKELCLQELNDQRAILLVNNKSDTSPPPSMEDKSSDVGYGRSISSSSSLRRGSKEKANFRFSAIFGSPTEEKSEPASVRNTILSRAFTKEKGVRKGKGKKEEEKVKEEEEILALPKFTEGSPEKEWNPPPDPEFCVYVLEVTKSILPIVNLKEQIEVLAKYVADKMGGKIPKEKLADFSWELHISELKFQLKSNVVPIGYIKKGIFYHRALLFKALADKIGVGCSLVRGEYSRGWNEVKLVNEARKGMIGNLPPPEEYIVDLMFHPGNLLKLRSKEADLYRFL" } }, { "url": "https://www.uniprot.org/uniprot/A2AU72#A2AU72-1", "isoform_ac": "A2AU72-1", "locus": { "end_pos": 19201768, "strand": "-", "start_pos": 19310123, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000114640", "id": "ENSMUST00000114640", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000110287", "id": "ENSMUSP00000110287", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AU72-1|ARMC3_MOUSE Isoform 1 of Armadillo repeat-containing protein 3 OS=Mus musculus OX=10090 GN=Armc3 PE=1 SV=1 CANONICAL=A2AU72-1", "length": 881, "sequence": "MGKKIKKEVEPPPKDVFDPITIESKKAATVVLMLKSPEEDILAKACEAIYKFALKGEENKATLLELGAVEPLTKLLTHEDKTVRRNAMMIFGILASNSDVKKLLRELEVMNSVIAQLSPEEEVVIHEFASLCLANMSVEYTGKVQIFEHGGLEPLIRLLSSSDPDVKKNSIECIYNLVQDFQCRTTLQELNAIPPILELLRSEYPIIQLLALKTLGVITCDKEARTMLKENQGLDHLTKILETKELNDLHVEALSVIANCLEDMDTMVLMQQTGSLKKVLSFAESSTIPDIQKNAAKAIAKAAYDPENRKVFHEQEVEKCLVTLLGSDSDGTKIAASQAISALCENLSCKEFFNTQGIPQIVQLLRSDNEEVREAAALALANLTTSSPANANAAAEADAIDPLINILSSKRDGAIANAATVLTNMATQEPLRAIIQNHEIMHALLGPLHSTNTLVQSTAALTVAATACDVEARTQLRNCGGLVPLVGLLHSKNDEVRRHASWAVMVCAGDEPMAVELCRLGALNILEEINRSLSRKNKFSEAAYNKLLNNNLSLKYSQTGYLSSSNIISDGFYDYGRINPGTKLLSLKELCLQELNDQRAILLVNNKSDTSPPPSMEDKSSDVGYGRSISSSSSLRRGSKEKANAIFGSPTEEKSEPASVRNTILSRAFTKEKGVSKKKSRLQLICSSYLLWKGKGKKEEEKVKEEEEILALPKFTEGSPEKEWNPPPDPEFCVYVLEVTKSILPIVNLKEQIEVLAKYVADKMGGKIPKEKLADFSWELHISELKFQLKSNVVPIGYIKKGIFYHRALLFKALADKIGVGCSLVRGEYSRGWNEVKLVNEARKGMIGNLPPPEEYIVDLMFHPGNLLKLRSKEADLYRFL" } }, { "url": "https://www.uniprot.org/uniprot/A2AU72#A2AU72-2", "isoform_ac": "A2AU72-2", "locus": {}, "sequence": { "header": "sp|A2AU72-2|ARMC3_MOUSE Isoform 2 of Armadillo repeat-containing protein 3 OS=Mus musculus OX=10090 GN=Armc3 PE=1 SV=1 CANONICAL=A2AU72-1", "length": 684, "sequence": "MGKKIKKEVEPPPKDVFDPITIESKKAATVVLMLKSPEEDILAKACEAIYKFALKGEENKATLLELGAVEPLTKLLTHEDKTVRRNAMMIFGILASNSDVKKLLRELEVMNSVIAQLSPEEEVVIHEFASLCLANMSVEYTGKVQIFEHGGLEPLIRLLSSSDPDVKKNSIECIYNLVQDFQCRTTLQELNAIPPILELLRSEYPIIQLLALKTLGVITCDKEARTMLKENQGLDHLTKILETKELNDLHVEALSVIANCLEDMDTMVLMQQTGSLKKVLSFAESSTIPDIQKNAAKAIAKAAYDPENRKVFHEQEVEKCLVTLLGSDSDGTKIAASQAISALCENLSCKEFFNTQGIPQIVQLLRSDNEEVREAAALALANLTTSSPANANAAAEADAIDPLINILSSKRDGAIANAATVLTNMATQEPLRAIIQNHEIMHALLGPLHSTNTLVQSTAALTVAATACDVEARTQLRNCGGLVPLVGLLHSKNDEVRRHASWAVMVCAGDEPMAVELCRLGALNILEEINRSLSRKNKFSEAAYNKLLNNNLSLKYSQTGYLSSSNIISDGFYDYGRINPGTKLLSLKELCLQELNDQRAILLVNNKSDTSPPPSMEDKSSDVGYGRSISSSSSLRRGSKEKANFRFSAIFGSPTEEKSEPASVRNTILSRAFTKEKGVRKGKG" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:70882", "resource": "KEGG Pathway", "id": "mmu:70882", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074552.1", "annotation": "Armc3 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074552.1", "id": "NP_001074552.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "M0R914-1", "protein_name": "Armadillo repeat-containing 3", "sequence": { "length": 900, "sequence": "MAPAGLIVLELDKGSLGTKNQFGAEHAGAAQRRLATSINTDPQRPVQFVTCKEPLLRDLTPRRMGKKIKKEVEPPPKDVFDPLTIESKKAATVVLMLKSPEEDILAKACEAIYKFALKGEENKATLLELGAVEPLTKLLTHEDKIVRRNAMMIFGILASNSDVKKLLRELEVMSSVIAQLSPEEEVVIHEFASLCLANMSVEYTGKVQIFEHGGLEPLIRLLSSPDPDVKKNSIECIYNLVQDFQCRTTLQELNAIPPILELLKSEYPIIQLLALKTLGVITCDKEARTTLKDNQGLDHLTKILETKELNDLHVEALAVIANCLEDMDTMVLMQQSGSLKKVLSFAENSTIPDIQKNAAKAITKAAYDPENRKVFHEQEVEKCLVTLLGSDSDGTKIAASQAISAMCENLSCKEFFNTQGIPQIVQLLKSDNEEVREAAALALANLTTSSPANANAAAEADAIDPLINILSSKRDGAVANAATVLTNMAIQEPLRAIIQNHEIMRALLGPLHSTNTVVQSTAALTVAATACDVESRNELKNCGGLEPLIELLHSKNDEVRRHASWAIMVCAGDELMAVELCRLGALDILEEINRSLSRKNKFSEAAYNKLLNNNLSLKYSQTGYLSSSNIISDGFYDYGRINPGTKLLPLKELCLQELNDQRAILLVNNKSDISPPPSMEDKSSDVGYGRSISSSSSLRRASKEKANAGFGSPTEEKSEPASGRNTVLSRGATKEKGARKGKGKKEEEKVKEEEEVLAVPKLTESPEKEWYPPPDPEFCLYVLEVIKTILPIVNIKEQIEVLAKFVADKMGGKIAKEKLADFSWELHISELKFQLKSNVIPIGYIKKGIFYHRALLFKALADKIGVGCSLVRDEYIVDLMFHPGTLLKLRSKEADLYRFL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AU72/", "id": "A2AU72", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Armc3", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q5W041-2", "protein_name": "Armadillo repeat-containing protein 3", "sequence": { "length": 872, "sequence": "MGKKIKKEVEPPPKDVFDPLMIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACDVEARTELRNSGGLEPLVELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGALDILEEVNVSGTRKNKFSEAAYNKLLNNNLSLKYSQTGYLSSSNIINDGFYDYGRINPGTKLLPLKELCLQEPSDLRAVLLINSKSYVSPPSSMEDKSDVGYGRSISSSSSLRRSSKEKNKKNSYHFSAGFGSPIEDKSEPASGRNTVLSKSATKEKGWRKSKGKKEEEKVKEEEEVMVVPKFVGEGSSDKEWCPPSDPDFSMYVYEVTKSILPITNIKEQIEDLAKYVAEKMGGKIPKEKLPDFSWELHISELKFQLKSNVIPIGHVKKGIFYHRALLFKALADRIGIGCSLVRGEYGRAWNEVMLQNDSRKGVIGGLPAPEMYVIDLMFHPGGLMKLRSREADLYRFI" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/31589", "id": "31589", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AU72/", "id": "A2AU72", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "ARMC3", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074552.1", "ac": "NP_001074552.1", "name": "armadillo repeat-containing protein 3 isoform 1", "summary": "" }, "go_annotation": {}, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AU72", "type": "synonym", "resource": "RefSeq", "name": "4921513G22Rik" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AU72", "type": "synonym", "resource": "RefSeq", "name": "Armc3" }, { "url": "https://www.uniprot.org/uniprot/A2AU72", "type": "recommended", "resource": "UniProtKB", "name": "Armc3" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037683", "id": "ENSMUSG00000037683", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/70882", "id": "70882", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000225", "id": "IPR000225", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "id": "IPR011989", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "id": "IPR016024", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:70882", "id": "mmu:70882", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:1918132", "id": "1918132", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/GCQFERA/", "id": "GCQFERA", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=206276at2759", "id": "206276at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00514", "id": "PF00514", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2AU72", "id": "PR_A2AU72", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074552.1", "id": "NP_001074552.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AU72", "id": "A2AU72", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 97357.0, "chemical_mass": 97357.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AU72", "name": "Armc3", "locus": { "end_pos": 19310241, "strand": "+", "start_pos": 19199302, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000037683", "id": "ENSMUSG00000037683", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AU72#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Armadillo repeat-containing protein 3" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AU72", "type": "synonym", "resource": "RefSeq", "name": "armadillo repeat-containing protein 3 isoform 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AU72", "type": "synonym", "resource": "RefSeq", "name": "armadillo repeat-containing protein 3" } ] }