{
    "uniprot_canonical_ac": "A2AQW0-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2AQW0-1|M3K15_MOUSE Isoform 1 of Mitogen-activated protein kinase kinase kinase 15  OS=Mus musculus OX=10090 GN=Map3k15 PE=1 SV=1 CANONICAL=A2AQW0-1", 
        "length": 1331, 
        "sequence": "MEGGGGSGGGGGPVPAEAPEEAGEPPQGRLPPGPEGAAGLAEPESTGDAAGGEAEGGRGPRRALRAVYVRSESSQGAAAGGGPEAGALKCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDADVAIVDMSDISRQPSLFYHLGVRESFDMANNVILYYDTDADTALSLKDMVTQKNTASSGNYYFIPYTVTPCADYFCCESDAQRRASEYMQPNWDTILGPLCMPLVDRFTSLLKDIRVTSCAYYKETLLNDIRKAREKYQGDELAKELTRIKFRMDNIEVLTSDIIINLLLSYRDIQDYDAMVKLVETLKMLPTCDLADQHNIKFHYAFALNRRNSTGDREKALQVMLQVLQSCDHPAPDMFCLCGRIYKDIFLDSGCEEDASRDSAIEWYRKGFELQSSLYSGINLAVLLIVSGQQFETSMELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFTVSMLASDIGKAVQAAERLFKLKPPVWYLRSLVQNLLLIQRFKKPITEHSPRQERLNFWLDIIFEATNEVTNGLRFPVLVIEPTKVYQPSYVSINNEAEERTVSLWHVSPTEMKQIHEWNFTASSIKGISLSKFDERCCFLYVHDNSDDFQIYFSTEDQCNRFCSLVKEMLNNGVGSTVELEGEADGDTLEYEYDHDANGERVVLGKGSYGIVYAGRDLSNQVRIAIKEIPERDIRYSQPLHEEIALHKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSRPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPQKRVTAADLLQEGFLRQVNKGKKNRIAFKPSEGVRSGTGTLALPSSGELVGSSSSEHGSISPDSDAQPDAFFEKVQVPKHQLSHLLSVPDESPALDDRSTALPPEERDPGLFLLRKDSERRAILYRILWEEQNQVASNLQECVVQSSEELLLSVSHIKQIIGILRDFIRSPEHRVMAATISKLKVDLDFDSSSINQIHLILFGFQDAVNRILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELQAHFEPASETEGVDKDTEVEGDYPLVDLLSQEVHVTPRGTRPGSVAIQEGQPHQQDPSLQLSKLRQETNRLWEHLVQKEREYQNLLRLILDQKTQELYHLQLQYKSNGGTENPPPPDGLGTDRELIDWLQLQGVDANTIEKIVEEDYTLSDILNDITKEDLRCLRLRGGVLCRLWHAVSQHRRQMQESSQ"
    }, 
    "uniprot_id": "M3K15_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "2.7.11.25", 
            "activity": ""
        }, 
        {
            "ec": "2.7.11.25", 
            "activity": "ATP + a protein = ADP + a phosphoprotein."
        }
    ], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AQW0", 
                    "id": "A2AQW0", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/27708103", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "27708103"
                }
            ], 
            "title": "Ventral CA1 neurons store social memory.", 
            "journal": "Science (New York, N.Y.)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156557.2", 
                    "id": "NP_001156557.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Okuyama T, Kitamura T, Roy DS, Itohara S, Tonegawa S", 
            "date": "2016"
        }
    ], 
    "uniprot_ac": "A2AQW0", 
    "site_annotation": [
        {
            "end_pos": 340, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 338
        }, 
        {
            "end_pos": 579, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 577
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AQW0#A2AQW0-1", 
            "isoform_ac": "A2AQW0-1", 
            "locus": {
                "end_pos": 159988433, 
                "strand": "-", 
                "start_pos": 160122996, 
                "chromosome": "X", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000033665", 
                        "id": "ENSMUST00000033665", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000033665", 
                        "id": "ENSMUSP00000033665", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2AQW0-1|M3K15_MOUSE Isoform 1 of Mitogen-activated protein kinase kinase kinase 15  OS=Mus musculus OX=10090 GN=Map3k15 PE=1 SV=1 CANONICAL=A2AQW0-1", 
                "length": 1331, 
                "sequence": "MEGGGGSGGGGGPVPAEAPEEAGEPPQGRLPPGPEGAAGLAEPESTGDAAGGEAEGGRGPRRALRAVYVRSESSQGAAAGGGPEAGALKCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDADVAIVDMSDISRQPSLFYHLGVRESFDMANNVILYYDTDADTALSLKDMVTQKNTASSGNYYFIPYTVTPCADYFCCESDAQRRASEYMQPNWDTILGPLCMPLVDRFTSLLKDIRVTSCAYYKETLLNDIRKAREKYQGDELAKELTRIKFRMDNIEVLTSDIIINLLLSYRDIQDYDAMVKLVETLKMLPTCDLADQHNIKFHYAFALNRRNSTGDREKALQVMLQVLQSCDHPAPDMFCLCGRIYKDIFLDSGCEEDASRDSAIEWYRKGFELQSSLYSGINLAVLLIVSGQQFETSMELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFTVSMLASDIGKAVQAAERLFKLKPPVWYLRSLVQNLLLIQRFKKPITEHSPRQERLNFWLDIIFEATNEVTNGLRFPVLVIEPTKVYQPSYVSINNEAEERTVSLWHVSPTEMKQIHEWNFTASSIKGISLSKFDERCCFLYVHDNSDDFQIYFSTEDQCNRFCSLVKEMLNNGVGSTVELEGEADGDTLEYEYDHDANGERVVLGKGSYGIVYAGRDLSNQVRIAIKEIPERDIRYSQPLHEEIALHKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSRPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPQKRVTAADLLQEGFLRQVNKGKKNRIAFKPSEGVRSGTGTLALPSSGELVGSSSSEHGSISPDSDAQPDAFFEKVQVPKHQLSHLLSVPDESPALDDRSTALPPEERDPGLFLLRKDSERRAILYRILWEEQNQVASNLQECVVQSSEELLLSVSHIKQIIGILRDFIRSPEHRVMAATISKLKVDLDFDSSSINQIHLILFGFQDAVNRILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELQAHFEPASETEGVDKDTEVEGDYPLVDLLSQEVHVTPRGTRPGSVAIQEGQPHQQDPSLQLSKLRQETNRLWEHLVQKEREYQNLLRLILDQKTQELYHLQLQYKSNGGTENPPPPDGLGTDRELIDWLQLQGVDANTIEKIVEEDYTLSDILNDITKEDLRCLRLRGGVLCRLWHAVSQHRRQMQESSQ"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:270672", 
            "resource": "KEGG Pathway", 
            "id": "mmu:270672", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AQW0#function", 
            "annotation": "May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AQW0#function", 
                    "id": "A2AQW0", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6ZN16-1", 
            "protein_name": "Mitogen-activated protein kinase kinase kinase 15", 
            "sequence": {
                "length": 1313, 
                "sequence": "MESGGGNAPAGALGAASESPQCPPPPGVEGAAGPAEPDGAAEGAAGGSGEGESGGGPRRALRAVYVRSESSQGGAAGGPEAGARQCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDADVAVVDMSDVSRQPSLFYHLGVRESFDMANNVILYHDTDADTALSLKDMVTQKNTASSGNYYFIPYIVTPCADYFCCESDAQRRASEYMQPNWDNILGPLCMPLVDRFISLLKDIHVTSCVYYKETLLNDIRKAREKYQGEELAKELARIKLRMDNTEVLTSDIIINLLLSYRDIQDYDAMVKLVETLEMLPTCDLADQHNIKFHYAFALNRRNSTGDREKALQIMLQVLQSCDHPGPDMFCLCGRIYKDIFLDSDCKDDTSRDSAIEWYRKGFELQSSLYSGINLAVLLIVAGQQFETSLELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFSVSMLAHDVGKAVQAAERLFKLKPPVWYLRSLVQNLLLIRRFKKTIIEHSPRQERLNFWLDIIFEATNEVTNGLRFPVLVIEPTKVYQPSYVSINNEAEERTVSLWHVSPTEMKQMHEWNFTASSIKGISLSKFDERCCFLYVHDNSDDFQIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDTLEYEYDHDANGERVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSVSPDSDAQPDALFERTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQGLFLLRKDSERRAILYKILWEEQNQVASNLQECVAQSSEELHLSVGHIKQIIGILRDFIRSPEHRVMATTISKLKVDLDFDSSSISQIHLVLFGFQDAVNKILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELRAHFEPTCETEGVDKDMDEAEEGYPPATGPGQEAQPHQQHLSLQLGELRQETNRLLEHLVEKEREYQNLLRQTLEQKTQELYHLQLKLKSNCITENPAGPYGQRTDKELIDWLRLQGADAKTIEKIVEEGYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQEASETKDKA"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/50401", 
                    "id": "50401", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A2AQW0/", 
                    "id": "A2AQW0", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "MAP3K15", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156557.2", 
        "ac": "NP_001156557.2", 
        "name": "mitogen-activated protein kinase kinase kinase 15", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQW0", 
                                "id": "A2AQW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein kinase activity", 
                        "id": "GO:0004672"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004709", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQW0", 
                                "id": "A2AQW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "MAP kinase kinase kinase activity", 
                        "id": "GO:0004709"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQW0", 
                                "id": "A2AQW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ATP binding", 
                        "id": "GO:0005524"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQW0", 
                                "id": "A2AQW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "metal ion binding", 
                        "id": "GO:0046872"
                    }
                ], 
                "total": 4, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000186", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQW0", 
                                "id": "A2AQW0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "activation of MAPKK activity", 
                        "id": "GO:0000186"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AQW0", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "BC031147; MEKK15"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AQW0", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Map3k15"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AQW0", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Map3k15"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031303", 
            "id": "ENSMUSG00000031303", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/270672", 
            "id": "270672", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", 
            "id": "IPR000719", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", 
            "id": "IPR008271", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", 
            "id": "IPR011009", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", 
            "id": "IPR013761", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", 
            "id": "IPR017441", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR025136", 
            "id": "IPR025136", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR043969", 
            "id": "IPR043969", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:270672", 
            "id": "mmu:270672", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2448588", 
            "id": "2448588", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/PRMDIAC/", 
            "id": "PRMDIAC", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=226722at2759", 
            "id": "226722at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00069", 
            "id": "PF00069", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF13281", 
            "id": "PF13281", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF19039", 
            "id": "PF19039", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A2AQW0", 
            "id": "PR_A2AQW0", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156557.2", 
            "id": "NP_001156557.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AQW0", 
            "id": "A2AQW0", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 149327.0, 
        "chemical_mass": 149327.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AQW0", 
            "name": "Map3k15", 
            "locus": {
                "end_pos": 160123351, 
                "strand": "+", 
                "start_pos": 159988433, 
                "chromosome": "X", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000031303", 
                        "id": "ENSMUSG00000031303", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AQW0#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "2.7.11.25"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AQW0#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "MAPK/ERK kinase kinase 15"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AQW0", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "MEK kinase 15; MAPK/ERK kinase kinase 15"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AQW0#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "MEK kinase 15"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AQW0#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "MEKK 15"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AQW0#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Mitogen-activated protein kinase kinase kinase 15"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AQW0", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "mitogen-activated protein kinase kinase kinase 15"
        }
    ]
}