{ "uniprot_canonical_ac": "A2AQ92-1", "ptm_annotation": [], "sequence": { "header": "tr|A2AQ92-1|A2AQ92_MOUSE Isoform 1 of NAD(P)H oxidase (H(2)O(2)-forming) OS=Mus musculus OX=10090 GN=Duox1 PE=3 SV=1 CANONICAL=A2AQ92-1", "length": 1551, "sequence": "MGFHLALAWILLVGTLASLGAQNSISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLKEPYLPNPRHLSNRVMRGSAGQPSLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIYIPHGDPVFDPDKRGNVVLPFQRSRWDRNTGQSPSNPRDQSNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPSDSQSSLLMWMAPDPSTGQGGPRGVYAFGAQRGNREPFLQALGLLWFRYHNLCARKLAQEHPHWGDEELFQHARKRVIATYQNIAMYEWLPSFLKQTPPEYPGYRPFLDPSISPEFVVASEQFLSTMVPSGVYMRNASCHFQGIPSHNSSVSGALRVCNSYWSREHPKLQRAEDVDALLLGMASQIAEREDHVVVEDMQDFWPGPLKFSRTDYLASCLQRGRDLGLPSYTKAREALGLSPISHWQDINPALSRSNGTVLEATAALYNQDLSRLELLPGGLLESHGDPGPLFSTIVLDQFVRLRDGDRYWFENTRNGLFSKEEIAEIRNTSLRDILVAVTNVDPSALQPNVFFWLAGDPCPQPSQLSAKGLPACAPLFIRDYFEGSGFGFGLTIGTLCCFPLVSLLSAWIVARLRKRNFKRLQRQDRQSIMSEKLVGGVEALEWQGRNEPCRPVLVHLQPGQIRVVDGRLTVLRTIQLRPPQQVNLILSSNRGRRTLLLKIPKEYDLVLLFNMEEERQALVENVRGALKENGLSFQEWELREQELMRAAVTRQQRGHLLETFFRHLFSQVLDINQADAGTLPLDSSTKVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGVEVPEVIKNLCRRASYISQEKICPSPRMSAHCARNNMKTASSPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSRRHQTVQQFKRFIENYRRHIGCVAVFYTITGALFLERAYYYAFAAHHSGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRLIASTAIILTVLHSAGHVVNVYLFSISPLSVLSCLFPGLFHDDGSEFPQKYYWWFFQTVPGLTGVLLLLALAIMYVFASHHFRRRSFRGFWLTHHLYIFLYILLIIHGSFALIQMPRFHIFFLVPAIIYVGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSPPTGDTCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDRQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF" }, "uniprot_id": "A2AQ92_MOUSE", "enzyme_annotation": [ { "ec": "1.6.3.1", "activity": "" }, { "ec": "1.6.3.1", "activity": "NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2)." } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AQ92", "id": "A2AQ92", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17643428", "type": [ "PubMed" ], "id": "17643428" } ], "title": "Duox1 is the main source of hydrogen peroxide in the rat thyroid cell line PCCl3.", "journal": "Experimental cell research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "id": "NP_001092767.1", "database": "RefSeq" } ], "authors": "Rigutto S, Hoste C, Dumont JE, Corvilain B, Miot F, De Deken X", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19005069", "type": [ "PubMed" ], "id": "19005069" } ], "title": "Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "id": "NP_001092767.1", "database": "RefSeq" } ], "authors": "Cheret C, Gervais A, Lelli A, Colin C, Amar L, Ravassard P, Mallet J, Cumano A, Krause KH, Mallat M", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20233719", "type": [ "PubMed" ], "id": "20233719" } ], "title": "Mammalian numb-interacting protein 1/dual oxidase maturation factor 1 directs neuronal fate in stem cells.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "id": "NP_001092767.1", "database": "RefSeq" } ], "authors": "Kennedy KA, Ostrakhovitch EA, Sandiford SD, Dayarathna T, Xie X, Waese EY, Chang WY, Feng Q, Skerjanc IS, Stanford WL, Li SS", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27650496", "type": [ "PubMed" ], "id": "27650496" } ], "title": "The NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "id": "NP_001092767.1", "database": "RefSeq" } ], "authors": "Heppner DE, Hristova M, Dustin CM, Danyal K, Habibovic A, van der Vliet A", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28337995", "type": [ "PubMed" ], "id": "28337995" } ], "title": "Cigarette Smoke Impairs A2A Adenosine Receptor Mediated Wound Repair through Up-regulation of Duox-1 Expression.", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "id": "NP_001092767.1", "database": "RefSeq" } ], "authors": "Tian Z, Zhang H, Dixon J, Traphagen N, Wyatt TA, Kharbanda K, Simet Chadwick S, Kolliputi N, Allen-Gipson DS", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28982074", "type": [ "PubMed" ], "id": "28982074" } ], "title": "Autophagy regulates DUOX1 localization and superoxide production in airway epithelial cells during chronic IL-13 stimulation.", "journal": "Redox biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "id": "NP_001092767.1", "database": "RefSeq" } ], "authors": "Dickinson JD, Sweeter JM, Warren KJ, Ahmad IM, De Deken X, Zimmerman MC, Brody SL", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30559322", "type": [ "PubMed" ], "id": "30559322" } ], "title": "Duox1 Regulates Primary B Cell Function under the Influence of IL-4 through BCR-Mediated Generation of Hydrogen Peroxide.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "id": "NP_001092767.1", "database": "RefSeq" } ], "authors": "Sugamata R, Donko A, Murakami Y, Boudreau HE, Qi CF, Kwon J, Leto TL", "date": "2019" } ], "uniprot_ac": "A2AQ92", "site_annotation": [ { "end_pos": 1482, "annotation": "n_glycosylation_sequon", "start_pos": 1480 }, { "end_pos": 344, "annotation": "n_glycosylation_sequon", "start_pos": 342 }, { "end_pos": 356, "annotation": "n_glycosylation_sequon", "start_pos": 354 }, { "end_pos": 463, "annotation": "n_glycosylation_sequon", "start_pos": 461 }, { "end_pos": 536, "annotation": "n_glycosylation_sequon", "start_pos": 534 }, { "end_pos": 96, "annotation": "n_glycosylation_sequon", "start_pos": 94 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AQ92#A2AQ92-1", "isoform_ac": "A2AQ92-1", "locus": { "end_pos": 122315703, "strand": "-", "start_pos": 122347389, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000099461", "id": "ENSMUST00000099461", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000097060", "id": "ENSMUSP00000097060", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AQ92-1|A2AQ92_MOUSE Isoform 1 of NAD(P)H oxidase (H(2)O(2)-forming) OS=Mus musculus OX=10090 GN=Duox1 PE=3 SV=1 CANONICAL=A2AQ92-1", "length": 1551, "sequence": "MGFHLALAWILLVGTLASLGAQNSISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLKEPYLPNPRHLSNRVMRGSAGQPSLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIYIPHGDPVFDPDKRGNVVLPFQRSRWDRNTGQSPSNPRDQSNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPSDSQSSLLMWMAPDPSTGQGGPRGVYAFGAQRGNREPFLQALGLLWFRYHNLCARKLAQEHPHWGDEELFQHARKRVIATYQNIAMYEWLPSFLKQTPPEYPGYRPFLDPSISPEFVVASEQFLSTMVPSGVYMRNASCHFQGIPSHNSSVSGALRVCNSYWSREHPKLQRAEDVDALLLGMASQIAEREDHVVVEDMQDFWPGPLKFSRTDYLASCLQRGRDLGLPSYTKAREALGLSPISHWQDINPALSRSNGTVLEATAALYNQDLSRLELLPGGLLESHGDPGPLFSTIVLDQFVRLRDGDRYWFENTRNGLFSKEEIAEIRNTSLRDILVAVTNVDPSALQPNVFFWLAGDPCPQPSQLSAKGLPACAPLFIRDYFEGSGFGFGLTIGTLCCFPLVSLLSAWIVARLRKRNFKRLQRQDRQSIMSEKLVGGVEALEWQGRNEPCRPVLVHLQPGQIRVVDGRLTVLRTIQLRPPQQVNLILSSNRGRRTLLLKIPKEYDLVLLFNMEEERQALVENVRGALKENGLSFQEWELREQELMRAAVTRQQRGHLLETFFRHLFSQVLDINQADAGTLPLDSSTKVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGVEVPEVIKNLCRRASYISQEKICPSPRMSAHCARNNMKTASSPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSRRHQTVQQFKRFIENYRRHIGCVAVFYTITGALFLERAYYYAFAAHHSGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRLIASTAIILTVLHSAGHVVNVYLFSISPLSVLSCLFPGLFHDDGSEFPQKYYWWFFQTVPGLTGVLLLLALAIMYVFASHHFRRRSFRGFWLTHHLYIFLYILLIIHGSFALIQMPRFHIFFLVPAIIYVGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSPPTGDTCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDRQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:99439", "resource": "KEGG Pathway", "id": "mmu:99439", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-209968", "resource": "Reactome", "id": "R-MMU-209968", "name": "Thyroxine biosynthesis" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "annotation": "Cigarette smoke impairs A2A adenosine receptor mediated wound repair through up-regulation of Duox-1 expression. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "id": "NP_001092767.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "annotation": "Duox1 is the main source of H(2)O(2) in the rat thyroid cell line PCCl3.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "id": "NP_001092767.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AQ92#function", "annotation": "Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AQ92#function", "id": "A2AQ92", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "annotation": "Reactive Oxygen Species levels were elevated and DUOX1 expression was increased 70-fold in OVA-allergen challenged lungs.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "id": "NP_001092767.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "annotation": "Redox-dependent regulation of EGFR activation in airway epithelial cells was found to strongly depend on activation of either DUOX1 or NOX2.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "id": "NP_001092767.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "annotation": "This study shows that Duox1 regulates primary B cell function under the influence of IL-4 through BCR-mediated generation of hydrogen peroxide", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "id": "NP_001092767.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q8CIY2-1", "protein_name": "Dual oxidase 1", "sequence": { "length": 1551, "sequence": "MAVYSAVAWILLFGVLASLGAQNPVSWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLREPYLPNPRHLSNRVMRGPAGQPSLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIYIPRGDPVFDPDKRGNVVLPFQRSRWDRSTGQSPSNPRDLTNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPRNSQNSLLMWMAPDPATGQGGPQGLYAFGAQRGNREPFLQALGLLWFRYHNLCAKRLAQEHPHWGDEELFQHARKRVIATYQNIAMYEWLPSFLKQTPPEYPGYHPFLDPSISPEFVVASEQFLSTMVPPGVYMRNASCHFQGIANRNSSVSGALRVCNSYWSRENPKLQRAEDVDALLLGMASQIAEREDHLVVEDVQDFWPGPLKFSRTDYLASCLQRGRDLGLPSYTKAREALGLPPVSHWQDINPALSRSNGTVLEATAALYNQDLSRLELLAGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENNRNGLFSKEEIAEIRNTSLRDILVAVTNVDPSALQPSVFFWLAGDPCPQPSQLSTQGLPACAPLFVRDYFKGSGFGFGLTIGTLCCFPLVSLLSAWIVARLRMRNFKRLQRQDRQSIMCEKLVGGVEALEWQGRKEPCRPVLVHLQPGQIRVVDGRLTVLRTIQLRPPQQVNLILSSNRGRRTLLLKIPKEYDLVLLFNMEEERQALVENIRAALKENGLSFQEWELREQELMRAAVTRQQRGHLLETFFRHLFSQVLDINQADAGTLPLDSSTKVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKDQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGVEVPEVIKNLCRRASYISQEKICPSPRMSAHCARNNTKTASSPQRLQCPVDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSRRHQTVQQFKRFIENYRRHIGCVAVFYTITGALFLERAYYYAFAAHHSGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRFIASTAIILTVLHSAGHVVNVYLFSISPLSVLSCLFPDLFHDDGSEFPQKYYWWFFQTVPGLTGVLLLLALAIMYVFASHHFRRRSFRGFWLTHHLYIFLYILLIIHGSFALIQMPRFHIFFLVPAIIYVGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSPPTGDTCARYPKLYLDGPFGEGHQEWHKFEVSVLVGAGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDSRDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSVTHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINKQDRTHFSHHYENF" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/68136", "id": "68136", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Duox1", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9NRD9-1", "protein_name": "Dual oxidase 1", "sequence": { "length": 1551, "sequence": "MGFCLALAWTLLVGAWTPLGAQNPISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLGEPHLPNPRDLSNTISRGPAGLASLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDPANQVTGWLDGSAIYGSSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATAALYNQDLSWLELLPGGLLESHRDPGPLFSTIVLEQFVRLRDGDRYWFENTRNGLFSKKEIEEIRNTTLQDVLVAVINIDPSALQPNVFVWHKGDPCPQPRQLSTEGLPACAPSVVRDYFEGSGFGFGVTIGTLCCFPLVSLLSAWIVARLRMRNFKRLQGQDRQSIVSEKLVGGMEALEWQGHKEPCRPVLVYLQPGQIRVVDGRLTVLRTIQLQPPQKVNFVLSSNRGRRTLLLKIPKEYDLVLLFNLEEERQALVENLRGALKESGLSIQEWELREQELMRAAVTREQRRHLLETFFRHLFSQVLDINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHNSELRFTQLCVKGVEVPEVIKDLCRRASYISQDMICPSPRVSARCSRSDIETELTPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSCLHQTVQQFKRFIENYRRHIGCVAVFYAIAGGLFLERAYYYAFAAHHTGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRLIASTAIVLTVLHSVGHVVNVYLFSISPLSVLSCLFPGLFHDDGSELPQKYYWWFFQTVPGLTGVVLLLILAIMYVFASHHFRRRSFRGFWLTHHLYILLYVLLIIHGSFALIQLPRFHIFFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTGDRCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVEENDHQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AQ92/", "id": "A2AQ92", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/68136", "id": "68136", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "DUOX1", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092767.1", "ac": "NP_001092767.1", "name": "dual oxidase 1 precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016175", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AQ92", "id": "A2AQ92", "database": "UniProtKB" } ], "name": "superoxide-generating NADPH oxidase activity", "id": "GO:0016175" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AQ92", "id": "A2AQ92", "database": "UniProtKB" } ], "name": "calcium ion binding", "id": "GO:0005509" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AQ92", "id": "A2AQ92", "database": "UniProtKB" } ], "name": "heme binding", "id": "GO:0020037" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016174", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AQ92", "id": "A2AQ92", "database": "UniProtKB" } ], "name": "NAD(P)H oxidase (H(2)O(2)-forming activity", "id": "GO:0016174" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004601", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AQ92", "id": "A2AQ92", "database": "UniProtKB" } ], "name": "peroxidase activity", "id": "GO:0004601" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043020", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AQ92", "id": "A2AQ92", "database": "UniProtKB" } ], "name": "NADPH oxidase complex", "id": "GO:0043020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "20233719", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AQ92", "id": "A2AQ92", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AQ92", "id": "A2AQ92", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AQ92", "id": "A2AQ92", "database": "UniProtKB" } ], "name": "cell surface", "id": "GO:0009986" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031252", 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