{ "uniprot_canonical_ac": "A2APV2-1", "ptm_annotation": [], "sequence": { "header": "sp|A2APV2-1|FMNL2_MOUSE Isoform 1 of Formin-like protein 2 OS=Mus musculus OX=10090 GN=Fmnl2 PE=1 SV=2 CANONICAL=A2APV2-1", "length": 1086, "sequence": "MGNAGSMDSQQTDFKAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTMESTVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVMASGTLSTGSELAVGNYVGSVPGATTSGPSVPPPPPLPPSSDTSEAAQNGTASPPMSPPPPPPPPPPPPPPPPPPLPGPAAETSPAPPLPPPPPPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKITQKASSKVTLLEANRAKNLAITLRKAGKSADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLLQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFLLHNEGKLKKLQEDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDAKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITALKKNNITKFPNVHSRVRISSSTPVVEDTQS" }, "uniprot_id": "FMNL2_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APV2", "id": "A2APV2", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": [ "PubMed" ], "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "id": "NP_765997.2", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16490788", "type": [ "PubMed" ], "id": "16490788" } ], "title": "Formins regulate actin filament flexibility through long range allosteric interactions.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "id": "NP_765997.2", "database": "RefSeq" } ], "authors": "Bugyi B, Papp G, Hild G, Lorinczy D, Nevalainen EM, Lappalainen P, Somogyi B, Nyitrai M", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22608513", "type": [ "PubMed" ], "id": "22608513" } ], "title": "FMNL2 drives actin-based protrusion and migration downstream of Cdc42.", "journal": "Current biology : CB", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "id": "NP_765997.2", "database": "RefSeq" } ], "authors": "Block J, Breitsprecher D, Kuhn S, Winterhoff M, Kage F, Geffers R, Duwe P, Rohn JL, Baum B, Brakebusch C, Geyer M, Stradal TE, Faix J, Rottner K", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24430873", "type": [ "PubMed" ], "id": "24430873" } ], "title": "Critical roles for multiple formins during cardiac myofibril development and repair.", "journal": "Molecular biology of the cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "id": "NP_765997.2", "database": "RefSeq" } ], "authors": "Rosado M, Barber CF, Berciu C, Feldman S, Birren SJ, Nicastro D, Goode BL", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26272686", "type": [ "PubMed" ], "id": "26272686" } ], "title": "Expression of multiple formins in adult tissues and during developmental stages of mouse brain.", "journal": "Gene expression patterns : GEP", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "id": "NP_765997.2", "database": "RefSeq" } ], "authors": "Dutta P, Maiti S", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28327544", "type": [ "PubMed" ], "id": "28327544" } ], "title": "FMNL formins boost lamellipodial force generation.", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "id": "NP_765997.2", "database": "RefSeq" } ], "authors": "Kage F, Winterhoff M, Dimchev V, Mueller J, Thalheim T, Freise A, Bruhmann S, Kollasser J, Block J, Dimchev G, Geyer M, Schnittler HJ, Brakebusch C, Stradal TE, Carlier MF, Sixt M, Kas J, Faix J, Rottner K", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28852060", "type": [ "PubMed" ], "id": "28852060" } ], "title": "FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42.", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "id": "NP_765997.2", "database": "RefSeq" } ], "authors": "Kage F, Steffen A, Ellinger A, Ranftler C, Gehre C, Brakebusch C, Pavelka M, Stradal T, Rottner K", "date": "2017" } ], "uniprot_ac": "A2APV2", "site_annotation": [ { "end_pos": 1063, "annotation": "n_glycosylation_sequon", "start_pos": 1061 }, { "end_pos": 403, "annotation": "n_glycosylation_sequon", "start_pos": 401 }, { "end_pos": 547, "annotation": "n_glycosylation_sequon", "start_pos": 545 }, { "end_pos": 641, "annotation": "n_glycosylation_sequon", "start_pos": 639 }, { "end_pos": 762, "annotation": "n_glycosylation_sequon", "start_pos": 760 }, { "end_pos": 791, "annotation": "n_glycosylation_sequon", "start_pos": 789 }, { "end_pos": 834, "annotation": "n_glycosylation_sequon", "start_pos": 832 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2APV2#A2APV2-1", "isoform_ac": "A2APV2-1", "locus": { "end_pos": 52858143, "strand": "-", "start_pos": 53130505, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000127122", "id": "ENSMUST00000127122", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000118658", "id": "ENSMUSP00000118658", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2APV2-1|FMNL2_MOUSE Isoform 1 of Formin-like protein 2 OS=Mus musculus OX=10090 GN=Fmnl2 PE=1 SV=2 CANONICAL=A2APV2-1", "length": 1086, "sequence": "MGNAGSMDSQQTDFKAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTMESTVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVMASGTLSTGSELAVGNYVGSVPGATTSGPSVPPPPPLPPSSDTSEAAQNGTASPPMSPPPPPPPPPPPPPPPPPPLPGPAAETSPAPPLPPPPPPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKITQKASSKVTLLEANRAKNLAITLRKAGKSADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLLQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFLLHNEGKLKKLQEDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDAKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITALKKNNITKFPNVHSRVRISSSTPVVEDTQS" } }, { "url": "https://www.uniprot.org/uniprot/A2APV2#A2APV2-2", "isoform_ac": "A2APV2-2", "locus": {}, "sequence": { "header": "sp|A2APV2-2|FMNL2_MOUSE Isoform 2 of Formin-like protein 2 OS=Mus musculus OX=10090 GN=Fmnl2 PE=1 SV=2 CANONICAL=A2APV2-1", "length": 1032, "sequence": "MGNAGSMDSQQTDFKAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTMESTVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVMASGTLSTGSELAVGNYVGSVPGATTSGPSVPPPPPLPPSSDTSEAAQNGTASPPMSPPPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKITQKASSKVTLLEANRAKNLAITLRKAGKSADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLLQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFLLHNEGKLKKLQEDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDAKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITVLETNPTDEPMR" } }, { "url": "https://www.uniprot.org/uniprot/A2APV2#A2APV2-3", "isoform_ac": "A2APV2-3", "locus": { "end_pos": 52858143, "strand": "-", "start_pos": 53131946, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000090952", "id": "ENSMUST00000090952", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000088472", "id": "ENSMUSP00000088472", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2APV2-3|FMNL2_MOUSE Isoform 3 of Formin-like protein 2 OS=Mus musculus OX=10090 GN=Fmnl2 PE=1 SV=2 CANONICAL=A2APV2-1", "length": 1091, "sequence": "MGNAGSMDSQQTDFKAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTMESTVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVMASGTLSTGSELAVGNYVGSVPGATTSGPSVPPPPPLPPSSDTSEAAQNGTASPPMSPPPPPPPPPPPPPPPPPPLPGPAAETSPAPPLPPPPPPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKITQKASSKVTLLEANRAKNLAITLRKAGKSADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLLQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFLLHNEGKLKKLQEDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDAKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITDLRNQPYRRADAVRRSVRRRFDDQNLRSVNGAEITM" } }, { "url": "https://www.uniprot.org/uniprot/A2APV2#A2AQW2-1", "isoform_ac": "A2AQW2-1", "locus": { "end_pos": 52858143, "strand": "-", "start_pos": 53128805, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000155586", "id": "ENSMUST00000155586", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000117822", "id": "ENSMUSP00000117822", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AQW2-1|FMNL2_MOUSE Computationally mapped isoform of Formin-like protein 2 OS=Mus musculus OX=10090 GN=Fmnl2 PE=1 SV=2 CANONICAL=A2APV2-1", "length": 1085, "sequence": "MGNAGSMDSQQTDFKAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTMESTVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVMASGTLSTGSELAVGNYVGSVPGATTSGPSVPPPPPLPPSSDTSEAAQNGTASPPMSPPPPPPPPPPPPPPPPPPLPGPAAETSPAPPLPPPPPPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKITQKASSKVTLLEANRAKNLAITLRKAGKSADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLLQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFLLHNEGKLKKLQEDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDAKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITVLKTVPFTARTAKRGSRFFCEPVLTEEYHY" } }, { "url": "https://www.uniprot.org/uniprot/A2APV2#E9PXE6-1", "isoform_ac": "E9PXE6-1", "locus": { "end_pos": 52858143, "strand": "-", "start_pos": 53131875, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000050719", "id": "ENSMUST00000050719", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000057084", "id": "ENSMUSP00000057084", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9PXE6-1|FMNL2_MOUSE Computationally mapped isoform of Formin-like protein 2 OS=Mus musculus OX=10090 GN=Fmnl2 PE=1 SV=2 CANONICAL=A2APV2-1", "length": 1034, "sequence": "MGNAGSMDSQQTDFKAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTMESTVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVMASGTLSTGSELAVGNYVGSVPGATTSGPSVPPPPPLPPSSDTSEAAQNGTASPPMSPPPPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKITQKASSKVTLLEANRAKNLAITLRKAGKSADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLLQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFLLHNEGKLKKLQEDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDAKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITEILETNPTDEPMR" } }, { "url": "https://www.uniprot.org/uniprot/A2APV2#F8VPR2-1", "isoform_ac": "F8VPR2-1", "locus": { "end_pos": 52858143, "strand": "-", "start_pos": 53131875, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000049483", "id": "ENSMUST00000049483", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000047260", "id": "ENSMUSP00000047260", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F8VPR2-1|FMNL2_MOUSE Computationally mapped isoform of Formin-like protein 2 OS=Mus musculus OX=10090 GN=Fmnl2 PE=1 SV=1 CANONICAL=A2APV2-1", "length": 1083, "sequence": "MGNAGSMDSQQTDFKAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTMESTVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVMASGTLSTGSELAVGNYVGSVPGATTSGPSVPPPPPLPPSSDTSEAAQNGTASPPMSPPPPPPPPPPPPPPPPPPLPGPAAETSPAPPLPPPPPPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKITQKASSKVTLLEANRAKNLAITLRKAGKSADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLLQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFLLHNEGKLKKLQEDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDAKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITALKKNNITKFPNVHSRILETNPTDEPMR" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71409", "resource": "KEGG Pathway", "id": "mmu:71409", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5663220", "resource": "Reactome", "id": "R-MMU-5663220", "name": "RHO GTPases Activate Formins" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "annotation": "FMNL1 and FMNL2 are required non-redundantly in the repair of damaged myofibrils.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "id": "NP_765997.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "annotation": "FMNL2 is a novel elongation factor of actin filaments that constitutes the first Cdc42 effector promoting cell migration and actin polymerization at the tips of lamellipodia.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "id": "NP_765997.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "annotation": "Force generation in lamellipodia strongly depends on FMNL formin activity. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "id": "NP_765997.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "annotation": "MDia1-FH2 has an effect on the conformation of actin filaments", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "id": "NP_765997.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "annotation": "Our data thus link FMNL2/3 formins to actin assembly-dependent functions of Cdc42 in anterograde transport through the Golgi apparatus. Erratum:[Sci Rep. 2019 Nov 26;9(1):18008. PMID: 31767955] Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "id": "NP_765997.2", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2APV2#function", "annotation": "Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APV2#function", "id": "A2APV2", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q96PY5-1", "protein_name": "Formin-like protein 2", "sequence": { "length": 1086, "sequence": "MGNAGSMDSQQTDFRAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTVESSVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITVLKTVPFTARTAKRGSRFFCEPVLTEEYHY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/70871", "id": "70871", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "FMNL2", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "ac": "NP_765997.2", "name": "formin-like protein 2", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APV2", "id": "A2APV2", "database": "UniProtKB" } ], "name": "actin filament binding", "id": "GO:0051015" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017048", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APV2", "id": "A2APV2", "database": "UniProtKB" } ], "name": "Rho GTPase binding", "id": "GO:0017048" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APV2", "id": "A2APV2", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APV2", "id": "A2APV2", "database": "UniProtKB" } ], "name": "cell migration", "id": "GO:0016477" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APV2", "id": "A2APV2", "database": "UniProtKB" } ], "name": "regulation of cell shape", "id": "GO:0008360" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APV2", "id": "A2APV2", "database": "UniProtKB" } ], "name": "cytoskeleton organization", "id": "GO:0007010" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030866", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APV2", "id": "A2APV2", "database": "UniProtKB" } ], "name": "cortical actin cytoskeleton organization", "id": "GO:0030866" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022604", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APV2", "id": "A2APV2", "database": "UniProtKB" } ], "name": "regulation of cell morphogenesis", "id": "GO:0022604" } ], "total": 5, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2APV2", "type": "synonym", "resource": "RefSeq", "name": "5430425K04Rik; m; Man" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2APV2", "type": "synonym", "resource": "RefSeq", "name": "Fmnl2" }, { "url": "https://www.uniprot.org/uniprot/A2APV2", "type": "recommended", "resource": "UniProtKB", "name": "Fmnl2" }, { "url": "https://www.uniprot.org/uniprot/A2APV2", "type": "synonym", "resource": "UniProtKB", "name": "Kiaa1902" }, { "url": "https://www.uniprot.org/uniprot/A2APV2", "type": "synonym", "resource": "UniProtKB", "name": "Man" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000036053", "id": "ENSMUSG00000036053", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/71409", "id": "71409", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2APV2*", "id": "A2APV2", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR010472", "id": "IPR010472", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR010473", "id": "IPR010473", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014768", "id": "IPR014768", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015425", "id": "IPR015425", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "id": "IPR016024", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027656", "id": "IPR027656", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR042201", "id": "IPR042201", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR043592", "id": "IPR043592", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71409", "id": "mmu:71409", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:1918659", "id": "1918659", "database": "MGI" }, { "url": "http://www.orthodb.org/?query=288325at2759", "id": "288325at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45857", "id": "PTHR45857", "database": "PANTHER" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45857:SF5", "id": "PTHR45857:SF5", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF02181", "id": "PF02181", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF06367", "id": "PF06367", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF06371", "id": "PF06371", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2APV2", "id": "PR_A2APV2", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5663220", "id": "R-MMU-5663220", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_765997.2", "id": "NP_765997.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2APV2", "id": "A2APV2", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APV2", "id": "A2APV2", "database": "UniProtKB" } ], "start_pos": "188", "end_pos": "188", "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 123101.0, "chemical_mass": 123101.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2APV2", "name": "Fmnl2", "locus": { "end_pos": 53133804, "strand": "+", "start_pos": 52857860, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000036053", "id": "ENSMUSG00000036053", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2APV2#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Formin-like protein 2" }, { "url": "https://www.uniprot.org/uniprot/A2APV2#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Protein Man" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2APV2", "type": "synonym", "resource": "RefSeq", "name": "formin-like domain containing protein MAN; protein Man" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2APV2", "type": "synonym", "resource": "RefSeq", "name": "formin-like protein 2" } ] }