{ "uniprot_canonical_ac": "A2AJ88-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AJ88-1|PLPL7_MOUSE Isoform 1 of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 1352, "sequence": "MQNEEDACLEAGYCLGTTLSSWRLHFMEEQSQSTMLMGIGIGALLTLAFVGITFFFVYRRVRRLRRAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSARAAVSSTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAGRAKRQMSYGPEEQLERSLRPSEFSSSDHGSSCVTVSGPLLKRSCSVPLPSNHGEVDELRQSQGSGSNTSAFQESHEGATSDLGMAYNRARILPHSDEQLGNSLASKSKKSVVAETPSAIFHYSENFRDETGACGKTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTLVSKQGDQDVNILFVVSGMLHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVKRMSSFVRQIDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSATGHQLGFNTASSKWDLGNPPGNLSTVAALPASEDVPLTAFALELQHALSAIGPVLLLTSDNIKQRLGSAALDSIHEYRLSSWLGQQEDIHRIVLYQADGTLTPWTQRCIRQADCILIVGLGEQEPAVGELEQMLESTAVRAQKQLILLHKEDGPVPSRTVEWLNMRSWCSGHLHLCCPRRVFSKRSLPKLVEMYTRVFQRPPDRHSDFSRLARMLTGNAIALVLGGGGARGCAQVGILRALAECGVPVDIIGGTSIGAFMGALFAEERSYSQTRIRAKQWAEGMTSMMKTILDLTYPITSMFSGTGFNSSISNIFKDRQIEDLWLPYFAITTDITASAMRVHTDGSLWRYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYRTLDFGKFDEICEVGYQHGRTVFDIWVRSGVLEKMLQDQQGTSKRKDCGVFTCPNSSFTDLAEIVSRIEPAKVAAVDDESDYQTEYEEELPAIPKETYADFQSTGIELDSDSEYEPSMLQGPPSLTSPEQSQDSFPWLPNQDDQGPRLEHPS" }, "uniprot_id": "PLPL7_MOUSE", "enzyme_annotation": [ { "ec": "3.1.1.-", "activity": "" }, { "ec": "3.1.1.5", "activity": "" }, { "ec": "3.1.1.5", "activity": "2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate." } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": [ "PubMed" ], "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12640454", "type": [ "PubMed" ], "id": "12640454" } ], "title": "Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity.", "journal": "Nature genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ], "authors": "Winrow CJ, Hemming ML, Allen DM, Quistad GB, Casida JE, Barlow C", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15226823", "type": [ "PubMed" ], "id": "15226823" } ], "title": "Genomic analysis of mouse retinal development.", "journal": "PLoS biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ], "authors": "Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "type": [ "PubMed" ], "id": "17242355" } ], "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18086666", "type": [ "PubMed" ], "id": "18086666" } ], "title": "Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ], "authors": "Lass A., Zechner R., Zimmermann R., Kohlwein S.D., Kienesberger P.C., Wolinski H., Preiss-Landl K.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18486363", "type": [ "PubMed" ], "id": "18486363" } ], "title": "Identification and characterization of a splice variant of the catalytic domain of mouse NTE-related esterase.", "journal": "Gene", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ], "authors": "Chang PA, Long DX, Sun Q, Wang Q, Bu YQ, Wu YJ", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22307796", "type": [ "PubMed" ], "id": "22307796" } ], "title": "Degradation of mouse NTE-related esterase by macroautophagy and the proteasome.", "journal": "Molecular biology reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ], "authors": "Chang PA, Chen YY, Long DX, Qin WZ, Mou XL", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22326266", "type": [ "PubMed" ], "id": "22326266" } ], "title": "Identification of two novel splicing variants of murine NTE-related esterase.", "journal": "Gene", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ], "authors": "Wang Z.X., Chang P.A., Long D.X., Wu Y.J., Qin W.Z., Wei C.Y.", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28887301", "type": [ "PubMed" ], "id": "28887301" } ], "title": "The phospholipase PNPLA7 functions as a lysophosphatidylcholine hydrolase and interacts with lipid droplets through its catalytic domain.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ], "authors": "Zechner R., Huang F., Xie H., Chang P.A., Heier C., Eichmann T.O., Kien B.", "date": "2017" } ], "uniprot_ac": "A2AJ88", "site_annotation": [ { "end_pos": 104, "annotation": "n_glycosylation_sequon", "start_pos": 102 }, { "end_pos": 1038, "annotation": "n_glycosylation_sequon", "start_pos": 1036 }, { "end_pos": 1257, "annotation": "n_glycosylation_sequon", "start_pos": 1255 }, { "end_pos": 403, "annotation": "n_glycosylation_sequon", "start_pos": 401 }, { "end_pos": 752, "annotation": "n_glycosylation_sequon", "start_pos": 750 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88#A0A0A6YWJ6-1", "isoform_ac": "A0A0A6YWJ6-1", "locus": { "end_pos": 24980082, "strand": "-", "start_pos": 24987191, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000137913", "id": "ENSMUST00000137913", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000141577", "id": "ENSMUSP00000141577", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0A6YWJ6-1|PLPL7_MOUSE Computationally mapped isoform of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 222, "sequence": "MEEQSQSTMLMGIGIGALLTLAFVGITFFFVYRRVRRLRRAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDAHRMAPKWWSKRSCQGTVSTVSSAFWM" } }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#A2AJ88-1", "isoform_ac": "A2AJ88-1", "locus": { "end_pos": 24976284, "strand": "-", "start_pos": 25053790, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000045295", "id": "ENSMUST00000045295", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000044078", "id": "ENSMUSP00000044078", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AJ88-1|PLPL7_MOUSE Isoform 1 of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 1352, "sequence": "MQNEEDACLEAGYCLGTTLSSWRLHFMEEQSQSTMLMGIGIGALLTLAFVGITFFFVYRRVRRLRRAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSARAAVSSTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAGRAKRQMSYGPEEQLERSLRPSEFSSSDHGSSCVTVSGPLLKRSCSVPLPSNHGEVDELRQSQGSGSNTSAFQESHEGATSDLGMAYNRARILPHSDEQLGNSLASKSKKSVVAETPSAIFHYSENFRDETGACGKTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTLVSKQGDQDVNILFVVSGMLHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVKRMSSFVRQIDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSATGHQLGFNTASSKWDLGNPPGNLSTVAALPASEDVPLTAFALELQHALSAIGPVLLLTSDNIKQRLGSAALDSIHEYRLSSWLGQQEDIHRIVLYQADGTLTPWTQRCIRQADCILIVGLGEQEPAVGELEQMLESTAVRAQKQLILLHKEDGPVPSRTVEWLNMRSWCSGHLHLCCPRRVFSKRSLPKLVEMYTRVFQRPPDRHSDFSRLARMLTGNAIALVLGGGGARGCAQVGILRALAECGVPVDIIGGTSIGAFMGALFAEERSYSQTRIRAKQWAEGMTSMMKTILDLTYPITSMFSGTGFNSSISNIFKDRQIEDLWLPYFAITTDITASAMRVHTDGSLWRYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYRTLDFGKFDEICEVGYQHGRTVFDIWVRSGVLEKMLQDQQGTSKRKDCGVFTCPNSSFTDLAEIVSRIEPAKVAAVDDESDYQTEYEEELPAIPKETYADFQSTGIELDSDSEYEPSMLQGPPSLTSPEQSQDSFPWLPNQDDQGPRLEHPS" } }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#A2AJ88-2", "isoform_ac": "A2AJ88-2", "locus": {}, "sequence": { "header": "sp|A2AJ88-2|PLPL7_MOUSE Isoform 2 of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 1326, "sequence": "MQNEEDACLEAGYCLGTTLSSWRLHFMEEQSQSTMLMGIGIGALLTLAFVGITFFFVYRRVRRLRRAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSARAAVSSTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAGRAKRQMSYGPEEQLERSLRPSEFSSSDHGSSCVTVSGPLLKRSCSVPLPSNHGEVDELRQSQGSGSNTSAFQESHEGATSDLGMAYNRARILPHSDEQLGNSLASKSKKSVVAETPSAIFHYSENFRDETGACGKTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTLVSKQGDQDVNILFVVSGMLHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVKRMSSFVRQIDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSATGHQLGFNTASSKWDLGNPPGNLSTVAALPASEDVPLTAFALELQHALSAIGPVLLLTSDNIKQRLGSAALDSIHEYRLSSWLGQQEDIHRIVLYQADGTLTPWTQRCIRQADCILIVGLGEQEPAVGELEQMLESTAVRAQKQLILLHKEDGPVPSRTVEWLNMRSWCSGHLHLCCPRRVFSKRSLPKLVEMYTRVFQRPPDRHSDFSRLARMLTGNAIALVLGGGGARGCAQVGILRALAECGVPVDIIGGTSIGAFMGALFAEERSYSQTRIRAKQWAEGMTSMMKTILDLTYPITSMFSGTGFNSSISNIFKDRQIEDLWLPYFAITTDITASAMRVHTDGSLWRYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYRTLDFGKFDEICEVGYQHGRTVFDIWVRSGVLEKMLQDQQGTSKRKDCGVFTCPNSSFTDLAEIVSRIEPAKVAAVDDESDYQTEYEEELPAIPKETYADFQSTGIELDSDSVRNMSLRCCKDPPA" } }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#A2AJ88-3", "isoform_ac": "A2AJ88-3", "locus": {}, "sequence": { "header": "sp|A2AJ88-3|PLPL7_MOUSE Isoform 3 of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 833, "sequence": "MQNEEDACLEAGYCLGTTLSSWRLHFMEEQSQSTMLMGIGIGALLTLAFVGITFFFVYRRVRRLRRAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSARAAVSSTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAGRAKRQMSYGPEEQLERSLRPSEFSSSDHGSSCVTVSGPLLKRSCSVPLPSNHGEVDELRQSQGSGSNTSAFQESHEGATSDLGMAYNRARILPHSDEQLGNSLASKSKKSVVAETPSAIFHYSENFRDETGACGKTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTLVSKQGDQDVNILFVVSGMLHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVKRMSSFVRQIDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSATGHQLGFNTASSKWDLGNPPGNLSTVAALPASEDVPLTAFALELQHALSAIASMSTGSPVGWASRRTSNGLCCIRQTAHSHRGPSAASGRLTASSSWAWVSKSQQ" } }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#B0R009-1", "isoform_ac": "B0R009-1", "locus": { "end_pos": 24979874, "strand": "-", "start_pos": 24981868, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000153618", "id": "ENSMUST00000153618", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000117428", "id": "ENSMUSP00000117428", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|B0R009-1|PLPL7_MOUSE Computationally mapped isoform of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 120, "sequence": "MPGLLSCLAGYCLGTTLSSWRLHFMEEQSQSTMLMGIGIGALLTLAFVGITFFFVYRRVRRLRRAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKR" } }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#B0R010-1", "isoform_ac": "B0R010-1", "locus": { "end_pos": 24980763, "strand": "-", "start_pos": 24995310, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000152777", "id": "ENSMUST00000152777", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122394", "id": "ENSMUSP00000122394", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|B0R010-1|PLPL7_MOUSE Computationally mapped isoform of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 179, "sequence": "MFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSA" } }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#B0R011-1", "isoform_ac": "B0R011-1", "locus": { "end_pos": 24996157, "strand": "-", "start_pos": 25010743, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000146153", "id": "ENSMUST00000146153", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000117907", "id": "ENSMUSP00000117907", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|B0R011-1|PLPL7_MOUSE Computationally mapped isoform of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 187, "sequence": "IIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAGRAKRQMSYGPEEQLERSLRPSEFSSSVPLPSNHGEVDELRQSQGSGSNTSAFQESHEGATSDLGMAYNRARILPHSDEQLGNSLASKSKKSVVAETPSAIFHYSENFRDETGACGKTDAIFRAATKDLLTLMKLDDPSLLDGRVA" } }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#F6UDU9-1", "isoform_ac": "F6UDU9-1", "locus": { "end_pos": 25051666, "strand": "-", "start_pos": 25053031, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000155601", "id": "ENSMUST00000155601", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000115952", "id": "ENSMUSP00000115952", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6UDU9-1|PLPL7_MOUSE Computationally mapped isoform of Patatin-like phospholipase domain-containing protein 7 OS=Mus musculus OX=10090 GN=Pnpla7 PE=1 SV=1 CANONICAL=A2AJ88-1", "length": 158, "sequence": "TDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYRTLDFGKFDEICEVGYQHGRTVFDIWVRSGVLEKMLQDQQGTSKRKDCGVFTCPNSSFTDLAEIVSRIEPAKVAAVDEQHVLQNSLLHVPS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:241274", "resource": "KEGG Pathway", "id": "mmu:241274", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "annotation": "A splice variant of the catalytic domain of mouse NRE (mNRECV) was identified in multiple adult tissues, including brain, kidney, liver and testis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#function", "annotation": "Lacks lysophospholipase activity.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88#function", "id": "A2AJ88", "database": "UniProtKB" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#function", "annotation": "Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine (PubMed:18086666, PubMed:28887301). Also can deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and lysophosphatidic acid (C16:0) (PubMed:22326266, PubMed:18086666, PubMed:28887301).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88#function", "id": "A2AJ88", "database": "UniProtKB" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#function", "annotation": "Lysophospholipase.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88#function", "id": "A2AJ88", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "annotation": "The transmembrane and regulatory domain played a role in the degradation of mouse NTE-related esterase by macroautophagy and the proteasome respectively.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "annotation": "There was a nutritional regulation of murine NTE-related esterase expression at the mRNA levels via alternative splicing.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q5BK26-1", "protein_name": "Patatin-like phospholipase domain-containing protein 7", "sequence": { "length": 1349, "sequence": "MQKEEDVCPEAGYCLGTALSSWGLHFMEEHSQSTMLMGIGIGVLLTLAFVGLAAFFVYRKVSRFRRAEPIPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTAAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSARAAVASTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAGRAKRQMSYGPEEQLERSPRLSEFNSSDQRSVAVSGPLLKRSCSVPLPPIHGEIDELRQAQGSGSNTSAFQESQEGATSDLGMAYNRARILPHSEEQLGSSLASKSKKSVVAETSAVFHYSEKPRDEPGPSGRTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTIVSKQGDQDVNILFVVSGMLHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVRRMSSFVRQIDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVEMLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSGTGHQLGFNTASSKWDLGNPPGNLSTVAAMPVSEDVPLTAFALELQHALSAIGPVLLLTSDNIKQRLGSAALDSIHEYRLSSWLGQQEDIHRIVLYQADSTLTPWTQRCIRQADCILIVGLGDQEPALGELEQMLESTAVRAQKQLILLHKEEGPAPSRTVEWLNMRSWCSGHLHLCCPRRVFSKRSLPKLVEMYTRIFQRPPDRHSDFSRLARILTGNAIALVLGGGGARGCAQVGILRALAECGIPVDIIGGTSIGAFMGALFAEERSYSQIRIRAKQWAEDMTSMVKTILDLTYPITSMFSGTGFNSSISNIFKDRQIEDLWLPYFAITTDITASAMRVHTDGALWRYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYRTLDFGKFDEICEVGYQHGPAGFDIWVRSGVLEKMLQDQQGTSKRMDCGVFTCPNSSFTDLAEIVSRIEPAKVAAVDDESDYQTEYEEELPAIPKETYADFQSTGIELDSDSECEPSMSQGPHSLTSPKQSQDSFPWLPNQDDQGPRLYRPS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/62431", "id": "62431", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Pnpla7", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q6ZV29-1", "protein_name": "Patatin-like phospholipase domain-containing protein 7", "sequence": { "length": 1317, "sequence": "MEEEKDDSPQLTGIAVGALLALALVGVLILFMFRRLRQFRQAQPTPQYRFRKRDKVMFYGRKIMRKVTTLPNTLVENTALPRQRARKRTKVLSLAKRILRFKKEYPALQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHIVFVQLQEGEHVFQPREPDPSICVVQDGRLEVCIQDTDGTEVVVKEVLAGDSVHSLLSILDIITGHAAPYKTVSVRAAIPSTILRLPAAAFHGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNAESQAIPLVSVASVAAGKAKKQVFYGEEERLKKPPRLQESCDSDHGGGRPAAAGPLLKRSHSVPAPSIRKQILEELEKPGAGDPDPSAPQGGPGSATSDLGMACDRARVFLHSDEHPGSSVASKSRKSVMVAEIPSTVSQHSESHTDETLASRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLHVPAGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIMRKQPTVVLGVAHTVVKRMSSFVRQIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGPVTGHQLGLPTEGSKWDLGNPAVNLSTVAVMPVSEEVPLTAFALELEHALSAIGPTLLLTSDNIKRRLGSAALDSVHEYRLSSWLGQQEDTHRIVLYQADGTLTPWTQRCVRQADCILIVGLGDQEPTVGELERMLESTAVRAQKQLILLHREEGPAPARTVEWLNMRSWCSGHLHLCCPRRVFSRRSLPKLVEMYKHVFQRPPDRHSDFSRLARVLTGNAIALVLGGGGARGCAQVGVLKALAECGIPVDMVGGTSIGAFVGALYSEERNYSQMRIRAKQWAEGMTSLMKAALDLTYPITSMFSGAGFNSSIFSVFKDQQIEDLWIPYFAITTDITASAMRVHTDGSLWWYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEVVKSSDYCEYLRPPIDSYSTLDFGKFNEICEVGYQHGRTVFDIWGRSGVLEKMLRDQQGPSKKPASAVLTCPNASFTDLAEIVSRIEPAKPAMVDDESDYQTEYEEELLDVPRDAYADFQSTSAQQGSDLEDESSLRHRHPSLAFPKLSEGSSDQDG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/62431", "id": "62431", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "PNPLA7", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "ac": "NP_666363.3", "name": "patatin-like phospholipase domain-containing protein 7", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004622", "pmid": "22326266", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "lysophospholipase activity", "id": "GO:0004622" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052689", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "carboxylic ester hydrolase activity", "id": "GO:0052689" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102545", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "phosphatidyl phospholipase B activity", "id": "GO:0102545" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "pmid": "22326266", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "pmid": "18086666", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "lipid droplet", "id": "GO:0005811" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "pmid": "28887301", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "lipid droplet", "id": "GO:0005811" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "pmid": "28887301", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034638", "pmid": "28887301", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "name": "phosphatidylcholine catabolic process", "id": "GO:0034638" } ], "total": 1, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AJ88", "type": "synonym", "resource": "RefSeq", "name": "BC027342; E430013P11Rik; N; Nre" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AJ88", "type": "synonym", "resource": "RefSeq", "name": "Pnpla7" }, { "url": "https://www.uniprot.org/uniprot/A2AJ88", "type": "recommended", "resource": "UniProtKB", "name": "Pnpla7" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000036833", "id": "ENSMUSG00000036833", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00038", "id": "cd00038", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3259499", "id": "CHEMBL3259499", "database": "ChEMBL" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/241274", "id": "241274", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000595", "id": "IPR000595", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002641", "id": "IPR002641", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014710", "id": "IPR014710", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016035", "id": "IPR016035", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018490", "id": "IPR018490", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:241274", "id": "mmu:241274", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2385325", "id": "2385325", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/YPKATAH/", "id": "YPKATAH", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=253518at2759", "id": "253518at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00027", "id": "PF00027", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF01734", "id": "PF01734", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2AJ88", "id": "PR_A2AJ88", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666363.3", "id": "NP_666363.3", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [], "recommended_name": { "id": "DOID:0050753", "url": "http://disease-ontology.org/term/DOID:0050753", "resource": "Disease Ontology", "name": "cerebellar ataxia", "description": "A hereditary ataxia that is characterized by ataxia originating in the cerebellum." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/0050753#disease-associations", "id": "0050753", "database": "Alliance of Genome Resources" } ] }, { "synonyms": [ { "id": "DOID:1289", "url": "http://disease-ontology.org/term/DOID:1289", "resource": "Disease Ontology", "name": "degenerative disease", "description": "" } ], "recommended_name": { "id": "DOID:1289", "url": "http://disease-ontology.org/term/DOID:1289", "resource": "Disease Ontology", "name": "neurodegenerative disease", "description": "A central nervous system disease that results in the progressive deterioration of function or structure of neurons." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/1289#disease-associations", "id": "1289", "database": "Alliance of Genome Resources" } ] }, { "synonyms": [ { "id": "DOID:1432", "url": "http://disease-ontology.org/term/DOID:1432", "resource": "Disease Ontology", "name": "vision impairment", "description": "" }, { "id": "DOID:1432", "url": "http://disease-ontology.org/term/DOID:1432", "resource": "Disease Ontology", "name": "vision loss", "description": "" }, { "id": "DOID:1432", "url": "http://disease-ontology.org/term/DOID:1432", "resource": "Disease Ontology", "name": "visual impairment", "description": "" } ], "recommended_name": { "id": "DOID:1432", "url": "http://disease-ontology.org/term/DOID:1432", "resource": "Disease Ontology", "name": "blindness", "description": "An eye disease characterized by a lack or loss of vision." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/1432#disease-associations", "id": "1432", "database": "Alliance of Genome Resources" } ] }, { "synonyms": [ { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "MASA syndrome", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "Gareis-Mason syndrome", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "L1 syndrome", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "Clasped thumb and mental retardation", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "intellectual disability-aphasia-shuffling gait-adducted thumbs syndrome", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "spastic paraplegia 1, X-linked", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "crash syndrome", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "X-linked spastic paraplegia 1", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "spastic paraplegia, X-linked", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "SPG1", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "X-linked corpus callosum agenesis", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "mental retardation, aphasia, shuffling Gait, and adducted thumbs", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "spastic paraplegia 1", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "thumb congenital clasped with mental retardation", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "X-linked complicated hereditary spastic paraplegia type 1", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "mental retardation aphasia shuffling Gait adducted thumbs (MASA)", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "adducted thumb with mental retardation", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "thumb, congenital Clasped, with mental retardation", "description": "" }, { "id": "MONDO:0010559", "url": "https://monarchinitiative.org/disease/MONDO:0010559", "resource": "MONDO", "name": "hereditary spastic paraplegia 1", "description": "" }, { "id": "DOID:2476", "url": "http://disease-ontology.org/term/DOID:2476", "resource": "Disease Ontology", "name": "French settlement disease", "description": "" }, { "id": "DOID:2476", "url": "http://disease-ontology.org/term/DOID:2476", "resource": "Disease Ontology", "name": "Strumpell-Lorrain disease", "description": "" }, { "id": "DOID:2476", "url": "http://disease-ontology.org/term/DOID:2476", "resource": "Disease Ontology", "name": "familial spastic paraplegia", "description": "" }, { "id": "DOID:2476", "url": "http://disease-ontology.org/term/DOID:2476", "resource": "Disease Ontology", "name": "hereditary spastic paraparesis", "description": "" } ], "recommended_name": { "id": "DOID:2476", "url": "http://disease-ontology.org/term/DOID:2476", "resource": "Disease Ontology", "name": "hereditary spastic paraplegia", "description": "A paraplegia that is characterized by progressive stiffness and contraction (spasticity) in the lower limbs." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/2476#disease-associations", "id": "2476", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [ { "residue": "Ser", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": "1280", "end_pos": "1280", "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "start_pos": "1280", "end_pos": "1280", "kinase_uniprot_canonical_ac": "" }, { "residue": "Thr", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "start_pos": "1284", "end_pos": "1284", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "id": "17242355", "database": "PubMed" } ], "start_pos": "341", "end_pos": "341", "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "start_pos": "341", "end_pos": "341", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "id": "A2AJ88", "database": "UniProtKB" } ], "start_pos": "379", "end_pos": "379", "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 150494.0, "chemical_mass": 150494.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88", "name": "Pnpla7", "locus": { "end_pos": 25054057, "strand": "+", "start_pos": 24976033, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000036833", "id": "ENSMUSG00000036833", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AJ88#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "3.1.1.-" }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "3.1.1.5" }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "NRE" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AJ88", "type": "synonym", "resource": "RefSeq", "name": "NTE-related esterase; neuropathy target esterase-related esterase" }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "NTE-related esterase" }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Neuropathy target esterase-related esterase" }, { "url": "https://www.uniprot.org/uniprot/A2AJ88#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Patatin-like phospholipase domain-containing protein 7" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AJ88", "type": "synonym", "resource": "RefSeq", "name": "patatin-like phospholipase domain-containing protein 7" } ] }