{ "uniprot_canonical_ac": "A2AHL1-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AHL1-1|ANO3_MOUSE Isoform 1 of Anoctamin-3 OS=Mus musculus OX=10090 GN=Ano3 PE=1 SV=1 CANONICAL=A2AHL1-1", "length": 981, "sequence": "MVHHSGSIQSFKQQKGMNISKSEITTEASLKPSRRSLPCLAQSYAHSKSLSQSASLFQSTESESQAPTSVTFLSADKPEHVTSEESRKDSTLKCSFADLSDFCLALGKDKDYLDESEHANYDRSRLLNDFVTKDKPASKTKLSKNDMSYIASSGLLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAIANPDIMFIKIHIPWDTLCKYAERLNIRVPFRKKCYYTDQKNKSKSRVQNYFKRIKKWMSQNPMVLDKSAFPELEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLITNGSYIAAFPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRMYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEVINPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFVKQHWQFATSGAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVKQNENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQEMMYEAELEHLQQQRRKSGQPIHHEWP" }, "uniprot_id": "ANO3_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "predicted.uniprotkb_gly" ], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18729231", "type": [ "PubMed" ], "id": "18729231" } ], "title": "Expression of TMEM16 paralogs during murine embryogenesis.", "journal": "Dev. Dyn.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121575.1", "id": "NP_001121575.1", "database": "RefSeq" } ], "authors": "Harfe B.D., Rock J.R.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19059364", "type": [ "PubMed" ], "id": "19059364" } ], "title": "Expression patterns of the Tmem16 gene family during cephalic development in the mouse.", "journal": "Gene expression patterns : GEP", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121575.1", "id": "NP_001121575.1", "database": "RefSeq" } ], "authors": "Gritli-Linde A, Vaziri Sani F, Rock JR, Hallberg K, Iribarne D, Harfe BD, Linde A", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20056604", "type": [ "PubMed" ], "id": "20056604" } ], "title": "Expression and function of epithelial anoctamins.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "authors": "Kunzelmann K., Schreiber R., Kongsuphol P., Martins J.R., Mirza M., Uliyakina I., Warth R.", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22302790", "type": [ "PubMed" ], "id": "22302790" } ], "title": "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age.", "journal": "Exp. Physiol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "authors": "Gray M.A., Winpenny J.P.", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23532839", "type": [ "PubMed" ], "id": "23532839" } ], "title": "Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "authors": "Nagata S., Suzuki J., Fujii T., Ishihara K., Imao T., Kuba H.", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23872594", "type": [ "PubMed" ], "id": "23872594" } ], "title": "TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing.", "journal": "Nat. Neurosci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "authors": "Wang X., Huang F., Huang B., Jan Y.N., Basbaum A.I., Jan L.Y., Ostertag E.M., Nuwal T.", "date": "2013" } ], "uniprot_ac": "A2AHL1", "site_annotation": [ { "end_pos": 20, "annotation": "n_glycosylation_sequon", "start_pos": 18 }, { "end_pos": 243, "annotation": "n_glycosylation_sequon", "start_pos": 241 }, { "end_pos": 304, "annotation": "n_glycosylation_sequon", "start_pos": 302 }, { "end_pos": 335, "annotation": "n_glycosylation_sequon", "start_pos": 333 }, { "end_pos": 427, "annotation": "n_glycosylation_sequon", "start_pos": 425 }, { "end_pos": 450, "annotation": "n_glycosylation_sequon", "start_pos": 448 }, { "end_pos": 457, "annotation": "n_glycosylation_sequon", "start_pos": 455 }, { "end_pos": 652, "annotation": "n_glycosylation_sequon", "start_pos": 650 }, { "end_pos": 868, "annotation": "n_glycosylation_sequon", "start_pos": 866 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1#A2AHK9-1", "isoform_ac": "A2AHK9-1", "locus": { "end_pos": 110713278, "strand": "+", "start_pos": 110761564, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000140777", "id": "ENSMUST00000140777", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122387", "id": "ENSMUSP00000122387", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AHK9-1|ANO3_MOUSE Computationally mapped isoform of Anoctamin-3 OS=Mus musculus OX=10090 GN=Ano3 PE=1 SV=1 CANONICAL=A2AHL1-1", "length": 181, "sequence": "GAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRMYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWAPGRICRSPFHTCCGLFETQDMNTSNIPQDPWLLIGQHMKEPV" } }, { "url": "https://www.uniprot.org/uniprot/A2AHL1#A2AHL1-1", "isoform_ac": "A2AHL1-1", "locus": { "end_pos": 110658143, "strand": "+", "start_pos": 110950103, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000099623", "id": "ENSMUST00000099623", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000097219", "id": "ENSMUSP00000097219", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AHL1-1|ANO3_MOUSE Isoform 1 of Anoctamin-3 OS=Mus musculus OX=10090 GN=Ano3 PE=1 SV=1 CANONICAL=A2AHL1-1", "length": 981, "sequence": "MVHHSGSIQSFKQQKGMNISKSEITTEASLKPSRRSLPCLAQSYAHSKSLSQSASLFQSTESESQAPTSVTFLSADKPEHVTSEESRKDSTLKCSFADLSDFCLALGKDKDYLDESEHANYDRSRLLNDFVTKDKPASKTKLSKNDMSYIASSGLLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAIANPDIMFIKIHIPWDTLCKYAERLNIRVPFRKKCYYTDQKNKSKSRVQNYFKRIKKWMSQNPMVLDKSAFPELEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLITNGSYIAAFPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRMYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEVINPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFVKQHWQFATSGAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVKQNENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQEMMYEAELEHLQQQRRKSGQPIHHEWP" } }, { "url": "https://www.uniprot.org/uniprot/A2AHL1#A2AHL1-2", "isoform_ac": "A2AHL1-2", "locus": {}, "sequence": { "header": "sp|A2AHL1-2|ANO3_MOUSE Isoform 2 of Anoctamin-3 OS=Mus musculus OX=10090 GN=Ano3 PE=1 SV=1 CANONICAL=A2AHL1-1", "length": 637, "sequence": "MVHHSGSIQSFKQQKGMNISKSEITTEASLKPSRRSLPCLAQSYAHSKSLSQSASLFQSTESESQAPTSVTFLSADKPEHVTSEESRKDSTLKCSFADLSDFCLALGKDKDYLDESEHANYDRSRLLNDFVTKDKPASKTKLSKNDMSYIASSGLLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAIANPDIMFIKIHIPWDTLCKYAERLNIRVPFRKKCYYTDQKNKSKSRVQNYFKRIKKWMSQNPMVLDKSAFPELEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLITNGSYIAAFPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRMYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEVINPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFVKQHWQFATSGAAVCINFIIIMLLNLAYEKIAYLLTNLGKFIFLILLVVSK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:228432", "resource": "KEGG Pathway", "id": "mmu:228432", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2672351", "resource": "Reactome", "id": "R-MMU-2672351", "name": "Stimuli-sensing channels" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121575.1", "annotation": "Data report the expression of Tmem16c during murine embryogenesis with an emphasis on the respiratory, digestive, skeletal, and integumentary systems.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121575.1", "id": "NP_001121575.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121575.1", "annotation": "During mouse cephalic development: detectable in the subventricular zone and differentiating fields, patent in the submandibular autonomic ganglia, detected in osteoblasts and chondrocytes, in palate, tooth and tongue", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121575.1", "id": "NP_001121575.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AHL1#function", "annotation": "Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (PubMed:23532839). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:23532839). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (PubMed:23872594).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1#function", "id": "A2AHL1", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "F1M0A0-1", "protein_name": "Anoctamin", "sequence": { "length": 972, "sequence": "MVHHSGSIQSFKQQKGMNISKSEITTEASLKPSRRSLPCLAQSYAHSKSLSQSASLFQSTESESQAPTSVTFLSADKPEHVTSEESRKDSTLKCSFADLSEFCLALGKDKDYMDESEHANYDRSRLLNDFVTKDKPESKTKLSKNDMNYIASSGLLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAVANPDIMFIKVHIPWDTLCKYAERLNIRVPFRKKCYYTDQKNKSMSRVQKYFKRIKKWMSQNPMVLDKSAFPELEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLINNGSYIAAFPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEIINPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFIKQHWQFATSGAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVKQNENCLKGYVNNSLSFFDLSELGIGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQEMMYEAELEHLQQQNEWP" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AHL1/", "id": "A2AHL1", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Ano3", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9BYT9-1", "protein_name": "Anoctamin-3", "sequence": { "length": 981, "sequence": "MVHHSGSIQSFKQQKGMNISKSEITKETSLKPSRRSLPCLAQSYAYSKSLSQSTSLFQSTESESQAPTSITLISTDKAEQVNTEENKNDSVLRCSFADLSDFCLALGKDKDYTDESEHATYDRSRLINDFVIKDKSEFKTKLSKNDMNYIASSGPLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAIASPDIMFIKIHIPWDTLCKYAERLNIRMPFRKKCYYTDGRSKSMGRMQTYFRRIKNWMAQNPMVLDKSAFPDLEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLINNGSYIAAFPPHEGAYKSSQPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGLFTMNNSQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVMEQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIHDASIPQWENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKGLHDRIRREKYLVQEMMYEAELEHLQQQRRKSGQPVHHEWP" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AHL1/", "id": "A2AHL1", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/57147", "id": "57147", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "ANO3", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121575.1", "ac": "NP_001121575.1", "name": "anoctamin-3 isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005254", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "chloride channel activity", "id": "GO:0005254" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017128", "pmid": "23532839", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "phospholipid scramblase activity", "id": "GO:0017128" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "protein dimerization activity", "id": "GO:0046983" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "transmembrane transport", "id": "GO:0055085" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902476", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "chloride transmembrane transport", "id": "GO:1902476" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061590", "pmid": "23532839", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "calcium activated phosphatidylcholine scrambling", "id": "GO:0061590" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061591", "pmid": "23532839", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "calcium activated galactosylceramide scrambling", "id": "GO:0061591" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016048", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "detection of temperature stimulus", "id": "GO:0016048" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050982", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "id": "A2AHL1", "database": "UniProtKB" } ], "name": "detection of mechanical stimulus", "id": "GO:0050982" } ], "total": 6, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AHL1", "type": "synonym", "resource": "RefSeq", "name": "AI838058; B230324K02Rik; Tmem16c" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AHL1", "type": "synonym", "resource": "RefSeq", "name": "Ano3" }, { "url": "https://www.uniprot.org/uniprot/A2AHL1", "type": "recommended", "resource": "UniProtKB", "name": "Ano3" }, { "url": "https://www.uniprot.org/uniprot/A2AHL1", "type": "synonym", "resource": "UniProtKB", "name": "Tmem16c" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074968", "id": "ENSMUSG00000074968", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/228432", "id": "228432", "database": "GeneID" }, { "url": "https://acgg.asia/gpdb2/GPDB0001651", "id": "GPDB0001651", "database": "GlycoProtDB" }, { "url": "https://acgg.asia/gpdb2/GPDB0001652", "id": "GPDB0001652", "database": "GlycoProtDB" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007632", "id": "IPR007632", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR031292", "id": "IPR031292", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032394", "id": "IPR032394", "database": "InterPro" }, { "url": 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"https://monarchinitiative.org/disease/MONDO:0014019", "resource": "MONDO", "name": "dystonic disorder caused by mutation in ANO3", "description": "" }, { "id": "MONDO:0014019", "url": "https://monarchinitiative.org/disease/MONDO:0014019", "resource": "MONDO", "name": "dystonia type 24", "description": "" }, { "id": "MONDO:0014019", "url": "https://monarchinitiative.org/disease/MONDO:0014019", "resource": "MONDO", "name": "DYT24", "description": "" }, { "id": "MONDO:0014019", "url": "https://monarchinitiative.org/disease/MONDO:0014019", "resource": "MONDO", "name": "dystonia 24; DYT24", "description": "" }, { "id": "MONDO:0014019", "url": "https://monarchinitiative.org/disease/MONDO:0014019", "resource": "MONDO", "name": "DYT-ANO3", "description": "" } ], "recommended_name": { "id": "DOID:0090052", "url": "http://disease-ontology.org/term/DOID:0090052", "resource": "Disease Ontology", "name": "dystonia 24", "description": "A focal dystonia that is characterized by focal dystonia affecting the neck, laryngeal muscles, and muscles of the upper limbs, and has_material_basis_in autosomal dominant inheritance of heterozygous mutation in the anoctamin 3 (ANO3) gene on chromosome 11p14." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/0090052#disease-associations", "id": "0090052", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [], "mass": { "monoisotopic_mass": 114568.0, "chemical_mass": 114568.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1", "name": "Ano3", "locus": { "end_pos": 110655201, "strand": "-", "start_pos": 110950923, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000074968", "id": "ENSMUSG00000074968", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AHL1#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Anoctamin-3" }, { "url": 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