{ "uniprot_canonical_ac": "A2AC93-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AC93-1|DNAI2_MOUSE Isoform 1 of Dynein intermediate chain 2, axonemal OS=Mus musculus OX=10090 GN=Dnai2 PE=1 SV=2 CANONICAL=A2AC93-1", "length": 623, "sequence": "MEIVYVYLKKRSEFGKQCNFSDRQAELNIDILPNPELAALYVERNPVDTGIQCSASMSEHEANTERFEMESCGVNHVEGGWPKDVNPQELEQTIRFRKKVEKDENYINAVMQLGSIMEHCIKQNNAIDIYEEYFDDEEAVEVTEEAPSAKTINVFRDPQEIKRTATHLSWHPDGNRKLAVAYSCLKFQRAPMSMNYDSYIWDLENPNRPEIALKPLSPLVTLEYNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIEFSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKISEPIEVVIMDISRKEQLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKAKTQAEKIVCTFYGHHGPIYALQRNPFYPKNFLTVGDWTARIWSEDSRESSIMWTKYHMAYLSDGAWSPVRPAVFFTTKMDGTLDIWDLVFKQCDPALSLKVCDDPLFCLRVQDNGCLIACGSELGTTTLLEVSSSLSTLQRNEKNIASSIFERETRREKILEARHREMRLKEKGKVEGKEDDQKEEEAALDLDELVGKAEEEFFEVIFSELKRKEAEALKKKPKPRKKSSVKVEAEEEVEENVGEEEEAGGIIGIDAVEDMSEEAGEEQEDVPT" }, "uniprot_id": "DNAI2_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18547164", "type": [ "PubMed" ], "id": "18547164" } ], "title": "Mouse dynein axonemal intermediate chain 2: cloning and expression.", "journal": "DNA Cell Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050.2", "id": "NP_001030050.2", "database": "RefSeq" } ], "authors": "Wu J., Yang Z.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19052621", "type": [ "PubMed" ], "id": "19052621" } ], "title": "Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins.", "journal": "Nature", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050.2", "id": "NP_001030050.2", "database": "RefSeq" } ], "authors": "Reinhardt R., Zentgraf H., Zhang Q., Mizuno H., Takeda H., Watanabe Y., Hagiwara H., Fliegauf M., Loges N.T., Olbrich H., Omran H., Miyawaki A., Yagi T., Tsukahara T., O'Toole E., Mitchell D.R., Seithe H., Koshida S., Hara C., Kamiya R., Kawano H., Kobayashi D., Leblond G.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23525783", "type": [ "PubMed" ], "id": "23525783" } ], "title": "The establishment of rotational polarity in the airway and ependymal cilia: analysis with a novel cilium motility mutant mouse.", "journal": "American journal of physiology. Lung cellular and molecular physiology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050.2", "id": "NP_001030050.2", "database": "RefSeq" } ], "authors": "Matsuo M, Shimada A, Koshida S, Saga Y, Takeda H", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23872636", "type": [ "PubMed" ], "id": "23872636" } ], "title": "DYX1C1 is required for axonemal dynein assembly and ciliary motility.", "journal": "Nature genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050.2", "id": "NP_001030050.2", "database": "RefSeq" } ], "authors": "Tarkar A, Loges NT, Slagle CE, Francis R, Dougherty GW, Tamayo JV, Shook B, Cantino M, Schwartz D, Jahnke C, Olbrich H, Werner C, Raidt J, Pennekamp P, Abouhamed M, Hjeij R, Kohler G, Griese M, Li Y, Lemke K, Klena N, Liu X, Gabriel G, Tobita K, Jaspers M, Morgan LC, Shapiro AJ, Letteboer SJ, Mans DA, Carson JL, Leigh MW, Wolf WE, Chen S, Lucas JS, Onoufriadis A, Plagnol V, Schmidts M, Boldt K, Roepman R, Zariwala MA, Lo CW, Mitchison HM, Knowles MR, Burdine RD, Loturco JJ, Omran H", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24421334", "type": [ "PubMed" ], "id": "24421334" } ], "title": "Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm.", "journal": "J. Cell Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050.2", "id": "NP_001030050.2", "database": "RefSeq" } ], "authors": "Nakamura T., Asai Y., Fukumoto A., Takeda H., Hamada H., Matsuo M., Hasegawa T., Shinohara K., Shiratori H., Dong F., Botilde Y., Nabeshima R.", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27823762", "type": [ "PubMed" ], "id": "27823762" } ], "title": "Alterations in oviductal cilia morphology and reduced expression of axonemal dynein in diabetic NOD mice.", "journal": "Tissue & cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050.2", "id": "NP_001030050.2", "database": "RefSeq" } ], "authors": "Shorter SL, Albaghdadi AJ, Kan FW", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29916806", "type": [ "PubMed" ], "id": "29916806" } ], "title": "ZMYND10 functions in a chaperone relay during axonemal dynein assembly.", "journal": "eLife", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050.2", "id": "NP_001030050.2", "database": "RefSeq" } ], "authors": "Mali GR, Yeyati PL, Mizuno S, Dodd DO, Tennant PA, Keighren MA, Zur Lage P, Shoemark A, Garcia-Munoz A, Shimada A, Takeda H, Edlich F, Takahashi S, von Kreigsheim A, Jarman AP, Mill P", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30387321", "type": [ "PubMed" ], "id": "30387321" } ], "title": "Dynein axonemal intermediate chain 2 plays a role in gametogenesis by activation of Stat3.", "journal": "Journal of cellular and molecular medicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050.2", "id": "NP_001030050.2", "database": "RefSeq" } ], "authors": "Yang Z, Xu B, Hu X, Yao X, Tang Y, Qian C, Wang S, Chen H, Bai X, Wu J", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30718399", "type": [ "PubMed" ], "id": "30718399" } ], "title": "Inositol hexakisphosphate kinase 3 promotes focal adhesion turnover via interactions with dynein intermediate chain 2.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050.2", "id": "NP_001030050.2", "database": "RefSeq" } ], "authors": "Rojas T, Cheng W, Gao Z, Liu X, Wang Y, Malla AP, Chin AC, Romer LH, Snyder SH, Fu C", "date": "2019" } ], "uniprot_ac": "A2AC93", "site_annotation": [ { "end_pos": 21, "annotation": "n_glycosylation_sequon", "start_pos": 19 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AC93#A2AC93-1", "isoform_ac": "A2AC93-1", "locus": { "end_pos": 114732913, "strand": "-", "start_pos": 114757268, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000069325", "id": "ENSMUST00000069325", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000065787", "id": "ENSMUSP00000065787", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AC93-1|DNAI2_MOUSE Isoform 1 of Dynein intermediate chain 2, axonemal OS=Mus musculus OX=10090 GN=Dnai2 PE=1 SV=2 CANONICAL=A2AC93-1", "length": 623, "sequence": "MEIVYVYLKKRSEFGKQCNFSDRQAELNIDILPNPELAALYVERNPVDTGIQCSASMSEHEANTERFEMESCGVNHVEGGWPKDVNPQELEQTIRFRKKVEKDENYINAVMQLGSIMEHCIKQNNAIDIYEEYFDDEEAVEVTEEAPSAKTINVFRDPQEIKRTATHLSWHPDGNRKLAVAYSCLKFQRAPMSMNYDSYIWDLENPNRPEIALKPLSPLVTLEYNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIEFSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKISEPIEVVIMDISRKEQLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKAKTQAEKIVCTFYGHHGPIYALQRNPFYPKNFLTVGDWTARIWSEDSRESSIMWTKYHMAYLSDGAWSPVRPAVFFTTKMDGTLDIWDLVFKQCDPALSLKVCDDPLFCLRVQDNGCLIACGSELGTTTLLEVSSSLSTLQRNEKNIASSIFERETRREKILEARHREMRLKEKGKVEGKEDDQKEEEAALDLDELVGKAEEEFFEVIFSELKRKEAEALKKKPKPRKKSSVKVEAEEEVEENVGEEEEAGGIIGIDAVEDMSEEAGEEQEDVPT" } }, { "url": "https://www.uniprot.org/uniprot/A2AC93#A2AC93-2", "isoform_ac": "A2AC93-2", "locus": {}, "sequence": { "header": "sp|A2AC93-2|DNAI2_MOUSE Isoform 2 of Dynein intermediate chain 2, axonemal OS=Mus musculus OX=10090 GN=Dnai2 PE=1 SV=2 CANONICAL=A2AC93-1", "length": 611, "sequence": "MEIVYVYLKKRSEFGKQCNFSDRQAELNIDILPNPELAALYVERNPVDTGIQCSASMSEHEANTERFEMESCGVNHVEGGWPKDVNPQELEQTIRFRKKVEKDENYINAVMQLGSIMEHCIKQNNAIDIYEEYFDDEEAVEVTEEAPSAKTINVFRDPQEIKRTATHLSWHPDGNRKLAVAYSCLKFQRAPMSMNYDSYIWDLENPNRPEIALKPLSPLVTLEYNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIEFSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKISEPIEVVIMDISRKEQLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKAKTQAEKIVCTFYGHHGPIYALQRNPFYPKNFLTVGDWTARIWSEDSRESSIMWTKYHMAYLSDGAWSPVRPAVFFTTKMDGTLDIWDLVFKQCDPALSLKDNGCLIACGSELGTTTLLEVSSSLSTLQRNEKNIASSIFERETRREKILEARHREMRLKEKGKVEGKEDDQKEEEAALDLDELVGKAEEEFFEVIFSELKRKEAEALKKKPKPRKKSSVKVEAEEEVEENVGEEEEAGGIIGIDAVEDMSEEAGEEQEDVPT" } }, { "url": "https://www.uniprot.org/uniprot/A2AC93#R4GML5-1", "isoform_ac": "R4GML5-1", "locus": { "end_pos": 114732913, "strand": "-", "start_pos": 114754462, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000141762", "id": "ENSMUST00000141762", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000114700", "id": "ENSMUSP00000114700", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|R4GML5-1|DNAI2_MOUSE Computationally mapped isoform of Dynein intermediate chain 2, axonemal OS=Mus musculus OX=10090 GN=Dnai2 PE=1 SV=1 CANONICAL=A2AC93-1", "length": 562, "sequence": "MEIVYVYLKKRSEFGKQCNFSDRQAELNIDILPNPELAALYVERNPVDTGIQCSASMSEHEANTERFEMESCGVNHVEGGWPKDVNPQELEQTIRFRKKVEKDENYINAVMQLGSIMEHCIKQNNAIDIYEEYFDDEEAVEVTEEAPSAKTINVFRDPQEIKRTATHLSWHPDGNRKLAVAYSCLKFQRAPMSMNYDSYIWDLENPNRPEIALKPLSPLVTLEYNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIEFSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKISEPIEVVIMDISRKEQLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKAKTQAEKIVCTFYGHHGPIYALQRNPFYPKNFLTVGDWTARIWSEDSRESSIMWTKYHMAYLSDGAWSPVRPAVFFTTKMDGTLDIWDLVFKQCDPALSLKDNGCLIACGSELGTTTLLEVSSSLSTLQRNEKNIASSIFERETRREKILEARHREMRLKEKGKVEGKEDDQKEEEAALDLDELVGKAEEEFFEVIFSELKRKEAEALKKKPKP" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:432611", "resource": "KEGG Pathway", "id": "mmu:432611", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050.2", "annotation": "Dnaic2 plays a role in oogenesis and spermatogenesis by activation of Stat3.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050.2", "id": "NP_001030050.2", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AC93#function", "annotation": "Part of the dynein complex of respiratory cilia.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93#function", "id": "A2AC93", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050.2", "annotation": "Results obtained with Western blot analysis revealed that the expression of DNAI2 protein was significantly less in oviducts of dNOD mice as compared to that of cNOD mice corroborating the results obtained with immunohistochemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050.2", "id": "NP_001030050.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050.2", "annotation": "These data suggest that Dnaic2 plays a role in ovarian follicular development.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050.2", "id": "NP_001030050.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q66HC9-1", "protein_name": "Dynein intermediate chain 2, axonemal", "sequence": { "length": 619, "sequence": "MEIVYVYVKKRSEFGKQCNFSDRQAELNIDISPNPELAALYVERNPVDTGIQCSASMSEHEANTERFEMENCGVNHVEGGWPKDVNPQELEQTIRFRKKVEKDENYINAVMQLGSIMEHCIKQNNAIDIYEEYFDDEEAVEVTEEAPSAKTINVFRDPQEIKRTATHLSWHPDGNKKLAVAYSCLQFQRSPMGMSHDSYIWDLENPNRPEIALKPSSPLITLEYNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIEFSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKISEPTEVVIMDITRKEQLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKAKTPAEKIVCTFSGHHGPIYALQRNPFYPKNFLTVGDWAARIWSEESRESSIMWTRYHMAYLSDGAWSPVRPAVFFTTKMDGTLDIWDLVFKQCDPALSLKVCDDPLFCLRVQDTGCLIACGSELGTTTLLEVSSSLSTLQRNERNIASSIFERETRREKILEARHREMRLKEKGKAEGRDDDQKEEETALDLDELVNKAEEEFFEVIFAELKRKEAEALKKKPKPKKASIEVEGEDELEDIAGEEEESGIIMGEDTGEDDMDEKNEGGAP" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AC93/", "id": "A2AC93", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/11311", "id": "11311", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Dnai2", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9GZS0-1", "protein_name": "Dynein intermediate chain 2, axonemal", "sequence": { "length": 605, "sequence": "MEIVYVYVKKRSEFGKQCNFSDRQAELNIDIMPNPELAEQFVERNPVDTGIQCSISMSEHEANSERFEMETRGVNHVEGGWPKDVNPLELEQTIRFRKKVEKDENYVNAIMQLGSIMEHCIKQNNAIDIYEEYFNDEEAMEVMEEDPSAKTINVFRDPQEIKRAATHLSWHPDGNRKLAVAYSCLDFQRAPVGMSSDSYIWDLENPNKPELALKPSSPLVTLEFNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIESSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKMSEPTEVVILDITKKEQLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKAKTSAEKIVCTFPGHHGPIYALQRNPFYPKNFLTVGDWTARIWSEDSRESSIMWTKYHMAYLTDAAWSPVRPTVFFTTRMDGTLDIWDFMFEQCDPTLSLKVCDEALFCLRVQDNGCLIACGSQLGTTTLLEVSPGLSTLQRNEKNVASSMFERETRREKILEARHREMRLKEKGKAEGRDEEQTDEELAVDLEALVSKAEEEFFDIIFAELKKKEADAIKLTPVPQQPSPEEDQVVEEGEEAAGEEGDEEVEEDLA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11311", "id": "11311", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "DNAI2", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050.2", "ac": "NP_001030050.2", "name": "dynein intermediate chain 2, axonemal", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045503", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "dynein light chain binding", "id": "GO:0045503" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045504", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "dynein heavy chain binding", "id": "GO:0045504" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003777", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "microtubule motor activity", "id": "GO:0003777" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "29916806", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "pmid": "29916806", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "cilium", "id": "GO:0005929" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "pmid": "18547164", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "external side of plasma membrane", "id": "GO:0009897" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "pmid": "29916806", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "axoneme", "id": "GO:0005930" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097729", "pmid": "23525783", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "9+2 motile cilium", "id": "GO:0097729" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "microtubule", "id": "GO:0005874" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "sperm flagellum", "id": "GO:0036126" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005858", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "axonemal dynein complex", "id": "GO:0005858" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036157", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "outer dynein arm", "id": "GO:0036157" } ], "total": 9, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007018", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "microtubule-based movement", "id": "GO:0007018" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "cilium assembly", "id": "GO:0060271" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007368", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "determination of left/right symmetry", "id": "GO:0007368" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003341", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "cilium movement", "id": "GO:0003341" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036158", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "name": "outer dynein arm assembly", "id": "GO:0036158" } ], "total": 5, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AC93", "type": "synonym", "resource": "RefSeq", "name": "Dnai2" }, { "url": "https://www.uniprot.org/uniprot/A2AC93", "type": "recommended", "resource": "UniProtKB", "name": "Dnai2" }, { "url": "https://www.uniprot.org/uniprot/A2AC93", "type": "synonym", "resource": "UniProtKB", "name": "Dnaic2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AC93", "type": "synonym", "resource": "RefSeq", "name": "b2b3405C; b2b3405Clo; C030015H18Rik; Dnaic2; Gm728" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000034706", "id": "ENSMUSG00000034706", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/432611", "id": "432611", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AC93*", "id": "A2AC93", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "id": "IPR001680", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "id": "IPR015943", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017986", "id": "IPR017986", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "id": "IPR036322", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:432611", "id": "mmu:432611", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2685574", "id": "2685574", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/HSHHDPV/", "id": "HSHHDPV", "database": "OMA" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2AC93", "id": "PR_A2AC93", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030050.2", "id": "NP_001030050.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AC93", "id": "A2AC93", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [ { "id": "DOID:0050144", "url": "http://disease-ontology.org/term/DOID:0050144", "resource": "Disease Ontology", "name": "Kartagener's syndrome", "description": "" } ], "recommended_name": { "id": "DOID:0050144", "url": "http://disease-ontology.org/term/DOID:0050144", "resource": "Disease Ontology", "name": "Kartagener syndrome", "description": "A primary ciliary dyskinesia that is characterized by sinusitis, bronchiectasis and situs inversus with dextrocardia resulting from dysfunction of the cilia during embryologic development." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/0050144#disease-associations", "id": "0050144", "database": "Alliance of Genome Resources" } ] }, { "synonyms": [ { "id": "MONDO:0012906", "url": "https://monarchinitiative.org/disease/MONDO:0012906", "resource": "MONDO", "name": "ciliary dyskinesia, primary, type 9", "description": "" }, { "id": "MONDO:0012906", "url": "https://monarchinitiative.org/disease/MONDO:0012906", "resource": "MONDO", "name": "CILD9", "description": "" }, { "id": "MONDO:0012906", "url": "https://monarchinitiative.org/disease/MONDO:0012906", "resource": "MONDO", "name": "ciliary dyskinesia, primary, 9", "description": "" }, { "id": "MONDO:0012906", "url": "https://monarchinitiative.org/disease/MONDO:0012906", "resource": "MONDO", "name": "DNAI2 primary ciliary dyskinesia", "description": "" }, { "id": "MONDO:0012906", "url": "https://monarchinitiative.org/disease/MONDO:0012906", "resource": "MONDO", "name": "primary ciliary dyskinesia caused by mutation in DNAI2", "description": "" }, { "id": "MONDO:0012906", "url": "https://monarchinitiative.org/disease/MONDO:0012906", "resource": "MONDO", "name": "primary ciliary dyskinesia 9 with or without situs inversus", "description": "" }, { "id": "MONDO:0012906", "url": "https://monarchinitiative.org/disease/MONDO:0012906", "resource": "MONDO", "name": "ciliary dyskinesia, primary, 9, with or without situs inversus", "description": "" }, { "id": "MONDO:0012906", "url": "https://monarchinitiative.org/disease/MONDO:0012906", "resource": "MONDO", "name": "primary ciliary dyskinesia type 9", "description": "" }, { "id": "MONDO:0012906", "url": "https://monarchinitiative.org/disease/MONDO:0012906", "resource": "MONDO", "name": "ciliary dyskinesia, primary, 9; CILD9", "description": "" }, { "id": "DOID:0110622", "url": "http://disease-ontology.org/term/DOID:0110622", "resource": "Disease Ontology", "name": "CILD9", "description": "" }, { "id": "DOID:0110622", "url": "http://disease-ontology.org/term/DOID:0110622", "resource": "Disease Ontology", "name": "primary ciliary dyskinesia 9 with or without situs inversus", "description": "" } ], "recommended_name": { "id": "DOID:0110622", "url": "http://disease-ontology.org/term/DOID:0110622", "resource": "Disease Ontology", "name": "primary ciliary dyskinesia 9", "description": "A primary ciliary dyskinesia that is characterized by autosomal recessive inheritance with outer dynein arm defect, neonatal respiratory distress, sinusitis, otitis, bronchiectasis, and variable occurence of laterality defects and has_material_basis_in homozygous mutation in the DNAI2 gene on chromosome 17q25." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/0110622#disease-associations", "id": "0110622", "database": "Alliance of Genome Resources" } ] }, { "synonyms": [ { "id": "DOID:10003", "url": "http://disease-ontology.org/term/DOID:10003", "resource": "Disease Ontology", "name": "central hearing loss", "description": "" }, { "id": "DOID:10003", "url": "http://disease-ontology.org/term/DOID:10003", "resource": "Disease Ontology", "name": "Perceptive hearing loss", "description": "" }, { "id": "DOID:10003", "url": "http://disease-ontology.org/term/DOID:10003", "resource": "Disease Ontology", "name": "High frequency deafness", "description": "" }, { "id": "DOID:10003", "url": "http://disease-ontology.org/term/DOID:10003", "resource": "Disease Ontology", "name": "Sensorineural Deafness", "description": "" }, { "id": "DOID:10003", "url": "http://disease-ontology.org/term/DOID:10003", "resource": "Disease Ontology", "name": "High Frequency Hearing Loss", "description": "" }, { "id": "DOID:10003", "url": "http://disease-ontology.org/term/DOID:10003", "resource": "Disease Ontology", "name": "Sensory hearing loss", "description": "" }, { "id": "DOID:10003", "url": "http://disease-ontology.org/term/DOID:10003", "resource": "Disease Ontology", "name": "Perceptive deafness", "description": "" }, { "id": "DOID:10003", "url": "http://disease-ontology.org/term/DOID:10003", "resource": "Disease Ontology", "name": "high-frequency hearing loss", "description": "" }, { "id": "DOID:10003", "url": "http://disease-ontology.org/term/DOID:10003", "resource": "Disease Ontology", "name": "Perceptive hearing loss or deafness", "description": "" } ], "recommended_name": { "id": "DOID:10003", "url": "http://disease-ontology.org/term/DOID:10003", "resource": "Disease Ontology", "name": "sensorineural hearing loss", "description": "" }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/10003#disease-associations", "id": "10003", "database": "Alliance of Genome Resources" } ] }, { "synonyms": [ { "id": "MONDO:0009484", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "resource": "MONDO", "name": "primary ciliary dyskinesia 1", "description": "" }, { "id": "MONDO:0009484", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "resource": "MONDO", "name": "PCD", "description": "" }, { "id": "MONDO:0009484", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "resource": "MONDO", "name": "immotile cilia syndrome", "description": "" }, { "id": "MONDO:0009484", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "resource": "MONDO", "name": "ciliary dyskinesia, primary, 1", "description": "" }, { "id": "MONDO:0009484", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "resource": "MONDO", "name": "Kartagener syndrome", "description": "" }, { "id": "MONDO:0009484", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "resource": "MONDO", "name": "ciliary dyskinesia, primary, 1; CILD1", "description": "" }, { "id": "MONDO:0009484", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "resource": "MONDO", "name": "DNAI1 primary ciliary dyskinesia", "description": "" }, { "id": "MONDO:0009484", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "resource": "MONDO", "name": "dextrocardia, bronchiectasis, and sinusitis", "description": "" }, { "id": "MONDO:0009484", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "resource": "MONDO", "name": "ciliary dyskinesia, primary, 1, with or without situs inversus", "description": "" }, { "id": "MONDO:0009484", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "resource": "MONDO", "name": "Polynesian bronchiectasis", "description": "" }, { "id": "MONDO:0009484", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "resource": "MONDO", "name": "primary ciliary dyskinesia caused by mutation in DNAI1", "description": "" }, { "id": "MONDO:0009484", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "resource": "MONDO", "name": "primary ciliary dyskinesia type 1", "description": "" }, { "id": "MONDO:0009484", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "resource": "MONDO", "name": "CILD1", "description": "" }, { "id": "MONDO:0009484", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "resource": "MONDO", "name": "primary ciliary dyskinesia 1 with or without situs inversus", "description": "" }, { "id": "MONDO:0009484", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "resource": "MONDO", "name": "Siewert syndrome", "description": "" }, { "id": "MONDO:0009484", "url": "https://monarchinitiative.org/disease/MONDO:0009484", "resource": "MONDO", "name": "ciliary dyskinesia, primary, type 1", "description": "" }, { "id": "DOID:9562", "url": "http://disease-ontology.org/term/DOID:9562", "resource": "Disease Ontology", "name": "ciliary motility disorder", "description": "" }, { "id": "DOID:9562", "url": "http://disease-ontology.org/term/DOID:9562", "resource": "Disease Ontology", "name": "immotile ciliary syndrome", "description": "" } ], "recommended_name": { "id": "DOID:9562", "url": "http://disease-ontology.org/term/DOID:9562", "resource": "Disease Ontology", "name": "primary ciliary dyskinesia", "description": "A ciliopathy that is characterized by impaired function of the cilia lining the respiratory tract (lower and upper, sinuses, Eustachian tube, middle ear) and fallopian tube." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/9562#disease-associations", "id": "9562", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [], "mass": { "monoisotopic_mass": 70968.0, "chemical_mass": 70968.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AC93", "name": "Dnai2", "locus": {} } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AC93#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Axonemal dynein intermediate chain 2" }, { "url": "https://www.uniprot.org/uniprot/A2AC93#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Dynein intermediate chain 2, axonemal" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AC93", "type": "synonym", "resource": "RefSeq", "name": "dynein intermediate chain 2, axonemal" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AC93", "type": "synonym", "resource": "RefSeq", "name": "dynein, axonemal, intermediate polypeptide 2" } ] }