{
    "uniprot_canonical_ac": "A2A7Y5-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2A7Y5-1|MIIP_MOUSE Isoform 1 of Migration and invasion-inhibitory protein  OS=Mus musculus OX=10090 GN=Miip PE=2 SV=1 CANONICAL=A2A7Y5-1", 
        "length": 387, 
        "sequence": "MPNMAETKDPVRLRLLSLELLKQLWAGHEAMCRSVVRAASGSNLDCSSNNLEMPLSQETSSASSVAPSSQDKRHMLDPLDSRRDDTFDVAWYVKFNSRMDSFLPATGQHQEPQEELRPPSVPLLATQGLKGPVSLGGPKGLGPDKTQVPRSILSRLSKPSKPRVTSQESAVPESSWHSRPYLGYDWIAGSLDNSSPVTSEPEAFFSMLQRFRENNKEDCVCNSPEAVFPGLQESSGVEEDHECMYCYRINRRLFPEPVDPGAPCRLCGIPRDEKGPGTLVEPVQVRVSIPLSIMDPPHQYRIHRRKSFDASDTLALPRHCLLGWDILPPKSEKTSVPKSLDLWSSVSYGAGQRRDLSATSPPCQALPAQVTPPLWSEPQVAQLCPSH"
    }, 
    "uniprot_id": "MIIP_MOUSE", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A7Y5", 
                    "id": "A2A7Y5", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [], 
    "uniprot_ac": "A2A7Y5", 
    "site_annotation": [
        {
            "end_pos": 195, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 193
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A7Y5#A2A7Y5-1", 
            "isoform_ac": "A2A7Y5-1", 
            "locus": {
                "end_pos": 147861017, 
                "strand": "+", 
                "start_pos": 147866357, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000172710", 
                        "id": "ENSMUST00000172710", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000134085", 
                        "id": "ENSMUSP00000134085", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2A7Y5-1|MIIP_MOUSE Isoform 1 of Migration and invasion-inhibitory protein  OS=Mus musculus OX=10090 GN=Miip PE=2 SV=1 CANONICAL=A2A7Y5-1", 
                "length": 387, 
                "sequence": "MPNMAETKDPVRLRLLSLELLKQLWAGHEAMCRSVVRAASGSNLDCSSNNLEMPLSQETSSASSVAPSSQDKRHMLDPLDSRRDDTFDVAWYVKFNSRMDSFLPATGQHQEPQEELRPPSVPLLATQGLKGPVSLGGPKGLGPDKTQVPRSILSRLSKPSKPRVTSQESAVPESSWHSRPYLGYDWIAGSLDNSSPVTSEPEAFFSMLQRFRENNKEDCVCNSPEAVFPGLQESSGVEEDHECMYCYRINRRLFPEPVDPGAPCRLCGIPRDEKGPGTLVEPVQVRVSIPLSIMDPPHQYRIHRRKSFDASDTLALPRHCLLGWDILPPKSEKTSVPKSLDLWSSVSYGAGQRRDLSATSPPCQALPAQVTPPLWSEPQVAQLCPSH"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A7Y5#A2A7Y5-2", 
            "isoform_ac": "A2A7Y5-2", 
            "locus": {
                "end_pos": 147860939, 
                "strand": "+", 
                "start_pos": 147866357, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000119975", 
                        "id": "ENSMUST00000119975", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000113897", 
                        "id": "ENSMUSP00000113897", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2A7Y5-2|MIIP_MOUSE Isoform 2 of Migration and invasion-inhibitory protein  OS=Mus musculus OX=10090 GN=Miip PE=2 SV=1 CANONICAL=A2A7Y5-1", 
                "length": 389, 
                "sequence": "MPNMAETKDPVRLRLLSLELLKQLWAGHEAMCRSVVRAASGSNLDCSSNNLEMPLSQETSSASSVAPSSQDKRHMLDPLDSRRDDTFDVAWYVKFNSRMDSFLPATGQHQEPQEELRPPSVPLLATQGLKGPVSLGGPKGLGPDKTQVPRSILSRLSKPSKPRVTSQESAVPESSWHSRPYLGYDWIAGSLDNSSPVTSEPEAFFSMLQRFRENNKEDCVCNSPEAVFPGLQESSGVEEDHECMYCYRINRRLFPEPVDPGAPCRLCGIPRDEKGPGTLVEPVQVRVSIPLSIMDPPHQYRIHRRKSFDASDTLALPRHCLLGWDILPPKSEKTSVPKSLDLWSSVSYGAGQRRDLSATSPPCQKPRGQTAQKTTVFYQCQQPPLRRSP"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:28010", 
            "resource": "KEGG Pathway", 
            "id": "mmu:28010", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A7Y5#function", 
            "annotation": "Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A7Y5#function", 
                    "id": "A2A7Y5", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q5JXC2-1", 
            "protein_name": "Migration and invasion-inhibitory protein", 
            "sequence": {
                "length": 388, 
                "sequence": "MVEAEELAQLRLLNLELLRQLWVGQDAVRRSVARAASESSLESSSSYNSETPSTPETSSTSLSTSCPRGRSSVWGPPDACRGDLRDVARSGVASLPPAKCQHQESLGRPRPHSAPSLGTSSLRDPEPSGRLGDPGPQEAQTPRSILAQQSKLSKPRVTFSEESAVPKRSWRLRPYLGYDWIAGSLDTSSSITSQPEAFFSKLQEFRETNKEECICSHPEPQLPGLRESSGSGVEEDHECVYCYRVNRRLFPVPVDPGTPCRLCRTPRDQQGPGTLAQPAHVRVSIPLSILEPPHRYHIHRRKSFDASDTLALPRHCLLGWDIFPPKSEKSSAPRNLDLWSSVSAEAQHQKLSGTSSPFHPASPMQMLPPTPTWSVPQVPRPHVPRQKP"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/15879", 
                    "id": "15879", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "MIIP", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q6AYH0-1", 
            "protein_name": "Migration and invasion-inhibitory protein", 
            "sequence": {
                "length": 389, 
                "sequence": "MTNMAETKDTVQLRLLSLELLKQLWAGHEAMCQSVTRAASESNLDYSSSSNNLEMPLSQETSASSVAPNSQDKRHVWDPLDSHRGDTYDVAWYGKVNSRVDSLPPATCQHQEPQEGLRPSSVPLLATEGLKRPVSLGGPKGLGPDKAQVPRSLPLRLGKLSKPKVTFSQESSVPESSWYSRPCLDYDWTAGSLDSSSPVSSESEAYFSMLQRFREDNREDCVCNSPEAVFPELQESSGVEEDHECVYCYRINRRLFPEPLDPGAPCCLCGIPRDEQGPQTLVEPVQVRVSIPLSIMDPPHQYRIHRRKSFDASDTFALPRHCLLGWDILPPKSEKTSVPKSLDLWSSVSHGAAQRRNLSATNPSYQALRSRVPPPFWSEPQVARLCPSH"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/15879", 
                    "id": "15879", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "gene_name": "Miip", 
            "tax_id": 10116
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020536.2", 
        "ac": "NP_001020536.2", 
        "name": "migration and invasion-inhibitory protein isoform 2", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A7Y5", 
                                "id": "A2A7Y5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of cell migration", 
                        "id": "GO:0030336"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010972", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A7Y5", 
                                "id": "A2A7Y5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of G2/M transition of mitotic cell cycle", 
                        "id": "GO:0010972"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A7Y5", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "AA553001; AI853621; D4Wsu114; D4Wsu114e; IIP45"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A7Y5", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "D4Wsu114e"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A7Y5", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Iip45"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A7Y5", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Miip"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A7Y5", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Miip"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000029022", 
            "id": "ENSMUSG00000029022", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/28010", 
            "id": "28010", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR031466", 
            "id": "IPR031466", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:28010", 
            "id": "mmu:28010", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:106506", 
            "id": "106506", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/PHVPRQK/", 
            "id": "PHVPRQK", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1259790at2759", 
            "id": "1259790at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34831", 
            "id": "PTHR34831", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF15734", 
            "id": "PF15734", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A2A7Y5", 
            "id": "PR_A2A7Y5", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020536.2", 
            "id": "NP_001020536.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A7Y5", 
            "id": "A2A7Y5", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [
        {
            "residue": "Ser", 
            "kinase_gene_name": "", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A7Y5", 
                    "id": "A2A7Y5", 
                    "database": "UniProtKB"
                }
            ], 
            "start_pos": "307", 
            "end_pos": "307", 
            "kinase_uniprot_canonical_ac": ""
        }
    ], 
    "mass": {
        "monoisotopic_mass": 42828.0, 
        "chemical_mass": 42828.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A7Y5", 
            "name": "Miip", 
            "locus": {
                "end_pos": 147860778, 
                "strand": "-", 
                "start_pos": 147868816, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000029022", 
                        "id": "ENSMUSG00000029022", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A7Y5#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "IIp45"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A7Y5#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Invasion-inhibitory protein 45"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A7Y5#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Migration and invasion-inhibitory protein"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A7Y5", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "invasion inhibitory protein 45"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A7Y5", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "migration and invasion-inhibitory protein isoform 2"
        }
    ]
}