{ "uniprot_canonical_ac": "A2A7Q9-1", "ptm_annotation": [], "sequence": { "header": "sp|A2A7Q9-1|RN19B_MOUSE Isoform 1 of E3 ubiquitin-protein ligase RNF19B OS=Mus musculus OX=10090 GN=Rnf19b PE=1 SV=2 CANONICAL=A2A7Q9-1", "length": 732, "sequence": "MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTFHSVFSASARGRRARTKPQAEPPPPAAPPPPPPPAPAPVEAQAPPVEALPSEPAAEAEAEAVAAGPEEDEAAEGGGAEEVECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDSASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQVAEKEEEGNGAGGGSGGSEDDPPYKHQSCEQKDCLASKAWDISLAQPESIRSDLESSDTQSDDVPDITSDECGSPRSHAAACPSTPQVHGAPSPSAHKNLAAPAEGQTVLKSEEYEVE" }, "uniprot_id": "RN19B_MOUSE", "enzyme_annotation": [ { "ec": "2.3.2.31", "activity": "" }, { "ec": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine." } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10912506", "type": [ "PubMed" ], "id": "10912506" } ], "title": "Gene structure of human and mouse NKLAM, a gene associated with cellular cytotoxicity.", "journal": "Immunogenetics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "authors": "Anderson J., Esposito A., Kornbluth J., Portis T.", "date": "2000" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27485036", "type": [ "PubMed" ], "id": "27485036" } ], "title": "Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation.", "journal": "Sci. Rep.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "authors": "Kaneko M., Nomura Y., Watanabe T., Wu Y., Kanemoto S., Imaizumi K., Asada R., Iwase I., Matsuhisa K., Okuma Y., Takai T., Yamasaki Y.", "date": "2016" } ], "uniprot_ac": "A2A7Q9", "site_annotation": [ { "end_pos": 247, "annotation": "n_glycosylation_sequon", "start_pos": 245 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9#A2A7Q8-1", "isoform_ac": "A2A7Q8-1", "locus": { "end_pos": 129058814, "strand": "-", "start_pos": 129080547, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000152565", "id": "ENSMUST00000152565", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119611", "id": "ENSMUSP00000119611", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2A7Q8-1|RN19B_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase RNF19B OS=Mus musculus OX=10090 GN=Rnf19b PE=1 SV=8 CANONICAL=A2A7Q9-1", "length": 352, "sequence": "MHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPDDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYS" } }, { "url": "https://www.uniprot.org/uniprot/A2A7Q9#A2A7Q9-1", "isoform_ac": "A2A7Q9-1", "locus": { "end_pos": 129058271, "strand": "-", "start_pos": 129084187, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000030584", "id": "ENSMUST00000030584", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000030584", "id": "ENSMUSP00000030584", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A7Q9-1|RN19B_MOUSE Isoform 1 of E3 ubiquitin-protein ligase RNF19B OS=Mus musculus OX=10090 GN=Rnf19b PE=1 SV=2 CANONICAL=A2A7Q9-1", "length": 732, "sequence": "MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTFHSVFSASARGRRARTKPQAEPPPPAAPPPPPPPAPAPVEAQAPPVEALPSEPAAEAEAEAVAAGPEEDEAAEGGGAEEVECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDSASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQVAEKEEEGNGAGGGSGGSEDDPPYKHQSCEQKDCLASKAWDISLAQPESIRSDLESSDTQSDDVPDITSDECGSPRSHAAACPSTPQVHGAPSPSAHKNLAAPAEGQTVLKSEEYEVE" } }, { "url": "https://www.uniprot.org/uniprot/A2A7Q9#B2KG08-1", "isoform_ac": "B2KG08-1", "locus": { "end_pos": 129058814, "strand": "-", "start_pos": 129084187, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000097874", "id": "ENSMUST00000097874", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000095484", "id": "ENSMUSP00000095484", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|B2KG08-1|RN19B_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase RNF19B OS=Mus musculus OX=10090 GN=Rnf19b PE=1 SV=1 CANONICAL=A2A7Q9-1", "length": 551, "sequence": "MHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDSASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQVAEKEEEGNGAGGGSGGSEDDPPYKHQSCEQKDCLASKAWDISLAQPESIRSDLESSDTQSDDVPDITSDECGSPRSHAAACPSTPQVHGAPSPSAHKNLAAPAEGQTVLKSEEYEVE" } }, { "url": "https://www.uniprot.org/uniprot/A2A7Q9#E9Q2L7-1", "isoform_ac": "E9Q2L7-1", "locus": { "end_pos": 129058271, "strand": "-", "start_pos": 129084187, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000168461", "id": "ENSMUST00000168461", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000131373", "id": "ENSMUSP00000131373", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9Q2L7-1|RN19B_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase RNF19B OS=Mus musculus OX=10090 GN=Rnf19b PE=1 SV=1 CANONICAL=A2A7Q9-1", "length": 731, "sequence": "MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTFHSVFSASARGRRARTKPQAEPPPPAAPPPPPPPAPAPVEAQAPPVEALPSEPAAEAEAEAVAAGPEEDEAAEGGGAEEVECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPDDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDSASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQVAEKEEEGNGAGGGSGGSEDDPPYKHQSCEQKDCLASKAWDISLAQPESIRSDLESSDTQSDDVPDITSDECGSPRSHAAACPSTPQVHGAPSPSAHKNLAAPAEGQTVLKSEEYEVE" } }, { "url": "https://www.uniprot.org/uniprot/A2A7Q9#F6TQN1-1", "isoform_ac": "F6TQN1-1", "locus": { "end_pos": 129078971, "strand": "-", "start_pos": 129085812, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000130803", "id": "ENSMUST00000130803", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000121004", "id": "ENSMUSP00000121004", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6TQN1-1|RN19B_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase RNF19B OS=Mus musculus OX=10090 GN=Rnf19b PE=1 SV=1 CANONICAL=A2A7Q9-1", "length": 247, "sequence": "XGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDSASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVYLLPYAVKDGASRQQPLWKILLLRLHRPPCISLHIGTGNAVNGLGVSVRKCPRDVPVRLKEPVGEKRQTVWRPLKCKQPTRDLQFF" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", "resource": "Reactome", "id": "R-MMU-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9#function", "annotation": "E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9#function", "id": "A2A7Q9", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K6H9-1", "protein_name": "RBR-type E3 ubiquitin transferase", "sequence": { "length": 654, "sequence": "MEALPSEPAAEAEAEAAAARPEEDEAAEGGGAEEVECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPDDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDSASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQVAENEEEGNGGGAGGGSGGSEDDPPYKHQSCEQKDCLASKAWDISLAQPESIRSDLESSDTQSDDVPDITSDECGSPRPHTAACPSTPRVHGAPSPSAHKSLAAPAEGQTVLKPEEYEVE" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A7Q9/", "id": "A2A7Q9", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Rnf19b", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q6ZMZ0-1", "protein_name": "E3 ubiquitin-protein ligase RNF19B", "sequence": { "length": 732, "sequence": "MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPAAQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQPESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQTVLKPEGGEARV" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A7Q9/", "id": "A2A7Q9", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "RNF19B", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031624", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "ubiquitin conjugating enzyme binding", "id": "GO:0031624" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "ubiquitin protein ligase activity", "id": "GO:0061630" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "ubiquitin binding", "id": "GO:0043130" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "ubiquitin ligase complex", "id": "GO:0000151" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044194", "pmid": "19915045", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "cytolytic granule", "id": "GO:0044194" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" } ], "total": 7, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "protein polyubiquitination", "id": "GO:0000209" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032436", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0032436" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032609", "pmid": "19915045", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "interferon-gamma production", "id": "GO:0032609" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042267", "pmid": "19915045", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "natural killer cell mediated cytotoxicity", "id": "GO:0042267" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "adaptive immune response", "id": "GO:0002250" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051865", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "name": "protein autoubiquitination", "id": "GO:0051865" } ], "total": 7, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "type": "synonym", "resource": "UniProtKB", "name": "Ibrdc3" }, { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "type": "synonym", "resource": "UniProtKB", "name": "Nklam" }, { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "type": "recommended", "resource": "UniProtKB", "name": "Rnf19b" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000028793", "id": "ENSMUSG00000028793", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "id": "IPR001841", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002867", "id": "IPR002867", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "id": "IPR013083", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR031127", "id": "IPR031127", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR044066", "id": "IPR044066", "database": "InterPro" }, { "url": "http://www.informatics.jax.org/marker/MGI:1922484", "id": "1922484", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/LTSDECG/", "id": "LTSDECG", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=257621at2759", "id": "257621at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11685", "id": "PTHR11685", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF01485", "id": "PF01485", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2A7Q9", "id": "PR_A2A7Q9", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", "id": "R-MMU-983168", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006503521.1", "id": "XP_006503521.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "id": "A2A7Q9", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 78127.0, "chemical_mass": 78127.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9", "name": "Rnf19b", "locus": { "end_pos": 129085886, "strand": "+", "start_pos": 129058271, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000028793", "id": "ENSMUSG00000028793", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2A7Q9#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "2.3.2.31" }, { "url": "https://www.uniprot.org/uniprot/A2A7Q9#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "E3 ubiquitin-protein ligase RNF19B" }, { "url": "https://www.uniprot.org/uniprot/A2A7Q9#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "IBR domain-containing protein 3" }, { "url": "https://www.uniprot.org/uniprot/A2A7Q9#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Natural killer lytic-associated molecule" }, { "url": "https://www.uniprot.org/uniprot/A2A7Q9#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "RING finger protein 19B" } ] }