{ "uniprot_canonical_ac": "A2A6Q5-1", "ptm_annotation": [ { "annotation": "Phosphorylated. Phosphorylation on Ser-427 and Thr-447 occurs specifically during mitosis (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6Q5", "id": "A2A6Q5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2A6Q5-1|CDC27_MOUSE Isoform 1 of Cell division cycle protein 27 homolog OS=Mus musculus OX=10090 GN=Cdc27 PE=1 SV=1 CANONICAL=A2A6Q5-1", "length": 825, "sequence": "MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDLVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNTCTTLVSNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSTVISPDNVPLGPGTAILSKQVQNKPKTGRSLLGGPTALSPLTPSFGILPLETPSPGDGSYLQNYTNTPSVIDVAPTGAPTKKSVARMGQTGTKSVFSQSGNSREVTPVLVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGLTQPSINDSLEITKLDSSIISEGKITTVTPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYSTGWVLCQIGRAYFELSEYMQAERIFSEVRRIESFRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF" }, "uniprot_id": "CDC27_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6Q5", "id": "A2A6Q5", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": [ "PubMed" ], "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272917.1", "id": "NP_001272917.1", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15029244", "type": [ "PubMed" ], "id": "15029244" } ], "title": "Mammalian Cdh1/Fzr mediates its own degradation.", "journal": "The EMBO journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272917.1", "id": "NP_001272917.1", "database": "RefSeq" } ], "authors": "Listovsky T, Oren YS, Yudkovsky Y, Mahbubani HM, Weiss AM, Lebendiker M, Brandeis M", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20439707", "type": [ "PubMed" ], "id": "20439707" } ], "title": "C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272917.1", "id": "NP_001272917.1", "database": "RefSeq" } ], "authors": "Pawar SA, Sarkar TR, Balamurugan K, Sharan S, Wang J, Zhang Y, Dowdy SF, Huang AM, Sterneck E", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20716133", "type": [ "PubMed" ], "id": "20716133" } ], "title": "The novel protein MANI modulates neurogenesis and neurite-cone growth.", "journal": "J. Cell. Mol. Med.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6Q5", "id": "A2A6Q5", "database": "UniProtKB" } ], "authors": "Heese K., Akatsu H., Mishra M.", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22898775", "type": [ "PubMed" ], "id": "22898775" } ], "title": "Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.", "journal": "Developmental cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272917.1", "id": "NP_001272917.1", "database": "RefSeq" } ], "authors": "Xie L, Hoffmann AD, Burnicka-Turek O, Friedland-Little JM, Zhang K, Moskowitz IP", "date": "2012" } ], "uniprot_ac": "A2A6Q5", "site_annotation": [ { "end_pos": 177, "annotation": "n_glycosylation_sequon", "start_pos": 175 }, { "end_pos": 192, "annotation": "n_glycosylation_sequon", "start_pos": 190 }, { "end_pos": 302, "annotation": "n_glycosylation_sequon", "start_pos": 300 }, { "end_pos": 427, "annotation": "n_glycosylation_sequon", "start_pos": 425 }, { "end_pos": 762, "annotation": "n_glycosylation_sequon", "start_pos": 760 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A6Q5#A2A6Q5-1", "isoform_ac": "A2A6Q5-1", "locus": { "end_pos": 104505601, "strand": "+", "start_pos": 104550389, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000093923", "id": "ENSMUST00000093923", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000091452", "id": "ENSMUSP00000091452", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A6Q5-1|CDC27_MOUSE Isoform 1 of Cell division cycle protein 27 homolog OS=Mus musculus OX=10090 GN=Cdc27 PE=1 SV=1 CANONICAL=A2A6Q5-1", "length": 825, "sequence": "MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDLVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNTCTTLVSNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSTVISPDNVPLGPGTAILSKQVQNKPKTGRSLLGGPTALSPLTPSFGILPLETPSPGDGSYLQNYTNTPSVIDVAPTGAPTKKSVARMGQTGTKSVFSQSGNSREVTPVLVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGLTQPSINDSLEITKLDSSIISEGKITTVTPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYSTGWVLCQIGRAYFELSEYMQAERIFSEVRRIESFRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF" } }, { "url": "https://www.uniprot.org/uniprot/A2A6Q5#A2A6Q5-2", "isoform_ac": "A2A6Q5-2", "locus": {}, "sequence": { "header": "sp|A2A6Q5-2|CDC27_MOUSE Isoform 2 of Cell division cycle protein 27 homolog OS=Mus musculus OX=10090 GN=Cdc27 PE=1 SV=1 CANONICAL=A2A6Q5-1", "length": 830, "sequence": "MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDLVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNTCTTLVSNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSTVISPDNVPLGPGTAILSKQVQNKPKTGRSLLGGPTALSPLTPSFGILPLETPSPGDGSYLQNYTNTPSVIDVAPTGAPTKKTFCVLQSVARMGQTGTKSVFSQSGNSREVTPVLVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGLTQPSINDSLEITKLDSSIISEGKITTVTPQIQAFNLQKAAAGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYSTGWVLCQIGRAYFELSEYMQAERIFSEVRRIESFRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF" } }, { "url": "https://www.uniprot.org/uniprot/A2A6Q5#A2A6Q5-3", "isoform_ac": "A2A6Q5-3", "locus": { "end_pos": 104505601, "strand": "+", "start_pos": 104550389, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000106962", "id": "ENSMUST00000106962", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000102575", "id": "ENSMUSP00000102575", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A6Q5-3|CDC27_MOUSE Isoform 3 of Cell division cycle protein 27 homolog OS=Mus musculus OX=10090 GN=Cdc27 PE=1 SV=1 CANONICAL=A2A6Q5-1", "length": 831, "sequence": "MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDLVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNTCTTLVSNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSTVISPDNVPLGPGTAILSKQVQNKPKTGRSLLGGPTALSPLTPSFGILPLETPSPGDGSYLQNYTNTPSVIDVAPTGAPTKKTFCVLQSVARMGQTGTKSVFSQSGNSREVTPVLVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGLTQPSINDSLEITKLDSSIISEGKITTVTPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYSTGWVLCQIGRAYFELSEYMQAERIFSEVRRIESFRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF" } }, { "url": "https://www.uniprot.org/uniprot/A2A6Q5#Q8R568-1", "isoform_ac": "Q8R568-1", "locus": { "end_pos": 104520831, "strand": "+", "start_pos": 104550389, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000106961", "id": "ENSMUST00000106961", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000102574", "id": "ENSMUSP00000102574", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q8R568-1|CDC27_MOUSE Computationally mapped isoform of Cell division cycle protein 27 homolog OS=Mus musculus OX=10090 GN=Cdc27 PE=1 SV=1 CANONICAL=A2A6Q5-1", "length": 399, "sequence": "MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDLVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNTCTTLVSNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSTVISPDNVPLGPGTAILSKQVQNKPKTGRSLLGGPTALSPLTPSFGILPLETPSPGDGSYLQNYTNTPSVIDVAPTGAPTKKTFCVLQSVARMGQTGTKSVFSQSGNSREVTPVLVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKKV" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:217232", "resource": "KEGG Pathway", "id": "mmu:217232", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-141430", "resource": "Reactome", "id": "R-MMU-141430", "name": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-174048", "resource": "Reactome", "id": "R-MMU-174048", "name": "APC/C:Cdc20 mediated degradation of Cyclin B" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-174084", "resource": "Reactome", "id": "R-MMU-174084", "name": "Autodegradation of Cdh1 by Cdh1:APC/C" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-174154", "resource": "Reactome", "id": "R-MMU-174154", "name": "APC/C:Cdc20 mediated degradation of Securin" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-174178", "resource": "Reactome", "id": "R-MMU-174178", "name": "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-174184", "resource": "Reactome", "id": "R-MMU-174184", "name": "Cdc20:Phospho-APC/C mediated degradation of Cyclin A" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-176407", "resource": "Reactome", "id": "R-MMU-176407", "name": "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-176408", "resource": "Reactome", "id": "R-MMU-176408", "name": "Regulation of APC/C activators between G1/S and early anaphase" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-176409", "resource": "Reactome", "id": "R-MMU-176409", "name": "APC/C:Cdc20 mediated degradation of mitotic proteins" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-176412", "resource": "Reactome", "id": "R-MMU-176412", "name": "Phosphorylation of the APC/C" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-179409", "resource": "Reactome", "id": "R-MMU-179409", "name": "APC-Cdc20 mediated degradation of Nek2A" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2467813", "resource": "Reactome", "id": "R-MMU-2467813", "name": "Separation of Sister Chromatids" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2559582", "resource": "Reactome", "id": "R-MMU-2559582", "name": "Senescence-Associated Secretory Phenotype (SASP)" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2559586", "resource": "Reactome", "id": "R-MMU-2559586", "name": "DNA Damage/Telomere Stress Induced Senescence" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-69017", "resource": "Reactome", "id": "R-MMU-69017", "name": "CDK-mediated phosphorylation and removal of Cdc6" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", "resource": "Reactome", "id": "R-MMU-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272917.1", "annotation": "Cdc27 directs cyclin D1 to alternative degradation by anaphase promoting complex/cyclosome.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272917.1", "id": "NP_001272917.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2A6Q5#function", "annotation": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A6Q5#function", "id": "A2A6Q5", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P30260-1", "protein_name": "Cell division cycle protein 27 homolog", "sequence": { "length": 824, "sequence": "MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCLPNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVISPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQNYTNTPPVIDVPSTGAPSKKSVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQPNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/960", "id": "960", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "CDC27", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q4V8A2-1", "protein_name": "Cell division cycle protein 27 homolog", "sequence": { "length": 824, "sequence": "MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDLVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNTCTALVSNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVISPDNVPLGTGPSILSKQVQNKPKTGRSLLGGPTALSPLTPSFGILPLETPSPGDGSYLQNYTNTPSVIDVPSTGAPTKKSVARMGHTGAKSVFSQSGNSREATPVLVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQPNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYSTGWVLCQIGRAYFELSEYMQAERIFSEVRRIESFRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF" }, 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