{ "uniprot_canonical_ac": "A2A699-1", "ptm_annotation": [], "sequence": { "header": "sp|A2A699-1|F1712_MOUSE Isoform 1 of Protein FAM171A2 OS=Mus musculus OX=10090 GN=Fam171a2 PE=1 SV=1 CANONICAL=A2A699-1", "length": 822, "sequence": "MPPPSGPGVLARLLPLLGLLLGGASRAPGKSPPEPPSPQEILIKVQVYVSGELVPLARASVDVFGNRTLLAAGTTDSEGVATLPLSYRLGTWVLVTAARPGFLTNSVPWRVDKLPLYASVSLYLLPERPATLILYEDLVHILLGSPGARSQPWVQFQRRAARLPVSSTYSQLWASLTPASTQQEMRAFPAFLGTEASSSGNGSWLELIPLAAVSVHLLTGNGTEVPLSGPIHLSLPVPSEPRALAVGTSIPAWRFDPKSGLWVRNGTGVIRKEGRQLYWTFVSPQLGYWVAAMASPTSGLVTITSGIQDIGTYHTIFLLTILAALALLVLILLCLLIYYCRRRCLKPRQQHRKLQLSGPSDNKRDQATSMSQLHLICGGPLEPTSSGDPEAPPPGSLHSAFSSSRDLASSRDDFFRAKPRSASRPAAEPPGARTVEGAGLKSARSVEGPGGLEPSLDEYRRGPAGAAAFLHEPPSPPPSFDHYLGHKGAAESKTPDFLLSQSVDQLARPPSLSQPGQLIFCGSIDHLKDNVYRNVMPTLVIPAHYVRLGGEAGAAGVGDEATPPEGSAAGPARPFPQPDPQRPLMQGHAGAGGDSGGGEGWGGGRSAPVSGSVTIPVLFNESTMAQLNGELQALTEKKLLELGVKPHPRAWFVSLDGRSNSQVRHSYIDLQAGSGGRSTDASLDSGVDVHEARPARRRLPREERERAQLPAPPPPAPPRLALSEDTEPSSSESRTGLCSPEDNSLTPLLDEVVAPEGRAATVPRGRGRSRGDSSRSSASELRRDSLTSPEDELGAEVGDEAGDKKSPWQRREERPLMVFNVK" }, "uniprot_id": "F1712_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "predicted.uniprotkb_gly", "reported.uniprotkb_gly", "reported_with_glycan.glyconnect" ], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A699", "id": "A2A699", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16452087", "type": [ "PubMed" ], "id": "16452087" } ], "title": "Comprehensive identification of phosphorylation sites in postsynaptic density preparations.", "journal": "Mol. Cell. Proteomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A699", "id": "A2A699", "database": "UniProtKB" } ], "authors": "Schoepfer R., Burlingame A.L., Thalhammer A., Specht C.G., Trinidad J.C.", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21677750", "type": [ "PubMed" ], "id": "21677750" } ], "title": "A conditional knockout resource for the genome-wide study of mouse gene function.", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954670.2", "id": "NP_954670.2", "database": "RefSeq" } ], "authors": "Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30899004", "type": [ "PubMed" ], "id": "30899004" } ], "title": "Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis.", "journal": "Nature communications", "evidence": [ { "url": "https://glyconnect.expasy.org/browser/proteins/2627", "id": "2627", "database": "GlyConnect" } ], "authors": "Riley NM, Hebert AS, Westphall MS, Coon JJ", "date": "2019" } ], "uniprot_ac": "A2A699", "site_annotation": [ { "end_pos": 203, "annotation": "n_glycosylation_sequon", "start_pos": 201 }, { "end_pos": 223, "annotation": "n_glycosylation_sequon", "start_pos": 221 }, { "end_pos": 267, "annotation": "n_glycosylation_sequon", "start_pos": 265 }, { "end_pos": 622, "annotation": "n_glycosylation_sequon", "start_pos": 620 }, { "end_pos": 68, "annotation": "n_glycosylation_sequon", "start_pos": 66 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A699#A2A699-1", "isoform_ac": "A2A699-1", "locus": { "end_pos": 102437466, "strand": "+", "start_pos": 102447515, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000049057", "id": "ENSMUST00000049057", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000038486", "id": "ENSMUSP00000038486", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A699-1|F1712_MOUSE Isoform 1 of Protein FAM171A2 OS=Mus musculus OX=10090 GN=Fam171a2 PE=1 SV=1 CANONICAL=A2A699-1", "length": 822, "sequence": "MPPPSGPGVLARLLPLLGLLLGGASRAPGKSPPEPPSPQEILIKVQVYVSGELVPLARASVDVFGNRTLLAAGTTDSEGVATLPLSYRLGTWVLVTAARPGFLTNSVPWRVDKLPLYASVSLYLLPERPATLILYEDLVHILLGSPGARSQPWVQFQRRAARLPVSSTYSQLWASLTPASTQQEMRAFPAFLGTEASSSGNGSWLELIPLAAVSVHLLTGNGTEVPLSGPIHLSLPVPSEPRALAVGTSIPAWRFDPKSGLWVRNGTGVIRKEGRQLYWTFVSPQLGYWVAAMASPTSGLVTITSGIQDIGTYHTIFLLTILAALALLVLILLCLLIYYCRRRCLKPRQQHRKLQLSGPSDNKRDQATSMSQLHLICGGPLEPTSSGDPEAPPPGSLHSAFSSSRDLASSRDDFFRAKPRSASRPAAEPPGARTVEGAGLKSARSVEGPGGLEPSLDEYRRGPAGAAAFLHEPPSPPPSFDHYLGHKGAAESKTPDFLLSQSVDQLARPPSLSQPGQLIFCGSIDHLKDNVYRNVMPTLVIPAHYVRLGGEAGAAGVGDEATPPEGSAAGPARPFPQPDPQRPLMQGHAGAGGDSGGGEGWGGGRSAPVSGSVTIPVLFNESTMAQLNGELQALTEKKLLELGVKPHPRAWFVSLDGRSNSQVRHSYIDLQAGSGGRSTDASLDSGVDVHEARPARRRLPREERERAQLPAPPPPAPPRLALSEDTEPSSSESRTGLCSPEDNSLTPLLDEVVAPEGRAATVPRGRGRSRGDSSRSSASELRRDSLTSPEDELGAEVGDEAGDKKSPWQRREERPLMVFNVK" } }, { "url": "https://www.uniprot.org/uniprot/A2A699#A2A699-2", "isoform_ac": "A2A699-2", "locus": {}, "sequence": { "header": "sp|A2A699-2|F1712_MOUSE Isoform 2 of Protein FAM171A2 OS=Mus musculus OX=10090 GN=Fam171a2 PE=1 SV=1 CANONICAL=A2A699-1", "length": 638, "sequence": "MRAFPAFLGTEASSSGNGSWLELIPLAAVSVHLLTGNGTEVPLSGPIHLSLPVPSEPRALAVGTSIPAWRFDPKSGLWVRNGTGVIRKEGRQLYWTFVSPQLGYWVAAMASPTSGLVTITSGIQDIGTYHTIFLLTILAALALLVLILLCLLIYYCRRRCLKPRQQHRKLQLSGPSDNKRDQATSMSQLHLICGGPLEPTSSGDPEAPPPGSLHSAFSSSRDLASSRDDFFRAKPRSASRPAAEPPGARTVEGAGLKSARSVEGPGGLEPSLDEYRRGPAGAAAFLHEPPSPPPSFDHYLGHKGAAESKTPDFLLSQSVDQLARPPSLSQPGQLIFCGSIDHLKDNVYRNVMPTLVIPAHYVRLGGEAGAAGVGDEATPPEGSAAGPARPFPQPDPQRPLMQGHAGAGGDSGGGEGWGGGRSAPVSGSVTIPVLFNESTMAQLNGELQALTEKKLLELGVKPHPRAWFVSLDGRSNSQVRHSYIDLQAGSGGRSTDASLDSGVDVHEARPARRRLPREERERAQLPAPPPPAPPRLALSEDTEPSSSESRTGLCSPEDNSLTPLLDEVVAPEGRAATVPRGRGRSRGDSSRSSASELRRDSLTSPEDELGAEVGDEAGDKKSPWQRREERPLMVFNVK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:217219", "resource": "KEGG Pathway", "id": "mmu:217219", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "A8MVW0-1", "protein_name": "Protein FAM171A2", "sequence": { "length": 826, "sequence": "MPPASGPSVLARLLPLLGLLLGSASRAPGKSPPEPPSPQEILIKVQVYVSGELVPLARASVDVFGNRTLLAAGTTDSEGVATLPLSYRLGTWVLVTAARPGFLTNSVPWRVDKLPLYASVSLYLLPERPATLILYEDLVHILLGSPGARSQPLVQFQRRAARLPVSSTYSQLWASLTPASTQQEMRAFPAFLGTEASSSGNGSWLELMPLTAVSVHLLTGNGTEVPLSGPIHLSLPVPSETRALTVGTSIPAWRFDPKSGLWVRNGTGVIRKEGRQLYWTFVSPQLGYWVAAMASPTAGLVTITSGIQDIGTYHTIFLLTILAALALLVLILLCLLIYYCRRRCLKPRQQHRKLQLSGPSDGNKRDQATSMSQLHLICGGPLEPAPSGDPEAPPPGPLHSAFSSSRDLASSRDDFFRTKPRSASRPAAEPSGARGGESAGLKGARSAEGPGGLEPGLEEHRRGPSGAAAFLHEPPSPPPPFDHYLGHKGAAEGKTPDFLLSQSVDQLARPPSLGQAGQLIFCGSIDHLKDNVYRNVMPTLVIPAHYVRLGGEAGAAGVGDEPAPPEGTAPGPARAFPQPDPQRPQMPGHSGPGGEGGGGGGEGWGAGRAAPVSGSVTIPVLFNESTMAQLNGELQALTEKKLLELGVKPHPRAWFVSLDGRSNSQVRHSYIDLQAGGGARSTDASLDSGVDVHEARPARRRPAREERERAPPAAPPPPPAPPRLALSEDTEPSSSESRTGLCSPEDNSLTPLLDEVAAPEGRAATVPRGRGRSRGDSSRSSASELRRDSLTSPEDELGAEVGDEAGDKKSPWQRREERPLMVFNVK" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A699/", "id": "A2A699", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/19144", "id": "19144", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "FAM171A2", "tax_id": 9606 }, { "uniprot_canonical_ac": "D3ZT47-1", "protein_name": "Family with sequence similarity 171, member A2", "sequence": { "length": 822, "sequence": "MPPPSGPGVLARLLPLLGLLLGGASRAPGKSPPEPPSPQEILIKVQVYVSGELVPLARASVDVFGNRTLLAAGTTDSEGVATLPLSYRLGTWVLVTAARPGFLTNSVPWRVDKLPLYASVSLYLLPERPATLILYEDLVHILLGSPGARSQPWVQFQRRAARLPVSSTYNQLWASLTPASTQQEMRAFPAFLGTEASSSGNGSWLELIPLTAVSVHLLTGNGTEVPLSGPIHLSLPVPSEPRALAVGTSIPAWRFDPKSGLWVRNGTGVIRKEGRQLYWTFVSPQLGYWVAAMASPTSGLVTITSGIQDIGTYHTIFLLTILAALALLVLILLCLLIYYCRRRCLKPRQQHRKLQLSGPSDNKRDQATSMSQLHLICGGPLEPTSSGDPEAPPPGSLHSAFSSSRDLASSRDDFFRAKPRSASRPAAEPPGARSVEGAGLKGARSVEGPGVLEPSLEEYRRGPAGAAAFLHEAPSPPPSFDHYLGHKGAAESKTPDFLLSQSVDQLARPPSLSQPGQLIFCGSIDHLKDNVYRNVMPTLVIPAHYVRLGGEAGAAGVGDEATPPEGSAAGPARPFPQPDPQRPLIQGHAGAGGDGGGGEGWGGGRSAPVSGSVTIPVLFNESTMAQLNGELQALTEKKLLELGVKPHPRAWFVSLDGRSNSQVRHSYIDLQAGGGGRSTDASLDSGVDVHEARPARRRPPREERERAQPPAPPPPAPPRLALSEDTEPSSSESRTGLCSPEDNSLTPLLDEVVAPEGRAATVPRGRGRSRGDSSRSSASELRRDSLTSPEDELGAEVGDEAGDKKSPWQRREERPLMVFNVK" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A699/", "id": "A2A699", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/19144", "id": "19144", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Fam171a2", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954670.2", "ac": "NP_954670.2", "name": "protein FAM171A2 precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A699", "id": "A2A699", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 1, "name": "Cellular Component" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A699", "type": "synonym", "resource": "RefSeq", "name": "Fam171a2" }, { "url": "https://www.uniprot.org/uniprot/A2A699", "type": "recommended", "resource": "UniProtKB", "name": "Fam171a2" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000034685", "id": "ENSMUSG00000034685", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/217219", "id": "217219", "database": "GeneID" }, { "url": "https://acgg.asia/gpdb2/GPDB0001612", "id": "GPDB0001612", "database": "GlycoProtDB" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2A699*", "id": "A2A699", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018890", "id": "IPR018890", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:217219", "id": "mmu:217219", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2448496", "id": "2448496", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/RPLMVFH/", "id": "RPLMVFH", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=615320at2759", "id": "615320at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31626", "id": "PTHR31626", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF10577", "id": "PF10577", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2A699", "id": "PR_A2A699", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954670.2", "id": "NP_954670.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2A699", "id": "A2A699", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [ { "residue": "Asn", "site_category": "predicted", "end_pos": 201, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A699#ptm_processing", "id": "A2A699", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 201, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "site_category": "predicted", "end_pos": 221, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A699#ptm_processing", "id": "A2A699", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 221, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "site_category": "reported_with_glycan", "end_pos": 265, "evidence": [ { "url": "https://glyconnect.expasy.org/browser/proteins/2627", "id": "2627", "database": "GlyConnect" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30899004", "id": "30899004", "database": "PubMed" } ], "subtype": "", "relation": "attached", "start_pos": 265, "glytoucan_ac": "G05724UK", "type": "N-linked" }, { "residue": "Asn", "site_category": "reported_with_glycan", "end_pos": 265, "evidence": [ { "url": "https://glyconnect.expasy.org/browser/proteins/2627", "id": "2627", "database": "GlyConnect" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30899004", "id": "30899004", "database": "PubMed" } ], "subtype": "", "relation": "attached", "start_pos": 265, "glytoucan_ac": "G06110VR", "type": "N-linked" }, { "residue": "Asn", "site_category": "reported_with_glycan", "end_pos": 265, "evidence": [ { "url": "https://glyconnect.expasy.org/browser/proteins/2627", "id": "2627", "database": "GlyConnect" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30899004", "id": "30899004", "database": "PubMed" } ], "subtype": "", "relation": "attached", "start_pos": 265, "glytoucan_ac": "G66538GV", "type": "N-linked" }, { "residue": "Asn", "site_category": "reported", "end_pos": 265, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A699#ptm_processing", "id": "A2A699", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 265, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "site_category": "reported_with_glycan", "end_pos": 66, "evidence": [ { "url": "https://glyconnect.expasy.org/browser/proteins/2627", "id": "2627", "database": "GlyConnect" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30899004", "id": "30899004", "database": "PubMed" } ], "subtype": "", "relation": "attached", "start_pos": 66, "glytoucan_ac": "G06110VR", "type": "N-linked" }, { "residue": "Asn", "site_category": "reported_with_glycan", "end_pos": 66, "evidence": [ { "url": "https://glyconnect.expasy.org/browser/proteins/2627", "id": "2627", "database": "GlyConnect" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30899004", "id": "30899004", "database": "PubMed" } ], "subtype": "", "relation": "attached", "start_pos": 66, "glytoucan_ac": "G63628AV", "type": "N-linked" }, { "residue": "Asn", "site_category": "reported_with_glycan", "end_pos": 66, "evidence": [ { "url": "https://glyconnect.expasy.org/browser/proteins/2627", "id": "2627", "database": "GlyConnect" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30899004", "id": "30899004", "database": "PubMed" } ], "subtype": "", "relation": "attached", "start_pos": 66, "glytoucan_ac": "G66538GV", "type": "N-linked" }, { "residue": "Asn", "site_category": "reported", "end_pos": 66, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A699#ptm_processing", "id": "A2A699", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 66, "glytoucan_ac": "", "type": "N-linked" } ], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": "369", "end_pos": "369", "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A699", "id": "A2A699", "database": "UniProtKB" } ], "start_pos": "369", "end_pos": "369", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": "371", "end_pos": "371", "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A699", "id": "A2A699", "database": "UniProtKB" } ], "start_pos": "371", "end_pos": "371", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": "785", "end_pos": "785", "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A699", "id": "A2A699", "database": "UniProtKB" } ], "start_pos": "785", "end_pos": "785", "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 87487.0, "chemical_mass": 87487.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A699", "name": "Fam171a2", "locus": { "end_pos": 102436981, "strand": "-", "start_pos": 102447682, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000034685", "id": "ENSMUSG00000034685", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2A699#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Protein FAM171A2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A699", "type": "synonym", "resource": "RefSeq", "name": "protein FAM171A2 precursor" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A699", "type": "synonym", "resource": "RefSeq", "name": "protein FAM171A2" } ] }