{
    "uniprot_canonical_ac": "A2A5Z6-1", 
    "ptm_annotation": [
        {
            "annotation": "Auto-ubiquitinated and ubiquitinated in the presence of RNF11 and UBE2D1 (By similarity). Ubiquitinated by the SCF(FBXL15) complex and TTC3, leading to its degradation by the proteasome (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                    "id": "A2A5Z6", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q9HAU4", 
                    "id": "Q9HAU4", 
                    "database": "PubMed"
                }
            ]
        }
    ], 
    "sequence": {
        "header": "sp|A2A5Z6-1|SMUF2_MOUSE Isoform 1 of E3 ubiquitin-protein ligase SMURF2  OS=Mus musculus OX=10090 GN=Smurf2 PE=1 SV=1 CANONICAL=A2A5Z6-1", 
        "length": 748, 
        "sequence": "MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPITGTNGATCGHSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVPLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKVNTRLKHCTPDSNVVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE"
    }, 
    "uniprot_id": "SMUF2_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "2.3.2.26", 
            "activity": ""
        }, 
        {
            "ec": "2.3.2.26", 
            "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine."
        }
    ], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                    "id": "A2A5Z6", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "12520002"
                }
            ], 
            "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", 
            "journal": "Nucleic acids research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
                    "id": "NP_079757.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", 
            "date": "2003"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/15820682", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "15820682"
                }
            ], 
            "title": "Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation.", 
            "journal": "Cell", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                    "id": "A2A5Z6", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Li C., Yamashita M., Deng C.X., Cheng S.Y., Zhang Y.E., Ying S.X., Zhang G.M.", 
            "date": "2005"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/16373342", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "16373342"
                }
            ], 
            "title": "Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.", 
            "journal": "J. Biol. Chem.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                    "id": "A2A5Z6", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
                    "id": "NP_079757.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Yao Z., Chen D., Xing L., Guo R., Boyce B.F., Zhang Y.E., Schwarz E.M., Kaneki H.", 
            "date": "2006"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/18448069", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "18448069"
                }
            ], 
            "title": "AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2.", 
            "journal": "Biochem. Biophys. Res. Commun.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                    "id": "A2A5Z6", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
                    "id": "NP_079757.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Lee Y.S., Han J.M., Kim S., Choi J.W., Bae S.-C., Son S.H., Jeon E.J., Park Y.I.", 
            "date": "2008"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/28468752", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "28468752"
                }
            ], 
            "title": "USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling.", 
            "journal": "The EMBO journal", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
                    "id": "NP_079757.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Zhou F, Xie F, Jin K, Zhang Z, Clerici M, Gao R, van Dinther M, Sixma TK, Huang H, Zhang L, Ten Dijke P", 
            "date": "2017"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/28611047", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "28611047"
                }
            ], 
            "title": "Smurf2-Mediated Stabilization of DNA Topoisomerase IIalpha Controls Genomic Integrity.", 
            "journal": "Cancer research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
                    "id": "NP_079757.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Emanuelli A, Borroni AP, Apel-Sarid L, Shah PA, Ayyathan DM, Koganti P, Levy-Cohen G, Blank M", 
            "date": "2017"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/29805305", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "29805305"
                }
            ], 
            "title": "Generation of Smurf2 Conditional Knockout Mice.", 
            "journal": "International journal of biological sciences", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
                    "id": "NP_079757.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Tang Y, Tang LY, Xu X, Li C, Deng C, Zhang YE", 
            "date": "2018"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/29853617", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "29853617"
                }
            ], 
            "title": "Bmp2 and Notch cooperate to pattern the embryonic endocardium.", 
            "journal": "Development (Cambridge, England)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
                    "id": "NP_079757.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Papoutsi T, Luna-Zurita L, Prados B, Zaffran S, de la Pompa JL", 
            "date": "2018"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/30758996", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "30758996"
                }
            ], 
            "title": "The HECT ubiquitin E3 ligase Smurf2 degrades mu-opioid receptor 1 in the ubiquitin-proteasome system in lung epithelial cells.", 
            "journal": "American journal of physiology. Cell physiology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
                    "id": "NP_079757.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Dong S, Liu J, Li L, Wang H, Ma H, Zhao Y, Zhao J", 
            "date": "2019"
        }
    ], 
    "uniprot_ac": "A2A5Z6", 
    "site_annotation": [
        {
            "end_pos": 127, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 125
        }, 
        {
            "end_pos": 322, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 320
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A5Z6#A0A338P709-1", 
            "isoform_ac": "A0A338P709-1", 
            "locus": {
                "end_pos": 106869105, 
                "strand": "+", 
                "start_pos": 106920232, 
                "chromosome": "11", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000139297", 
                        "id": "ENSMUST00000139297", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000156224", 
                        "id": "ENSMUSP00000156224", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A338P709-1|SMUF2_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase SMURF2  OS=Mus musculus OX=10090 GN=Smurf2 PE=1 SV=1 CANONICAL=A2A5Z6-1", 
                "length": 68, 
                "sequence": "MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLQ"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A5Z6#A2A5Z6-1", 
            "isoform_ac": "A2A5Z6-1", 
            "locus": {
                "end_pos": 106822668, 
                "strand": "+", 
                "start_pos": 106920232, 
                "chromosome": "11", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000167787", 
                        "id": "ENSMUST00000167787", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000129269", 
                        "id": "ENSMUSP00000129269", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2A5Z6-1|SMUF2_MOUSE Isoform 1 of E3 ubiquitin-protein ligase SMURF2  OS=Mus musculus OX=10090 GN=Smurf2 PE=1 SV=1 CANONICAL=A2A5Z6-1", 
                "length": 748, 
                "sequence": "MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPITGTNGATCGHSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVPLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKVNTRLKHCTPDSNVVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A5Z6#A2A5Z6-2", 
            "isoform_ac": "A2A5Z6-2", 
            "locus": {
                "end_pos": 106822668, 
                "strand": "+", 
                "start_pos": 106920232, 
                "chromosome": "11", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000103067", 
                        "id": "ENSMUST00000103067", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000099356", 
                        "id": "ENSMUSP00000099356", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2A5Z6-2|SMUF2_MOUSE Isoform 2 of E3 ubiquitin-protein ligase SMURF2  OS=Mus musculus OX=10090 GN=Smurf2 PE=1 SV=1 CANONICAL=A2A5Z6-1", 
                "length": 735, 
                "sequence": "MSNPGGRRNGPVKLRLTGLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPITGTNGATCGHSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVPLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKVNTRLKHCTPDSNVVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:66313", 
            "resource": "KEGG Pathway", 
            "id": "mmu:66313", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-201451", 
            "resource": "Reactome", 
            "id": "R-MMU-201451", 
            "name": "Signaling by BMP"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2173788", 
            "resource": "Reactome", 
            "id": "R-MMU-2173788", 
            "name": "Downregulation of TGF-beta receptor signaling"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2173795", 
            "resource": "Reactome", 
            "id": "R-MMU-2173795", 
            "name": "Downregulation of SMAD2/3:SMAD4 transcriptional activity"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-4608870", 
            "resource": "Reactome", 
            "id": "R-MMU-4608870", 
            "name": "Asymmetric localization of PCP proteins"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-4641257", 
            "resource": "Reactome", 
            "id": "R-MMU-4641257", 
            "name": "Degradation of AXIN"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5632684", 
            "resource": "Reactome", 
            "id": "R-MMU-5632684", 
            "name": "Hedgehog 'on' state"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5689880", 
            "resource": "Reactome", 
            "id": "R-MMU-5689880", 
            "name": "Ub-specific processing proteases"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8941858", 
            "resource": "Reactome", 
            "id": "R-MMU-8941858", 
            "name": "Regulation of RUNX3 expression and activity"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", 
            "resource": "Reactome", 
            "id": "R-MMU-983168", 
            "name": "Antigen processing: Ubiquitination & Proteasome degradation"
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
            "annotation": "AIMP1 negatively regulates TGF-beta signaling via stabilization of Smurf2.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
                    "id": "NP_079757.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
            "annotation": "Although conventional Smurf2 double knockout mice are early embryonic lethal, Cre-mediated recombination in mouse embryonic fibroblasts results in Smurf2 knockout cells that show it has roles in regulating many different signaling pathways and in genomic stability, cell polarity, tissue homeostasis and carcinogenesis Publication Status: Online-Only", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
                    "id": "NP_079757.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A5Z6#function", 
            "annotation": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level. Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A5Z6#function", 
                    "id": "A2A5Z6", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
            "annotation": "Results identified Smurf2 as an essential regulator of Topo IIalpha, providing novel insights into its control and into the suggested tumor-suppressor functions of Smurf2.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
                    "id": "NP_079757.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
            "annotation": "Smurf2 negatively regulates MOR1 activity by reducing its stability in lung epithelial cells.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
                    "id": "NP_079757.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
            "annotation": "Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
                    "id": "NP_079757.2", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9HAU4-1", 
            "protein_name": "E3 ubiquitin-protein ligase SMURF2", 
            "sequence": {
                "length": 748, 
                "sequence": "MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/41490", 
                    "id": "41490", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "SMURF2", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079757.2", 
        "ac": "NP_079757.2", 
        "name": "E3 ubiquitin-protein ligase SMURF2 isoform 1", 
        "summary": ""
    }, 
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            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ubiquitin protein ligase activity", 
                        "id": "GO:0061630"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "identical protein binding", 
                        "id": "GO:0042802"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005160", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transforming growth factor beta receptor binding", 
                        "id": "GO:0005160"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046332", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "SMAD binding", 
                        "id": "GO:0046332"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ubiquitin-protein transferase activity", 
                        "id": "GO:0004842"
                    }
                ], 
                "total": 5, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytosol", 
                        "id": "GO:0005829"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "plasma membrane", 
                        "id": "GO:0005886"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nuclear speck", 
                        "id": "GO:0016607"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "membrane raft", 
                        "id": "GO:0045121"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ubiquitin ligase complex", 
                        "id": "GO:0000151"
                    }
                ], 
                "total": 6, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", 
                        "id": "GO:0043161"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030514", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of BMP signaling pathway", 
                        "id": "GO:0030514"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein ubiquitination", 
                        "id": "GO:0016567"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045732", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of protein catabolic process", 
                        "id": "GO:0045732"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein polyubiquitination", 
                        "id": "GO:0000209"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030579", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ubiquitin-dependent SMAD protein catabolic process", 
                        "id": "GO:0030579"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901165", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of trophoblast cell migration", 
                        "id": "GO:1901165"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ubiquitin-dependent protein catabolic process", 
                        "id": "GO:0006511"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030512", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
                                "id": "A2A5Z6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of transforming growth factor beta receptor signaling pathway", 
                        "id": "GO:0030512"
                    }
                ], 
                "total": 9, 
                "name": "Biological Process"
            }
        ]
    }, 
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        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A5Z6", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "2810411E22Rik; AI558114; AI649275"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A5Z6", 
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            "resource": "RefSeq", 
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        {
            "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
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            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000018363", 
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            "id": "cd00201", 
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            "id": "66313", 
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            "url": "https://www.ebi.ac.uk/intact/interactors/id:A2A5Z6*", 
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        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", 
            "id": "IPR000008", 
            "database": "InterPro"
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            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000569", 
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            "database": "InterPro"
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        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR024928", 
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        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035983", 
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            "database": "InterPro"
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        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", 
            "id": "IPR036020", 
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            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:66313", 
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            "database": "KEGG Pathway"
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        {
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        {
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        {
            "url": "http://pfam.xfam.org/family/PF00632", 
            "id": "PF00632", 
            "database": "Pfam"
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        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A2A5Z6", 
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        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-201451", 
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        {
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            "database": "Reactome"
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        {
            "url": "https://www.uniprot.org/uniprot/A2A5Z6", 
            "id": "A2A5Z6", 
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            "resource": "UniProtKB", 
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}