{ "uniprot_canonical_ac": "A2A5N8-1", "ptm_annotation": [ { "annotation": "Ubiquitinated in a VCP/p97-dependent way following DNA damage, leading to its removal from DNA damage sites, promoting accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited to DNA damage sites.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2A5N8-1|LMBL1_MOUSE Isoform 1 of Lethal(3)malignant brain tumor-like protein 1 OS=Mus musculus OX=10090 GN=L3mbtl1 PE=2 SV=1 CANONICAL=A2A5N8-1", "length": 826, "sequence": "MEGHTDMEILRTVKGSSTGEVNVHLVARDSAGPHPQLPTTAFIIPTNAATLGLPSTALDVPYPREPVHVGALERVAGSEPVTATILPQLSTGTGTNSTVRLLDWTGVSAPLPGSGMRFRINEYAPLNMIGVERPRSPEQRHEGGMARRDAGIQHPDVHQDRQDITSLEPPVDASSCKCQACGPQQSSGLDVGSSGDRCSQPFQKRSVIVENSGCTIASELLKPMKKRKHKEYQSPSEESEPEAVKQGEGKDAEREPTPSTPENEEWSRSQLVSSEKKDGWSWESYLEEQKAVTAPVSLFQDSQAVTHNKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQLPKGYKEEEFSWSQYLRSTKAQAAPKHLFVSQSHSTPPVGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDDWGDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDSFCWEKYLEETGTSAVPNWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKLHFDGWSHNYDFWIDADHPDIHPAGWCSKTGHPLEPPLRPRESSSVSPGGCPPLSHRSPPHTKTSKYNFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAEKNQSRLKAELSDSETAARKKNPSNLSPRKKPRHQGRIGRPPKYRKIPEEDLQALPPSVVHQSLFMSTLPTHADRPLSVCWEQHCKLLPGVAGISASTVSKWTIEEVFGFVQTLTGSEDQARLFKDEMIDGEAFLLLTQADIVKIMSVKLGPALKIYNAILMFKNTDDAFK" }, "uniprot_id": "LMBL1_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16081246", "type": [ "PubMed" ], "id": "16081246" } ], "title": "L3mbtl, the mouse orthologue of the imprinted L3MBTL, displays a complex pattern of alternative splicing and escapes genomic imprinting.", "journal": "Genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074807.1", "id": "NP_001074807.1", "database": "RefSeq" } ], "authors": "Li J, Bench AJ, Piltz S, Vassiliou G, Baxter EJ, Ferguson-Smith AC, Green AR", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20592034", "type": [ "PubMed" ], "id": "20592034" } ], "title": "Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074807.1", "id": "NP_001074807.1", "database": "RefSeq" } ], "authors": "Qin J., Zhong L., Mostoslavsky R., Huang H.S., Akbarian S., Hock H., Van Buren D.", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25849281", "type": [ "PubMed" ], "id": "25849281" } ], "title": "Cognition and mood-related behaviors in L3mbtl1 null mutant mice.", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074807.1", "id": "NP_001074807.1", "database": "RefSeq" } ], "authors": "Shen EY, Jiang Y, Mao W, Futai K, Hock H, Akbarian S", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27081692", "type": [ "PubMed" ], "id": "27081692" } ], "title": "Characterization of non-canonical Polycomb Repressive Complex 1 subunits during early mouse embryogenesis.", "journal": "Epigenetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074807.1", "id": "NP_001074807.1", "database": "RefSeq" } ], "authors": "Eid A, Torres-Padilla ME", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29898393", "type": [ "PubMed" ], "id": "29898393" } ], "title": "Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1.", "journal": "Cell reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074807.1", "id": "NP_001074807.1", "database": "RefSeq" } ], "authors": "Mao W, Salzberg AC, Uchigashima M, Hasegawa Y, Hock H, Watanabe M, Akbarian S, Kawasawa YI, Futai K", "date": "2018" } ], "uniprot_ac": "A2A5N8", "site_annotation": [ { "end_pos": 660, "annotation": "n_glycosylation_sequon", "start_pos": 658 }, { "end_pos": 682, "annotation": "n_glycosylation_sequon", "start_pos": 680 }, { "end_pos": 98, "annotation": "n_glycosylation_sequon", "start_pos": 96 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8#A2A5N8-1", "isoform_ac": "A2A5N8-1", "locus": { "end_pos": 162947189, "strand": "-", "start_pos": 162974519, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000035751", "id": "ENSMUST00000035751", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000044038", "id": "ENSMUSP00000044038", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A5N8-1|LMBL1_MOUSE Isoform 1 of Lethal(3)malignant brain tumor-like protein 1 OS=Mus musculus OX=10090 GN=L3mbtl1 PE=2 SV=1 CANONICAL=A2A5N8-1", "length": 826, "sequence": "MEGHTDMEILRTVKGSSTGEVNVHLVARDSAGPHPQLPTTAFIIPTNAATLGLPSTALDVPYPREPVHVGALERVAGSEPVTATILPQLSTGTGTNSTVRLLDWTGVSAPLPGSGMRFRINEYAPLNMIGVERPRSPEQRHEGGMARRDAGIQHPDVHQDRQDITSLEPPVDASSCKCQACGPQQSSGLDVGSSGDRCSQPFQKRSVIVENSGCTIASELLKPMKKRKHKEYQSPSEESEPEAVKQGEGKDAEREPTPSTPENEEWSRSQLVSSEKKDGWSWESYLEEQKAVTAPVSLFQDSQAVTHNKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQLPKGYKEEEFSWSQYLRSTKAQAAPKHLFVSQSHSTPPVGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDDWGDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDSFCWEKYLEETGTSAVPNWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKLHFDGWSHNYDFWIDADHPDIHPAGWCSKTGHPLEPPLRPRESSSVSPGGCPPLSHRSPPHTKTSKYNFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAEKNQSRLKAELSDSETAARKKNPSNLSPRKKPRHQGRIGRPPKYRKIPEEDLQALPPSVVHQSLFMSTLPTHADRPLSVCWEQHCKLLPGVAGISASTVSKWTIEEVFGFVQTLTGSEDQARLFKDEMIDGEAFLLLTQADIVKIMSVKLGPALKIYNAILMFKNTDDAFK" } }, { "url": "https://www.uniprot.org/uniprot/A2A5N8#A2A6Y5-1", "isoform_ac": "A2A6Y5-1", "locus": { "end_pos": 162948188, "strand": "-", "start_pos": 162949538, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000124264", "id": "ENSMUST00000124264", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000116118", "id": "ENSMUSP00000116118", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2A6Y5-1|LMBL1_MOUSE Computationally mapped isoform of Lethal(3)malignant brain tumor-like protein 1 OS=Mus musculus OX=10090 GN=L3mbtl1 PE=2 SV=1 CANONICAL=A2A5N8-1", "length": 144, "sequence": "MIGVERPRSPEQRHEGGMARRDAGIQHPDVHQDRQDITSLEPPVDASSCKCQACGPQQSSGLDVGSSGDRCSQPFQKRSVIVENSGCTIASELLKPMKKRKHKEYQSPSEESEPEAVKQGEGKDAEREPTPSTPENEEWSRSQL" } }, { "url": "https://www.uniprot.org/uniprot/A2A5N8#Q3V558-1", "isoform_ac": "Q3V558-1", "locus": { "end_pos": 162947189, "strand": "-", "start_pos": 162948887, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000156954", "id": "ENSMUST00000156954", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000123217", "id": "ENSMUSP00000123217", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q3V558-1|LMBL1_MOUSE Computationally mapped isoform of Lethal(3)malignant brain tumor-like protein 1 OS=Mus musculus OX=10090 GN=L3mbtl1 PE=2 SV=1 CANONICAL=A2A5N8-1", "length": 244, "sequence": "MEGHTDMEILRTVKGSSTGEVNVHLVARDSAGPHPQLPTTAFIIPTNAATLGLPSTALDVPYPREPVHVGALERVAGSEPVTATILPQLSTGTGTNSTVRLLDWTGVSAPLPGSGMRFRINEYAPLNMIGVERPRSPEQRHEGGMARRDAGIQHPDVHQDRQDITSLEPPVDASSCKCQACGPQQSSGLDVGSSGDRCSQPFQKRSVIVENSGCTIASELLKPMKKRKHKEYQSPSEESEPEAV" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:241764", "resource": "KEGG Pathway", "id": "mmu:241764", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6804760", "resource": "Reactome", "id": "R-MMU-6804760", "name": "Regulation of TP53 Activity through Methylation" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074807.1", "annotation": "Generation and analysis of mice after disruption of L3MBTL1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074807.1", "id": "NP_001074807.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074807.1", "annotation": "L3mbtl1 (lethal 3 malignant brain tumor-like 1), a polycomb chromatin reader, is downregulated by neuronal activity and is essential for synaptic response and downscaling. L3mbtl1 knockout neurons enhanced synaptic transmission and restored homeostatic downscaling.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074807.1", "id": "NP_001074807.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074807.1", "annotation": "L3mbtl1 loss-of-function was associated with significant decreases in depression and and anxiety in some of the behavioral paradigms. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074807.1", "id": "NP_001074807.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2A5N8#function", "annotation": "Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8#function", "id": "A2A5N8", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZWK4-1", "protein_name": "Lethal(3)malignant brain tumor-like protein 1", "sequence": { "length": 826, "sequence": "MEGHSDMEIIRAVKGSATGEINVHLVARDSAGSHPHLPTTTFIIPTNAATLGLPSTALDVSYPREPVHVGAAERVAGSEPVTATILPQLSTGPGTNSTVRLLDWTGVSAPLAGSGMRFRINEYATQNMIEIERPRSPEQRHEGGTAGREADIQHPDVHKDPQEVIPQEPSVDAGSCKCQTCGPQQSIGLDVGSSGDRCPQPFQKRSVIVENSGCTVASELIKPMKKRKHKEYQSPSEESEPEAMKQGKGKDPDREPTPGTSENEEWSRSQLVSSEKKEGWSWESYLEEQKAVTAPVSLFQDSQAVTHNKNGFKLGMKLEGVDPQHPSMYFVLTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFSWSQYLRSTKAQAAPKHLFVSQSHSPPPVGFQVGMKLEAVDRMNPSLVCVASVTDVVASRFLVHFDDWDDTYDYWCDASSPYIHPVGWCQKQGKPLTPPQDYPDPDSFCWEKYLEETGTSAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKLHFDGWSHNYDFWIDADHPDIHPAGWCSKTGHPLEPPLRPRESSSASPGGCPPLSHRSPPHTKTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSETTARKKNQSNLSPRKKPRHQGRIGRPPKYRKMPDEDFQALPPSVVHQSLFMSTLPTHADRPLSVCWEQHCKLLPGVAGISASAVSKWTIEEVFGFVQTLTGSEDQARLFKEEMIDGEAFLLLTQADIVKIMSVKLGPALKIYNAILMFKNNDDVFK" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A5N8/", "id": "A2A5N8", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "L3mbtl1", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9Y468-5", "protein_name": "Lethal(3)malignant brain tumor-like protein 1", "sequence": { "length": 840, "sequence": "MHLVAGDSPGSGPHLPATAFIIPASSATLGLPSSALDVSCFPREPIHVGAPEQVAGCEPVSATVLPQLSAGPASSSTSTVRLLEWTEAAAPPPGGGLRFRISEYKPLNMAGVEQPPSPELRQEGVTEYEDGGAPAGDGEAGPQQAEDHPQNPPEDPNQDPPEDDSTCQCQACGPHQAAGPDLGSSNDGCPQLFQERSVIVENSSGSTSASELLKPMKKRKRREYQSPSEEESEPEAMEKQEEGKDPEGQPTASTPESEEWSSSQPATGEKKECWSWESYLEEQKAITAPVSLFQDSQAVTHNKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDNFCWEKYLEETGASAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLGPREPSSASPGGCPPLSYRSLPHTRTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSEASARKKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQTLTPDVVHQSLFMSALSAHPDRSLSVCWEQHCKLLPGVAGISASTVAKWTIDEVFGFVQTLTGCEDQARLFKDEARIVRVTHVSGKTLVWTVAQLGDLVCSDHLQEGKGILETGVHSLLCSLPTHLLAKLSFASDSQY" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A5N8/", "id": "A2A5N8", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/41846", "id": "41846", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "L3MBTL1", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074807.1", "ac": "NP_001074807.1", "name": "lethal(3)malignant brain tumor-like protein 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031493", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "nucleosomal histone binding", "id": "GO:0031493" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032093", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "SAM domain binding", "id": "GO:0032093" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "chromatin binding", "id": "GO:0003682" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "zinc ion binding", "id": "GO:0008270" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "identical protein binding", "id": "GO:0042802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "histone binding", "id": "GO:0042393" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031491", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "nucleosome binding", "id": "GO:0031491" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035064", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "methylated histone binding", "id": "GO:0035064" } ], "total": 8, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000793", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "condensed chromosome", "id": "GO:0000793" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "chromatin", "id": "GO:0000785" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0040029", "pmid": "16081246", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "regulation of gene expression, epigenetic", "id": "GO:0040029" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "negative regulation of transcription, DNA-templated", "id": "GO:0045892" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030097", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "hemopoiesis", "id": "GO:0030097" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "chromatin organization", "id": "GO:0006325" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045652", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "regulation of megakaryocyte differentiation", "id": "GO:0045652" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007088", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "name": "regulation of mitotic nuclear division", "id": "GO:0007088" } ], "total": 6, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A5N8", "type": "synonym", "resource": "RefSeq", "name": "C630004G01; L3MBT; L3mbtl; mKIAA0681" }, { "url": "https://www.uniprot.org/uniprot/A2A5N8", "type": "synonym", "resource": "UniProtKB", "name": "Kiaa0681" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A5N8", "type": "synonym", "resource": "RefSeq", "name": "L3mbtl1" }, { "url": "https://www.uniprot.org/uniprot/A2A5N8", "type": "recommended", "resource": "UniProtKB", "name": "L3mbtl1" }, { "url": "https://www.uniprot.org/uniprot/A2A5N8", "type": "synonym", "resource": "UniProtKB", "name": "L3mbtl" }, { "url": 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{ "url": "http://www.informatics.jax.org/marker/MGI:2676663", "id": "2676663", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/RKNQQRD/", "id": "RKNQQRD", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=63195at2759", "id": "63195at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00536", "id": "PF00536", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF01530", "id": "PF01530", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF02820", "id": "PF02820", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2A5N8", "id": "PR_A2A5N8", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6804760", "id": "R-MMU-6804760", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074807.1", "id": "NP_001074807.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2A5N8", "id": "A2A5N8", "database": "UniProtKB" } ], "expression_disease": [], 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"https://www.uniprot.org/uniprot/A2A5N8#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "L(3)mbt-like" }, { "url": "https://www.uniprot.org/uniprot/A2A5N8#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Lethal(3)malignant brain tumor-like protein 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A5N8", "type": "synonym", "resource": "RefSeq", "name": "lethal(3)malignant brain tumor-like protein 1" } ] }