{ "uniprot_canonical_ac": "A1Z198-1", "ptm_annotation": [], "sequence": { "header": "sp|A1Z198-1|NL1B2_MOUSE Isoform 1 of NACHT, LRR and PYD domains-containing protein 1b allele 2 OS=Mus musculus OX=10090 GN=Nlrp1b PE=2 SV=1 CANONICAL=A1Z198-1", "length": 1177, "sequence": "MEESQYKQEHNKKVAQDEGQEDKDTIFETIEAIEAKLMELKTNPESTFNYGIFPEVYMNQGEEILYPAWSLKEENLFQTFKSLRLFQKLCPRGSGNLVKKSWYPCVPEEGGHIINIQDLFGPNIGTQKEPQLVIIEGAAGIGKSTLARQVKRAWMEGELYRDHFQHVFFFSCRELAQCKKLSLAELITQGQDVPTAPINQILSHPEKLLFILDGIDEPAWVLADQNPELCLYWSQTQPVHTLLGSLLGKSILPEASFLLTTRTTALQKFIPSLPQSCQVEVLGFSDFEQEIYIYKYFAKQIFGIKALMMVESNPVLLTLCEVPWVCWLVCNCLKKQMEQGGDVSLTSQTTTAICLKYISLTIPVHHMRTQLRALCSLAAEGIWKRRTLFSESDLCKQGLDEDAVAIFLKTGVLQKQASSLSYSFAHLCLQEFFASMSCILEDSEERHGDMEMDRIVETLVERYGRQNLFEAPTVRFLFGLLSKEGLKEMEKLFSCSLPGKTKLKLLWHILGKSQPHQPPCLGLLHCLYENQDMKLLTHVMHDLQGTIVPDTDDITHTVLQTNVKHLVVRTDMELMVVTFCIQFCSHMRSLQLNMEGQQGYALTAPRMVLYRWTPITNASWKILFYNLKFNSNLEGLDLSGNPLSYSAVQYLCDAMIYPGCQLKTLWLVECGLTPTYCSLLASVLSACSSLRELDLQLNDLCDDGVRMLCEGLRNRACNLRILRLDLYSLSAQVITELRTLEENNLKLHISSIWMPQMMVPTENMDEEDILTSFKQQRQQSGANPMEILGTEEDFWGPIGPVATEVVYRERNLYRVQLPMAGSYHCPSTRLHFVVTRAVTIEIEFCAWSQFLDKTPLQQSHMVVGPLFDIKAEQGAVTAVYLPHFVSLKDTKASTFDFKVAHFQEHGMVLETPDRVKPGYTVLKNPSFSPMGVVLRIIPAARHFIPITSITLIYYRVNQEEVTLHLYLVPNDCTIQKAIDDEEMKFQFVRINKPPPVDNLFIGSRYIVSGSENLEITPKELELCYRSSKEFQLFSEIYVGNMGSEIKLQIKNKKHMKLIWEALLKPGDLRPALPRIAQALKDAPSLLHFMDQHREQLVARVTSVDPLLDKLHGLVLNEESYEAVRAENTNQDKMRKLFNLSRSWSRACKDLFYQALKETHPHLVMDLLEKSGGVSLGS" }, "uniprot_id": "NL1B2_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16429160", "type": [ "PubMed" ], "id": "16429160" } ], "title": "Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin.", "journal": "Nat. Genet.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "id": "NP_001035786.1", "database": "RefSeq" } ], "authors": "Boyden E.D., Dietrich W.F.", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17442855", "type": [ "PubMed" ], "id": "17442855" } ], "title": "Caspase-1 inflammasomes in infection and inflammation.", "journal": "Journal of leukocyte biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "id": "NP_001035786.1", "database": "RefSeq" } ], "authors": "Lamkanfi M, Kanneganti TD, Franchi L, Nunez G", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18511561", "type": [ "PubMed" ], "id": "18511561" } ], "title": "A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "authors": "Hsu L.C., Dixit V.M., Karin M., Ali S.R., Eckmann L., Humke E.W., Mariathasan S., McGillivray S., Nizet V., Powell J.J., Tseng P.H.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19651869", "type": [ "PubMed" ], "id": "19651869" } ], "title": "Expression of Nlrp1b inflammasome components in human fibroblasts confers susceptibility to anthrax lethal toxin.", "journal": "Infection and immunity", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "id": "NP_001035786.1", "database": "RefSeq" } ], "authors": "Liao KC, Mogridge J", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19949100", "type": [ "PubMed" ], "id": "19949100" } ], "title": "Cutting edge: resistance to Bacillus anthracis infection mediated by a lethal toxin sensitive allele of Nalp1b/Nlrp1b.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "id": "NP_001035786.1", "database": "RefSeq" } ], "authors": "Terra JK, Cote CK, France B, Jenkins AL, Bozue JA, Welkos SL, LeVine SM, Bradley KA", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21170303", "type": [ "PubMed" ], "id": "21170303" } ], "title": "Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment.", "journal": "PLoS Pathog.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "id": "NP_001035786.1", "database": "RefSeq" } ], "authors": "Liu S., Leppla S.H., Eckhaus M., Cataisson C., Crown D., Moayeri M., Newman Z.L., Okugawa S., Sastalla I.", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23506131", "type": [ "PubMed" ], "id": "23506131" } ], "title": "Transcriptional analysis of the three Nlrp1 paralogs in mice.", "journal": "BMC Genomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "authors": "Leppla S.H., Masters S.L., Crown D., McKenzie A., Moayeri M., Sastalla I.", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24218483", "type": [ "PubMed" ], "id": "24218483" } ], "title": "NLRP1 is an inflammasome sensor for Toxoplasma gondii.", "journal": "Infect. Immun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "authors": "Boothroyd J.C., Chavarria-Smith J., Ewald S.E.", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24492532", "type": [ "PubMed" ], "id": "24492532" } ], "title": "Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "authors": "Lamkanfi M., Vande Walle L., Kanneganti T.D., Fossoul A., Gurung P., Van Opdenbosch N.", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26253422", "type": [ "PubMed" ], "id": "26253422" } ], "title": "Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes.", "journal": "J. Neuroinflamm.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "authors": "Timmerman V., De Winter V., Lamkanfi M., Ydens E., Janssens S., Demon D., Lornet G.", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29396289", "type": [ "PubMed" ], "id": "29396289" } ], "title": "Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome.", "journal": "Cell chemical biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "id": "NP_001035786.1", "database": "RefSeq" } ], "authors": "Okondo MC, Rao SD, Taabazuing CY, Chui AJ, Poplawski SE, Johnson DC, Bachovchin DA", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30872531", "type": [ "PubMed" ], "id": "30872531" } ], "title": "N-terminal degradation activates the NLRP1B inflammasome.", "journal": "Science (New York, N.Y.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "id": "NP_001035786.1", "database": "RefSeq" } ], "authors": "Chui AJ, Okondo MC, Rao SD, Gai K, Griswold AR, Johnson DC, Ball DP, Taabazuing CY, Orth EL, Vittimberga BA, Bachovchin DA", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31100244", "type": [ "PubMed" ], "id": "31100244" } ], "title": "When Degradation Elicits the Alarm: N-Terminal Degradation of NLRP1B Unleashes Its Inflammasome Activity.", "journal": "Molecular cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "id": "NP_001035786.1", "database": "RefSeq" } ], "authors": "Eldeeb MA, Fahlman RP, Esmaili M, Fon EA", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31554824", "type": [ "PubMed" ], "id": "31554824" } ], "title": "Nlrp1b1 negatively modulates obesity-induced inflammation by promoting IL-18 production.", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "id": "NP_001035786.1", "database": "RefSeq" } ], "authors": "Salazar-Leon J, Valdez-Hernandez AL, Garcia-Jimenez S, Roman-Dominguez L, Huanosta-Murillo E, Bonifaz LC, Perez-Martinez L, Pedraza-Alva G", "date": "2019" } ], "uniprot_ac": "A1Z198", "site_annotation": [ { "end_pos": 1140, "annotation": "n_glycosylation_sequon", "start_pos": 1138 }, { "end_pos": 619, "annotation": "n_glycosylation_sequon", "start_pos": 617 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1Z198#A1Z198-1", "isoform_ac": "A1Z198-1", "locus": { "end_pos": 71156003, "strand": "+", "start_pos": 71201298, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000108515", "id": "ENSMUST00000108515", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000104155", "id": "ENSMUSP00000104155", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1Z198-1|NL1B2_MOUSE Isoform 1 of NACHT, LRR and PYD domains-containing protein 1b allele 2 OS=Mus musculus OX=10090 GN=Nlrp1b PE=2 SV=1 CANONICAL=A1Z198-1", "length": 1177, "sequence": "MEESQYKQEHNKKVAQDEGQEDKDTIFETIEAIEAKLMELKTNPESTFNYGIFPEVYMNQGEEILYPAWSLKEENLFQTFKSLRLFQKLCPRGSGNLVKKSWYPCVPEEGGHIINIQDLFGPNIGTQKEPQLVIIEGAAGIGKSTLARQVKRAWMEGELYRDHFQHVFFFSCRELAQCKKLSLAELITQGQDVPTAPINQILSHPEKLLFILDGIDEPAWVLADQNPELCLYWSQTQPVHTLLGSLLGKSILPEASFLLTTRTTALQKFIPSLPQSCQVEVLGFSDFEQEIYIYKYFAKQIFGIKALMMVESNPVLLTLCEVPWVCWLVCNCLKKQMEQGGDVSLTSQTTTAICLKYISLTIPVHHMRTQLRALCSLAAEGIWKRRTLFSESDLCKQGLDEDAVAIFLKTGVLQKQASSLSYSFAHLCLQEFFASMSCILEDSEERHGDMEMDRIVETLVERYGRQNLFEAPTVRFLFGLLSKEGLKEMEKLFSCSLPGKTKLKLLWHILGKSQPHQPPCLGLLHCLYENQDMKLLTHVMHDLQGTIVPDTDDITHTVLQTNVKHLVVRTDMELMVVTFCIQFCSHMRSLQLNMEGQQGYALTAPRMVLYRWTPITNASWKILFYNLKFNSNLEGLDLSGNPLSYSAVQYLCDAMIYPGCQLKTLWLVECGLTPTYCSLLASVLSACSSLRELDLQLNDLCDDGVRMLCEGLRNRACNLRILRLDLYSLSAQVITELRTLEENNLKLHISSIWMPQMMVPTENMDEEDILTSFKQQRQQSGANPMEILGTEEDFWGPIGPVATEVVYRERNLYRVQLPMAGSYHCPSTRLHFVVTRAVTIEIEFCAWSQFLDKTPLQQSHMVVGPLFDIKAEQGAVTAVYLPHFVSLKDTKASTFDFKVAHFQEHGMVLETPDRVKPGYTVLKNPSFSPMGVVLRIIPAARHFIPITSITLIYYRVNQEEVTLHLYLVPNDCTIQKAIDDEEMKFQFVRINKPPPVDNLFIGSRYIVSGSENLEITPKELELCYRSSKEFQLFSEIYVGNMGSEIKLQIKNKKHMKLIWEALLKPGDLRPALPRIAQALKDAPSLLHFMDQHREQLVARVTSVDPLLDKLHGLVLNEESYEAVRAENTNQDKMRKLFNLSRSWSRACKDLFYQALKETHPHLVMDLLEKSGGVSLGS" } }, { "url": "https://www.uniprot.org/uniprot/A1Z198#A1Z198-2", "isoform_ac": "A1Z198-2", "locus": { "end_pos": 71156003, "strand": "+", "start_pos": 71228467, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000094046", "id": "ENSMUST00000094046", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000091588", "id": "ENSMUSP00000091588", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1Z198-2|NL1B2_MOUSE Isoform 2 of NACHT, LRR and PYD domains-containing protein 1b allele 2 OS=Mus musculus OX=10090 GN=Nlrp1b PE=2 SV=1 CANONICAL=A1Z198-1", "length": 1174, "sequence": "MEQSQPKKKSRTKVAQHEGQLNLNPTFKTRKRKEVELMKRRPKPEGHLKLGTIPKVHIKQKGETLDPTWSRKRKNLVQKLTNLLLFEKLCSRGSENLIRKSWYSCEEEERGHMIEIQDLFGPNRGTHKKPQLVIIEGAAGIGKSTLARQVKRAWKEGQLYRNHFQHVFFLSCRELAQYEQLSLAELIAQGQEVPTVPIRQILSHPKELLFILDGIDEPAWVLADQNPELCLHWSQRQPVHTLLGSLLGKSILPGASFLLTARTTALQKIIPYVGQPRRVEVLGFSKFEREVYFRKYFVKESDAIAAFRLVVSNPVLLTLCEVPWVCWLVCTCLKKQMEQGGELSLTSQTTTALCLKYLSLTIPGQHMRTQLRALCSLAAEGICQRRTLFSESDLCKQGLAEDAIATFLKIGILQKQASSLSYSFAHLCLQEFFAVMSYILEDSDERCDGMEFKRTVETLIEVYGRHTLCEEPTVHFLFGLVNEQGMREMKKIFDCKLPLGTELKMLKSTLGNPTYQHHLGLLHCLYESQEEVLLTYVLCNLHLTGPDKNYMEATVSQTNVKHLVIQTDMELMVVTFCIQFCCHVRSLRVNMKGQQGHKLTVASMVLYRWTPITNASWKILFYNLKFNSNLEGLDLSGNPLSYSAVQYLCDAMIYPGCQLKTLWLVECGLTPTYCSLLASVLSACSSLRELDLQLNDLCDDGVRMLCEGLRNRACNLRILRLDLYSLSAQVITELRTLEENNLKLHISSIWMPQMMVPTENMDEEDILTSFKQQRQQSGANPMEILGTEEDFWGPIGPVATEVVYRERNLYRVQLPMAGSYHCPSTRLHFVVTRAVTIEIEFCAWSQFLDKTPLQQSHMVVGPLFDIKAEQGAVTAVYLPHFVSLKDTKASTFDFKVAHFQEHGMVLETPDRVKPGYTVLKNPSFSPMGVVLRIIPAARHFIPITSITLIYYRVNQEEVTLHLYLVPNDCTIQKAIDDEEMKFQFVRINKPPPVDNLFIGSRYIVSGSENLEITPKELELCYRSSKEFQLFSEIYVGNMGSEIKLQIKNKKHMKLIWEALLKPGDLRPALPRIAQALKDAPSLLHFMDQHREQLVARVTSVDPLLDKLHGLVLNEESYEAVRAENTNQDKMRKLFNLSRSWSRACKDLFYQALKETHPHLVMDLLEKSGGVSLGS" } }, { "url": "https://www.uniprot.org/uniprot/A1Z198#A1Z198-3", "isoform_ac": "A1Z198-3", "locus": { "end_pos": 71172365, "strand": "+", "start_pos": 71228467, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000136493", "id": "ENSMUST00000136493", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000121155", "id": "ENSMUSP00000121155", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1Z198-3|NL1B2_MOUSE Isoform 3 of NACHT, LRR and PYD domains-containing protein 1b allele 2 OS=Mus musculus OX=10090 GN=Nlrp1b PE=2 SV=1 CANONICAL=A1Z198-1", "length": 673, "sequence": "MEQSQPKKKSRTKVAQHEGQLNLNPTFKTRKRKEVELMKRRPKPEGHLKLGTIPKVHIKQKGETLDPTWSRKRKNLVQKLTNLLLFEKLCSRGSENLIRKSWYSCEEEERGHMIEIQDLFGPNRGTHKKPQLVIIEGAAGIGKSTLARQVKRAWKEGQLYRNHFQHVFFLSCRELAQYEQLSLAELIAQGQEVPTVPIRQILSHPKELLFILDGIDEPAWVLADQNPELCLHWSQRQPVHTLLGSLLGKSILPGASFLLTARTTALQKIIPYVGQPRRVEVLGFSKFEREVYFRKYFVKESDAIAAFRLVVSNPVLLTLCEVPWVCWLVCTCLKKQMEQGGELSLTSQTTTALCLKYLSLTIPGQHMRTQLRALCSLAAEGICQRRTLFSESDLCKQGLAEDAIATFLKIGILQKQASSLSYSFAHLCLQEFFAVMSYILEDSDERCDGMEFKRTVETLIEVYGRHTLCEEPTVHFLFGLVNEQGMREMKKIFDCKLPLGTELKMLKSTLGNPTYQHHLGLLHCLYESQEEVLLTYVLCNLHLTGPDKNYMEATVSQTNVKHLVIQTDMELMVVTFCIQFCCHVRSLRVNMKGQQGHKLTVASMVLYRWTPITNASWKILFYNLKFNSNLEGLDLSGNPLSYSAVQYLCDAMIYPGCQLKTLCSAVESLEFCT" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:637515", "resource": "KEGG Pathway", "id": "mmu:637515", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "annotation": "An extremely polymorphic gene in this locus, Nalp1b, is the primary mediator of mouse macrophage susceptibility to LeTx (lethal toxin)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "id": "NP_001035786.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "annotation": "Animals expressing a lethal toxin (LT)-sensitive allele of Nlrp1b showed an early inflammatory response to LT and increased resistance to infection by B. anthracis", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "id": "NP_001035786.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A1Z198#function", "annotation": "As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of Nlrp1b, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (By similarity). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Might be activated by Toxoplasma gondii, although at a lower extent than allele 1 (PubMed:24218483). Contrary to Nlrp1b allele 1, allele 2 is not activated by Bacillus anthracis lethal toxin (PubMed:16429160, PubMed:21170303, PubMed:24492532).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198#function", "id": "A1Z198", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "annotation": "Data confirm an inverse relationship between murine macrophage sensitivity to lethal toxin and mouse susceptibility to spore infection, and establish roles for Nlrp1b(S), caspase-1, and IL-1beta in countering anthrax infection. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "id": "NP_001035786.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "annotation": "Lethal factor directly cleaves NLRP1B, inducing the N-end rule-mediated degradation of the NLRP1B N terminus and freeing the NLRP1B C terminus to activate caspase-1.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "id": "NP_001035786.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "annotation": "NLRP1B also encompassessome additional unique structural features.For instance, the NLRP1B bears a C-termi-nal caspase activation and recruitmentdomain (CARD).", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "id": "NP_001035786.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "annotation": "Nlrp1b1 negatively modulates obesity-induced inflammation by promoting IL-18 production. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "id": "NP_001035786.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "annotation": "The authors demonstrate that transfection of human fibroblasts with plasmids encoding murine Nlrp1b and procaspase-1 was sufficient to confer susceptibility to lethal toxin-mediated death on the cells.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "id": "NP_001035786.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9C000-1", "protein_name": "NACHT, LRR and PYD domains-containing protein 1", "sequence": { "length": 1473, "sequence": "MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPWIHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTSTAVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLPLSS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/19080", "id": "19080", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "NLRP1", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "ac": "NP_001035786.1", "name": "NLR family, pyrin domain containing 1B isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "enzyme binding", "id": "GO:0019899" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "protein domain specific binding", "id": "GO:0019904" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061702", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "inflammasome complex", "id": "GO:0061702" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072558", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "NLRP1 inflammasome complex", "id": "GO:0072558" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043280", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "positive regulation of cysteine-type endopeptidase activity involved in apoptotic process", "id": "GO:0043280" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030163", "pmid": "23230290", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "protein catabolic process", "id": "GO:0030163" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070269", "pmid": "22753929", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "pyroptosis", "id": "GO:0070269" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032611", "pmid": "23230290", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "interleukin-1 beta production", "id": "GO:0032611" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032610", "pmid": "22753929", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "interleukin-1 alpha production", "id": "GO:0032610" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904784", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "NLRP1 inflammasome complex assembly", "id": "GO:1904784" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "inflammatory response", "id": "GO:0006954" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "innate immune response", "id": "GO:0045087" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051402", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "neuron apoptotic process", "id": "GO:0051402" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006919", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "name": "activation of cysteine-type endopeptidase activity involved in apoptotic process", "id": "GO:0006919" } ], "total": 10, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A1Z198", "type": "synonym", "resource": "RefSeq", "name": "Na; Nalp1b" }, { "url": "https://www.uniprot.org/uniprot/A1Z198", "type": "synonym", "resource": "UniProtKB", "name": "Nalp1b" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1Z198", "type": "synonym", "resource": "RefSeq", "name": "Nlrp1b" }, { "url": "https://www.uniprot.org/uniprot/A1Z198", "type": "recommended", "resource": "UniProtKB", "name": "Nlrp1b" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000070390", "id": "ENSMUSG00000070390", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08330", "id": "cd08330", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/637515", "id": "637515", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001315", "id": "IPR001315", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "id": "IPR001611", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007111", "id": "IPR007111", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "id": "IPR011029", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR025307", "id": "IPR025307", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "id": "IPR027417", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "id": "IPR032675", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR033516", "id": "IPR033516", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041075", "id": "IPR041075", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041267", "id": "IPR041267", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:637515", "id": "mmu:637515", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:3582959", "id": "3582959", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/GSERMEI/", "id": "GSERMEI", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=114368at2759", "id": "114368at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00619", "id": "PF00619", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF05729", "id": "PF05729", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF13516", "id": "PF13516", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF13553", "id": "PF13553", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF17776", "id": "PF17776", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF17779", "id": "PF17779", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035786.1", "id": "NP_001035786.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A1Z198", "id": "A1Z198", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [ { "id": "MONDO:0008661", "url": "https://monarchinitiative.org/disease/MONDO:0008661", "resource": "MONDO", "name": "vitiligo-associated multiple autoimmune disease susceptibility 6", "description": "" }, { "id": "MONDO:0008661", "url": "https://monarchinitiative.org/disease/MONDO:0008661", "resource": "MONDO", "name": "vitiligo-associated multiple autoimmune disease susceptibility 6; VAMAS6", "description": "" }, { "id": "MONDO:0008661", "url": "https://monarchinitiative.org/disease/MONDO:0008661", "resource": "MONDO", "name": "VAMAS6", "description": "" } ], "recommended_name": { "id": "DOID:12306", "url": "http://disease-ontology.org/term/DOID:12306", "resource": "Disease Ontology", "name": "vitiligo", "description": "An autoimmune disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/12306#disease-associations", "id": "12306", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [], "mass": { "monoisotopic_mass": 134163.0, "chemical_mass": 134163.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A1Z198", "name": "Nlrp1b", "locus": { "end_pos": 71153102, "strand": "-", "start_pos": 71230733, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000070390", "id": "ENSMUSG00000070390", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A1Z198#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "NACHT, LRR and PYD domains-containing protein 1b allele 2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1Z198", "type": "synonym", "resource": "RefSeq", "name": "NLR family, pyrin domain containing 1B isoform 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1Z198", "type": "synonym", "resource": "RefSeq", "name": "OTTMUSPWKG00059388; NACHT-, LRR-, and PYD-containing protein 1 paralog b; NLR family, pyrin domain containing 1B, PWK/PhJ specific, allele 1; OTTMUSCASG00059402; NLR family, pyrin domain containing 1B, CAST/EiJ specific, allele 3" } ] }