{
    "uniprot_canonical_ac": "A1YIY0-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A1YIY0-1|FCRL6_MOUSE Isoform 1 of Fc receptor-like protein 6  OS=Mus musculus OX=10090 GN=Fcrl6 PE=2 SV=2 CANONICAL=A1YIY0-1", 
        "length": 268, 
        "sequence": "MLLWMVLLLCESMAEAQELFPNPELTEFTNSETMDVILKCTIKVDPKNPTLQLFYTFYKNNHVIQDRSPHSVFSAEAKEENSGLYQCMVDTEDGLIQKKSGYLDIQFWTPVSHPVLTLQHEATNLAVGDKVEFLCEAHQGSLPIFYSFYINGEILGKPLAPSGRAASLLASVKAEWSTKNYSCEAKNNISREISELKKFPLVVSGTAWIKSNMLPIWLPASLLGGMVIAAVVLMYFFKPCKKHARPETPTLKEPDSFLYVSVDNQRYK"
    }, 
    "uniprot_id": "FCRL6_MOUSE", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [
        "glycoprotein", 
        "predicted.uniprotkb_gly"
    ], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1YIY0", 
                    "id": "A1YIY0", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/16622424", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "16622424"
                }
            ], 
            "title": "New nomenclature for Fc receptor-like molecules.", 
            "journal": "Nature immunology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158197.1", 
                    "id": "NP_001158197.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Maltais LJ, Lovering RC, Taranin AV, Colonna M, Ravetch JV, Dalla-Favera R, Burrows PD, Cooper MD, Davis RS", 
            "date": "2006"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17213291", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "17213291"
                }
            ], 
            "title": "FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection.", 
            "journal": "Blood", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1YIY0", 
                    "id": "A1YIY0", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Cella M., Colonna M., Wilson T.J., Overton E.T., Presti R.M., Tassi I.", 
            "date": "2007"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24194600", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "24194600"
                }
            ], 
            "title": "The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.", 
            "journal": "Nucleic acids research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158197.1", 
                    "id": "NP_001158197.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H", 
            "date": "2014"
        }
    ], 
    "uniprot_ac": "A1YIY0", 
    "site_annotation": [
        {
            "end_pos": 182, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 180
        }, 
        {
            "end_pos": 190, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 188
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1YIY0#A1YIY0-1", 
            "isoform_ac": "A1YIY0-1", 
            "locus": {
                "end_pos": 172597659, 
                "strand": "+", 
                "start_pos": 172602460, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000094303", 
                        "id": "ENSMUST00000094303", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000091861", 
                        "id": "ENSMUSP00000091861", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A1YIY0-1|FCRL6_MOUSE Isoform 1 of Fc receptor-like protein 6  OS=Mus musculus OX=10090 GN=Fcrl6 PE=2 SV=2 CANONICAL=A1YIY0-1", 
                "length": 268, 
                "sequence": "MLLWMVLLLCESMAEAQELFPNPELTEFTNSETMDVILKCTIKVDPKNPTLQLFYTFYKNNHVIQDRSPHSVFSAEAKEENSGLYQCMVDTEDGLIQKKSGYLDIQFWTPVSHPVLTLQHEATNLAVGDKVEFLCEAHQGSLPIFYSFYINGEILGKPLAPSGRAASLLASVKAEWSTKNYSCEAKNNISREISELKKFPLVVSGTAWIKSNMLPIWLPASLLGGMVIAAVVLMYFFKPCKKHARPETPTLKEPDSFLYVSVDNQRYK"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1YIY0#A1YIY0-2", 
            "isoform_ac": "A1YIY0-2", 
            "locus": {}, 
            "sequence": {
                "header": "sp|A1YIY0-2|FCRL6_MOUSE Isoform 2 of Fc receptor-like protein 6  OS=Mus musculus OX=10090 GN=Fcrl6 PE=2 SV=2 CANONICAL=A1YIY0-1", 
                "length": 244, 
                "sequence": "MLLWMVLLLCESMAEAQELFPNPELTEFTNSETMDVILKCTIKVDPKNPTLQLFYTFYKNNHVIQDRSPHSVFSAEAKEENSGLYQCMVDTEDGLIQKKSGYLDIQFWTPVSHPVLTLQHEATNLAVGDKVEFLCEAHQGSLPIFYSFYINGEILGKPLAPSGRAASLLASVKAEWSTKNYSCEAKNNISREISELKKFPLVVSGTAWIKSNMLPIWLPASLLGGMVIAAVVLMYFFKPCKKHG"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:677296", 
            "resource": "KEGG Pathway", 
            "id": "mmu:677296", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2029481", 
            "resource": "Reactome", 
            "id": "R-MMU-2029481", 
            "name": "FCGR activation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2029482", 
            "resource": "Reactome", 
            "id": "R-MMU-2029482", 
            "name": "Regulation of actin dynamics for phagocytic cup formation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2029485", 
            "resource": "Reactome", 
            "id": "R-MMU-2029485", 
            "name": "Role of phospholipids in phagocytosis"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6798695", 
            "resource": "Reactome", 
            "id": "R-MMU-6798695", 
            "name": "Neutrophil degranulation"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A1YIY0#function", 
            "annotation": "Acts as a MHC class II receptor. When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells. Does not act as an Fc receptor.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1YIY0#function", 
                    "id": "A1YIY0", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6DN72-1", 
            "protein_name": "Fc receptor-like protein 6", 
            "sequence": {
                "length": 434, 
                "sequence": "MLLWTAVLLFVPCVGKTVWLYLQAWPNPVFEGDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKENQTLSMGAATVQSRGQYSCSGQVMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPREGSLVTLRCQTKLHPLRSALRLLFSFHKDGHTLQDRGPHPELCIPGAKEGDSGLYWCEVAPEGGQVQKQSPQLEVRVQAPVSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAPCGGTTSLLFPVKSEQDAGNYSCEAENSVSRERSEPKKLSLKGSQVLFTPASNWLVPWLPASLLGLMVIAAALLVYVRSWRKAGPLPSQIPPTAPGGEQCPLYANVHHQKGKDEGVVYSVVHRTSKRSEARSAEFTVGRKDSSIICAEVRCLQPSEVSSTEVNMRSRTLQEPLSDCEEVLC"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/88414", 
                    "id": "88414", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "FCRL6", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158197.1", 
        "ac": "NP_001158197.1", 
        "name": "Fc receptor-like protein 6 precursor", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1YIY0", 
                                "id": "A1YIY0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transmembrane signaling receptor activity", 
                        "id": "GO:0004888"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019903", 
                        "pmid": "17213291", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1YIY0", 
                                "id": "A1YIY0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein phosphatase binding", 
                        "id": "GO:0019903"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019902", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1YIY0", 
                                "id": "A1YIY0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "phosphatase binding", 
                        "id": "GO:0019902"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042289", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1YIY0", 
                                "id": "A1YIY0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "MHC class II protein binding", 
                        "id": "GO:0042289"
                    }
                ], 
                "total": 4, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005887", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1YIY0", 
                                "id": "A1YIY0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of plasma membrane", 
                        "id": "GO:0005887"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", 
                        "pmid": "17213291", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1YIY0", 
                                "id": "A1YIY0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "external side of plasma membrane", 
                        "id": "GO:0009897"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1YIY0", 
                                "id": "A1YIY0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "plasma membrane", 
                        "id": "GO:0005886"
                    }
                ], 
                "total": 3, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1YIY0", 
                                "id": "A1YIY0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cell surface receptor signaling pathway", 
                        "id": "GO:0007166"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050776", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1YIY0", 
                                "id": "A1YIY0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of immune response", 
                        "id": "GO:0050776"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1YIY0", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "FcRH; FcRH6; mIFG; mIFGP6; moFcR; moFcRH6"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1YIY0", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Fcrl6"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1YIY0", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Fcrl6"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000070504", 
            "id": "ENSMUSG00000070504", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/677296", 
            "id": "677296", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", 
            "id": "IPR007110", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", 
            "id": "IPR013783", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", 
            "id": "IPR036179", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR040878", 
            "id": "IPR040878", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:677296", 
            "id": "mmu:677296", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:3618339", 
            "id": "3618339", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/QHEATNL/", 
            "id": "QHEATNL", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1363268at2759", 
            "id": "1363268at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF13895", 
            "id": "PF13895", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF17736", 
            "id": "PF17736", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A1YIY0", 
            "id": "PR_A1YIY0", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2029481", 
            "id": "R-MMU-2029481", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2029482", 
            "id": "R-MMU-2029482", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2029485", 
            "id": "R-MMU-2029485", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6798695", 
            "id": "R-MMU-6798695", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158197.1", 
            "id": "NP_001158197.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1YIY0", 
            "id": "A1YIY0", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [
        {
            "residue": "Asn", 
            "site_category": "predicted", 
            "end_pos": 180, 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1YIY0#ptm_processing", 
                    "id": "A1YIY0", 
                    "database": "UniProtKB"
                }
            ], 
            "subtype": "", 
            "relation": "attached", 
            "start_pos": 180, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }, 
        {
            "residue": "Asn", 
            "site_category": "predicted", 
            "end_pos": 188, 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1YIY0#ptm_processing", 
                    "id": "A1YIY0", 
                    "database": "UniProtKB"
                }
            ], 
            "subtype": "", 
            "relation": "attached", 
            "start_pos": 188, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }
    ], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 30237.0, 
        "chemical_mass": 30237.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A1YIY0", 
            "name": "Fcrl6", 
            "locus": {
                "end_pos": 172596642, 
                "strand": "-", 
                "start_pos": 172602551, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000070504", 
                        "id": "ENSMUSG00000070504", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1YIY0", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Fc receptor-like protein 6 precursor"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1YIY0#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Fc receptor-like protein 6"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1YIY0#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "FcR-like protein 6"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1YIY0#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "FcRL6"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1YIY0", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "cell surface glycoprotein gp42; fcR-like protein 6; fc receptor-like protein 6"
        }
    ]
}