{
    "uniprot_canonical_ac": "A1L1L5-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A1L1L5-1|A1L1L5_RAT Isoform 1 of Ccnk protein  OS=Rattus norvegicus OX=10116 GN=Ccnk PE=1 SV=1 CANONICAL=A1L1L5-1", 
        "length": 589, 
        "sequence": "MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPPVPQAQPSQGSEAAQPQQKDAQQQQQQQQQQQQQQQQQAQQPKKPSPQPSPPRQAKRAVVVSPKEENKATEPPPPPKIPKLEAAHPPLPPAHPPPDRKLPLAPALGEAEPTGPVETSDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLTYHPHVYPPNPPPPPVPPPPASFPPPTIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR"
    }, 
    "uniprot_id": "A1L1L5_RAT", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                    "id": "A1L1L5", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22012619", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "22012619"
                }
            ], 
            "title": "The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.", 
            "journal": "Genes & development", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103142.1", 
                    "id": "NP_001103142.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Blazek D, Kohoutek J, Bartholomeeusen K, Johansen E, Hulinkova P, Luo Z, Cimermancic P, Ule J, Peterlin BM", 
            "date": "2011"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22547058", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "22547058"
                }
            ], 
            "title": "Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103142.1", 
                    "id": "NP_001103142.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Dai Q, Lei T, Zhao C, Zhong J, Tang YZ, Chen B, Yang J, Li C, Wang S, Song X, Li L, Li Q", 
            "date": "2012"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "22673903"
                }
            ], 
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", 
            "journal": "Nat. Commun.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                    "id": "A1L1L5", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", 
            "date": "2012"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22988298", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "22988298"
                }
            ], 
            "title": "Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II.", 
            "journal": "Molecular and cellular biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103142.1", 
                    "id": "NP_001103142.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Cheng SW, Kuzyk MA, Moradian A, Ichu TA, Chang VC, Tien JF, Vollett SE, Griffith M, Marra MA, Morin GB", 
            "date": "2012"
        }
    ], 
    "uniprot_ac": "A1L1L5", 
    "site_annotation": [
        {
            "end_pos": 192, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 190
        }, 
        {
            "end_pos": 9, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 7
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L1L5#A1L1L5-1", 
            "isoform_ac": "A1L1L5-1", 
            "locus": {
                "end_pos": 132097081, 
                "strand": "-", 
                "start_pos": 132112917, 
                "chromosome": "6", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000057171", 
                        "id": "ENSRNOT00000057171", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000053998", 
                        "id": "ENSRNOP00000053998", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A1L1L5-1|A1L1L5_RAT Isoform 1 of Ccnk protein  OS=Rattus norvegicus OX=10116 GN=Ccnk PE=1 SV=1 CANONICAL=A1L1L5-1", 
                "length": 589, 
                "sequence": "MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPPVPQAQPSQGSEAAQPQQKDAQQQQQQQQQQQQQQQQQAQQPKKPSPQPSPPRQAKRAVVVSPKEENKATEPPPPPKIPKLEAAHPPLPPAHPPPDRKLPLAPALGEAEPTGPVETSDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLTYHPHVYPPNPPPPPVPPPPASFPPPTIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:500715", 
            "resource": "KEGG Pathway", 
            "id": "rno:500715", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-112382", 
            "resource": "Reactome", 
            "id": "R-RNO-112382", 
            "name": "Formation of RNA Pol II elongation complex"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2173796", 
            "resource": "Reactome", 
            "id": "R-RNO-2173796", 
            "name": "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-674695", 
            "resource": "Reactome", 
            "id": "R-RNO-674695", 
            "name": "RNA Polymerase II Pre-transcription Events"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6796648", 
            "resource": "Reactome", 
            "id": "R-RNO-6796648", 
            "name": "TP53 Regulates Transcription of DNA Repair Genes"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6807505", 
            "resource": "Reactome", 
            "id": "R-RNO-6807505", 
            "name": "RNA polymerase II transcribes snRNA genes"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75955", 
            "resource": "Reactome", 
            "id": "R-RNO-75955", 
            "name": "RNA Polymerase II Transcription Elongation"
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "O75909-3", 
            "protein_name": "Cyclin-K", 
            "sequence": {
                "length": 580, 
                "sequence": "MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/14748", 
                    "id": "14748", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "CCNK", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103142.1", 
        "ac": "NP_001103142.1", 
        "name": "cyclin-K", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016538", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                                "id": "A1L1L5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cyclin-dependent protein serine/threonine kinase regulator activity", 
                        "id": "GO:0016538"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061575", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                                "id": "A1L1L5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cyclin-dependent protein serine/threonine kinase activator activity", 
                        "id": "GO:0061575"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                                "id": "A1L1L5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein kinase binding", 
                        "id": "GO:0019901"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004693", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                                "id": "A1L1L5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cyclin-dependent protein serine/threonine kinase activity", 
                        "id": "GO:0004693"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008353", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                                "id": "A1L1L5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "RNA polymerase II CTD heptapeptide repeat kinase activity", 
                        "id": "GO:0008353"
                    }
                ], 
                "total": 5, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                                "id": "A1L1L5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008024", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                                "id": "A1L1L5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cyclin/CDK positive transcription elongation factor complex", 
                        "id": "GO:0008024"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002944", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                                "id": "A1L1L5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cyclin K-CDK12 complex", 
                        "id": "GO:0002944"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002945", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                                "id": "A1L1L5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cyclin K-CDK13 complex", 
                        "id": "GO:0002945"
                    }
                ], 
                "total": 4, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                                "id": "A1L1L5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of transcription by RNA polymerase II", 
                        "id": "GO:0006357"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032786", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                                "id": "A1L1L5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of DNA-templated transcription, elongation", 
                        "id": "GO:0032786"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                                "id": "A1L1L5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "in utero embryonic development", 
                        "id": "GO:0001701"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                                "id": "A1L1L5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular response to DNA damage stimulus", 
                        "id": "GO:0006974"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000737", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                                "id": "A1L1L5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of stem cell differentiation", 
                        "id": "GO:2000737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044828", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                                "id": "A1L1L5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation by host of viral genome replication", 
                        "id": "GO:0044828"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001165", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1L5", 
                                "id": "A1L1L5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues", 
                        "id": "GO:2001165"
                    }
                ], 
                "total": 7, 
                "name": "Biological Process"
            }
        ]
    }, 
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        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1L1L5", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Ccnk"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1L1L5", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Ccnk"
        }
    ], 
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    "crossref": [
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            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000006985", 
            "id": "ENSRNOG00000006985", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00043", 
            "id": "cd00043", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/500715", 
            "id": "500715", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004367", 
            "id": "IPR004367", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006671", 
            "id": "IPR006671", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013763", 
            "id": "IPR013763", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036915", 
            "id": "IPR036915", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR043198", 
            "id": "IPR043198", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:500715", 
            "id": "rno:500715", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/AQPQQKD/", 
            "id": "AQPQQKD", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1437076at2759", 
            "id": "1437076at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10026", 
            "id": "PTHR10026", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00134", 
            "id": "PF00134", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-112382", 
            "id": "R-RNO-112382", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2173796", 
            "id": "R-RNO-2173796", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-674695", 
            "id": "R-RNO-674695", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6796648", 
            "id": "R-RNO-6796648", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6807505", 
            "id": "R-RNO-6807505", 
            "database": "Reactome"
        }, 
        {
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            "id": "R-RNO-75955", 
            "database": "Reactome"
        }, 
        {
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            "id": "NP_001103142.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1595690", 
            "id": "1595690", 
            "database": "RGD"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1L1L5", 
            "id": "A1L1L5", 
            "database": "UniProtKB"
        }
    ], 
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    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
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        "chemical_mass": 65367.0
    }, 
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                "strand": "+", 
                "start_pos": 132090218, 
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                "evidence": [
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                        "id": "ENSRNOG00000006985", 
                        "database": "Ensembl Gene"
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    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L1L5#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Ccnk protein"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1L1L5#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Cyclin K"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1L1L5", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "cyclin-K"
        }
    ]
}