{ "uniprot_canonical_ac": "A1L1K6-1", "ptm_annotation": [], "sequence": { "header": "tr|A1L1K6-1|A1L1K6_RAT Isoform 1 of General transcription factor IIIC, polypeptide 5 OS=Rattus norvegicus OX=10116 GN=Gtf3c5 PE=1 SV=1 CANONICAL=A1L1K6-1", "length": 515, "sequence": "MEAVESDADPKAAIPVDLRRERRLVCVEYPGVVQNEDKMLQTLGGEEGVSRIYTDPTKRLELYFRPKDPYCHPVCANRFSTSSLLLRVRKRTRRRRGVPGDEAHPHVTFDLEILGTISTIYKFQGMSDFQYLAVHTETDGTHVSMYDRVLMRKPEKEEFFHQELPLYIPPPIFSRLDTPVDYFYRPETQHREGYHNPSISGENLIGLSRARRPHNAIFVNFEDTEVPEQPLEAAVQTWKKACTNPIDQKVEEELRKLFDIRPIWSRNAVKSNVSVHPDKLKILLPYMAYYMITGPWRSLWIRFGYDPRKHPDAKIYQVLDFRIRCGMKYGYGSRDMPVKAKRSTYNYSLPITVKKTPSQPVTMHDLKQGLGPSGSDGPRKLTYNKYKLKDSVYIFREGALPPYRQMFYQLCDLNVEELQKIVHRNDGTESVCTEKDGWCLPKTTDHLRDTMSLMILQTIRSERPALFSNTGKADHGKEQLMFESGEEEEEEEEEEEFKPSDGSENEMETEILDYV" }, "uniprot_id": "A1L1K6_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1K6", "id": "A1L1K6", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22147266", "type": [ "PubMed" ], "id": "22147266" } ], "title": "Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation.", "journal": "Physiological genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073410.1", "id": "NP_001073410.1", "database": "RefSeq" } ], "authors": "Rajan S, Chu Pham Dang H, Djambazian H, Zuzan H, Fedyshyn Y, Ketela T, Moffat J, Hudson TJ, Sladek R", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23031840", "type": [ "PubMed" ], "id": "23031840" } ], "title": "A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries.", "journal": "Biochimica et biophysica acta", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073410.1", "id": "NP_001073410.1", "database": "RefSeq" } ], "authors": "Vannini A", "date": "2013" } ], "uniprot_ac": "A1L1K6", "site_annotation": [ { "end_pos": 274, "annotation": "n_glycosylation_sequon", "start_pos": 272 }, { "end_pos": 348, "annotation": "n_glycosylation_sequon", "start_pos": 346 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1L1K6#A1L1K6-1", "isoform_ac": "A1L1K6-1", "locus": { "end_pos": 7145750, "strand": "+", "start_pos": 7164420, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000015068", "id": "ENSRNOT00000015068", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000015068", "id": "ENSRNOP00000015068", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A1L1K6-1|A1L1K6_RAT Isoform 1 of General transcription factor IIIC, polypeptide 5 OS=Rattus norvegicus OX=10116 GN=Gtf3c5 PE=1 SV=1 CANONICAL=A1L1K6-1", "length": 515, "sequence": "MEAVESDADPKAAIPVDLRRERRLVCVEYPGVVQNEDKMLQTLGGEEGVSRIYTDPTKRLELYFRPKDPYCHPVCANRFSTSSLLLRVRKRTRRRRGVPGDEAHPHVTFDLEILGTISTIYKFQGMSDFQYLAVHTETDGTHVSMYDRVLMRKPEKEEFFHQELPLYIPPPIFSRLDTPVDYFYRPETQHREGYHNPSISGENLIGLSRARRPHNAIFVNFEDTEVPEQPLEAAVQTWKKACTNPIDQKVEEELRKLFDIRPIWSRNAVKSNVSVHPDKLKILLPYMAYYMITGPWRSLWIRFGYDPRKHPDAKIYQVLDFRIRCGMKYGYGSRDMPVKAKRSTYNYSLPITVKKTPSQPVTMHDLKQGLGPSGSDGPRKLTYNKYKLKDSVYIFREGALPPYRQMFYQLCDLNVEELQKIVHRNDGTESVCTEKDGWCLPKTTDHLRDTMSLMILQTIRSERPALFSNTGKADHGKEQLMFESGEEEEEEEEEEEFKPSDGSENEMETEILDYV" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:362095", "resource": "KEGG Pathway", "id": "rno:362095", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-76061", "resource": "Reactome", "id": "R-RNO-76061", "name": "RNA Polymerase III Transcription Initiation From Type 1 Promoter" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-76066", "resource": "Reactome", "id": "R-RNO-76066", "name": "RNA Polymerase III Transcription Initiation From Type 2 Promoter" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q8R2T8-1", "protein_name": "General transcription factor 3C polypeptide 5", "sequence": { "length": 520, "sequence": "MAAAEPDADPKAAIPVDLRRERRLVCVEYPGVVRNEAKMLQTLGGEESVSRIYTDPTKRLELYFRPKDPYCHPVCANRFSTSSLLLRIRKRTRRRRGVLGDEAHPQVTFNLEIIGIISTIYKFQGMSDFQYLAVHTEAGGKHVSMYDRVLMRKPEKEEFFHQELPLYIPPPIFSRLDTPVDYFYRPETQHREGYHNPTISGENLIGLSRARRPHNAIFVNFEDTEVPEQPLEAAVQTWKKACTNPIDQKVEEELRKLFDIRPVWSRNAVKSNVSVHPDKLKILLPYMAYYMITGPWRSLWIRFGYDPRKHPDAKIYQVLDFRIRCGMKYGYGSRDMPVKAKRSTYNYSLPITVKKTSNQPGTMHDLKQGLGPSGTDGPRKLTYNKYKLKDSVYIFREGALPPYRQMFYQLCDLNVEELQKIVHRNDGTETVCTERDGWCLPKTTDHLRDTMSLMILQTIRSERPALFSNTGKADRGKEQLMFESGEEEEEEEEEEEEEEEDFKPSDGSENEMETEILDYV" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A1L1K6/", "id": "A1L1K6", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/40806", "id": "40806", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Gtf3c5", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q9Y5Q8-1", "protein_name": "General transcription factor 3C polypeptide 5", "sequence": { "length": 519, "sequence": "MAAEAADLGLGAAVPVELRRERRMVCVEYPGVVRDVAKMLPTLGGEEGVSRIYADPTKRLELYFRPKDPYCHPVCANRFSTSSLLLRIRKRTRRQKGVLGTEAHSEVTFDMEILGIISTIYKFQGMSDFQYLAVHTEAGGKHTSMYDKVLMLRPEKEAFFHQELPLYIPPPIFSRLDAPVDYFYRPETQHREGYNNPPISGENLIGLSRARRPHNAIFVNFEDEEVPKQPLEAAAQTWRRVCTNPVDRKVEEELRKLFDIRPIWSRNAVKANISVHPDKLKVLLPFIAYYMITGPWRSLWIRFGYDPRKNPDAKIYQVLDFRIRCGMKHGYAPSDLPVKAKRSTYNYSLPITVKKTSSQLVTMHDLKQGLGPSGTSGARKPASSKYKLKDSVYIFREGALPPYRQMFYQLCDLNVEELQKIIHRNDGAENSCTERDGWCLPKTSDELRDTMSLMIRQTIRSKRPALFSSSAKADGGKEQLTYESGEDEEDEEEEEEEEEDFKPSDGSENEMETEILDYV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/40806", "id": "40806", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "GTF3C5", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073410.1", "ac": "NP_001073410.1", "name": "general transcription factor 3C polypeptide 5", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1K6", "id": "A1L1K6", "database": "UniProtKB" } ], "name": "DNA binding", "id": "GO:0003677" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000127", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1K6", "id": "A1L1K6", "database": "UniProtKB" } ], "name": "transcription factor TFIIIC complex", "id": "GO:0000127" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1K6", "id": "A1L1K6", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035914", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1K6", "id": "A1L1K6", "database": "UniProtKB" } ], "name": "skeletal muscle cell differentiation", "id": "GO:0035914" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006384", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L1K6", "id": "A1L1K6", "database": "UniProtKB" } ], "name": "transcription initiation from RNA polymerase III promoter", "id": "GO:0006384" } ], "total": 2, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A1L1K6", "type": "synonym", "resource": "RefSeq", "name": "Gtf3c5" }, { "url": "https://www.uniprot.org/uniprot/A1L1K6", "type": "recommended", "resource": "UniProtKB", "name": "Gtf3c5" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000010981", "id": "ENSRNOG00000010981", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/362095", "id": "362095", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019136", "id": "IPR019136", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR040454", "id": "IPR040454", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041499", "id": "IPR041499", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR042536", "id": "IPR042536", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:362095", "id": "rno:362095", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/CNERDGW/", "id": "CNERDGW", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1111142at2759", "id": "1111142at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13230", "id": "PTHR13230", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF09734", "id": "PF09734", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF17682", "id": "PF17682", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-76061", "id": "R-RNO-76061", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-76066", "id": "R-RNO-76066", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073410.1", "id": "NP_001073410.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305173", "id": "1305173", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A1L1K6", "id": "A1L1K6", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 59911.0, "chemical_mass": 59911.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A1L1K6", "name": "Gtf3c5", "locus": { "end_pos": 7144250, "strand": "-", "start_pos": 7164654, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000010981", "id": "ENSRNOG00000010981", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A1L1K6#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "General transcription factor IIIC subunit 5" }, { "url": "https://www.uniprot.org/uniprot/A1L1K6#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "General transcription factor IIIC, polypeptide 5" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1L1K6", "type": "synonym", "resource": "RefSeq", "name": "general transcription factor 3C polypeptide 5" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1L1K6", "type": "synonym", "resource": "RefSeq", "name": "general transcription factor IIIC, polypeptide 5" } ] }