{
    "uniprot_canonical_ac": "A1L1J8-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A1L1J8-1|A1L1J8_RAT Isoform 1 of RAB5B, member RAS oncogene family  OS=Rattus norvegicus OX=10116 GN=Rab5b PE=1 SV=1 CANONICAL=A1L1J8-1", 
        "length": 215, 
        "sequence": "MTSRSTARPNGQPQASKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASPSIVIALAGNKADLANKRMVEYEEAQAYADDNSLLFMETSAKTAMNVNDLFLAIAKKLPKSEPQNPGGAAGRSRGVDLHEQAQQNKSQCCSN"
    }, 
    "uniprot_id": "A1L1J8_RAT", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                    "id": "A1L1J8", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/10491193", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "10491193"
                }
            ], 
            "title": "Direct interaction of EEA1 with Rab5b.", 
            "journal": "European journal of biochemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073405.1", 
                    "id": "NP_001073405.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Callaghan J, Nixon S, Bucci C, Toh BH, Stenmark H", 
            "date": "1999"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/15326289", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "15326289"
                }
            ], 
            "title": "Identification and proteomic profiling of exosomes in human urine.", 
            "journal": "Proceedings of the National Academy of Sciences of the United States of America", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073405.1", 
                    "id": "NP_001073405.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Pisitkun T, Shen RF, Knepper MA", 
            "date": "2004"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17562788", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "17562788"
                }
            ], 
            "title": "Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways.", 
            "journal": "The Journal of cell biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073405.1", 
                    "id": "NP_001073405.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Fuchs E, Haas AK, Spooner RA, Yoshimura S, Lord JM, Barr FA", 
            "date": "2007"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/18445495", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "18445495"
                }
            ], 
            "title": "LRRK2 regulates synaptic vesicle endocytosis.", 
            "journal": "Experimental cell research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073405.1", 
                    "id": "NP_001073405.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Shin N, Jeong H, Kwon J, Heo HY, Kwon JJ, Yun HJ, Kim CH, Han BS, Tong Y, Shen J, Hatano T, Hattori N, Kim KS, Chang S, Seol W", 
            "date": "2008"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19717423", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "19717423"
                }
            ], 
            "title": "The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells.", 
            "journal": "Proceedings of the National Academy of Sciences of the United States of America", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073405.1", 
                    "id": "NP_001073405.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Zou L, Zhou J, Zhang J, Li J, Liu N, Chai L, Li N, Liu T, Li L, Xie Z, Liu H, Wan Y, Wu Y", 
            "date": "2009"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20458337", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "20458337"
                }
            ], 
            "title": "MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.", 
            "journal": "Immunology and cell biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073405.1", 
                    "id": "NP_001073405.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W", 
            "date": "2010"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20937701", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "20937701"
                }
            ], 
            "title": "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.", 
            "journal": "The Journal of cell biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073405.1", 
                    "id": "NP_001073405.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Yoshimura S, Gerondopoulos A, Linford A, Rigden DJ, Barr FA", 
            "date": "2010"
        }
    ], 
    "uniprot_ac": "A1L1J8", 
    "site_annotation": [
        {
            "end_pos": 210, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 208
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L1J8#A1L1J8-1", 
            "isoform_ac": "A1L1J8-1", 
            "locus": {
                "end_pos": 3106890, 
                "strand": "+", 
                "start_pos": 3114041, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000061878", 
                        "id": "ENSRNOT00000061878", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000058595", 
                        "id": "ENSRNOP00000058595", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A1L1J8-1|A1L1J8_RAT Isoform 1 of RAB5B, member RAS oncogene family  OS=Rattus norvegicus OX=10116 GN=Rab5b PE=1 SV=1 CANONICAL=A1L1J8-1", 
                "length": 215, 
                "sequence": "MTSRSTARPNGQPQASKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASPSIVIALAGNKADLANKRMVEYEEAQAYADDNSLLFMETSAKTAMNVNDLFLAIAKKLPKSEPQNPGGAAGRSRGVDLHEQAQQNKSQCCSN"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:288779", 
            "resource": "KEGG Pathway", 
            "id": "rno:288779", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695", 
            "resource": "Reactome", 
            "id": "R-RNO-6798695", 
            "name": "Neutrophil degranulation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8856828", 
            "resource": "Reactome", 
            "id": "R-RNO-8856828", 
            "name": "Clathrin-mediated endocytosis"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8873719", 
            "resource": "Reactome", 
            "id": "R-RNO-8873719", 
            "name": "RAB geranylgeranylation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8876198", 
            "resource": "Reactome", 
            "id": "R-RNO-8876198", 
            "name": "RAB GEFs exchange GTP for GDP on RABs"
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073405.1", 
            "annotation": "Results suggest that LRRK2, in conjunction with its interaction with Rab5b, plays an important role in synaptic function by modulating the endocytosis of synaptic vesicles.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073405.1", 
                    "id": "NP_001073405.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "P61020-1", 
            "protein_name": "Ras-related protein Rab-5B", 
            "sequence": {
                "length": 215, 
                "sequence": "MTSRSTARPNGQPQASKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASPSIVIALAGNKADLANKRMVEYEEAQAYADDNSLLFMETSAKTAMNVNDLFLAIAKKLPKSEPQNLGGAAGRSRGVDLHEQSQQNKSQCCSN"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/104027", 
                    "id": "104027", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "RAB5B", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "P61021-1", 
            "protein_name": "Ras-related protein Rab-5B", 
            "sequence": {
                "length": 215, 
                "sequence": "MTSRSTARPNGQPQASKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASPSIVIALAGNKADLANKRMVEYEEAQAYADDNSLLFMETSAKTAMNVNDLFLAIAKKLPKSEPQNLGGAAGRSRGVDLHEQSQQNKSQCCSN"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/104027", 
                    "id": "104027", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A1L1J8/", 
                    "id": "A1L1J8", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "gene_name": "Rab5b", 
            "tax_id": 10090
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073405.1", 
        "ac": "NP_001073405.1", 
        "name": "ras-related protein Rab-5B", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "GTPase activity", 
                        "id": "GO:0003924"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "GTP binding", 
                        "id": "GO:0005525"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030742", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "GTP-dependent protein binding", 
                        "id": "GO:0030742"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019003", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "GDP binding", 
                        "id": "GO:0019003"
                    }
                ], 
                "total": 4, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098993", 
                        "pmid": "20926670", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "anchored component of synaptic vesicle membrane", 
                        "id": "GO:0098993"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "early endosome", 
                        "id": "GO:0005769"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "plasma membrane", 
                        "id": "GO:0005886"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endomembrane system", 
                        "id": "GO:0012505"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endosome", 
                        "id": "GO:0005768"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "intracellular membrane-bounded organelle", 
                        "id": "GO:0043231"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular exosome", 
                        "id": "GO:0070062"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030139", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endocytic vesicle", 
                        "id": "GO:0030139"
                    }
                ], 
                "total": 8, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "intracellular protein transport", 
                        "id": "GO:0006886"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endocytosis", 
                        "id": "GO:0006897"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030100", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of endocytosis", 
                        "id": "GO:0030100"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007032", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endosome organization", 
                        "id": "GO:0007032"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019882", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "antigen processing and presentation", 
                        "id": "GO:0019882"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048227", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L1J8", 
                                "id": "A1L1J8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "plasma membrane to endosome transport", 
                        "id": "GO:0048227"
                    }
                ], 
                "total": 6, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L1J8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Rab5b_predicted"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1L1J8", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Rab5b"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1L1J8", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Rab5b"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1L1J8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "rCG_42413"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000006130", 
            "id": "ENSRNOG00000006130", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/288779", 
            "id": "288779", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A1L1J8*", 
            "id": "A1L1J8", 
            "database": "IntAct"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", 
            "id": "IPR001806", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", 
            "id": "IPR005225", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", 
            "id": "IPR027417", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:288779", 
            "id": "rno:288779", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/DTFHDNT/", 
            "id": "DTFHDNT", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1340129at2759", 
            "id": "1340129at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00071", 
            "id": "PF00071", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695", 
            "id": "R-RNO-6798695", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8856828", 
            "id": "R-RNO-8856828", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8873719", 
            "id": "R-RNO-8873719", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8876198", 
            "id": "R-RNO-8876198", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073405.1", 
            "id": "NP_001073405.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306489", 
            "id": "1306489", 
            "database": "RGD"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1L1J8", 
            "id": "A1L1J8", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [
        {
            "synonyms": [
                {
                    "id": "DOID:162", 
                    "url": "http://disease-ontology.org/term/DOID:162", 
                    "resource": "Disease Ontology", 
                    "name": "malignant neoplasm", 
                    "description": ""
                }, 
                {
                    "id": "DOID:162", 
                    "url": "http://disease-ontology.org/term/DOID:162", 
                    "resource": "Disease Ontology", 
                    "name": "malignant tumor", 
                    "description": ""
                }, 
                {
                    "id": "DOID:162", 
                    "url": "http://disease-ontology.org/term/DOID:162", 
                    "resource": "Disease Ontology", 
                    "name": "primary cancer", 
                    "description": ""
                }
            ], 
            "recommended_name": {
                "id": "DOID:162", 
                "url": "http://disease-ontology.org/term/DOID:162", 
                "resource": "Disease Ontology", 
                "name": "cancer", 
                "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis."
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/162#disease-associations", 
                    "id": "162", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "synonyms": [
                {
                    "id": "DOID:305", 
                    "url": "http://disease-ontology.org/term/DOID:305", 
                    "resource": "Disease Ontology", 
                    "name": "epithelial cancer", 
                    "description": ""
                }, 
                {
                    "id": "DOID:305", 
                    "url": "http://disease-ontology.org/term/DOID:305", 
                    "resource": "Disease Ontology", 
                    "name": "epithelioma", 
                    "description": ""
                }, 
                {
                    "id": "DOID:305", 
                    "url": "http://disease-ontology.org/term/DOID:305", 
                    "resource": "Disease Ontology", 
                    "name": "malignant Epithelioma", 
                    "description": ""
                }
            ], 
            "recommended_name": {
                "id": "DOID:305", 
                "url": "http://disease-ontology.org/term/DOID:305", 
                "resource": "Disease Ontology", 
                "name": "carcinoma", 
                "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells."
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/305#disease-associations", 
                    "id": "305", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }
    ], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 23675.0, 
        "chemical_mass": 23675.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L1J8", 
            "name": "Rab5b", 
            "locus": {
                "end_pos": 3104551, 
                "strand": "-", 
                "start_pos": 3123297, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000006130", 
                        "id": "ENSRNOG00000006130", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L1J8#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "RAB5B, member RAS oncogene family (Predicted), isoform CRA_c"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1L1J8#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "RAB5B, member RAS oncogene family"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1L1J8", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "ras-related protein Rab-5B"
        }
    ]
}