{
    "uniprot_canonical_ac": "A1L190-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A1L190-1|SYCE3_HUMAN Isoform 1 of Synaptonemal complex central element protein 3  OS=Homo sapiens OX=9606 GN=SYCE3 PE=1 SV=1 CANONICAL=A1L190-1", 
        "length": 88, 
        "sequence": "MDDADPEERNYDNMLKMLSDLNKDLEKLLEEMEKISVQATWMAYDMVVMRTNPTLAESMRRLEDAFVNCKEEMEKNWQELLHETKQRL"
    }, 
    "uniprot_id": "SYCE3_HUMAN", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Human", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L190", 
                    "id": "A1L190", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19323366", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "19323366"
                }
            ], 
            "title": "[Cloning and expression of a novel mouse testis gene TSEG-2].", 
            "journal": "Zhonghua nan ke xue = National journal of andrology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116697.1", 
                    "id": "NP_001116697.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Wang ZY, Tong QS, Zeng FQ, Liu Y, Gu ZH, Zheng LD, Cai JB, Jiang GS", 
            "date": "2009"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/21637789", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "21637789"
                }
            ], 
            "title": "A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility.", 
            "journal": "PLoS genetics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116697.1", 
                    "id": "NP_001116697.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Schramm S, Fraune J, Naumann R, Hernandez-Hernandez A, Hoog C, Cooke HJ, Alsheimer M, Benavente R", 
            "date": "2011"
        }
    ], 
    "uniprot_ac": "A1L190", 
    "site_annotation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L190#A1L190-1", 
            "isoform_ac": "A1L190-1", 
            "locus": {
                "end_pos": 50551248, 
                "strand": "+", 
                "start_pos": 50556405, 
                "chromosome": "22", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000406915", 
                        "id": "ENST00000406915", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000385480", 
                        "id": "ENSP00000385480", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A1L190-1|SYCE3_HUMAN Isoform 1 of Synaptonemal complex central element protein 3  OS=Homo sapiens OX=9606 GN=SYCE3 PE=1 SV=1 CANONICAL=A1L190-1", 
                "length": 88, 
                "sequence": "MDDADPEERNYDNMLKMLSDLNKDLEKLLEEMEKISVQATWMAYDMVVMRTNPTLAESMRRLEDAFVNCKEEMEKNWQELLHETKQRL"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:644186", 
            "resource": "KEGG Pathway", 
            "id": "hsa:644186", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1221632", 
            "resource": "Reactome", 
            "id": "R-HSA-1221632", 
            "name": "Meiotic synapsis"
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116697.1", 
            "annotation": "Cloning and expression analysis of a similar gene in mouse.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116697.1", 
                    "id": "NP_001116697.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1L190#function", 
            "annotation": "Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L190#function", 
                    "id": "A1L190", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "B5KM66-1", 
            "protein_name": "Synaptonemal complex central element protein 3", 
            "sequence": {
                "length": 88, 
                "sequence": "MADSDPGERSYDNMLKMLSDLNKDLEKLLEEMEKISVQATWMAYDMVVMRTNPTLAESMRRLEDAFLNCKEEMEKNWQELLTETKRKQ"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/85810", 
                    "id": "85810", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "gene_name": "Syce3", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "D3ZDD6-1", 
            "protein_name": "RCG59342", 
            "sequence": {
                "length": 88, 
                "sequence": "MADSDPGERSYDNMLKMLSDLNKDLERLLEEMEKISVQATWMAYDMVVMRTNPTLAESMRRLEDAFLNCKEEMEKNWQELLTETKRKQ"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/85810", 
                    "id": "85810", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "gene_name": "Syce3", 
            "tax_id": 10116
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116697.1", 
        "ac": "NP_001116697.1", 
        "name": "synaptonemal complex central element protein 3", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000801", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L190", 
                                "id": "A1L190", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "central element", 
                        "id": "GO:0000801"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L190", 
                                "id": "A1L190", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L190", 
                                "id": "A1L190", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "chromosome", 
                        "id": "GO:0005694"
                    }
                ], 
                "total": 3, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L190", 
                                "id": "A1L190", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "spermatogenesis", 
                        "id": "GO:0007283"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L190", 
                                "id": "A1L190", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of apoptotic process", 
                        "id": "GO:0043065"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L190", 
                                "id": "A1L190", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cell division", 
                        "id": "GO:0051301"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007130", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L190", 
                                "id": "A1L190", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "synaptonemal complex assembly", 
                        "id": "GO:0007130"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007131", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L190", 
                                "id": "A1L190", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "reciprocal meiotic recombination", 
                        "id": "GO:0007131"
                    }
                ], 
                "total": 5, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1L190", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "C22orf41; THEG2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1L190", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "C22orf41"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1L190", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "SYCE3"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1L190", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "SYCE3"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1L190", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "THEG2"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000217442", 
            "id": "ENSG00000217442", 
            "database": "Bgee"
        }, 
        {
            "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A1L190", 
            "id": "A1L190", 
            "database": "BioMuta"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=SYCE3", 
            "id": "SYCE3", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/644186", 
            "id": "644186", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=35245", 
            "id": "35245", 
            "database": "HGNC"
        }, 
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A1L190*", 
            "id": "A1L190", 
            "database": "IntAct"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR028145", 
            "id": "IPR028145", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:644186", 
            "id": "hsa:644186", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.omim.org/entry/615775", 
            "id": "615775", 
            "database": "MIM"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A1L190", 
            "id": "NX_A1L190", 
            "database": "neXtProt"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/MVVIRTN/", 
            "id": "MVVIRTN", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1545114at2759", 
            "id": "1545114at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36686", 
            "id": "PTHR36686", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF15191", 
            "id": "PF15191", 
            "database": "Pfam"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A1L190", 
            "id": "A1L190", 
            "database": "PHAROS"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A1L190", 
            "id": "PR_A1L190", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1221632", 
            "id": "R-HSA-1221632", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116697.1", 
            "id": "NP_001116697.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1L190", 
            "id": "A1L190", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [
        {
            "name": "Prostate cancer [DO disease name]", 
            "trend": "Up", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:10283", 
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "name": "NGP - new growth of prostate", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:10283", 
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "name": "hereditary prostate cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:10283", 
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of the prostate", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:10283", 
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "name": "prostate cancer, familial", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:10283", 
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "name": "prostate neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:10283", 
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "name": "prostatic cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:10283", 
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "name": "prostatic neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:10283", 
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "name": "tumor of the prostate", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:10283", 
                        "url": "http://disease-ontology.org/term/DOID:10283", 
                        "resource": "Disease Ontology", 
                        "name": "prostate cancer", 
                        "description": "A male reproductive organ cancer that is located_in the prostate."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1L190", 
                    "id": "A1L190", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:10283", 
            "significant": "No"
        }, 
        {
            "name": "Urinary bladder cancer [DO disease name]", 
            "trend": "Up", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:11054", 
                            "url": "http://disease-ontology.org/term/DOID:11054", 
                            "resource": "Disease Ontology", 
                            "name": "bladder cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:11054", 
                            "url": "http://disease-ontology.org/term/DOID:11054", 
                            "resource": "Disease Ontology", 
                            "name": "tumor of the bladder", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:11054", 
                        "url": "http://disease-ontology.org/term/DOID:11054", 
                        "resource": "Disease Ontology", 
                        "name": "urinary bladder cancer", 
                        "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1L190", 
                    "id": "A1L190", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:11054", 
            "significant": "Yes"
        }, 
        {
            "name": "Thyroid gland cancer [DO disease name]", 
            "trend": "Up", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "Thyroid gland neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "thyroid neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:1781", 
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "name": "thyroid gland cancer", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A1L190", 
                    "id": "A1L190", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:1781", 
            "significant": "Yes"
        }, 
        {
            "name": "Liver cancer [DO disease name]", 
            "trend": "Up", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "Ca liver - primary", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "Resectable malignant neoplasm of Liver", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "hepatic cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "hepatic neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "malignant hepato-biliary neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of liver", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of liver, primary", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of liver", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of liver", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "non-resectable primary hepatic malignant neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "primary liver cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "primary malignant neoplasm of Liver", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "resectable malignant neoplasm of the liver", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of liver, not specified as primary or secondary", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:3571", 
                        "url": "http://disease-ontology.org/term/DOID:3571", 
                        "resource": "Disease Ontology", 
                        "name": "liver cancer", 
                        "description": "A hepatobiliary system cancer that is located_in the liver."
                    }
                }
            ], 
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                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:3571", 
            "significant": "No"
        }, 
        {
            "name": "Lung squamous cell carcinoma [DO disease name]", 
            "trend": "Up", 
            "disease": [
                {
                    "synonyms": [
                        {
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                            "url": "http://disease-ontology.org/term/DOID:3907", 
                            "resource": "Disease Ontology", 
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                            "description": ""
                        }
                    ], 
                    "recommended_name": {
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                        "url": "http://disease-ontology.org/term/DOID:3907", 
                        "resource": "Disease Ontology", 
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                }
            ], 
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                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:3907", 
            "significant": "Yes"
        }, 
        {
            "name": "Lung adenocarcinoma [DO disease name]", 
            "trend": "Up", 
            "disease": [
                {
                    "synonyms": [
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                            "url": "http://disease-ontology.org/term/DOID:3910", 
                            "resource": "Disease Ontology", 
                            "name": "bronchogenic lung adenocarcinoma", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3910", 
                            "url": "http://disease-ontology.org/term/DOID:3910", 
                            "resource": "Disease Ontology", 
                            "name": "nonsmall cell adenocarcinoma", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
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                        "url": "http://disease-ontology.org/term/DOID:3910", 
                        "resource": "Disease Ontology", 
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            ], 
            "url": "http://disease-ontology.org/term/DOID:3910", 
            "significant": "No"
        }, 
        {
            "name": "Esophageal cancer [DO disease name]", 
            "trend": "Up", 
            "disease": [
                {
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                        {
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                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "Ca lower third oesophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "Ca middle third oesophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "esophagus cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of distal third of esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of lower third of oesophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of middle third of oesophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of proximal third of esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of upper third esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of Distal Third of esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of Proximal Third of esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of abdominal esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of the middle Third of the esophagus", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
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                        "url": "http://disease-ontology.org/term/DOID:5041", 
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                }
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                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:5041", 
            "significant": "Yes"
        }
    ], 
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    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 10601.0, 
        "chemical_mass": 10601.0
    }, 
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            "evidence": [
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            "evidence": [
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                    "id": "ENSG00000217442", 
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            ]
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        {
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                "uberon": "0000458", 
                "name": "Endocervix"
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            "present": "no", 
            "evidence": [
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                    "id": "ENSG00000217442", 
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        {
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                "name": "Endocervix"
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            "evidence": [
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                    "id": "ENSG00000217442", 
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        {
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                "uberon": "0000473", 
                "name": "Testis"
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            "evidence": [
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                    "id": "ENSG00000217442", 
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        }, 
        {
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                "uberon": "0000948", 
                "name": "Heart"
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            "present": "no", 
            "evidence": [
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                    "id": "ENSG00000217442", 
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        {
            "tissue": {
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                "uberon": "0000948", 
                "name": "Heart"
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                "uberon": "0000955", 
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            "evidence": [
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        }, 
        {
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                "uberon": "0000992", 
                "name": "Ovary"
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            "evidence": [
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        {
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        {
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        {
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                "name": "Esophagus"
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                "uberon": "0001150", 
                "name": "Body of pancreas"
            }, 
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                "uberon": "0001155", 
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                "uberon": "0001160", 
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            "evidence": [
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        {
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        {
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        {
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        }, 
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            "resource": "RefSeq", 
            "name": "testis highly expressed protein 2; testis highly expressed gene 2 protein"
        }
    ]
}