{
    "uniprot_canonical_ac": "A1KQY6-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A1KQY6-1|A1KQY6_RAT Isoform 1 of RCG55449  OS=Rattus norvegicus OX=10116 GN=St8sia4 PE=2 SV=1 CANONICAL=A1KQY6-1", 
        "length": 454, 
        "sequence": "MHKVSHLKRNPSPREAAQSDPSPASANCAAGRWAALENRESSTAERPSDLILGSRLHAPFANFRFLPLDYFPKTEPLYQEKVPELGQPGLSRAPKMRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELCLSRSLVNNSDKITRKAGSTIFQHSVQGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCMKQ"
    }, 
    "uniprot_id": "A1KQY6_RAT", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1KQY6", 
                    "id": "A1KQY6", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/10766765", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "10766765"
                }
            ], 
            "title": "Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III.", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446366.1", 
                    "id": "NP_446366.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Angata K, Suzuki M, McAuliffe J, Ding Y, Hindsgaul O, Fukuda M", 
            "date": "2000"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17176637", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "17176637"
                }
            ], 
            "title": "Molecular characterization of pig ST8Sia IV--a critical gene for the formation of neural cell adhesion molecule and its response to sialic acid supplement in piglets.", 
            "journal": "Nutritional neuroscience", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446366.1", 
                    "id": "NP_446366.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Wang B, Hu H, Yu B", 
            "date": "2006"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/18811928", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "18811928"
                }
            ], 
            "title": "Evolutionary history of the alpha2,8-sialyltransferase (ST8Sia) gene family: tandem duplications in early deuterostomes explain most of the diversity found in the vertebrate ST8Sia genes.", 
            "journal": "BMC evolutionary biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446366.1", 
                    "id": "NP_446366.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Harduin-Lepers A, Petit D, Mollicone R, Delannoy P, Petit JM, Oriol R", 
            "date": "2008"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24753009", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "24753009"
                }
            ], 
            "title": "Dynamic expression of the polysialyltransferase in adult rat hippocampus performing an olfactory associative task.", 
            "journal": "Hippocampus", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446366.1", 
                    "id": "NP_446366.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Manrique C, Migliorati M, Gilbert V, Brezun JM, Chaillan FA, Truchet B, Khrestchatisky M, Guiraudie-Capraz G, Roman FS", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/26844880", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "26844880"
                }
            ], 
            "title": "Expression of polysialyltransferases (STX and PST) in adult rat olfactory bulb after an olfactory associative discrimination task.", 
            "journal": "Neurobiology of learning and memory", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446366.1", 
                    "id": "NP_446366.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Mione J, Manrique C, Duhoo Y, Roman FS, Guiraudie-Capraz G", 
            "date": "2016"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/9352097", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "9352097"
                }
            ], 
            "title": "Developmental expression of two rat sialyltransferases that modify the neural cell adhesion molecule, N-CAM.", 
            "journal": "Brain research. Developmental brain research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446366.1", 
                    "id": "NP_446366.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Phillips GR, Krushel LA, Crossin KL", 
            "date": "1997"
        }
    ], 
    "uniprot_ac": "A1KQY6", 
    "site_annotation": [
        {
            "end_pos": 147, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 145
        }, 
        {
            "end_pos": 171, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 169
        }, 
        {
            "end_pos": 216, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 214
        }, 
        {
            "end_pos": 301, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 299
        }, 
        {
            "end_pos": 316, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 314
        }, 
        {
            "end_pos": 424, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 422
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1KQY6#A1KQY6-1", 
            "isoform_ac": "A1KQY6-1", 
            "locus": {
                "end_pos": 103117708, 
                "strand": "+", 
                "start_pos": 103207154, 
                "chromosome": "9", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000026010", 
                        "id": "ENSRNOT00000026010", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000026010", 
                        "id": "ENSRNOP00000026010", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A1KQY6-1|A1KQY6_RAT Isoform 1 of RCG55449  OS=Rattus norvegicus OX=10116 GN=St8sia4 PE=2 SV=1 CANONICAL=A1KQY6-1", 
                "length": 454, 
                "sequence": "MHKVSHLKRNPSPREAAQSDPSPASANCAAGRWAALENRESSTAERPSDLILGSRLHAPFANFRFLPLDYFPKTEPLYQEKVPELGQPGLSRAPKMRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELCLSRSLVNNSDKITRKAGSTIFQHSVQGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCMKQ"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:116696", 
            "resource": "KEGG Pathway", 
            "id": "rno:116696", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4085001", 
            "resource": "Reactome", 
            "id": "R-RNO-4085001", 
            "name": "Sialic acid metabolism"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-419037", 
            "resource": "Reactome", 
            "id": "R-RNO-419037", 
            "name": "NCAM1 interactions"
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446366.1", 
            "annotation": "After learning an olfactory discrimination task, no changes in the expression level of St8sia4 were observed in the olfactory bulb.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446366.1", 
                    "id": "NP_446366.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446366.1", 
            "annotation": "Results suggest that sialyltransferase-X is probably involved in the proliferation of neural progenitor cells; polysialyltransferase may play a key role in synaptic plasticity of mature neural networks", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446366.1", 
                    "id": "NP_446366.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q64692-1", 
            "protein_name": "CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase", 
            "sequence": {
                "length": 359, 
                "sequence": "MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELCLSRSLVNSSDKIIRKAGSTIFQHSVQGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLQVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCMKQ"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A1KQY6/", 
                    "id": "A1KQY6", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/4147", 
                    "id": "4147", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "gene_name": "St8sia4", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "Q92187-1", 
            "protein_name": "CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase", 
            "sequence": {
                "length": 359, 
                "sequence": "MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAGSSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCVKQ"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A1KQY6/", 
                    "id": "A1KQY6", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/4147", 
                    "id": "4147", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "ST8SIA4", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446366.1", 
        "ac": "NP_446366.1", 
        "name": "CMP-N-acetylneuraminate-poly-alpha-2, 8-sialyltransferase", 
        "summary": "enzyme involved in polysialylation of N-CAM [RGD, Feb 2006]."
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008373", 
                        "pmid": "9352097", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1KQY6", 
                                "id": "A1KQY6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "sialyltransferase activity", 
                        "id": "GO:0008373"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003828", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1KQY6", 
                                "id": "A1KQY6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity", 
                        "id": "GO:0003828"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1KQY6", 
                                "id": "A1KQY6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Golgi apparatus", 
                        "id": "GO:0005794"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1KQY6", 
                                "id": "A1KQY6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007162", 
                        "pmid": "9352097", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1KQY6", 
                                "id": "A1KQY6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of cell adhesion", 
                        "id": "GO:0007162"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006486", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1KQY6", 
                                "id": "A1KQY6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein glycosylation", 
                        "id": "GO:0006486"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009311", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1KQY6", 
                                "id": "A1KQY6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "oligosaccharide metabolic process", 
                        "id": "GO:0009311"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006491", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1KQY6", 
                                "id": "A1KQY6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "N-glycan processing", 
                        "id": "GO:0006491"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001574", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1KQY6", 
                                "id": "A1KQY6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ganglioside biosynthetic process", 
                        "id": "GO:0001574"
                    }
                ], 
                "total": 5, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A1KQY6", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "LOC501189"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1KQY6", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Siat 8D"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1KQY6", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Siat8d"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1KQY6", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "St8sia4"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1KQY6", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "St8sia4"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1KQY6", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "rCG_55449"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000019128", 
            "id": "ENSRNOG00000019128", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/116696", 
            "id": "116696", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001675", 
            "id": "IPR001675", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038578", 
            "id": "IPR038578", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:116696", 
            "id": "rno:116696", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/VRKRWTI/", 
            "id": "VRKRWTI", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=825014at2759", 
            "id": "825014at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00777", 
            "id": "PF00777", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-4085001", 
            "id": "R-RNO-4085001", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-419037", 
            "id": "R-RNO-419037", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446366.1", 
            "id": "NP_446366.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=621845", 
            "id": "621845", 
            "database": "RGD"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1KQY6", 
            "id": "A1KQY6", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 51762.0, 
        "chemical_mass": 51762.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A1KQY6", 
            "name": "St8sia4", 
            "locus": {
                "end_pos": 103117506, 
                "strand": "-", 
                "start_pos": 103207190, 
                "chromosome": "9", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000019128", 
                        "id": "ENSRNOG00000019128", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A1KQY6#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Alpha 2,8-sialyltransferase ST8Sia IV"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1KQY6", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "CMP-N-acetylneuraminate-poly-alpha-2, 8-sialyltransferase"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1KQY6#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "RCG55449"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1KQY6#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1KQY6", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "sialyltransferase 8 (alpha-2, 8-polysialyltransferase) D; sialyltransferase 8 (alpha-2, 8-polysialytransferase) D; sialyltransferase 8 (alpha-2, 8-sialytransferase) D; ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 4"
        }
    ]
}