{ "uniprot_canonical_ac": "A1A5R3-1", "ptm_annotation": [], "sequence": { "header": "tr|A1A5R3-1|A1A5R3_RAT Isoform 1 of KRR1 small subunit processome component OS=Rattus norvegicus OX=10116 GN=Krr1 PE=1 SV=1 CANONICAL=A1A5R3-1", "length": 380, "sequence": "MATSVDTPAKEARKSDSRQQKQKRENQDEGELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHVKATLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQAIRILQDDVACDIIKIGSLVRNKERFVKRRQRLIGPKGSTLKALELLTNCYVMVQGNTVSAIGPFSGLKEVRKVVLDTMKNIHPIYNIKTLMIKRELAKDSELRSQSWERFLPQFKHKNVNKRKEPKKKSVKKEYTPFPPPQPESQVDKELASGEYFLKANQKKRQKMEAIKAKQAEALTKRQEERNKAFIPPKEKPAVKPKEASTETKIDVAAIKEKVKKAKAKKLGALTAEEVKLKMEVDQKKQKRKK" }, "uniprot_id": "A1A5R3_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R3", "id": "A1A5R3", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22658674", "type": [ "PubMed" ], "id": "22658674" } ], "title": "Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.", "journal": "Cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101564.1", "id": "NP_001101564.1", "database": "RefSeq" } ], "authors": "Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW", "date": "2012" } ], "uniprot_ac": "A1A5R3", "site_annotation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1A5R3#A1A5R3-1", "isoform_ac": "A1A5R3-1", "locus": { "end_pos": 54756186, "strand": "-", "start_pos": 54767096, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000063917", "id": "ENSRNOT00000063917", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000059249", "id": "ENSRNOP00000059249", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A1A5R3-1|A1A5R3_RAT Isoform 1 of KRR1 small subunit processome component OS=Rattus norvegicus OX=10116 GN=Krr1 PE=1 SV=1 CANONICAL=A1A5R3-1", "length": 380, "sequence": "MATSVDTPAKEARKSDSRQQKQKRENQDEGELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHVKATLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQAIRILQDDVACDIIKIGSLVRNKERFVKRRQRLIGPKGSTLKALELLTNCYVMVQGNTVSAIGPFSGLKEVRKVVLDTMKNIHPIYNIKTLMIKRELAKDSELRSQSWERFLPQFKHKNVNKRKEPKKKSVKKEYTPFPPPQPESQVDKELASGEYFLKANQKKRQKMEAIKAKQAEALTKRQEERNKAFIPPKEKPAVKPKEASTETKIDVAAIKEKVKKAKAKKLGALTAEEVKLKMEVDQKKQKRKK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314830", "resource": "KEGG Pathway", "id": "rno:314830", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6791226", "resource": "Reactome", "id": "R-RNO-6791226", "name": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A1A5R3#function", "annotation": "Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R3#function", "id": "A1A5R3", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q13601-1", "protein_name": "KRR1 small subunit processome component homolog", "sequence": { "length": 381, "sequence": "MASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHVNATLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQAVRILQDDVACDIIKIGSLVRNKERFVKRRQRLIGPKGSTLKALELLTNCYIMVQGNTVSAIGPFSGLKEVRKVVLDTMKNIHPIYNIKSLMIKRELAKDSELRSQSWERFLPQFKHKNVNKRKEPKKKTVKKEYTPFPPPQPESQIDKELASGEYFLKANQKKRQKMEAIKAKQAEAISKRQEERNKAFIPPKEKPIVKPKEASTETKIDVASIKEKVKKAKNKKLGALTAEEIALKMEADEKKKKKKK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/5114", "id": "5114", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A1A5R3/", "id": "A1A5R3", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "KRR1", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8BGA5-1", "protein_name": "KRR1 small subunit processome component homolog", "sequence": { "length": 380, "sequence": "MATSAEAPAKEAQKRDSQPQKQKRETQDEAELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHVKATLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQAVRILQDDVACDIIKIGSLVRNKERFVKRRQRLIGPKGSTLKALELLTNCYVMVQGNTVSAIGPFSGLKEVRKVVLDTMKNIHPIYNIKTLMIKRELAKDSELRSQSWERFLPQFKHKNVNKRKEPKKKSVKKEYTPFPPPQPESQIDKELASGEYFLKASQKKRQKMEAIKAKQAEALTKRQEERNKAFIPPKEKPAVKPKEASTETKIDVAAIKEKVKKAKTKKLGALTAEEVKLKMEADEKKQKRKK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/5114", "id": "5114", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A1A5R3/", "id": "A1A5R3", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Krr1", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101564.1", "ac": "NP_001101564.1", "name": "KRR1 small subunit processome component homolog", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R3", "id": "A1A5R3", "database": "UniProtKB" } ], "name": "RNA binding", "id": "GO:0003723" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R3", "id": "A1A5R3", "database": "UniProtKB" } ], "name": "nucleolus", "id": "GO:0005730" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R3", "id": "A1A5R3", "database": "UniProtKB" } ], "name": "small-subunit processome", "id": "GO:0032040" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R3", "id": "A1A5R3", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045171", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R3", "id": "A1A5R3", "database": "UniProtKB" } ], "name": "intercellular bridge", "id": "GO:0045171" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5R3", "id": "A1A5R3", "database": "UniProtKB" } ], "name": "rRNA processing", "id": "GO:0006364" } ], "total": 1, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A1A5R3", "type": "synonym", "resource": "RefSeq", "name": "Hrb2" }, { "url": "https://www.uniprot.org/uniprot/A1A5R3", "type": "synonym", "resource": "UniProtKB", "name": "Hrb2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1A5R3", "type": "synonym", "resource": "RefSeq", "name": "Krr1" }, { "url": "https://www.uniprot.org/uniprot/A1A5R3", "type": "recommended", "resource": "UniProtKB", "name": "Krr1" }, { "url": "https://www.uniprot.org/uniprot/A1A5R3", "type": "synonym", "resource": "UniProtKB", "name": "rCG_48818" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000004035", "id": "ENSRNOG00000004035", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/314830", "id": "314830", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004087", "id": "IPR004087", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR024166", "id": "IPR024166", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036612", "id": "IPR036612", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041174", "id": "IPR041174", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314830", "id": "rno:314830", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/VHKKEKF/", "id": "VHKKEKF", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=944899at2759", "id": "944899at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12581", "id": "PTHR12581", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF17903", "id": "PF17903", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6791226", "id": "R-RNO-6791226", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101564.1", "id": "NP_001101564.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306183", "id": "1306183", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A1A5R3", "id": "A1A5R3", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 43623.0, "chemical_mass": 43623.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A1A5R3", "name": "Krr1", "locus": { "end_pos": 54767471, "strand": "+", "start_pos": 54756043, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000004035", "id": "ENSRNOG00000004035", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A1A5R3", "type": "synonym", "resource": "RefSeq", "name": "HIV-1 Rev binding protein 2; KRR1, small subunit (SSU) processome component, homolog" }, { "url": "https://www.uniprot.org/uniprot/A1A5R3#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "KRR-R motif-containing protein 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1A5R3", "type": "synonym", "resource": "RefSeq", "name": "KRR1 small subunit processome component homolog" }, { "url": "https://www.uniprot.org/uniprot/A1A5R3#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "KRR1 small subunit processome component" } ] }