{ "uniprot_canonical_ac": "A1A5Q4-1", "ptm_annotation": [], "sequence": { "header": "sp|A1A5Q4-1|CF206_RAT Isoform 1 of Cilia- and flagella-associated protein 206 OS=Rattus norvegicus OX=10116 GN=Cfap206 PE=2 SV=1 CANONICAL=A1A5Q4-1", "length": 622, "sequence": "MPPTQAESVIKNIIREIGQECAAHGEITSETVVAFMVKAVVLDPSNGFNMDRTLVKTDVQKLVKLCVARLLDNKNPSLDTIKMQVYFDMNYTSREDFLEEHHRVLESRLGIVSREITDTRACAKEELENLYRKIVSYVLLRSGLGSPTDIKIVREATAALQSVFPQAELCTFLTLSKKDKERQLKELTMIVTGIRLFNRDCGKGGEGIDDLPAILLEAIPATTHHIDSQLQIAQEQAFRYTAIIEKVTNNPLMAKELQPYMLKEALYNVRQYEIFLQTVLSDIITCAEEVELMTKQLAAQLEQLKMTVKSKTAVPTSQVFPIFIALASLWTSFQDETVLISVLSNLTTNLELFLGTHDLLFPEKVMQGLLDGVIVKTDMTRIEEHLEEKVQLADFRVLEWLFPETTANFNKLLIQYRGFCGYTFAVTDGLLLPGNPTIGILKYKEKYYTFNSRDAAYSFAENPDHYINLIKEKAKKNAELIQLLELHQQFETLIPYSQMKDVDKHFIKPITKCENGTQTDTHILPPTIVRSYEWNEWELRRKAIQLANLRQKMTHSVQTDLSHMRRDNASQVYPLKEVGTQSKREGSTRVPRPQIFIAGLRGGQSKTTHGVKINLTRAVDET" }, "uniprot_id": "CF206_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5Q4", "id": "A1A5Q4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A1A5Q4", "site_annotation": [ { "end_pos": 347, "annotation": "n_glycosylation_sequon", "start_pos": 345 }, { "end_pos": 517, "annotation": "n_glycosylation_sequon", "start_pos": 515 }, { "end_pos": 570, "annotation": "n_glycosylation_sequon", "start_pos": 568 }, { "end_pos": 616, "annotation": "n_glycosylation_sequon", "start_pos": 614 }, { "end_pos": 92, "annotation": "n_glycosylation_sequon", "start_pos": 90 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1A5Q4#A1A5Q4-1", "isoform_ac": "A1A5Q4-1", "locus": { "end_pos": 50148897, "strand": "+", "start_pos": 50192503, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000051243", "id": "ENSRNOT00000051243", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000045325", "id": "ENSRNOP00000045325", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1A5Q4-1|CF206_RAT Isoform 1 of Cilia- and flagella-associated protein 206 OS=Rattus norvegicus OX=10116 GN=Cfap206 PE=2 SV=1 CANONICAL=A1A5Q4-1", "length": 622, "sequence": "MPPTQAESVIKNIIREIGQECAAHGEITSETVVAFMVKAVVLDPSNGFNMDRTLVKTDVQKLVKLCVARLLDNKNPSLDTIKMQVYFDMNYTSREDFLEEHHRVLESRLGIVSREITDTRACAKEELENLYRKIVSYVLLRSGLGSPTDIKIVREATAALQSVFPQAELCTFLTLSKKDKERQLKELTMIVTGIRLFNRDCGKGGEGIDDLPAILLEAIPATTHHIDSQLQIAQEQAFRYTAIIEKVTNNPLMAKELQPYMLKEALYNVRQYEIFLQTVLSDIITCAEEVELMTKQLAAQLEQLKMTVKSKTAVPTSQVFPIFIALASLWTSFQDETVLISVLSNLTTNLELFLGTHDLLFPEKVMQGLLDGVIVKTDMTRIEEHLEEKVQLADFRVLEWLFPETTANFNKLLIQYRGFCGYTFAVTDGLLLPGNPTIGILKYKEKYYTFNSRDAAYSFAENPDHYINLIKEKAKKNAELIQLLELHQQFETLIPYSQMKDVDKHFIKPITKCENGTQTDTHILPPTIVRSYEWNEWELRRKAIQLANLRQKMTHSVQTDLSHMRRDNASQVYPLKEVGTQSKREGSTRVPRPQIFIAGLRGGQSKTTHGVKINLTRAVDET" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:366347", "resource": "KEGG Pathway", "id": "rno:366347", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A1A5Q4#function", "annotation": "Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (By similarity). Required for the establishment of radial spokes in sperm flagella (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5Q4#function", "id": "A1A5Q4", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q6PE87-1", "protein_name": "Cilia- and flagella-associated protein 206", "sequence": { "length": 622, "sequence": "MPPTQAESVIKNIIREIGQECAAHGEIASETVVAFMVKAVVLDPSNGFNMDRTLIKTDVQKLVKLCVARLLDNKNPSLDTIKMQVYFDMNYTSREDFLEEHHRVLESRLGIVSREITDNRASAREELENLYRKIVSYVLLRSGLGSPTDIKIVREATAALQSVFPQAELATFLTLSKKDKERQLKELTMIVTGIRLFNRDCGKGGEGIDDLPAILHEAIPTTTQHIDSQLQIAQDQAFRYTAILEKVTNNPLMAKELQPYMLKEALYNVRQYEIFLQTVLSDIITCAEEVEMMIKQLAAQLEQLKMAVKSKTAVPTSQVFPIFVALASLWMSFQDETVLISVLSNLTTNLELFLGTHELLFPEKVMLGLLDGVVVKSDLTRIEEHMEERVELADFRTQEWLFPETTANFNKLLIQYRGFCGYTFAVTDGLLLPGNPAIGILKYKEKYYTFSTRDAAYTFAENPDHYIHLIKEKAKKNAELIQLLELHQQFETLIPYSQMRDVDKHYIKPITKCDNGTQTDTHILPPTTMRTYEWNEWELRRKAIKLANLRQKITHSVQTDLSHMRRDNTSQVYPLKEASTQSKREGSSRVPRPQIFIAGLRGGQSKTTYGVKVNLTRAVDET" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/18713", "id": "18713", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A1A5Q4/", "id": "A1A5Q4", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Cfap206", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q8IYR0-1", "protein_name": "Cilia- and flagella-associated protein 206", "sequence": { "length": 622, "sequence": "MPPTQAESVIRSIIREIGQECAAHGEIVSETLIAFMVKAVVLDPSNGFNMDRTLMKSDVQNLVKLCMTRLLDTKNPSLDTIKMQVYFDMNYTNRVEFLEEHHRVLESRLGSVTREITDNRACAKEELESLYRKIISYVLLRSGLGSPTDIKTVREVTAALQSVFPQAELGTFLTLSKKDKERQLKELTMIVTGIRLFNRDCGKGGEGIDDLPAVLHVAIPATMQHIDYQLETARSQVYRYTAILEKAANDPLMRAELQPYMLKEALYNIRQYEVFLQIILSDIITGAQEVEMMTKQLGAHLEQLKMTIKSKIAVPTSQVFPIFIALSTLWTSLQDETIVVGVLSNLFTHIQPFLGAHELYFPERVMQCHLNGATVKTDVCRMKEHMEDRVNVADFRKLEWLFPETTANFDKLLIQYRGFCAYTFAATDGLLLPGNPAIGILKYKEKYYTFNSKDAAYSFAENPEHYIDIVREKAKKNTELIQLLELHQQFETFIPYSQMRDADKHYIKPITKCESSTQTNTHILPPTIVRSYEWNEWELRRKAIKLANLRQKVTHSVQTDLSHLRRENCSQVYPPKDTSTQSMREDSTGVPRPQIYLAGLRGGKSEITDEVKVNLTRDVDET" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/18713", "id": "18713", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A1A5Q4/", "id": "A1A5Q4", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "CFAP206", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073169.1", "ac": "NP_001073169.1", "name": "cilia- and flagella-associated protein 206", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001534", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5Q4", "id": "A1A5Q4", "database": "UniProtKB" } ], "name": "radial spoke", "id": "GO:0001534" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5Q4", "id": "A1A5Q4", "database": "UniProtKB" } ], "name": "motile cilium", "id": "GO:0031514" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5Q4", "id": "A1A5Q4", "database": "UniProtKB" } ], "name": "axoneme", "id": "GO:0005930" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5Q4", "id": "A1A5Q4", "database": "UniProtKB" } ], "name": "ciliary basal body", "id": "GO:0036064" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003341", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5Q4", "id": "A1A5Q4", "database": "UniProtKB" } ], "name": "cilium movement", "id": "GO:0003341" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003356", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5Q4", "id": "A1A5Q4", "database": "UniProtKB" } ], "name": "regulation of cilium beat frequency", "id": "GO:0003356" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035082", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5Q4", "id": "A1A5Q4", "database": "UniProtKB" } ], "name": "axoneme assembly", "id": "GO:0035082" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007288", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5Q4", "id": "A1A5Q4", "database": "UniProtKB" } ], "name": "sperm axoneme assembly", "id": "GO:0007288" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901317", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A5Q4", "id": "A1A5Q4", "database": "UniProtKB" } ], "name": "regulation of flagellated sperm motility", "id": "GO:1901317" } ], "total": 5, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A1A5Q4", "type": "synonym", "resource": "RefSeq", "name": "Cfap206" }, { "url": "https://www.uniprot.org/uniprot/A1A5Q4", "type": "recommended", "resource": "UniProtKB", "name": "Cfap206" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1A5Q4", "type": "synonym", "resource": "RefSeq", "name": "RGD1310641" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000009061", "id": "ENSRNOG00000009061", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/366347", "id": "366347", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR021897", "id": "IPR021897", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:366347", "id": "rno:366347", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/NQEWLFP/", "id": "NQEWLFP", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=357137at2759", "id": "357137at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21442", "id": "PTHR21442", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF12018", "id": "PF12018", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A1A5Q4", "id": "PR_A1A5Q4", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073169.1", "id": "NP_001073169.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310641", "id": "1310641", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A1A5Q4", "id": "A1A5Q4", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 70835.0, "chemical_mass": 70835.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A1A5Q4", "name": "Cfap206", "locus": { "end_pos": 50148658, "strand": "-", "start_pos": 50193571, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000009061", "id": "ENSRNOG00000009061", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A1A5Q4#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Cilia- and flagella-associated protein 206" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1A5Q4", "type": "synonym", "resource": "RefSeq", "name": "UPF0704 protein C6orf165 homolog" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1A5Q4", "type": "synonym", "resource": "RefSeq", "name": "cilia- and flagella-associated protein 206" } ] }