{ "uniprot_canonical_ac": "A1A546-1", "ptm_annotation": [], "sequence": { "header": "sp|A1A546-1|ISX_MOUSE Isoform 1 of Intestine-specific homeobox OS=Mus musculus OX=10090 GN=Isx PE=2 SV=2 CANONICAL=A1A546-1", "length": 240, "sequence": "MAGPTIHRDMEKSSGYCEAPENLGLSFSIEAILKKPTERRSLPRPQSICKEDSRQTTIPGSKLERPPQDQPQEEKKNKRRVRTTFTTEQLQELEKLFHFTHYPDIHVRSQLASRINLPEARVQIWFQNQRAKWRKQEKSGNLSAPQQPGEAGLALPSNMDVSGPVLTPTAMTTLVPPTECCLLSQTQLPSSWFPTQIPLVPWHPWDLQPLPGPLTQHPCVPTFMFPPLHPKWGSICATST" }, "uniprot_id": "ISX_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16971476", "type": [ "PubMed" ], "id": "16971476" } ], "title": "A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.", "journal": "Development", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "authors": "Hu M., Krieger M., Lepourcelet M., Shivdasani R.A., Choi M.Y., Gray P.A., Mechoor A., Romer A.I., Yesilaltay A.", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18093975", "type": [ "PubMed" ], "id": "18093975" } ], "title": "Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "id": "NP_001281207.1", "database": "RefSeq" } ], "authors": "Kimura K., Miki T., Takahashi Y., Takeuchi A., Abe T., Seino S., Iwanaga T., Seino Y., Kiyonari H., Oiso Y., Fujimoto W.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20932939", "type": [ "PubMed" ], "id": "20932939" } ], "title": "Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.", "journal": "Gene expression patterns : GEP", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "id": "NP_001281207.1", "database": "RefSeq" } ], "authors": "Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23393141", "type": [ "PubMed" ], "id": "23393141" } ], "title": "Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "id": "NP_001281207.1", "database": "RefSeq" } ], "authors": "Lobo GP, Amengual J, Baus D, Shivdasani RA, Taylor D, von Lintig J", "date": "2013" } ], "uniprot_ac": "A1A546", "site_annotation": [ { "end_pos": 143, "annotation": "n_glycosylation_sequon", "start_pos": 141 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1A546#A1A546-1", "isoform_ac": "A1A546-1", "locus": { "end_pos": 74873641, "strand": "-", "start_pos": 74892901, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000034034", "id": "ENSMUST00000034034", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000034034", "id": "ENSMUSP00000034034", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1A546-1|ISX_MOUSE Isoform 1 of Intestine-specific homeobox OS=Mus musculus OX=10090 GN=Isx PE=2 SV=2 CANONICAL=A1A546-1", "length": 240, "sequence": "MAGPTIHRDMEKSSGYCEAPENLGLSFSIEAILKKPTERRSLPRPQSICKEDSRQTTIPGSKLERPPQDQPQEEKKNKRRVRTTFTTEQLQELEKLFHFTHYPDIHVRSQLASRINLPEARVQIWFQNQRAKWRKQEKSGNLSAPQQPGEAGLALPSNMDVSGPVLTPTAMTTLVPPTECCLLSQTQLPSSWFPTQIPLVPWHPWDLQPLPGPLTQHPCVPTFMFPPLHPKWGSICATST" } }, { "url": "https://www.uniprot.org/uniprot/A1A546#A1A546-2", "isoform_ac": "A1A546-2", "locus": { "end_pos": 74873641, "strand": "-", "start_pos": 74892948, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000174427", "id": "ENSMUST00000174427", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000134368", "id": "ENSMUSP00000134368", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1A546-2|ISX_MOUSE Isoform 2 of Intestine-specific homeobox OS=Mus musculus OX=10090 GN=Isx PE=2 SV=2 CANONICAL=A1A546-1", "length": 242, "sequence": "MAGPTIHRDMEKSSGYCEAPENLGLSFSIEAILKKPTERRSLPRPQSICKEDSRQTTIPGSKLERPPQDQPQEEKKNKRRVRTTFTTEQLQELEKLFHFTHYPDIHVRSQLASRINLPEARVQIWFQNQRAKWRKQEKSGNLSAPQQPGSCADTHCYDYIGTSHRMLPTLSDSAPFKLVPYTDSPCPMAPMGPTAPAWPSHPASLCPYLHVPTPTPQVGQHLCNFNIGTDFSLSKQATLLSQ" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71597", "resource": "KEGG Pathway", "id": "mmu:71597", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "annotation": "Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "id": "NP_001281207.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "annotation": "Isx participates in the maintenance of vitamin A metabolism by regulating Bcmo1 expression in the intestine.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "id": "NP_001281207.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A1A546#function", "annotation": "Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546#function", "id": "A1A546", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "F1M478-1", "protein_name": "Intestine-specific homeobox", "sequence": { "length": 242, "sequence": "MAGPTIQRDIEKSSGYCEAPEKLGLSFSIEAILKRPTERRNLPRPQSIGGGDSRQTTTSGSKLEKPTQDQPQEERKNKRRVRTTFTTEQLQELEKLFHFTHYPDIHVRSQLASRINLPEARVQIWFQNQRAKWRKQEKSGSLSAPQQPGSCTDAHCSAHIGATHRMLPPLSDSARFKLVPCPDSPCPMAPMGPAAPAWPSHPAALCPYLHPPTPKPQVGQHLCNANIRTGFSLPKQATLLPQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/28312", "id": "28312", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Isx", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q2M1V0-1", "protein_name": "Intestine-specific homeobox", "sequence": { "length": 245, "sequence": "MCAEVGPALCRGMERNSLGCCEAPKKLSLSFSIEAILKRPARRSDMDRPEGPGEEGPGEAAASGSGLEKPPKDQPQEGRKSKRRVRTTFTTEQLHELEKIFHFTHYPDVHIRSQLAARINLPEARVQIWFQNQRAKWRKQEKIGNLGAPQQLSEASVALPTNLDVAGPTWTSTALRRLAPPTSCCPSAQDQLASAWFPAWITLLPAHPWETQPVPGLPIHQTCIPVLCILPPPHPKWGSICATST" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/28312", "id": "28312", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A1A546/", "id": "A1A546", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "ISX", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "ac": "NP_001281207.1", "name": "intestine-specific homeobox isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "pmid": "25701869", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "pmid": "25701869", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "sequence-specific DNA binding", "id": "GO:0043565" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000790", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "nuclear chromatin", "id": "GO:0000790" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "25701869", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048484", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "enteric nervous system development", "id": "GO:0048484" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "pmid": "18093975", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904479", "pmid": "25701869", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "negative regulation of intestinal absorption", "id": "GO:1904479" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901738", "pmid": "18093975", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "name": "regulation of vitamin A metabolic process", "id": "GO:1901738" } ], "total": 4, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A1A546", "type": "synonym", "resource": "RefSeq", "name": "9130012O13Rik; Pix-1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1A546", "type": "synonym", "resource": "RefSeq", "name": "Isx" }, { "url": "https://www.uniprot.org/uniprot/A1A546", "type": "recommended", "resource": "UniProtKB", "name": "Isx" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031621", "id": "ENSMUSG00000031621", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "id": "cd00086", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/71597", "id": "71597", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "id": "IPR001356", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "id": "IPR009057", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "id": "IPR017970", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71597", "id": "mmu:71597", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:1918847", "id": "1918847", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/WETQPLP/", "id": "WETQPLP", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1270742at2759", "id": "1270742at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00046", "id": "PF00046", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A1A546", "id": "PR_A1A546", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281207.1", "id": "NP_001281207.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A1A546", "id": "A1A546", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 27169.0, "chemical_mass": 27169.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A1A546", "name": "Isx", "locus": { "end_pos": 74893506, "strand": "+", "start_pos": 74873173, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000031621", "id": "ENSMUSG00000031621", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A1A546#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Intestine-specific homeobox" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1A546", "type": "synonym", "resource": "RefSeq", "name": "intestine-specific homeobox isoform 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1A546", "type": "synonym", "resource": "RefSeq", "name": "pancreas-intestine homeodomain transcription factor" } ] }