{
    "uniprot_canonical_ac": "A0S5V8-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A0S5V8-1|A0S5V8_RAT Isoform 1 of Chitinase  OS=Rattus norvegicus OX=10116 GN=Chit1 PE=2 SV=1 CANONICAL=A0S5V8-1", 
        "length": 464, 
        "sequence": "MVQSLALAGVTTLLMIQWGSAAKLFCYFTNWAQYRSGAARFLPRDVDPNLCTHVIYAFAGLNNHQVSTVEPNDELFYQELNSLKKRNPKLKTLLAVGGWSFGTQKFTDMVATASTRQTFVNSALSFLRTHGFDGLDLDWEYPGSRGSPAVDKERFTALIQDLAKAFQEEARASGKSRLLLTAAVPTGRGHVDAGYEVDKIVQSLDFINLMAYDFHSSWDKTTGHNSPLYKRQGETGKDAEKNVDAAVTLWLQKGTPASKLMLGMPAYGRSFTLASSSDSGVGAPATGPGAPGPYTKEKGILVYFEVCSWKGKQRIEDQKVPYVSQGNQWVGFDDRESFRAKAAYVKQKGLGGAMVWILDGDDFKGSFCNEGQYPLIRTLHQELSLSSGPPRSPEQEVPGPHQPSEPEQGPSPGLDDFCQGKADGLYPNPTEKSSFYSCGGGRLFQHSCPPGLVFIDSCKCCTWG"
    }, 
    "uniprot_id": "A0S5V8_RAT", 
    "enzyme_annotation": [
        {
            "ec": "3.2.1.14", 
            "activity": ""
        }, 
        {
            "ec": "3.2.1.14", 
            "activity": "Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins."
        }
    ], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0S5V8", 
                    "id": "A0S5V8", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/11085997", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "11085997"
                }
            ], 
            "title": "Identification of a novel acidic mammalian chitinase distinct from chitotriosidase.", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", 
                    "id": "NP_001073157.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Boot RG, Blommaart EF, Swart E, Ghauharali-van der Vlugt K, Bijl N, Moe C, Place A, Aerts JM", 
            "date": "2001"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17852345", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "17852345"
                }
            ], 
            "title": "Molecular cloning and characterization of rat chitotriosidase.", 
            "journal": "DNA sequence : the journal of DNA sequencing and mapping", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", 
                    "id": "NP_001073157.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Chen XH, Cai GP", 
            "date": "2008"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19725875", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "19725875"
                }
            ], 
            "title": "Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates.", 
            "journal": "The FEBS journal", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", 
                    "id": "NP_001073157.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Bussink AP, Verhoek M, Vreede J, Ghauharali-van der Vlugt K, Donker-Koopman WE, Sprenger RR, Hollak CE, Aerts JM, Boot RG", 
            "date": "2009"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24155872", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "24155872"
                }
            ], 
            "title": "Evidence supporting a role for mammalian chitinases in efficacy of caspofungin against experimental aspergillosis in immunocompromised rats.", 
            "journal": "PloS one", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", 
                    "id": "NP_001073157.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Verwer PE, ten Kate MT, Falcone FH, Morroll S, Verbrugh HA, Bakker-Woudenberg IA, van de Sande WW", 
            "date": "2013"
        }
    ], 
    "uniprot_ac": "A0S5V8", 
    "site_annotation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0S5V8#A0S5V8-1", 
            "isoform_ac": "A0S5V8-1", 
            "locus": {
                "end_pos": 50981282, 
                "strand": "-", 
                "start_pos": 50994432, 
                "chromosome": "13", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000080768", 
                        "id": "ENSRNOT00000080768", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000070204", 
                        "id": "ENSRNOP00000070204", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0S5V8-1|A0S5V8_RAT Isoform 1 of Chitinase  OS=Rattus norvegicus OX=10116 GN=Chit1 PE=2 SV=1 CANONICAL=A0S5V8-1", 
                "length": 464, 
                "sequence": "MVQSLALAGVTTLLMIQWGSAAKLFCYFTNWAQYRSGAARFLPRDVDPNLCTHVIYAFAGLNNHQVSTVEPNDELFYQELNSLKKRNPKLKTLLAVGGWSFGTQKFTDMVATASTRQTFVNSALSFLRTHGFDGLDLDWEYPGSRGSPAVDKERFTALIQDLAKAFQEEARASGKSRLLLTAAVPTGRGHVDAGYEVDKIVQSLDFINLMAYDFHSSWDKTTGHNSPLYKRQGETGKDAEKNVDAAVTLWLQKGTPASKLMLGMPAYGRSFTLASSSDSGVGAPATGPGAPGPYTKEKGILVYFEVCSWKGKQRIEDQKVPYVSQGNQWVGFDDRESFRAKAAYVKQKGLGGAMVWILDGDDFKGSFCNEGQYPLIRTLHQELSLSSGPPRSPEQEVPGPHQPSEPEQGPSPGLDDFCQGKADGLYPNPTEKSSFYSCGGGRLFQHSCPPGLVFIDSCKCCTWG"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:289032", 
            "resource": "KEGG Pathway", 
            "id": "rno:289032", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-189085", 
            "resource": "Reactome", 
            "id": "R-RNO-189085", 
            "name": "Digestion of dietary carbohydrate"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695", 
            "resource": "Reactome", 
            "id": "R-RNO-6798695", 
            "name": "Neutrophil degranulation"
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", 
            "annotation": "Expression of cloned cDNA of chitotriosidase demonstrates that the encoded protein is secreted extracellularly and has chitinolytic activity.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", 
                    "id": "NP_001073157.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", 
            "annotation": "Invasive pulmonary aspergillosis in immunocompromised rats caused a dramatic increase in chitinase activity. Publication Status: Online-Only", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", 
                    "id": "NP_001073157.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q13231-1", 
            "protein_name": "Chitotriosidase-1", 
            "sequence": {
                "length": 466, 
                "sequence": "MVRSVAWAGFMVLLMIPWGSAAKLVCYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAGMTNHQLSTTEWNDETLYQEFNGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFVNSAIRFLRKYSFDGLDLDWEYPGSQGSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLLSAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSWEKVTGHNSPLYKRQEESGAAASLNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDTRVGAPATGSGTPGPFTKEGGMLAYYEVCSWKGATKQRIQDQKVPYIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWALDLDDFAGFSCNQGRYPLIQTLRQELSLPYLPSGTPELEVPKPGQPSEPEHGPSPGQDTFCQGKADGLYPNPRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTWN"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/68318", 
                    "id": "68318", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A0S5V8/", 
                    "id": "A0S5V8", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "CHIT1", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q9D7Q1-1", 
            "protein_name": "Chitotriosidase-1", 
            "sequence": {
                "length": 464, 
                "sequence": "MVQSLAWAGVMTLLMVQWGSAAKLVCYLTNWSQYRTEAVRFFPRDVDPNLCTHVIFAFAGMDNHQLSTVEHNDELLYQELNSLKTKNPKLKTLLAVGGWTFGTQKFTDMVATASNRQTFVKSALSFLRTQGFDGLDLDWEFPGGRGSPTVDKERFTALIQDLAKAFQEEAQSSGKERLLLTAAVPSDRGLVDAGYEVDKIAQSLDFINLMAYDFHSSLEKTTGHNSPLYKRQGESGAAAEQNVDAAVTLWLQKGTPASKLILGMPTYGRSFTLASSSDNGVGAPATGPGAPGPYTKDKGVLAYYEACSWKERHRIEDQKVPYAFQDNQWVSFDDVESFKAKAAYLKQKGLGGAMVWVLDLDDFKGSFCNQGPYPLIRTLRQELNLPSETPRSPEQIIPEPRPSSMPEQGPSPGLDNFCQGKADGVYPNPGDESTYYNCGGGRLFQQSCPPGLVFRASCKCCTWS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/68318", 
                    "id": "68318", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A0S5V8/", 
                    "id": "A0S5V8", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "gene_name": "Chit1", 
            "tax_id": 10090
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", 
        "ac": "NP_001073157.1", 
        "name": "chitotriosidase-1 precursor", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008061", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0S5V8", 
                                "id": "A0S5V8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "chitin binding", 
                        "id": "GO:0008061"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004568", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0S5V8", 
                                "id": "A0S5V8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "chitinase activity", 
                        "id": "GO:0004568"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008843", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0S5V8", 
                                "id": "A0S5V8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endochitinase activity", 
                        "id": "GO:0008843"
                    }
                ], 
                "total": 3, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0S5V8", 
                                "id": "A0S5V8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular region", 
                        "id": "GO:0005576"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0S5V8", 
                                "id": "A0S5V8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular space", 
                        "id": "GO:0005615"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0S5V8", 
                                "id": "A0S5V8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "carbohydrate metabolic process", 
                        "id": "GO:0005975"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006032", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0S5V8", 
                                "id": "A0S5V8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "chitin catabolic process", 
                        "id": "GO:0006032"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0S5V8", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Chit1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0S5V8", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Chit1"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000028072", 
            "id": "ENSRNOG00000028072", 
            "database": "Bgee"
        }, 
        {
            "url": "http://www.cazy.org/fam/CBM14.html", 
            "id": "CBM14", 
            "database": "CAZy"
        }, 
        {
            "url": "http://www.cazy.org/fam/GH18.html", 
            "id": "GH18", 
            "database": "CAZy"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/289032", 
            "id": "289032", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001223", 
            "id": "IPR001223", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001579", 
            "id": "IPR001579", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002557", 
            "id": "IPR002557", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011583", 
            "id": "IPR011583", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", 
            "id": "IPR017853", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029070", 
            "id": "IPR029070", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036508", 
            "id": "IPR036508", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:289032", 
            "id": "rno:289032", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/FYYCSGG/", 
            "id": "FYYCSGG", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1289629at2759", 
            "id": "1289629at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00704", 
            "id": "PF00704", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF01607", 
            "id": "PF01607", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-189085", 
            "id": "R-RNO-189085", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798695", 
            "id": "R-RNO-6798695", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073157.1", 
            "id": "NP_001073157.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305646", 
            "id": "1305646", 
            "database": "RGD"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0S5V8", 
            "id": "A0S5V8", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 50782.0, 
        "chemical_mass": 50782.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0S5V8", 
            "name": "Chit1", 
            "locus": {
                "end_pos": 50994643, 
                "strand": "+", 
                "start_pos": 50974872, 
                "chromosome": "13", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000028072", 
                        "id": "ENSRNOG00000028072", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0S5V8#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "3.2.1.14"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0S5V8#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Chitinase"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0S5V8", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "chitotriosidase-1 precursor"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0S5V8", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "chitotriosidase-1; chitinase 1 (chitotriosidase)"
        }
    ]
}