{ "uniprot_canonical_ac": "A0JPQ5-1", "ptm_annotation": [], "sequence": { "header": "tr|A0JPQ5-1|A0JPQ5_RAT Isoform 1 of Similar to DNA segment, Chr 18, Wayne State University 98,-expressed OS=Rattus norvegicus OX=10116 GN=RGD1560212 PE=1 SV=1 CANONICAL=A0JPQ5-1", "length": 220, "sequence": "MNIRRARPDDLMNMQHCNLLCLPENYQMKYYFYHGLSWPQLSYIAEDEDGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFSAKYVSLHVRKSNRAALHLYSNTLNFQVSEVEPKYYADGEDAYAMKRDLSQMADELRRQLVLKKGRYVVLGSKENQGSTLPGSEEACQQENLAVGDSGSDGKDSTDVQDSLQTLGSAS" }, "uniprot_id": "A0JPQ5_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ5", "id": "A0JPQ5", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0JPQ5", "site_annotation": [ { "end_pos": 103, "annotation": "n_glycosylation_sequon", "start_pos": 101 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ5#A0JPQ5-1", "isoform_ac": "A0JPQ5-1", "locus": { "end_pos": 76730373, "strand": "-", "start_pos": 76731032, "chromosome": "18", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000082419", "id": "ENSRNOT00000082419", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074289", "id": "ENSRNOP00000074289", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0JPQ5-1|A0JPQ5_RAT Isoform 1 of Similar to DNA segment, Chr 18, Wayne State University 98,-expressed OS=Rattus norvegicus OX=10116 GN=RGD1560212 PE=1 SV=1 CANONICAL=A0JPQ5-1", "length": 220, "sequence": "MNIRRARPDDLMNMQHCNLLCLPENYQMKYYFYHGLSWPQLSYIAEDEDGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFSAKYVSLHVRKSNRAALHLYSNTLNFQVSEVEPKYYADGEDAYAMKRDLSQMADELRRQLVLKKGRYVVLGSKENQGSTLPGSEEACQQENLAVGDSGSDGKDSTDVQDSLQTLGSAS" } }, { "url": "https://www.uniprot.org/uniprot/A0JPQ5#D3ZSW5-1", "isoform_ac": "D3ZSW5-1", "locus": { "end_pos": 76725626, "strand": "-", "start_pos": 76740492, "chromosome": "18", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000089487", "id": "ENSRNOT00000089487", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000073923", "id": "ENSRNOP00000073923", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZSW5-1|A0JPQ5_RAT Computationally mapped isoform of Similar to DNA segment, Chr 18, Wayne State University 98,-expressed OS=Rattus norvegicus OX=10116 GN=RGD1560212 PE=1 SV=1 CANONICAL=A0JPQ5-1", "length": 142, "sequence": "MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:498890", "resource": "KEGG Pathway", "id": "rno:498890", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "M0R635-1", "protein_name": "N-alpha-acetyltransferase 11-like", "sequence": { "length": 220, "sequence": "MNIRRARPDDLMNMQHCNLLCLPENYQMKYYFYHGLSWPQLSYIAEDEDGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENFSAKYVSLHVRKSNRAALHLYSNTLNFQVSEVEPKYYADGEDAYAMKRDLSQMADELRRQLVLKKGRYVVLGSKENQGSTLPGSEEASQQENLAGGDSGSDGKDSTDVQDSLQTLGSAS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/135619", "id": "135619", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "LOC100909833", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071144.1", "ac": "NP_001071144.1", "name": "uncharacterized protein LOC498890", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004596", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ5", "id": "A0JPQ5", "database": "UniProtKB" } ], "name": "peptide alpha-N-acetyltransferase activity", "id": "GO:0004596" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990189", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ5", "id": "A0JPQ5", "database": "UniProtKB" } ], "name": "peptide-serine-N-acetyltransferase activity", "id": "GO:1990189" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990190", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ5", "id": "A0JPQ5", "database": "UniProtKB" } ], "name": "peptide-glutamate-N-acetyltransferase activity", "id": "GO:1990190" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031415", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ5", "id": "A0JPQ5", "database": "UniProtKB" } ], "name": "NatA complex", "id": "GO:0031415" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006474", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ5", "id": "A0JPQ5", "database": "UniProtKB" } ], "name": "N-terminal protein amino acid acetylation", "id": "GO:0006474" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017198", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ5", "id": "A0JPQ5", "database": "UniProtKB" } ], "name": "N-terminal peptidyl-serine acetylation", "id": "GO:0017198" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018002", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ5", "id": "A0JPQ5", "database": "UniProtKB" } ], "name": "N-terminal peptidyl-glutamic acid acetylation", "id": "GO:0018002" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ5", "type": "synonym", "resource": "UniProtKB", "name": "RGD1560212_predicted" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPQ5", "type": "synonym", "resource": "RefSeq", "name": "RGD1560212" }, { "url": "https://www.uniprot.org/uniprot/A0JPQ5", "type": "recommended", "resource": "UniProtKB", "name": "RGD1560212" }, { "url": "https://www.uniprot.org/uniprot/A0JPQ5", "type": "synonym", "resource": "UniProtKB", "name": "Txnl4a" }, { "url": "https://www.uniprot.org/uniprot/A0JPQ5", "type": "synonym", "resource": "UniProtKB", "name": "rCG_20515" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000057774", "id": "ENSRNOG00000057774", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/498890", "id": "498890", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000182", "id": "IPR000182", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016181", "id": "IPR016181", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:498890", "id": "rno:498890", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/HAISWPM/", "id": "HAISWPM", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1489230at2759", "id": "1489230at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00583", "id": "PF00583", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071144.1", "id": "NP_001071144.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1560212", "id": "1560212", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0JPQ5", "id": "A0JPQ5", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [ { "id": "MONDO:0010457", "url": "https://monarchinitiative.org/disease/MONDO:0010457", "resource": "MONDO", "name": "NAT1 deficiency", "description": "" }, { "id": "MONDO:0010457", "url": "https://monarchinitiative.org/disease/MONDO:0010457", "resource": "MONDO", "name": "N acetyltransferase deficiency", "description": "" }, { "id": "MONDO:0010457", "url": "https://monarchinitiative.org/disease/MONDO:0010457", "resource": "MONDO", "name": "Acetyl-CoA:arylamine n-acetyltransferase", "description": "" }, { "id": "MONDO:0010457", "url": "https://monarchinitiative.org/disease/MONDO:0010457", "resource": "MONDO", "name": "arylamine n-acetyltransferase 1", "description": "" }, { "id": "MONDO:0010457", "url": "https://monarchinitiative.org/disease/MONDO:0010457", "resource": "MONDO", "name": "Ogden syndrome; OGDNS", "description": "" }, { "id": "MONDO:0010457", "url": "https://monarchinitiative.org/disease/MONDO:0010457", "resource": "MONDO", "name": "N acetyltransferase 1 deficiency", "description": "" }, { "id": "MONDO:0010457", "url": "https://monarchinitiative.org/disease/MONDO:0010457", "resource": "MONDO", "name": "X-linked malformation and infantile lethality syndrome", "description": "" }, { "id": "MONDO:0010457", "url": "https://monarchinitiative.org/disease/MONDO:0010457", "resource": "MONDO", "name": "OGDNS", "description": "" }, { "id": "MONDO:0010457", "url": "https://monarchinitiative.org/disease/MONDO:0010457", "resource": "MONDO", "name": "N-terminal acetyltransferase deficiency", "description": "" }, { "id": "MONDO:0010457", "url": "https://monarchinitiative.org/disease/MONDO:0010457", "resource": "MONDO", "name": "N-alpha-acetyltransferase", "description": "" }, { "id": "MONDO:0010457", "url": "https://monarchinitiative.org/disease/MONDO:0010457", "resource": "MONDO", "name": "premature aging appearance-developmental delay-cardiac arrhythmia syndrome", "description": "" }, { "id": "DOID:0050781", "url": "http://disease-ontology.org/term/DOID:0050781", "resource": "Disease Ontology", "name": "N-alpha-acetyltransferase", "description": "" }, { "id": "DOID:0050781", "url": "http://disease-ontology.org/term/DOID:0050781", "resource": "Disease Ontology", "name": "N-terminal acetyltransferase deficiency", "description": "" }, { "id": "DOID:0050781", "url": "http://disease-ontology.org/term/DOID:0050781", "resource": "Disease Ontology", "name": "OGDNS", "description": "" }, { "id": "DOID:0050781", "url": "http://disease-ontology.org/term/DOID:0050781", "resource": "Disease Ontology", "name": "X-linked Malformation and Infantile Lethality Syndrome", "description": "" } ], "recommended_name": { "id": "DOID:0050781", "url": "http://disease-ontology.org/term/DOID:0050781", "resource": "Disease Ontology", "name": "Ogden syndrome", "description": "A syndrome characterized by postnatal growth failure, severely delayed psychomotor development, variable dysmorphic features, and hypotonia and has_material_basis_in X-linked recessive or X-linked dominant mutation in the NAA10 gene on chromosome Xq28." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/0050781#disease-associations", "id": "0050781", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [], "mass": { "monoisotopic_mass": 24826.0, "chemical_mass": 24826.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ5", "name": "RGD1560212", "locus": { "end_pos": 76731643, "strand": "+", "start_pos": 76725253, "chromosome": "18", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000057774", "id": "ENSRNOG00000057774", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ5#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Similar to DNA segment, Chr 18, Wayne State University 98, expressed (Predicted), isoform CRA_c" }, { "url": "https://www.uniprot.org/uniprot/A0JPQ5#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Similar to DNA segment, Chr 18, Wayne State University 98,-expressed" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPQ5", "type": "synonym", "resource": "RefSeq", "name": "uncharacterized protein LOC498890" } ] }