{ "uniprot_canonical_ac": "A0JPQ4-1", "ptm_annotation": [ { "annotation": "Disulfide bond formation at Cys-242 occurs in case of membrane damage that cause the entry of the oxidized milieu of the extracellular space, resulting in homooligomerization.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ] }, { "annotation": "S-nitrosylation at Cys-144 stabilizes TRIM72 and protects against oxidation-induced protein degradation and cell death.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q6ZMU5", "id": "Q6ZMU5", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A0JPQ4-1|TRI72_RAT Isoform 1 of Tripartite motif-containing protein 72 OS=Rattus norvegicus OX=10116 GN=Trim72 PE=1 SV=1 CANONICAL=A0JPQ4-1", "length": 477, "sequence": "MSTAPGLLRQELSCPLCLQLFDAPVTAECGHSFCRACLIRVAGEPADDGTVACPCCQASTRPQALSTNLQLARLVEGLAQVPQGHCEEHLDPLSIYCEQDRTLVCGVCASLGSHRGHRLLPAAEAHARLKTQLPQQKAQLQEACMRKEKSVAVLEHQLVEVEETVRQFRGAVGEQLGKMRMFLAALESSLDREAERVRGEAGVALRRELSSLNSYLEQLRQMEKVLEEVADKPQTEFLMKFCLVTSRLQKILSESPPPARLDIQLPVISDDFKFQVWKKMFRALMPELEELTFDPSSAHPSLVVSASGRRVECSEQKAPPAGEDTCQFDKTVAVVAKQLLSQGEHYWEVEVGDKPRWALGVMAADASRRGRLHAVPSQGLWLLGLRDGKILEAHVEAKEPRALRTPERPPARIGLYLSFADGVLTFYDASNTDALTPLFSFHERLPGPVYPMFDVCWHDKGKNSQPLLLVGPDSEQA" }, "uniprot_id": "TRI72_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19029292", "type": [ "PubMed" ], "id": "19029292" } ], "title": "MG53 regulates membrane budding and exocytosis in muscle cells.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Cai C, Masumiya H, Weisleder N, Pan Z, Nishi M, Komazaki S, Takeshima H, Ma J", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19043407", "type": [ "PubMed" ], "id": "19043407" } ], "title": "MG53 nucleates assembly of cell membrane repair machinery.", "journal": "Nature cell biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Cai C, Masumiya H, Weisleder N, Matsuda N, Nishi M, Hwang M, Ko JK, Lin P, Thornton A, Zhao X, Pan Z, Komazaki S, Brotto M, Takeshima H, Ma J", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19380584", "type": [ "PubMed" ], "id": "19380584" } ], "title": "Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Cai C, Weisleder N, Ko JK, Komazaki S, Sunada Y, Nishi M, Takeshima H, Ma J", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20516375", "type": [ "PubMed" ], "id": "20516375" } ], "title": "MG53 constitutes a primary determinant of cardiac ischemic preconditioning.", "journal": "Circulation", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Cao CM, Zhang Y, Weisleder N, Ferrante C, Wang X, Lv F, Zhang Y, Song R, Hwang M, Jin L, Guo J, Peng W, Li G, Nishi M, Takeshima H, Ma J, Xiao RP", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23965929", "type": [ "PubMed" ], "id": "23965929" } ], "title": "MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling.", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Yi JS, Park JS, Ham YM, Nguyen N, Lee NR, Hong J, Kim BW, Lee H, Lee CS, Jeong BC, Song HK, Cho H, Kim YK, Lee JS, Park KS, Shin H, Choi I, Lee SH, Park WJ, Park SY, Choi CS, Lin P, Karunasiri M, Tan T, Duann P, Zhu H, Ma J, Ko YG", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26306047", "type": [ "PubMed" ], "id": "26306047" } ], "title": "Modulation of wound healing and scar formation by MG53 protein-mediated cell membrane repair.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Li H, Duann P, Lin PH, Zhao L, Fan Z, Tan T, Zhou X, Sun M, Fu M, Orange M, Sermersheim M, Ma H, He D, Steinberg SM, Higgins R, Zhu H, John E, Zeng C, Guan J, Ma J", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26790476", "type": [ "PubMed" ], "id": "26790476" } ], "title": "Lack of MG53 in human heart precludes utility as a biomarker of myocardial injury or endogenous cardioprotective factor.", "journal": "Cardiovascular research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Lemckert FA, Bournazos A, Eckert DM, Kenzler M, Hawkes JM, Butler TL, Ceely B, North KN, Winlaw DS, Egan JR, Cooper ST", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27843952", "type": [ "PubMed" ], "id": "27843952" } ], "title": "Swimming Exercise Alleviated Insulin Resistance by Regulating Tripartite Motif Family Protein 72 Expression and AKT Signal Pathway in Sprague-Dawley Rats Fed with High-Fat Diet.", "journal": "Journal of diabetes research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Qi J, Yang B, Ren C, Fu J, Zhang J", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29233682", "type": [ "PubMed" ], "id": "29233682" } ], "title": "Potential role of MG53 in the regulation of transforming-growth-factor-beta1-induced atrial fibrosis and vulnerability to atrial fibrillation.", "journal": "Experimental cell research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Guo J, Jia F, Jiang Y, Li Q, Yang Y, Xiao M, Xiao H", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30760025", "type": [ "PubMed" ], "id": "30760025" } ], "title": "MG53, A Novel Regulator of KChIP2 and Ito,f, Plays a Critical Role in Electrophysiological Remodeling in Cardiac Hypertrophy.", "journal": "Circulation", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ], "authors": "Liu W, Wang G, Zhang C, Ding W, Cheng W, Luo Y, Wei C, Liu J", "date": "2019" } ], "uniprot_ac": "A0JPQ4", "site_annotation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4#A0JPQ4-1", "isoform_ac": "A0JPQ4-1", "locus": { "end_pos": 199450563, "strand": "-", "start_pos": 199457092, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000029994", "id": "ENSRNOT00000029994", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000030976", "id": "ENSRNOP00000030976", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0JPQ4-1|TRI72_RAT Isoform 1 of Tripartite motif-containing protein 72 OS=Rattus norvegicus OX=10116 GN=Trim72 PE=1 SV=1 CANONICAL=A0JPQ4-1", "length": 477, "sequence": "MSTAPGLLRQELSCPLCLQLFDAPVTAECGHSFCRACLIRVAGEPADDGTVACPCCQASTRPQALSTNLQLARLVEGLAQVPQGHCEEHLDPLSIYCEQDRTLVCGVCASLGSHRGHRLLPAAEAHARLKTQLPQQKAQLQEACMRKEKSVAVLEHQLVEVEETVRQFRGAVGEQLGKMRMFLAALESSLDREAERVRGEAGVALRRELSSLNSYLEQLRQMEKVLEEVADKPQTEFLMKFCLVTSRLQKILSESPPPARLDIQLPVISDDFKFQVWKKMFRALMPELEELTFDPSSAHPSLVVSASGRRVECSEQKAPPAGEDTCQFDKTVAVVAKQLLSQGEHYWEVEVGDKPRWALGVMAADASRRGRLHAVPSQGLWLLGLRDGKILEAHVEAKEPRALRTPERPPARIGLYLSFADGVLTFYDASNTDALTPLFSFHERLPGPVYPMFDVCWHDKGKNSQPLLLVGPDSEQA" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:365377", "resource": "KEGG Pathway", "id": "rno:365377", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-445355", "resource": "Reactome", "id": "R-RNO-445355", "name": "Smooth Muscle Contraction" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "annotation": "MG53 is a facilitator of rapid injury repair, a mediator of cell migration, and a modulator of myofibroblast differentiation during wound healing", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "annotation": "MG53 is an effective biomarker of myocardial injury and dysfunction in murine hearts. However, MG53 is not expressed in human heart and therefore does not hold utility as a clinical biomarker of myocardial injury", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "annotation": "MG53, a member of the muscle-specific transmembrane adaptor molecule (TRIM) protein family, is a crucial component of the cardiac ischemic preconditioning response.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A0JPQ4#function", "annotation": "Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4#function", "id": "A0JPQ4", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "annotation": "These findings establish MG53 as a novel regulator of KChIP2 and Ito,f by modulating NF-kappaB activity and reveal its critical role in electrophysiological remodeling in cardiac hypertrophy.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "annotation": "These results suggest that an 8-week swimming exercise improves HFD-induced insulin resistance maybe through a reduction of TRIM72 in skeletal muscle and enhancement of AKT signal transduction.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "annotation": "This suggests that MG53 is a potential regulator of atrial fibrosis induced by the TGF-beta1/Smad pathway in patients with atrial fibrillation .", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "id": "NP_001071143.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q1XH17-1", "protein_name": "Tripartite motif-containing protein 72", "sequence": { "length": 477, "sequence": "MSAAPGLLRQELSCPLCLQLFDAPVTAECGHSFCRACLIRVAGEPAADGTVACPCCQAPTRPQALSTNLQLSRLVEGLAQVPQGHCEEHLDPLSIYCEQDRTLVCGVCASLGSHRGHRLLPAAEAQARLKTQLPQQKMQLQEACMRKEKTVAVLEHQLVEVEETVRQFRGAVGEQLGKMRMFLAALESSLDREAERVRGDAGVALRRELSSLNSYLEQLRQMEKVLEEVADKPQTEFLMKFCLVTSRLQKILSESPPPARLDIQLPVISDDFKFQVWKKMFRALMPALEELTFDPSSAHPSLVVSSSGRRVECSDQKAPPAGEDTRQFDKAVAVVAQQLLSQGEHYWEVEVGDKPRWALGVMAADASRRGRLHAVPSQGLWLLGLRDGKILEAHVEAKEPRALRTPERPPARIGLYLSFADGVLAFYDASNPDVLTPIFSFHERLPGPVYPIFDVCWHDKGKNAQPLLLVGPEQEQA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/66924", "id": "66924", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0JPQ4/", "id": "A0JPQ4", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Trim72", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q6ZMU5-1", "protein_name": "Tripartite motif-containing protein 72", "sequence": { "length": 477, "sequence": "MSAAPGLLHQELSCPLCLQLFDAPVTAECGHSFCRACLGRVAGEPAADGTVLCPCCQAPTRPQALSTNLQLARLVEGLAQVPQGHCEEHLDPLSIYCEQDRALVCGVCASLGSHRGHRLLPAAEAHARLKTQLPQQKLQLQEACMRKEKSVAVLEHQLVEVEETVRQFRGAVGEQLGKMRVFLAALEGSLDREAERVRGEAGVALRRELGSLNSYLEQLRQMEKVLEEVADKPQTEFLMKYCLVTSRLQKILAESPPPARLDIQLPIISDDFKFQVWRKMFRALMPALEELTFDPSSAHPSLVVSSSGRRVECSEQKAPPAGEDPRQFDKAVAVVAHQQLSEGEHYWEVDVGDKPRWALGVIAAEAPRRGRLHAVPSQGLWLLGLREGKILEAHVEAKEPRALRSPERRPTRIGLYLSFGDGVLSFYDASDADALVPLFAFHERLPRPVYPFFDVCWHDKGKNAQPLLLVGPEGAEA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/66924", "id": "66924", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0JPQ4/", "id": "A0JPQ4", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "TRIM72", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071143.1", "ac": "NP_001071143.1", "name": "tripartite motif-containing protein 72", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "zinc ion binding", "id": "GO:0008270" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "identical protein binding", "id": "GO:0042802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "ubiquitin protein ligase activity", "id": "GO:0061630" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001786", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "phosphatidylserine binding", "id": "GO:0001786" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031624", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "ubiquitin conjugating enzyme binding", "id": "GO:0031624" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "cytoplasmic vesicle membrane", "id": "GO:0030659" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "sarcolemma", "id": "GO:0042383" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "protein ubiquitination", "id": "GO:0016567" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001778", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "plasma membrane repair", "id": "GO:0001778" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046627", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "negative regulation of insulin receptor signaling pathway", "id": "GO:0046627" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "protein homooligomerization", "id": "GO:0051260" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007517", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "muscle organ development", "id": "GO:0007517" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "exocytosis", "id": "GO:0006887" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010832", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "negative regulation of myotube differentiation", "id": "GO:0010832" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003012", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "muscle system process", "id": "GO:0003012" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043569", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "name": "negative regulation of insulin-like growth factor receptor signaling pathway", "id": "GO:0043569" } ], "total": 10, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "type": "synonym", "resource": "UniProtKB", "name": "Mg53" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPQ4", "type": "synonym", "resource": "RefSeq", "name": "RGD1562778" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPQ4", "type": "synonym", "resource": "RefSeq", "name": "Trim72" }, { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "type": "recommended", "resource": "UniProtKB", "name": "Trim72" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000022099", "id": "ENSRNOG00000022099", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00021", "id": "cd00021", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/365377", "id": "365377", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "id": "IPR000315", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "id": "IPR001841", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "id": "IPR001870", 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"RGD" }, { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "kinase_gene_name": "Oser1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "id": "22673903", "database": "PubMed" } ], "start_pos": "255", "end_pos": "255", "kinase_uniprot_canonical_ac": "Q703I1-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "id": "A0JPQ4", "database": "UniProtKB" } ], "start_pos": "255", "end_pos": "255", "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 52832.0, "chemical_mass": 52832.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4", "name": "Trim72", "locus": { "end_pos": 199457895, "strand": "+", "start_pos": 199449973, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000022099", "id": "ENSRNOG00000022099", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0JPQ4#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Mg53" }, { "url": "https://www.uniprot.org/uniprot/A0JPQ4#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Mitsugumin-53" }, { "url": "https://www.uniprot.org/uniprot/A0JPQ4#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Tripartite motif-containing protein 72" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPQ4", "type": "synonym", "resource": "RefSeq", "name": "mg53; mitsugumin-53; tripartite motif containing 72, E3 ubiquitin protein ligase" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPQ4", "type": "synonym", "resource": "RefSeq", "name": "tripartite motif-containing protein 72" } ] }