{
    "uniprot_canonical_ac": "A0JPN6-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A0JPN6-1|MED22_RAT Isoform 1 of Mediator of RNA polymerase II transcription subunit 22  OS=Rattus norvegicus OX=10116 GN=Med22 PE=2 SV=1 CANONICAL=A0JPN6-1", 
        "length": 200, 
        "sequence": "MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRALQEECDRKLITLRDEVSIDLYELEEEYYSSSSSLCEANDLPLCEAYWRLDLDTDSADGLSAPLLASPETGAGPLQSAAPVHSHGGGPGPTEHT"
    }, 
    "uniprot_id": "MED22_RAT", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0JPN6", 
                    "id": "A0JPN6", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/14638676", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "14638676"
                }
            ], 
            "title": "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071147.1", 
                    "id": "NP_001071147.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW", 
            "date": "2004"
        }
    ], 
    "uniprot_ac": "A0JPN6", 
    "site_annotation": [
        {
            "end_pos": 34, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 32
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JPN6#A0JPN6-1", 
            "isoform_ac": "A0JPN6-1", 
            "locus": {
                "end_pos": 4862293, 
                "strand": "+", 
                "start_pos": 4866640, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000006720", 
                        "id": "ENSRNOT00000006720", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000006720", 
                        "id": "ENSRNOP00000006720", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A0JPN6-1|MED22_RAT Isoform 1 of Mediator of RNA polymerase II transcription subunit 22  OS=Rattus norvegicus OX=10116 GN=Med22 PE=2 SV=1 CANONICAL=A0JPN6-1", 
                "length": 200, 
                "sequence": "MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRALQEECDRKLITLRDEVSIDLYELEEEYYSSSSSLCEANDLPLCEAYWRLDLDTDSADGLSAPLLASPETGAGPLQSAAPVHSHGGGPGPTEHT"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JPN6#A0JPN6-2", 
            "isoform_ac": "A0JPN6-2", 
            "locus": {}, 
            "sequence": {
                "header": "sp|A0JPN6-2|MED22_RAT Isoform 2 of Mediator of RNA polymerase II transcription subunit 22  OS=Rattus norvegicus OX=10116 GN=Med22 PE=2 SV=1 CANONICAL=A0JPN6-1", 
                "length": 140, 
                "sequence": "MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRALQEECDRKLITLRDEVSIDLYELEEEYYSSRYK"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:100911917", 
            "resource": "KEGG Pathway", 
            "id": "rno:100911917", 
            "name": ""
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:499762", 
            "resource": "KEGG Pathway", 
            "id": "rno:499762", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JPN6#function", 
            "annotation": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0JPN6#function", 
                    "id": "A0JPN6", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q15528-1", 
            "protein_name": "Mediator of RNA polymerase II transcription subunit 22", 
            "sequence": {
                "length": 200, 
                "sequence": "MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRTLQEECDRKLITLRDEISIDLYELEEEYYSSSSSLCEANDLPLCEAYGRLDLDTDSADGLSAPLLASPEPSAGPLQVAAPAHSHAGGPGPTEHA"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/4913", 
                    "id": "4913", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "MED22", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q62276-1", 
            "protein_name": "Mediator of RNA polymerase II transcription subunit 22", 
            "sequence": {
                "length": 200, 
                "sequence": "MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRALQEECDRKLITLRDEVSIDLYELEEEYYSSSSSLCEANDLPLCEAYWRLDLDADSADGLSAPLLASPETGAGPLQSAAPVHSHGGGPGPTEHT"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/4913", 
                    "id": "4913", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "gene_name": "Med22", 
            "tax_id": 10090
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071147.1", 
        "ac": "NP_001071147.1", 
        "name": "mediator of RNA polymerase II transcription subunit 22", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPN6", 
                                "id": "A0JPN6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transcription coregulator activity", 
                        "id": "GO:0003712"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPN6", 
                                "id": "A0JPN6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "mediator complex", 
                        "id": "GO:0016592"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0JPN6", 
                                "id": "A0JPN6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of transcription by RNA polymerase II", 
                        "id": "GO:0006357"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPN6", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Med22"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JPN6", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Med22"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPN6", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "RGD1564893; Surf5"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JPN6", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Surf5"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000005059", 
            "id": "ENSRNOG00000005059", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/100911917", 
            "id": "100911917", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/499762", 
            "id": "499762", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009332", 
            "id": "IPR009332", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038427", 
            "id": "IPR038427", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:100911917", 
            "id": "rno:100911917", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:499762", 
            "id": "rno:499762", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/TQCEQDT/", 
            "id": "TQCEQDT", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1573728at2759", 
            "id": "1573728at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12434", 
            "id": "PTHR12434", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF06179", 
            "id": "PF06179", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A0JPN6", 
            "id": "PR_A0JPN6", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071147.1", 
            "id": "NP_001071147.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1564893", 
            "id": "1564893", 
            "database": "RGD"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JPN6", 
            "id": "A0JPN6", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 22312.0, 
        "chemical_mass": 22312.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JPN6", 
            "name": "Med22", 
            "locus": {
                "end_pos": 5453614, 
                "strand": "-", 
                "start_pos": 5458782, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000049749", 
                        "id": "ENSRNOG00000049749", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0JPN6#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Mediator complex subunit 22"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JPN6#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Mediator of RNA polymerase II transcription subunit 22"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0JPN6#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Surfeit locus protein 5"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPN6", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "mediator of RNA polymerase II transcription subunit 22"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPN6", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "surfeit 5; surfeit locus protein 5"
        }
    ]
}