{ "uniprot_canonical_ac": "A0FKI7-1", "ptm_annotation": [], "sequence": { "header": "sp|A0FKI7-1|ACBD5_RAT Isoform 1 of Acyl-CoA-binding domain-containing protein 5 OS=Rattus norvegicus OX=10116 GN=Acbd5 PE=1 SV=1 CANONICAL=A0FKI7-1", "length": 506, "sequence": "MLFLSFYAGSWESWICCCCVIPVDRPWDRGRRWQLEMADTRSVYETRFEAAVKVIQSLPKNGSFQPTNEMMLRFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEMKKIIETMPMTEKVEELLHVIGPFYEIVEDKKNSKSSDLTSDLGNVLTSSNAKAVNGKAESSDSGAESEEEEAQEELKGAEQSGSDDKKMMTKSTDKNLEIIVTNGYKDSFAQDSDIHTDSSRSARRSEDKKPTDQSSQQTGNTVLCVHQDTNEDPGEDASGVHHLTSDSDSEVYCDSMEQFGQEEYYLGGDPAQHLEGSGFCEDAQLSPGNGSIGKMQMRAVKGKGEVKHGGEDGRSSSGTPHREKRGGESEDISGVRRGRGHRMPHLSEGTKGRQVGSGGDGERWGSDRGSRGSLNEQIALVLIRLQEDMQNVLQRLHKLETLTASQAKLSWQTSNQPSSQRPSWWPFEMSPGALAFAIIWPFIAQWLVHLYYQRRRRKLN" }, "uniprot_id": "ACBD5_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7", "id": "A0FKI7", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7", "id": "A0FKI7", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24535825", "type": [ "PubMed" ], "id": "24535825" } ], "title": "Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy.", "journal": "The Journal of cell biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071103.1", "id": "NP_001071103.1", "database": "RefSeq" } ], "authors": "Nazarko TY, Ozeki K, Till A, Ramakrishnan G, Lotfi P, Yan M, Subramani S", "date": "2014" } ], "uniprot_ac": "A0FKI7", "site_annotation": [ { "end_pos": 337, "annotation": "n_glycosylation_sequon", "start_pos": 335 }, { "end_pos": 63, "annotation": "n_glycosylation_sequon", "start_pos": 61 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7#A0A096MJJ6-1", "isoform_ac": "A0A096MJJ6-1", "locus": { "end_pos": 89884414, "strand": "+", "start_pos": 89923327, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076964", "id": "ENSRNOT00000076964", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068154", "id": "ENSRNOP00000068154", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJJ6-1|ACBD5_RAT Computationally mapped isoform of Acyl-CoA-binding domain-containing protein 5 OS=Rattus norvegicus OX=10116 GN=Acbd5 PE=1 SV=1 CANONICAL=A0FKI7-1", "length": 470, "sequence": "MADTRSVYETRFEAAVKVIQSLPKNGSFQPTNEMMLRFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEMKKIIETMPMTEKVEELLHVIGPFYEIVEDKKNSKSSDLTSDLGNVLTSSNAKAVNGKAESSDSGAESEEEEAQEELKGAEQSGSDDKKMMTKSTDKNLEIIVTNGYKDSFAQDSDIHTDSSRSARRSEDKKPTDQSSQQTGNTVLCVHQDTNEDPGEDASGVHHLTSDSDSEVYCDSMEQFGQEEYYLGGDPAQHLEGSGFCEDAQLSPGNGSIGKMQMRAVKGKGEVKHGGEDGRSSSGTPHREKRGGESEDISGVRRGRGHRMPHLSEGTKGRQVGSGGDGERWGSDRGSRGSLNEQIALVLIRLQEDMQNVLQRLHKLETLTASQAKLSWQTSNQPSSQRPSWWPFEMSPGALAFAIIWPFIAQWLVHLYYQRRRRKLN" } }, { "url": "https://www.uniprot.org/uniprot/A0FKI7#A0FKI7-1", "isoform_ac": "A0FKI7-1", "locus": {}, "sequence": { "header": "sp|A0FKI7-1|ACBD5_RAT Isoform 1 of Acyl-CoA-binding domain-containing protein 5 OS=Rattus norvegicus OX=10116 GN=Acbd5 PE=1 SV=1 CANONICAL=A0FKI7-1", "length": 506, "sequence": "MLFLSFYAGSWESWICCCCVIPVDRPWDRGRRWQLEMADTRSVYETRFEAAVKVIQSLPKNGSFQPTNEMMLRFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEMKKIIETMPMTEKVEELLHVIGPFYEIVEDKKNSKSSDLTSDLGNVLTSSNAKAVNGKAESSDSGAESEEEEAQEELKGAEQSGSDDKKMMTKSTDKNLEIIVTNGYKDSFAQDSDIHTDSSRSARRSEDKKPTDQSSQQTGNTVLCVHQDTNEDPGEDASGVHHLTSDSDSEVYCDSMEQFGQEEYYLGGDPAQHLEGSGFCEDAQLSPGNGSIGKMQMRAVKGKGEVKHGGEDGRSSSGTPHREKRGGESEDISGVRRGRGHRMPHLSEGTKGRQVGSGGDGERWGSDRGSRGSLNEQIALVLIRLQEDMQNVLQRLHKLETLTASQAKLSWQTSNQPSSQRPSWWPFEMSPGALAFAIIWPFIAQWLVHLYYQRRRRKLN" } }, { "url": "https://www.uniprot.org/uniprot/A0FKI7#A0FKI7-2", "isoform_ac": "A0FKI7-2", "locus": {}, "sequence": { "header": "sp|A0FKI7-2|ACBD5_RAT Isoform 2 of Acyl-CoA-binding domain-containing protein 5 OS=Rattus norvegicus OX=10116 GN=Acbd5 PE=1 SV=1 CANONICAL=A0FKI7-1", "length": 471, "sequence": "MADTRSVYETRFEAAVKVIQSLPKNGSFQPTNEMMLRFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEMKKIIETMPMTEKVEELLHVIGPFYEIVEDKKNSKSSDLTSDLGNVLTSSNAKAVNGKAESSDSGAESEEEEAQEELKGAEQSGSDDKKMMTKSTDKNLEIIVTNGYKDSFAQDSDIHTDSSRSARRSEDKKPTDQSSQQTGNTVLCVHQDTNEDPGEDASGVHHLTSDSDSEVYCDSMEQFGQEEYYLGGDPAQHLEGSGFCEDAQLSPGNGSIGKMQMRAVKGKGEVKHGGEDGRSSSGTPHREKRGGESEDISGVRRGRVGHRMPHLSEGTKGRQVGSGGDGERWGSDRGSRGSLNEQIALVLIRLQEDMQNVLQRLHKLETLTASQAKLSWQTSNQPSSQRPSWWPFEMSPGALAFAIIWPFIAQWLVHLYYQRRRRKLN" } }, { "url": "https://www.uniprot.org/uniprot/A0FKI7#A0FKI7-3", "isoform_ac": "A0FKI7-3", "locus": {}, "sequence": { "header": "sp|A0FKI7-3|ACBD5_RAT Isoform 3 of Acyl-CoA-binding domain-containing protein 5 OS=Rattus norvegicus OX=10116 GN=Acbd5 PE=1 SV=1 CANONICAL=A0FKI7-1", "length": 507, "sequence": "MLFLSFYAGSWESWICCCCVIPVDRPWDRGRRWQLEMADTRSVYETRFEAAVKVIQSLPKNGSFQPTNEMMLRFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEMKKIIETMPMTEKVEELLHVIGPFYEIVEDKKNSKSSDLTSDLGNVLTSSNAKAVNGKAESSDSGAESEEEEAQEELKGAEQSGSDDKKMMTKSTDKNLEIIVTNGYKDSFAQDSDIHTDSSRSARRSEDKKPTDQSSQQTGNTVLCVHQDTNEDPGEDASGVHHLTSDSDSEVYCDSMEQFGQEEYYLGGDPAQHLEGSGFCEDAQLSPGNGSIGKMQMRAVKGKGEVKHGGEDGRSSSGTPHREKRGGESEDISGVRRGRVGHRMPHLSEGTKGRQVGSGGDGERWGSDRGSRGSLNEQIALVLIRLQEDMQNVLQRLHKLETLTASQAKLSWQTSNQPSSQRPSWWPFEMSPGALAFAIIWPFIAQWLVHLYYQRRRRKLN" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:307170", "resource": "KEGG Pathway", "id": "rno:307170", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-390918", "resource": "Reactome", "id": "R-RNO-390918", "name": "Peroxisomal lipid metabolism" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9603798", "resource": "Reactome", "id": "R-RNO-9603798", "name": "Class I peroxisomal membrane protein import" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7#function", "annotation": "Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7#function", "id": "A0FKI7", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q5T8D3-1", "protein_name": "Acyl-CoA-binding domain-containing protein 5", "sequence": { "length": 534, "sequence": "MFQFHAGSWESWCCCCLIPADRPWDRGQHWQLEMADTRSVHETRFEAAVKVIQSLPKNGSFQPTNEMMLKFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEMKKIIETMPMTEKVEELLRVIGPFYEIVEDKKSGRSSDITSVRLEKISKCLEDLGNVLTSTPNAKTVNGKAESSDSGAESEEEEAQEEVKGAEQSDNDKKMMKKSADHKNLEVIVTNGYDKDGFVQDIQNDIHASSSLNGRSTEEVKPIDENLGQTGKSAVCIHQDINDDHVEDVTGIQHLTSDSDSEVYCDSMEQFGQEESLDSFTSNNGPFQYYLGGHSSQPMENSGFREDIQVPPGNGNIGNMQVVAVEGKGEVKHGGEDGRNNSGAPHREKRGGETDEFSNVRRGRGHRMQHLSEGTKGRQVGSGGDGERWGSDRGSRGSLNEQIALVLMRLQEDMQNVLQRLQKLETLTALQAKSSTSTLQTAPQPTSQRPSWWPFEMSPGVLTFAIIWPFIAQWLVYLYYQRRRRKLN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/12541", "id": "12541", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "ACBD5", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q5XG73-1", "protein_name": "Acyl-CoA-binding domain-containing protein 5", "sequence": { "length": 508, "sequence": "MLFLAFHAGSWGSWCCCCCVITADRPWDRGRRWQLEMADTPSVYETRFEAAVKVIQSLPKNGSFQPTNEMMLKFYSFYKQATEGPCKLSRPGFWDPIGRYKWDAWSSLGDMTKEEAMIAYVEEMKKIIETMPMTEKVEELLHVIGPFYEIVEDKKSSKSSDLTSDLGNVLTSSNAKAVNGKAESSDSGAESEEEEAQEELKGAEQSGSDDKKTLKKSADKNLEIIVTNGYKGSFVQDIQSDIHTDSSRSTRSSEDEKPGDESSQQTGHTIVCAHQDRNEDPSEDASGIHHLTSDSDSEVYCDSMEQFGQEEYYLGGDPTQHLESSGFCEDAQQSPGNGSIGKMWMVAVKGKGEVKHGGEDGRSSSGAPHRETRGGESEDFSSVRRGRGNRIPHLSEGPKGRQVGSGGDGERWGSDRGSRGSLNEQIALVLIRLQEDMQNVLQRLHKLETLTASQAKLSLQTSNQPSSQRPAWWPFEMSPGALAFAIIWPFIAQWLAHLYYQRRRRKLN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/12541", "id": "12541", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Acbd5", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071103.1", "ac": "NP_001071103.1", "name": "acyl-CoA-binding domain-containing protein 5", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7", "id": "A0FKI7", "database": "UniProtKB" } ], "name": "lipid binding", "id": "GO:0008289" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000062", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7", "id": "A0FKI7", "database": "UniProtKB" } ], "name": "fatty-acyl-CoA binding", "id": "GO:0000062" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7", "id": "A0FKI7", "database": "UniProtKB" } ], "name": "peroxisomal membrane", "id": "GO:0005778" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7", "id": "A0FKI7", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030242", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7", "id": "A0FKI7", "database": "UniProtKB" } ], "name": "autophagy of peroxisome", "id": "GO:0030242" } ], "total": 1, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0FKI7", "type": "synonym", "resource": "RefSeq", "name": "Acbd5" }, { "url": "https://www.uniprot.org/uniprot/A0FKI7", "type": "recommended", "resource": "UniProtKB", "name": "Acbd5" } ], "pro_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00435", "id": "cd00435", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/307170", "id": "307170", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000582", "id": "IPR000582", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014352", "id": "IPR014352", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016347", "id": "IPR016347", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR022408", "id": "IPR022408", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035984", "id": "IPR035984", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:307170", "id": "rno:307170", "database": "KEGG Pathway" }, { "url": "http://www.orthodb.org/?query=1546859at2759", "id": "1546859at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00887", "id": "PF00887", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A0FKI7", "id": "PR_A0FKI7", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-390918", "id": "R-RNO-390918", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9603798", "id": "R-RNO-9603798", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071103.1", "id": "NP_001071103.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309411", "id": "1309411", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0FKI7", "id": "A0FKI7", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "kinase_gene_name": "Oser1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "id": "22673903", "database": "PubMed" } ], "start_pos": "184", "end_pos": "184", "kinase_uniprot_canonical_ac": "Q703I1-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7", "id": "A0FKI7", "database": "UniProtKB" } ], "start_pos": "184", "end_pos": "184", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "Oser1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "id": "22673903", "database": "PubMed" } ], "start_pos": "185", "end_pos": "185", "kinase_uniprot_canonical_ac": "Q703I1-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7", "id": "A0FKI7", "database": "UniProtKB" } ], "start_pos": "185", "end_pos": "185", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "Oser1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "id": "22673903", "database": "PubMed" } ], "start_pos": "187", "end_pos": "187", "kinase_uniprot_canonical_ac": "Q703I1-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7", "id": "A0FKI7", "database": "UniProtKB" } ], "start_pos": "187", "end_pos": "187", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "Oser1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "id": "22673903", "database": "PubMed" } ], "start_pos": "191", "end_pos": "191", "kinase_uniprot_canonical_ac": "Q703I1-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7", "id": "A0FKI7", "database": "UniProtKB" } ], "start_pos": "191", "end_pos": "191", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7", "id": "A0FKI7", "database": "UniProtKB" } ], "start_pos": "206", "end_pos": "206", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7", "id": "A0FKI7", "database": "UniProtKB" } ], "start_pos": "233", "end_pos": "233", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7", "id": "A0FKI7", "database": "UniProtKB" } ], "start_pos": "301", "end_pos": "301", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7", "id": "A0FKI7", "database": "UniProtKB" } ], "start_pos": "403", "end_pos": "403", "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 56782.0, "chemical_mass": 56782.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7", "name": "Acbd5", "locus": { "end_pos": 89883615, "strand": "-", "start_pos": 89923423, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000017642", "id": "ENSRNOG00000017642", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0FKI7#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Acyl-CoA-binding domain-containing protein 5" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0FKI7", "type": "synonym", "resource": "RefSeq", "name": "acyl-CoA-binding domain-containing protein 5" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0FKI7", "type": "synonym", "resource": "RefSeq", "name": "acyl-Coenzyme A binding domain containing 5" } ] }