{ "uniprot_canonical_ac": "A0FGR8-1", "ptm_annotation": [], "sequence": { "header": "sp|A0FGR8-1|ESYT2_HUMAN Isoform 1 of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1 CANONICAL=A0FGR8-1", "length": 921, "sequence": "MTANRDAALSSHRHPGCAQRPRTPTFASSSQRRSAFGFDDGNFPGLGERSHAPGSRLGARRRAKTARGLRGHRQRGAGAGLSRPGSARAPSPPRPGGPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT" }, "uniprot_id": "ESYT2_HUMAN", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "reported_with_glycan.oglcnac_db" ], "species": [ { "common_name": "Human", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11543631", "type": [ "PubMed" ], "id": "11543631" } ], "title": "Genomic analysis of synaptotagmin genes.", "journal": "Genomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Craxton M.A.", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17081983", "type": [ "PubMed" ], "id": "17081983" } ], "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Blagoev B., Gnad F., Kumar C., Macek B., Mann M., Mortensen P., Olsen J.V.", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17360437", "type": [ "PubMed" ], "id": "17360437" } ], "title": "E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Suedhof T.C., Chang W.-P., Min S.-W.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17924679", "type": [ "PubMed" ], "id": "17924679" } ], "title": "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.", "journal": "J. Proteome Res.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Chan K.C., Dimitrov D.S., Issaq H.J., Veenstra T.D., Yu L.R., Zhu Z.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18691976", "type": [ "PubMed" ], "id": "18691976" } ], "title": "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.", "journal": "Mol. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Bairlein M., Daub H., Gnad F., Greff Z., Keri G., Korner R., Mann M., Olsen J.V., Oppermann F.S., Stemmann O.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20833364", "type": [ "PubMed" ], "id": "20833364" } ], "title": "Extended-synaptotagmin-2 mediates FGF receptor endocytosis and ERK activation in vivo.", "journal": "Dev. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Moss T., Baril J., Bellenfant S., Guillou F., Jean S., Mikryukov A., Tremblay M.G.", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23791178", "type": [ "PubMed" ], "id": "23791178" } ], "title": "PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins.", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Gracheva E.O., De Camilli P., Borgese N., Pirruccello M., Bagriantsev S.N., Colombo S.F., Giordano F., Idevall-Hagren O., Milosevic I., Saheki Y.", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24373768", "type": [ "PubMed" ], "id": "24373768" } ], "title": "Structure and Ca(2+)-binding properties of the tandem C(2) domains of E-Syt2.", "journal": "Structure", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Xu J., Sudhof T.C., Zhou A., Tomchick D.R., Bacaj T., Rizo J.", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24847877", "type": [ "PubMed" ], "id": "24847877" } ], "title": "Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer.", "journal": "Nature", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Wu X., De Camilli P., Wenk M.R., Reinisch K.M., Torta F., Schauder C.M., Narayanaswamy P., Saheki Y.", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27044890", "type": [ "PubMed" ], "id": "27044890" } ], "title": "Dynamic formation of ER-PM junctions presents a lipid phosphatase to regulate phosphoinositides.", "journal": "J. Cell Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Kruse M., Hille B., Dickson E.J., Jensen J.B., Traynor-Kaplan A.E., Vivas O.", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28411811", "type": [ "PubMed" ], "id": "28411811" } ], "title": "A novel strategy for global mapping of O-GlcNAc proteins and peptides using selective enzymatic deglycosylation, HILIC enrichment and mass spectrometry identification.", "journal": "Talanta", "evidence": [ { "url": "https://data.glygen.org/GLYDS000517", "id": "GLYDS000517", "database": "GlyGen" } ], "authors": "Shen B, Zhang W, Shi Z, Tian F, Deng Y, Sun C, Wang G, Qin W, Qian X", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28510447", "type": [ "PubMed" ], "id": "28510447" } ], "title": "Synthesis of a Highly Azide-Reactive and Thermosensitive Biofunctional Reagent for Efficient Enrichment and Large-Scale Identification of O-GlcNAc Proteins by Mass Spectrometry.", "journal": "Analytical chemistry", "evidence": [ { "url": "https://data.glygen.org/GLYDS000517", "id": "GLYDS000517", "database": "GlyGen" } ], "authors": "Zhang W, Liu T, Dong H, Bai H, Tian F, Shi Z, Chen M, Wang J, Qin W, Qian X", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29351928", "type": [ "PubMed" ], "id": "29351928" } ], "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "evidence": [ { "url": "https://data.glygen.org/GLYDS000517", "id": "GLYDS000517", "database": "GlyGen" } ], "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30220461", "type": [ "PubMed" ], "id": "30220461" } ], "title": "Aster proteins facilitate nonvesicular plasma membrane to ER cholesterol transport in mammalian cells.", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "authors": "Jiang H., Li S., He C., Xiao X., Young S.G., Ikonen E., Lee R., Gatta A.T., Levine T.P., Hong C., Ferrari A., Fairall L., Tontonoz P., Schwabe J.W.R., Lee S.D., Sandhu J., Pfisterer S.G., Bentolila L.A., Ferng A., Ford D.A., Gurnett J.E., Hartman C.L., Orozco J.L., Strugatsky D., Vashi D., Weston T.A.", "date": "2018" } ], "uniprot_ac": "A0FGR8", "site_annotation": [ { "end_pos": 201, "annotation": "n_glycosylation_sequon", "start_pos": 199 }, { "end_pos": 332, "annotation": "n_glycosylation_sequon", "start_pos": 330 }, { "end_pos": 435, "annotation": "n_glycosylation_sequon", "start_pos": 433 }, { "end_pos": 513, "annotation": "n_glycosylation_sequon", "start_pos": 511 }, { "end_pos": 589, "annotation": "n_glycosylation_sequon", "start_pos": 587 }, { "end_pos": 645, "annotation": "n_glycosylation_sequon", "start_pos": 643 }, { "end_pos": 780, "annotation": "n_glycosylation_sequon", "start_pos": 778 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8#A0A087WXU3-1", "isoform_ac": "A0A087WXU3-1", "locus": { "end_pos": 158734210, "strand": "+", "start_pos": 158830038, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000613624", "id": "ENST00000613624", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000481296", "id": "ENSP00000481296", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A087WXU3-1|ESYT2_HUMAN Computationally mapped isoform of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1 CANONICAL=A0FGR8-1", "length": 921, "sequence": "MTANRDAALSSHRHPGCAQRPRTPTFASSSQRRSAFGFDDGNFPGLGERSHAPGSRLGARRRAKTARGLRGHRQRGAGAGLSRPGSARAPSPPRPGAPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT" } }, { "url": "https://www.uniprot.org/uniprot/A0FGR8#A0A499FIX8-1", "isoform_ac": "A0A499FIX8-1", "locus": { "end_pos": 158734210, "strand": "+", "start_pos": 158829418, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000251527", "id": "ENST00000251527", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000251527", "id": "ENSP00000251527", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A499FIX8-1|ESYT2_HUMAN Computationally mapped isoform of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1 CANONICAL=A0FGR8-1", "length": 845, "sequence": "MSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT" } }, { "url": "https://www.uniprot.org/uniprot/A0FGR8#A0FGR8-1", "isoform_ac": "A0FGR8-1", "locus": {}, "sequence": { "header": "sp|A0FGR8-1|ESYT2_HUMAN Isoform 1 of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1 CANONICAL=A0FGR8-1", "length": 921, "sequence": "MTANRDAALSSHRHPGCAQRPRTPTFASSSQRRSAFGFDDGNFPGLGERSHAPGSRLGARRRAKTARGLRGHRQRGAGAGLSRPGSARAPSPPRPGGPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT" } }, { "url": "https://www.uniprot.org/uniprot/A0FGR8#A0FGR8-2", "isoform_ac": "A0FGR8-2", "locus": { "end_pos": 158734210, "strand": "+", "start_pos": 158829562, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000652148", "id": "ENST00000652148", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000499020", "id": "ENSP00000499020", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0FGR8-2|ESYT2_HUMAN Isoform 2 of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1 CANONICAL=A0FGR8-1", "length": 893, "sequence": "MTPPSRAEAGVRRSRVPSEGRWRGAEPPGISASTQPASAGRAARHCGAMSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT" } }, { "url": "https://www.uniprot.org/uniprot/A0FGR8#A0FGR8-4", "isoform_ac": "A0FGR8-4", "locus": {}, "sequence": { "header": "sp|A0FGR8-4|ESYT2_HUMAN Isoform 4 of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1 CANONICAL=A0FGR8-1", "length": 527, "sequence": "MWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTSQSRSRPPASPRTSRCPSPPRSCGKG" } }, { "url": "https://www.uniprot.org/uniprot/A0FGR8#A0FGR8-5", "isoform_ac": "A0FGR8-5", "locus": {}, "sequence": { "header": "sp|A0FGR8-5|ESYT2_HUMAN Isoform 5 of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1 CANONICAL=A0FGR8-1", "length": 328, "sequence": "MPVLPPCVLQVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT" } }, { "url": "https://www.uniprot.org/uniprot/A0FGR8#A0FGR8-6", "isoform_ac": "A0FGR8-6", "locus": {}, "sequence": { "header": "sp|A0FGR8-6|ESYT2_HUMAN Isoform 6 of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1 CANONICAL=A0FGR8-1", "length": 942, "sequence": "MTANRDAALSSHRHPGCAQRPRTPTFASSSQRRSAFGFDDGNFPGLGERSHAPGSRLGARRRAKTARGLRGHRQRGAGAGLSRPGSARAPSPPRPGGPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSNPLEFNPDVLKKTAVQRALKSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT" } }, { "url": "https://www.uniprot.org/uniprot/A0FGR8#H7BXI1-1", "isoform_ac": "H7BXI1-1", "locus": { "end_pos": 158734210, "strand": "+", "start_pos": 158829418, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000275418", "id": "ENST00000275418", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000275418", "id": "ENSP00000275418", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H7BXI1-1|ESYT2_HUMAN Computationally mapped isoform of Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=2 CANONICAL=A0FGR8-1", "length": 866, "sequence": "MSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSNPLEFNPDVLKKTAVQRALKSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:57488", "resource": "KEGG Pathway", "id": "hsa:57488", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660662", "resource": "Reactome", "id": "R-HSA-1660662", "name": "Glycosphingolipid metabolism" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8#function", "annotation": "Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8#function", "id": "A0FGR8", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q3TZZ7-1", "protein_name": "Extended synaptotagmin-2", "sequence": { "length": 845, "sequence": "MSSAGGEGPEAGPGRAGGRSEPEAPGSALSVDLPGLLGQLARSFALLLPVYALGYLGLSFSWVLLALGLLAWCRRSRGLKASRLCRALALLEDEEQAVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANAHLSTFSFTKVDVGQQPLRVNGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDIPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPIPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSKVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLKLEWLTLMPDAANLDKVLADIRADKDQASDGLSSALLILYLDSARNLPSGKKINSNPNPLVQMSVGHKAQESKIRYKTSEPVWEENFTFFIHNPRRQDLEVEVKDEQHQCSLGSLRIPLSQLLTSDNMTINQRFQLSNSGPNSTLKMKIALRVLHLEKQERPPDYQHSAQVKRPSVSKEGRKMPIKSQMSASPGTGGANTAPSTPVMGVDDKPAMEEKPQPPEASPLGHRDLGRSSSSLLASPSHIAAKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHSCRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVVLASEELAKGWTQWYDLTEDGTRPQVIT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/32699", "id": "32699", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Esyt2", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [ { "sequence_org": "I", "alt_nt": "null", "chr_id": "7", "ref_nt": "G", "chr_pos": "158767712A>", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1400069529", "id": "rs1400069529", "database": "dbSNP" }, { "url": "http://gnomad.broadinstitute.org/awesome?query=rs1400069529", "id": "rs1400069529", "database": "gnomAD" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_mut": "T", "start_pos": 365, "keywords": [ "ebi", "germline" ], "end_pos": 365, "minor_allelic_frequency": "", "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NRI->NRT)." }, { "sequence_org": "G", "alt_nt": "null", "chr_id": "7", "ref_nt": "T", "chr_pos": "158759539C>", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756687768", "id": "rs756687768", "database": "dbSNP" }, { "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756687768", "id": "rs756687768", "database": "ExAC" }, { "url": "https://www.ncbi.nlm.nih.gov/snp/rs756687768#frequency_tab", "id": "rs756687768", "database": "TOPMed" }, { "url": "http://gnomad.broadinstitute.org/awesome?query=rs756687768", "id": "rs756687768", "database": "gnomAD" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_mut": "S", "start_pos": 532, "keywords": [ "ebi", "germline" ], "end_pos": 532, "minor_allelic_frequency": "", "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NDG->NDS)." }, { "sequence_org": "K", "alt_nt": "null", "chr_id": "7", "ref_nt": "G", "chr_pos": "158749712T>", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1289205068", "id": "rs1289205068", "database": "dbSNP" }, { "url": "http://gnomad.broadinstitute.org/awesome?query=rs1289205068", "id": "rs1289205068", "database": "gnomAD" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "sequence_mut": "N", "start_pos": 553, "keywords": [ "ebi", "germline" ], "end_pos": 553, "minor_allelic_frequency": "", "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KIS->NIS)." }, { "sequence_org": "T", "alt_nt": "null", "chr_id": "7", "ref_nt": "T", "chr_pos": "158743599G>", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1203482867", "id": "rs1203482867", "database": "dbSNP" }, { "url": "http://gnomad.broadinstitute.org/awesome?query=rs1203482867", "id": "rs1203482867", "database": "gnomAD" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "sequence_mut": "N", "start_pos": 630, "keywords": [ "ebi", "germline" ], "end_pos": 630, "minor_allelic_frequency": "", "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TVS->NVS)." }, { "sequence_org": "A", "alt_nt": "null", "chr_id": "7", "ref_nt": "T", "chr_pos": "158741587C>", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs773507830", "id": "rs773507830", "database": "dbSNP" }, { "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs773507830", "id": "rs773507830", "database": "ExAC" }, { "url": "http://gnomad.broadinstitute.org/awesome?query=rs773507830", "id": "rs773507830", "database": "gnomAD" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_mut": "T", "start_pos": 702, "keywords": [ "ebi", "germline" ], "end_pos": 702, "minor_allelic_frequency": "", "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NTA->NTT)." }, { "sequence_org": "I", "alt_nt": "null", "chr_id": "7", "ref_nt": "G", "chr_pos": "158737171A>", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs753041016", "id": "rs753041016", "database": "dbSNP" }, { "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs753041016", "id": "rs753041016", "database": "ExAC" }, { "url": "http://gnomad.broadinstitute.org/awesome?query=rs753041016", "id": "rs753041016", "database": "gnomAD" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_mut": "T", "start_pos": 814, "keywords": [ "ebi", "germline" ], "end_pos": 814, "minor_allelic_frequency": "", "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLI->NLT)." }, { "sequence_org": "G", "alt_nt": "null", "chr_id": "7", "ref_nt": "T", "chr_pos": "158735541C>", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs761987692", "id": "rs761987692", "database": "dbSNP" }, { "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs761987692", "id": "rs761987692", "database": "ExAC" }, { "url": "https://www.ncbi.nlm.nih.gov/snp/rs761987692#frequency_tab", "id": "rs761987692", "database": "TOPMed" }, { "url": "http://gnomad.broadinstitute.org/awesome?query=rs761987692", "id": "rs761987692", "database": "gnomAD" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_mut": "S", "start_pos": 878, "keywords": [ "ebi", "germline" ], "end_pos": 878, "minor_allelic_frequency": "", "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NSG->NSS)." }, { "sequence_org": "D", "alt_nt": "null", "chr_id": "7", "ref_nt": "T", "chr_pos": "158734248C>", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1335511014", "id": "rs1335511014", "database": "dbSNP" }, { "url": "https://www.ncbi.nlm.nih.gov/snp/rs1335511014#frequency_tab", "id": "rs1335511014", "database": "TOPMed" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_mut": "N", "start_pos": 909, "keywords": [ "ebi", "germline" ], "end_pos": 909, "minor_allelic_frequency": "", "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DLT->NLT)." } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "pmid": "23791178", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "identical protein binding", "id": "GO:0042802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "pmid": "24847877", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "identical protein binding", "id": "GO:0042802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "pmid": "24373768", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "calcium ion binding", "id": "GO:0005509" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045296", "pmid": "25468996", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "cadherin binding", "id": "GO:0045296" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005544", "pmid": "17360437", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "calcium-dependent phospholipid binding", "id": "GO:0005544" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008429", "pmid": "24847877", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "phosphatidylethanolamine binding", "id": "GO:0008429" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031210", "pmid": "24847877", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "phosphatidylcholine binding", "id": "GO:0031210" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "pmid": "24847877", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "phosphatidylinositol binding", "id": "GO:0035091" } ], "total": 8, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031227", "pmid": "23791178", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "intrinsic component of endoplasmic reticulum membrane", "id": "GO:0031227" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044232", "pmid": "23791178", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "organelle membrane contact site", "id": "GO:0044232" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005887", "pmid": "17360437", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "integral component of plasma membrane", "id": "GO:0005887" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "pmid": "19946888", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031234", "pmid": "23791178", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "extrinsic component of cytoplasmic side of plasma membrane", "id": "GO:0031234" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140268", "pmid": "30220461", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "endoplasmic reticulum-plasma membrane contact site", "id": "GO:0140268" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140268", "pmid": "27044890", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "endoplasmic reticulum-plasma membrane contact site", "id": "GO:0140268" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" } ], "total": 8, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "lipid transport", "id": "GO:0006869" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "endocytosis", "id": "GO:0006897" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006687", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "glycosphingolipid metabolic process", "id": "GO:0006687" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061817", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "id": "A0FGR8", "database": "UniProtKB" } ], "name": "endoplasmic reticulum-plasma membrane tethering", "id": "GO:0061817" } ], "total": 4, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0FGR8", "type": "recommended", "resource": "UniProtKB", "name": "ESYT2" }, { "url": "https://www.uniprot.org/uniprot/A0FGR8", "type": "synonym", "resource": "UniProtKB", "name": "FAM62B" }, { "url": "https://www.uniprot.org/uniprot/A0FGR8", "type": "synonym", "resource": "UniProtKB", "name": "KIAA1228" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117868", "id": "ENSG00000117868", "database": "Bgee" }, { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0FGR8", "id": "A0FGR8", "database": "BioMuta" }, { "url": 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