{ "uniprot_canonical_ac": "A0AUV4-1", "ptm_annotation": [], "sequence": { "header": "sp|A0AUV4-1|SMKY_MOUSE Isoform 1 of Sperm motility kinase Y OS=Mus musculus OX=10090 GN=Gm7168 PE=2 SV=1 CANONICAL=A0AUV4-1", "length": 508, "sequence": "MPAHIEEELPPPSPQPSNPEDGELYSQYKVVRTLGHGTYAKVLLAKHWLTGTPVAVKVLLKNKPCFQPAMKEANIMKKIKHPNIVSLLQVFETKTRGYLIMELVEGQELYEYIKSSGHIEEDEARQIFLQILSAVSYCHGLGIVHRDLKPDNIMIDDKGSIKIIDFGLSTQVKPGDLLDEHCGAYAFGAPELFLWKSYDGTKSDLWALGVILYYMVVGKVPFDSYIIPELQRQILAGVYPAPCGVSNELKDLLSLLMTVNPKYRPTVTEVMKHPWLRGHCKGLTNIHEEPVPVRPDPDIVDAMQYIGFQAKDIRESLTKEKFNEMSAAYYLLEEQALQREVRSTQAPTVSQVKAPFPSMDAGEASCLKIKRSGSASILGRSVWPPSIDQEPAYVQKVRQRAGRRSSGHGLLFEANQMTPTQDQHHIRAMSVPCMLSTSSISEESVSEKREENLSHIALAEDKPIRSRGWCRGIMRWTRRVGNAIRTLCCCIPSRKTPQLGQSRVSPQK" }, "uniprot_id": "SMKY_MOUSE", "enzyme_annotation": [ { "ec": "2.7.11.1", "activity": "" }, { "ec": "2.7.11.1", "activity": "ATP + a protein = ADP + a phosphoprotein." } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AUV4", "id": "A0AUV4", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [], "uniprot_ac": "A0AUV4", "site_annotation": [ { "end_pos": 454, "annotation": "n_glycosylation_sequon", "start_pos": 452 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0AUV4#A0A0R4J163-1", "isoform_ac": "A0A0R4J163-1", "locus": { "end_pos": 13948373, "strand": "-", "start_pos": 13949896, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000088809", "id": "ENSMUST00000088809", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000094997", "id": "ENSMUSP00000094997", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0R4J163-1|SMKY_MOUSE Computationally mapped isoform of Sperm motility kinase Y OS=Mus musculus OX=10090 GN=Gm7168 PE=2 SV=1 CANONICAL=A0AUV4-1", "length": 508, "sequence": "MPAHIEEELPPPSPQPSNPEDGELYSQYKVVRTLGHGTYAKVLLAKHWLTGTPVAVKVLLKNKPCFQPAMKEANIMKKIKHPNIVSLLQVFETKTRGYLIMELVEGQELYEYIKSSGHIEEDEARQIFLQILSAVSYCHGLGIVHRDLKPDNIMIDDKGSIKIIDFGLSTQVKPGDLLDEHCGAYAFGAPELFLWKSYDGTKSDLWALGVILYYMVVGKVPFDSYIIPELQRQILAGVYPAPCGVSNELKDLLSLLMTVNPKYRPTVTEVMKHPWLRGHCKGLTNIHEEPVPVRPDPDIVDAMQYIGFQAKDIRESLTKEKFNEMSAAYYLLEEQALQREVRSTQAPTVSQVKAPFPSMDAGEASCLKIKRSGSASILGRSVWPPSIDQEPAYVQKVRQRAGRRSSGHGLLFEPNQMTPTQDQHHIRAMSVPCMLSTSSISEESVSEKREENLSHIALAEDKPIRSRGWCRGIMRWTRRVGNAIRTLCCCIPSRKTPQLGQSRVSPQK" } }, { "url": "https://www.uniprot.org/uniprot/A0AUV4#A0AUV4-1", "isoform_ac": "A0AUV4-1", "locus": {}, "sequence": { "header": "sp|A0AUV4-1|SMKY_MOUSE Isoform 1 of Sperm motility kinase Y OS=Mus musculus OX=10090 GN=Gm7168 PE=2 SV=1 CANONICAL=A0AUV4-1", "length": 508, "sequence": "MPAHIEEELPPPSPQPSNPEDGELYSQYKVVRTLGHGTYAKVLLAKHWLTGTPVAVKVLLKNKPCFQPAMKEANIMKKIKHPNIVSLLQVFETKTRGYLIMELVEGQELYEYIKSSGHIEEDEARQIFLQILSAVSYCHGLGIVHRDLKPDNIMIDDKGSIKIIDFGLSTQVKPGDLLDEHCGAYAFGAPELFLWKSYDGTKSDLWALGVILYYMVVGKVPFDSYIIPELQRQILAGVYPAPCGVSNELKDLLSLLMTVNPKYRPTVTEVMKHPWLRGHCKGLTNIHEEPVPVRPDPDIVDAMQYIGFQAKDIRESLTKEKFNEMSAAYYLLEEQALQREVRSTQAPTVSQVKAPFPSMDAGEASCLKIKRSGSASILGRSVWPPSIDQEPAYVQKVRQRAGRRSSGHGLLFEANQMTPTQDQHHIRAMSVPCMLSTSSISEESVSEKREENLSHIALAEDKPIRSRGWCRGIMRWTRRVGNAIRTLCCCIPSRKTPQLGQSRVSPQK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:635895", "resource": "KEGG Pathway", "id": "mmu:635895", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0AUV4#function", "annotation": "May play a role in sperm motility, especially in the regulation of flagellar function.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AUV4#function", "id": "A0AUV4", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "F1M3Z2-1", "protein_name": "Similar to putative protein kinase", "sequence": { "length": 509, "sequence": "MPTETEEELPTPTPEPSISEEGNFHSQYQVLGTIGQGGNAKVLLAHHRLTGTPVAVKVLRKDKQWFQPAMMEANIMRKINHPNIVSLIQVIEKETRIYLIMELVEGQVLYQYIRESGHIEEDEARQIFEQILSAVSYCHXXGKGIVHRDLKLDNIMIDKNKKVKVIDFGLSTQFQPGKMLNHHCGTYSFGSPELLLGHRYDGPKNDMWIIGVVLYCMVVGKLPFDSVIIQELQRQVVAGVYPAPCGVSKELEDLLSKLLRVNLNFRPTARKAMKHPWFKEHWNGLIGPYEEMLPLTPDPAILDAMKSIGFQASVVKHSLKQRKYNEEMATYFFLQKQALQGDGCTAQAQQVSSLAAPSLDPAAAFRLEPKRSGSLPVLGTLRVSSSHGHVSHYGQNAHPKGGKRSTVAGRLRPLPMTPTQDHYHKCAVSVPCIQTTSIFTEKSSNKEIKEDNPLSHRAPLEDKPIPSRVRHRGFKGWTRNIANALIKLCCCMPRRKKPRLGQNRISPQK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/133217", "id": "133217", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "RGD1561667", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116449.1", "ac": "NP_001116449.1", "name": "sperm motility kinase Y", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AUV4", "id": "A0AUV4", "database": "UniProtKB" } ], "name": "protein serine/threonine kinase activity", "id": "GO:0004674" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AUV4", "id": "A0AUV4", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AUV4", "id": "A0AUV4", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AUV4", "id": "A0AUV4", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AUV4", "id": "A0AUV4", "database": "UniProtKB" } ], "name": "protein phosphorylation", "id": "GO:0006468" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0AUV4", "id": "A0AUV4", "database": "UniProtKB" } ], "name": "intracellular signal transduction", "id": "GO:0035556" } ], "total": 2, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0AUV4", "type": "synonym", "resource": "RefSeq", "name": "EG635895" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0AUV4", "type": "synonym", "resource": "RefSeq", "name": "Gm7168" }, { "url": "https://www.uniprot.org/uniprot/A0AUV4", "type": "recommended", "resource": "UniProtKB", "name": "Gm7168" } ], "pro_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/gene/635895", "id": "635895", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "id": "IPR000719", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "id": "IPR008271", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "id": "IPR011009", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015940", "id": "IPR015940", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "id": "IPR017441", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:635895", "id": "mmu:635895", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:3643198", "id": "3643198", "database": "MGI" }, { "url": "http://www.orthodb.org/?query=1127668at2759", "id": "1127668at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00069", "id": "PF00069", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A0AUV4", "id": "PR_A0AUV4", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116449.1", "id": "NP_001116449.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A0AUV4", "id": "A0AUV4", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 57058.0, "chemical_mass": 57058.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0AUV4", "name": "Gm7168", "locus": { "end_pos": 13950678, "strand": "+", "start_pos": 13948373, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000067941", "id": "ENSMUSG00000067941", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0AUV4#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "2.7.11.1" }, { "url": "https://www.uniprot.org/uniprot/A0AUV4#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Sperm motility kinase Y" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0AUV4", "type": "synonym", "resource": "RefSeq", "name": "sperm motility kinase Y" } ] }