{
    "uniprot_canonical_ac": "A0A539-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A0A539-1|TVB42_HUMAN Isoform 1 of T cell receptor beta variable 4-2  OS=Homo sapiens OX=9606 GN=TRBV4-2 PE=3 SV=1 CANONICAL=A0A539-1", 
        "length": 114, 
        "sequence": "MGCRLLCCAVLCLLGAVPMETGVTQTPRHLVMGMTNKKSLKCEQHLGHNAMYWYKQSAKKPLELMFVYNFKEQTENNSVPSRFSPECPNSSHLFLHLHTLQPEDSALYLCASSQ"
    }, 
    "uniprot_id": "TVB42_HUMAN", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [
        "glycoprotein", 
        "predicted.uniprotkb_gly"
    ], 
    "species": [
        {
            "common_name": "Human", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A539", 
                    "id": "A0A539", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/15040585", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "15040585"
                }
            ], 
            "title": "The many important facets of T-cell repertoire diversity.", 
            "journal": "Nat. Rev. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A539", 
                    "id": "A0A539", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Messaoudi I., Nikolich-Zugich J., Slifka M.K.", 
            "date": "2004"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20452950", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "20452950"
                }
            ], 
            "title": "Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.", 
            "journal": "Cold Spring Harb. Perspect. Biol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A539", 
                    "id": "A0A539", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Gagnon E., Wucherpfennig K.W., Call M.E., Call M.J., Huseby E.S.", 
            "date": "2010"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/23524462", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "23524462"
                }
            ], 
            "title": "T cell receptor signalling networks: branched, diversified and bounded.", 
            "journal": "Nat. Rev. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A539", 
                    "id": "A0A539", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Zamoyska R., Brownlie R.J.", 
            "date": "2013"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24600447", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "24600447"
                }
            ], 
            "title": "Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics.", 
            "journal": "Front. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A539", 
                    "id": "A0A539", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Lefranc M.P.", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/25493333", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "25493333"
                }
            ], 
            "title": "T cell antigen receptor recognition of antigen-presenting molecules.", 
            "journal": "Annu. Rev. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A539", 
                    "id": "A0A539", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Rossjohn J., Gras S., McCluskey J., Godfrey D.I., Miles J.J., Turner S.J.", 
            "date": "2015"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/8650574", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "8650574"
                }
            ], 
            "title": "The complete 685-kilobase DNA sequence of the human beta T cell receptor locus.", 
            "journal": "Science", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A539", 
                    "id": "A0A539", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Hood L., Koop B.F., Rowen L.", 
            "date": "1996"
        }
    ], 
    "uniprot_ac": "A0A539", 
    "site_annotation": [
        {
            "end_pos": 78, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 76
        }, 
        {
            "end_pos": 91, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 89
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A539#A0A539-1", 
            "isoform_ac": "A0A539-1", 
            "locus": {
                "end_pos": 142345532, 
                "strand": "-", 
                "start_pos": 142345983, 
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                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000390392", 
                        "id": "ENST00000390392", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000374915", 
                        "id": "ENSP00000374915", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A0A539-1|TVB42_HUMAN Isoform 1 of T cell receptor beta variable 4-2  OS=Homo sapiens OX=9606 GN=TRBV4-2 PE=3 SV=1 CANONICAL=A0A539-1", 
                "length": 114, 
                "sequence": "MGCRLLCCAVLCLLGAVPMETGVTQTPRHLVMGMTNKKSLKCEQHLGHNAMYWYKQSAKKPLELMFVYNFKEQTENNSVPSRFSPECPNSSHLFLHLHTLQPEDSALYLCASSQ"
            }
        }
    ], 
    "pathway": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A539#function", 
            "annotation": "V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A539#function", 
                    "id": "A0A539", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [
        {
            "sequence_org": "P", 
            "start_pos": 18, 
            "alt_nt": "A", 
            "chr_id": "7", 
            "ref_nt": "C", 
            "chr_pos": "142045525", 
            "disease": [
                {
                    "synonyms": [], 
                    "recommended_name": {
                        "id": "DOID:1324", 
                        "url": "http://disease-ontology.org/term/DOID:1324", 
                        "resource": "Disease Ontology", 
                        "name": "lung cancer", 
                        "description": "A respiratory system cancer that is located_in the lung."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A539", 
                    "id": "A0A539", 
                    "database": "BioMuta"
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            ], 
            "glycoeffect": [], 
            "frequency": "2.4", 
            "sequence_mut": "H", 
            "subjects_tested": "1514", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 2 out of 6 filters: patient freq. (2.4%); patient count (36/1514).", 
            "end_pos": 18, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "36"
        }, 
        {
            "sequence_org": "M", 
            "alt_nt": "null", 
            "chr_id": "7", 
            "ref_nt": "C", 
            "chr_pos": "142345793T>", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs748400625", 
                    "id": "rs748400625", 
                    "database": "dbSNP"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs748400625", 
                    "id": "rs748400625", 
                    "database": "ExAC"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/snp/rs748400625#frequency_tab", 
                    "id": "rs748400625", 
                    "database": "TOPMed"
                }, 
                {
                    "url": "http://gnomad.broadinstitute.org/awesome?query=rs748400625", 
                    "id": "rs748400625", 
                    "database": "gnomAD"
                }
            ], 
            "glycoeffect": [
                "n-glyco-sequon-gain"
            ], 
            "sequence_mut": "T", 
            "start_pos": 51, 
            "keywords": [
                "ebi", 
                "germline"
            ], 
            "end_pos": 51, 
            "minor_allelic_frequency": "", 
            "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NAM->NAT)."
        }, 
        {
            "sequence_org": "N", 
            "alt_nt": "null", 
            "chr_id": "7", 
            "ref_nt": "G", 
            "chr_pos": "142345867A>", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1391555112", 
                    "id": "rs1391555112", 
                    "database": "dbSNP"
                }, 
                {
                    "url": "http://gnomad.broadinstitute.org/awesome?query=rs1391555112", 
                    "id": "rs1391555112", 
                    "database": "gnomAD"
                }
            ], 
            "glycoeffect": [
                "n-glyco-sequon-loss"
            ], 
            "sequence_mut": "D", 
            "start_pos": 76, 
            "keywords": [
                "ebi", 
                "germline"
            ], 
            "end_pos": 76, 
            "minor_allelic_frequency": "", 
            "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NNS->DNS)."
        }, 
        {
            "sequence_org": "N", 
            "start_pos": 76, 
            "alt_nt": "G", 
            "chr_id": "7", 
            "ref_nt": "A", 
            "chr_pos": "142045699", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:10534", 
                            "url": "http://disease-ontology.org/term/DOID:10534", 
                            "resource": "Disease Ontology", 
                            "name": "gastric cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:10534", 
                            "url": "http://disease-ontology.org/term/DOID:10534", 
                            "resource": "Disease Ontology", 
                            "name": "gastric neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:10534", 
                        "url": "http://disease-ontology.org/term/DOID:10534", 
                        "resource": "Disease Ontology", 
                        "name": "stomach cancer", 
                        "description": "A gastrointestinal system cancer that is located_in the stomach."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A539", 
                    "id": "A0A539", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [
                "n-glyco-sequon-loss"
            ], 
            "frequency": "0.1", 
            "sequence_mut": "S", 
            "subjects_tested": "1044", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NNS->SNS).", 
            "end_pos": 76, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }, 
        {
            "sequence_org": "S", 
            "alt_nt": "null", 
            "chr_id": "7", 
            "ref_nt": "A", 
            "chr_pos": "142345874G>", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1167900681", 
                    "id": "rs1167900681", 
                    "database": "dbSNP"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/snp/rs1167900681#frequency_tab", 
                    "id": "rs1167900681", 
                    "database": "TOPMed"
                }, 
                {
                    "url": "http://gnomad.broadinstitute.org/awesome?query=rs1167900681", 
                    "id": "rs1167900681", 
                    "database": "gnomAD"
                }
            ], 
            "glycoeffect": [
                "n-glyco-sequon-loss", 
                "o-glyco-site-loss"
            ], 
            "sequence_mut": "N", 
            "start_pos": 78, 
            "keywords": [
                "ebi", 
                "germline"
            ], 
            "end_pos": 78, 
            "minor_allelic_frequency": "", 
            "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NNS->NNN)."
        }, 
        {
            "sequence_org": "N", 
            "alt_nt": "null", 
            "chr_id": "7", 
            "ref_nt": "G", 
            "chr_pos": "142345906A>", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1234817207", 
                    "id": "rs1234817207", 
                    "database": "dbSNP"
                }, 
                {
                    "url": "http://gnomad.broadinstitute.org/awesome?query=rs1234817207", 
                    "id": "rs1234817207", 
                    "database": "gnomAD"
                }
            ], 
            "glycoeffect": [
                "n-glyco-sequon-loss"
            ], 
            "sequence_mut": "D", 
            "start_pos": 89, 
            "keywords": [
                "ebi", 
                "germline"
            ], 
            "end_pos": 89, 
            "minor_allelic_frequency": "", 
            "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NSS->DSS)."
        }, 
        {
            "sequence_org": "N", 
            "alt_nt": "null", 
            "chr_id": "7", 
            "ref_nt": "A", 
            "chr_pos": "142345908C>", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs949173951", 
                    "id": "rs949173951", 
                    "database": "dbSNP"
                }, 
                {
                    "url": "http://gnomad.broadinstitute.org/awesome?query=rs949173951", 
                    "id": "rs949173951", 
                    "database": "gnomAD"
                }
            ], 
            "glycoeffect": [
                "n-glyco-sequon-loss"
            ], 
            "sequence_mut": "K", 
            "start_pos": 89, 
            "keywords": [
                "ebi", 
                "germline"
            ], 
            "end_pos": 89, 
            "minor_allelic_frequency": "", 
            "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NSS->KSS)."
        }, 
        {
            "sequence_org": "S", 
            "start_pos": 91, 
            "alt_nt": "T", 
            "chr_id": "7", 
            "ref_nt": "C", 
            "chr_pos": "142045744", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:4159", 
                            "url": "http://disease-ontology.org/term/DOID:4159", 
                            "resource": "Disease Ontology", 
                            "name": "CA - skin cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:4159", 
                            "url": "http://disease-ontology.org/term/DOID:4159", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of skin", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:4159", 
                            "url": "http://disease-ontology.org/term/DOID:4159", 
                            "resource": "Disease Ontology", 
                            "name": "melanoma and Non-melanoma skin cancer", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:4159", 
                        "url": "http://disease-ontology.org/term/DOID:4159", 
                        "resource": "Disease Ontology", 
                        "name": "skin cancer", 
                        "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A539", 
                    "id": "A0A539", 
                    "database": "BioMuta"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs758688041", 
                    "id": "rs758688041", 
                    "database": "dbSNP"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs758688041", 
                    "id": "rs758688041", 
                    "database": "ExAC"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs758688041", 
                    "id": "rs758688041", 
                    "database": "NCI-TCGA"
                }, 
                {
                    "url": "http://gnomad.broadinstitute.org/awesome?query=rs758688041", 
                    "id": "rs758688041", 
                    "database": "gnomAD"
                }
            ], 
            "glycoeffect": [
                "n-glyco-sequon-loss", 
                "o-glyco-site-loss"
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            "frequency": "0.1", 
            "sequence_mut": "F", 
            "subjects_tested": "820", 
            "keywords": [
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                "somatic", 
                "cancer", 
                "disease", 
                "ebi", 
                "germline"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NSS->NSF).", 
            "end_pos": 91, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }
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    "cluster_types": [], 
    "refseq": {}, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A539", 
                                "id": "A0A539", 
                                "database": "UniProtKB"
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                        ], 
                        "name": "plasma membrane", 
                        "id": "GO:0005886"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", 
                        "pmid": "", 
                        "evidence": [
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                                "url": "https://www.uniprot.org/uniprot/A0A539", 
                                "id": "A0A539", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "T cell receptor complex", 
                        "id": "GO:0042101"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A539", 
                                "id": "A0A539", 
                                "database": "UniProtKB"
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                        ], 
                        "name": "cell surface receptor signaling pathway", 
                        "id": "GO:0007166"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", 
                        "pmid": "", 
                        "evidence": [
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                                "url": "https://www.uniprot.org/uniprot/A0A539", 
                                "id": "A0A539", 
                                "database": "UniProtKB"
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                        ], 
                        "name": "adaptive immune response", 
                        "id": "GO:0002250"
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                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A539", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "TCRBV7S3A2T"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A539", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "TCRBV7S3A2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A539", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "TRBV4-2"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211745", 
            "id": "ENSG00000211745", 
            "database": "Bgee"
        }, 
        {
            "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A539", 
            "id": "A0A539", 
            "database": "BioMuta"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=TRBV4-2", 
            "id": "TRBV4-2", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=12216", 
            "id": "12216", 
            "database": "HGNC"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", 
            "id": "IPR007110", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", 
            "id": "IPR013106", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", 
            "id": "IPR013783", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", 
            "id": "IPR036179", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A0A539", 
            "id": "NX_A0A539", 
            "database": "neXtProt"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/PLELMFI/", 
            "id": "PLELMFI", 
            "database": "OMA"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF07686", 
            "id": "PF07686", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A0A539", 
            "id": "PR_A0A539", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A539", 
            "id": "A0A539", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [
        {
            "residue": "Asn", 
            "site_category": "predicted", 
            "end_pos": 76, 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A539#ptm_processing", 
                    "id": "A0A539", 
                    "database": "UniProtKB"
                }
            ], 
            "subtype": "", 
            "relation": "attached", 
            "start_pos": 76, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }, 
        {
            "residue": "Asn", 
            "site_category": "predicted", 
            "end_pos": 89, 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A539#ptm_processing", 
                    "id": "A0A539", 
                    "database": "UniProtKB"
                }
            ], 
            "subtype": "", 
            "relation": "attached", 
            "start_pos": 89, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }
    ], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 12890.0, 
        "chemical_mass": 12890.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A539", 
            "name": "TRBV4-2", 
            "locus": {
                "end_pos": 142345985, 
                "strand": "+", 
                "start_pos": 142345421, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000211745", 
                        "id": "ENSG00000211745", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A539#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "T cell receptor beta variable 4-2"
        }
    ]
}