{ "uniprot_canonical_ac": "A0A494BA31-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A494BA31-1|A0A494BA31_MOUSE Isoform 1 of Anion exchange protein OS=Mus musculus OX=10090 GN=Slc4a9 PE=3 SV=1 CANONICAL=A0A494BA31-1", "length": 952, "sequence": "MKLPGQGDFESSDAHENAHSEEPDSGLGPGPGLNGPSGIDIGESQVSKDPLLFIQLNELLGWPQALEWRETGRWLLFEEKLDMGAGRWSAPHVPTLELPSLQKLRSLLAEGIVLLDCQAQSLLELVEQVVSGESLSPELRGQLQALLLQRPQHHIQTMGIRPCRESNAFRKASRDEDAPLKHQNPLRQKLPAGAEAAAVLAGELGFLEQPLGAFVRLRNPIVLEPLTEMILPSRFFCLLLGPPTLGRSYHEMGRAAAVLLSDPQFQWSVRRASHLPDLLAALDAFLQEVTALPPGRWDRTARIPPPKYLPSQHKRFPSKLQEVTSLSRQSAALAEDKHHHGPHTPIPELQRTGRLFGGLIQDVRRKACWYTSDFLDALHPQCFSAVFYIYLATVTNAITFGGLLGDATEGAQGVLESFLGTAVAGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVTAFCLALVATEASLLVRYFTRFTEEGFCALISLIFIYDAMGKMLNLIRAYPIQRPGSSAYGCFCQYPGTGGNTSEWTSAKLKDTEDILSVPGLVNASFLPPPECIRQGGHPLGPSCHTVPDIAFFSLLLFFTSFLCAIALKHIKNSRFFPSVVRKVLGDFSSVLAILLGCGLDTFLGLATPKLLVPTEFKPTLSGRGWLVSPFGANPWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLFTSALGLPWYVSATVISLAHIDSLRRESKACIPGEAPNFLGIREQRLTGLVVFVLTGVSIFLAPVLKFIPMPVLYGIFLYMGVAALSSIQFVKRVQLLLMPRKHQPDMLLLRHVPLSRVHLFTAIQLACLGLLWVVKSTPAAIVFPLMLLGLVAIRKALEWVFSPQELLWLDELMPEEEETIPENRSEPEHLFSGNDSEDSELMYQPKAPEINISVN" }, "uniprot_id": "A0A494BA31_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "id": "A0A494BA31", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14592810", "type": [ "PubMed" ], "id": "14592810" } ], "title": "A SCL4A10 gene product maps selectively to the basolateral plasma membrane of choroid plexus epithelial cells.", "journal": "American journal of physiology. Cell physiology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258473.1", "id": "NP_001258473.1", "database": "RefSeq" } ], "authors": "Praetorius J, Nejsum LN, Nielsen S", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16159312", "type": [ "PubMed" ], "id": "16159312" } ], "title": "The forkhead transcription factor Foxi1 directly activates the AE4 promoter.", "journal": "The Biochemical journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258473.1", "id": "NP_001258473.1", "database": "RefSeq" } ], "authors": "Kurth I, Hentschke M, Hentschke S, Borgmeyer U, Gal A, Hubner CA", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17409310", "type": [ "PubMed" ], "id": "17409310" } ], "title": "Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-/HCO3- exchanger (slc4a1).", "journal": "Journal of the American Society of Nephrology : JASN", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258473.1", "id": "NP_001258473.1", "database": "RefSeq" } ], "authors": "Stehberger PA, Shmukler BE, Stuart-Tilley AK, Peters LL, Alper SL, Wagner CA", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23610411", "type": [ "PubMed" ], "id": "23610411" } ], "title": "Renal intercalated cells are rather energized by a proton than a sodium pump.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258473.1", "id": "NP_001258473.1", "database": "RefSeq" } ], "authors": "Chambrey R, Kurth I, Peti-Peterdi J, Houillier P, Purkerson JM, Leviel F, Hentschke M, Zdebik AA, Schwartz GJ, Hubner CA, Eladari D", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25745107", "type": [ "PubMed" ], "id": "25745107" } ], "title": "Ae4 (Slc4a9) Anion Exchanger Drives Cl- Uptake-dependent Fluid Secretion by Mouse Submandibular Gland Acinar Cells.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258473.1", "id": "NP_001258473.1", "database": "RefSeq" } ], "authors": "Pena-Munzenmayer G, Catalan MA, Kondo Y, Jaramillo Y, Liu F, Shull GE, Melvin JE", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27114614", "type": [ "PubMed" ], "id": "27114614" } ], "title": "Ae4 (Slc4a9) is an electroneutral monovalent cation-dependent Cl-/HCO3- exchanger.", "journal": "The Journal of general physiology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258473.1", "id": "NP_001258473.1", "database": "RefSeq" } ], "authors": "Pena-Munzenmayer G, George AT, Shull GE, Melvin JE, Catalan MA", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28705898", "type": [ "PubMed" ], "id": "28705898" } ], "title": "Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.", "journal": "Development (Cambridge, England)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258473.1", "id": "NP_001258473.1", "database": "RefSeq" } ], "authors": "Rutledge EA, Benazet JD, McMahon AP", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28994389", "type": [ "PubMed" ], "id": "28994389" } ], "title": "Molecular architecture underlying fluid absorption by the developing inner ear.", "journal": "eLife", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258473.1", "id": "NP_001258473.1", "database": "RefSeq" } ], "authors": "Honda K, Kim SH, Kelly MC, Burns JC, Constance L, Li X, Zhou F, Hoa M, Kelley MW, Wangemann P, Morell RJ, Griffith AJ", "date": "2017" } ], "uniprot_ac": "A0A494BA31", "site_annotation": [ { "end_pos": 548, "annotation": "n_glycosylation_sequon", "start_pos": 546 }, { "end_pos": 571, "annotation": "n_glycosylation_sequon", "start_pos": 569 }, { "end_pos": 922, "annotation": "n_glycosylation_sequon", "start_pos": 920 }, { "end_pos": 933, "annotation": "n_glycosylation_sequon", "start_pos": 931 }, { "end_pos": 950, "annotation": "n_glycosylation_sequon", "start_pos": 948 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31#A0A494BA31-1", "isoform_ac": "A0A494BA31-1", "locus": { "end_pos": 36528187, "strand": "-", "start_pos": 36541249, "chromosome": "18", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000236124", "id": "ENSMUST00000236124", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000157862", "id": "ENSMUSP00000157862", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A494BA31-1|A0A494BA31_MOUSE Isoform 1 of Anion exchange protein OS=Mus musculus OX=10090 GN=Slc4a9 PE=3 SV=1 CANONICAL=A0A494BA31-1", "length": 952, "sequence": "MKLPGQGDFESSDAHENAHSEEPDSGLGPGPGLNGPSGIDIGESQVSKDPLLFIQLNELLGWPQALEWRETGRWLLFEEKLDMGAGRWSAPHVPTLELPSLQKLRSLLAEGIVLLDCQAQSLLELVEQVVSGESLSPELRGQLQALLLQRPQHHIQTMGIRPCRESNAFRKASRDEDAPLKHQNPLRQKLPAGAEAAAVLAGELGFLEQPLGAFVRLRNPIVLEPLTEMILPSRFFCLLLGPPTLGRSYHEMGRAAAVLLSDPQFQWSVRRASHLPDLLAALDAFLQEVTALPPGRWDRTARIPPPKYLPSQHKRFPSKLQEVTSLSRQSAALAEDKHHHGPHTPIPELQRTGRLFGGLIQDVRRKACWYTSDFLDALHPQCFSAVFYIYLATVTNAITFGGLLGDATEGAQGVLESFLGTAVAGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVTAFCLALVATEASLLVRYFTRFTEEGFCALISLIFIYDAMGKMLNLIRAYPIQRPGSSAYGCFCQYPGTGGNTSEWTSAKLKDTEDILSVPGLVNASFLPPPECIRQGGHPLGPSCHTVPDIAFFSLLLFFTSFLCAIALKHIKNSRFFPSVVRKVLGDFSSVLAILLGCGLDTFLGLATPKLLVPTEFKPTLSGRGWLVSPFGANPWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLFTSALGLPWYVSATVISLAHIDSLRRESKACIPGEAPNFLGIREQRLTGLVVFVLTGVSIFLAPVLKFIPMPVLYGIFLYMGVAALSSIQFVKRVQLLLMPRKHQPDMLLLRHVPLSRVHLFTAIQLACLGLLWVVKSTPAAIVFPLMLLGLVAIRKALEWVFSPQELLWLDELMPEEEETIPENRSEPEHLFSGNDSEDSELMYQPKAPEINISVN" } }, { "url": "https://www.uniprot.org/uniprot/A0A494BA31#A0A494BAI0-1", "isoform_ac": "A0A494BAI0-1", "locus": { "end_pos": 36528187, "strand": "-", "start_pos": 36541249, "chromosome": "18", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000236779", "id": "ENSMUST00000236779", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000158033", "id": "ENSMUSP00000158033", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A494BAI0-1|A0A494BA31_MOUSE Computationally mapped isoform of Anion exchange protein OS=Mus musculus OX=10090 GN=Slc4a9 PE=3 SV=1 CANONICAL=A0A494BA31-1", "length": 871, "sequence": "MKLPGQGDFESSDAHENAHSEEPDSGLGPGPGLNGPSGIDIGESQVSKDPLLFIQLNELLGWPQALEWRETGRWLLFEEKLDMGAGRWSAPHVPTLELPSLQKLRSLLAEGIVLLDCQAQSLLELVEQVVSGESLSPELRGQLQALLLQRPQHHIQTMGIRPCRESNAFRKASRDEDAPLKHQNPLRQKLPAGAEAAAVLAGELGFLEQPLGAFVRLRNPIVLEPLTEMILPSRFFCLLLGPPTLGRSYHEMGRAAAVLLSDPQFQWSVRRASHLPDLLAALDAFLQEVTALPPGRWDRTARIPPPKYLPSQHKRFPSKLQEVTSLSRQSAALAEDKHHHGPHTPIPELQRTGRLFGGLIQDVRRKACWYTSDFLDALHPQCFSAVFYIYLATVTNAITFGGLLGDATEGAQGVLESFLGTAVAGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVTAFCLALVATEASLLVRYFTRFTEEGFCALISLIFIYDAMGKMLNLIRAYPIQRPGSSAYGCFCQYPGTGGNTSEWTSAKLKDTEDILSVPGLVNASFLPPPECIRQGGHPLGPSCHTVPDIAFFSLLLFFTSFLCAIALKHIKNSRFFPSVVRKVLGDFSSVLAILLGCGLDTFLGLATPKLLVPTEFKPTLSGRGWLVSPFGANPWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLFTSALGLPWYVSATVISLAHIDSLRRESKACIPGEAPNFLGIREQRLTGLVVFVLTGVSIFLAPVLKLLGLVAIRKALEWVFSPQELLWLDELMPEEEETIPENRSEPEHLFSGNDSEDSELMYQPKAPEINISVN" } }, { "url": "https://www.uniprot.org/uniprot/A0A494BA31#A0A494BAK5-1", "isoform_ac": "A0A494BAK5-1", "locus": { "end_pos": 36529227, "strand": "-", "start_pos": 36541249, "chromosome": "18", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000237595", "id": "ENSMUST00000237595", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000158130", "id": "ENSMUSP00000158130", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A494BAK5-1|A0A494BA31_MOUSE Computationally mapped isoform of Anion exchange protein OS=Mus musculus OX=10090 GN=Slc4a9 PE=3 SV=1 CANONICAL=A0A494BA31-1", "length": 821, "sequence": "SGESLSPELRGQLQALLLQRPQHHIQTMGIRPCRESNAFRKASRDEDAPLKHQNPLRQKLPAGAEAAAVLAGELGFLEQPLGAFVRLRNPIVLEPLTEMILPSRFFCLLLGPPTLGRSYHEMGRAAAVLLSDPQFQWSVRRASHLPDLLAALDAFLQEVTALPPGRWDRTARIPPPKYLPSQHKRFPSKLQEVTSLSRQSAALAEDKHHHGPHTPIPELQRTGRLFGGLIQDVRRKACWYTSDFLDALHPQCFSAVFYIYLATVTNAITFGGLLGDATEGAQGVLESFLGTAVAGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVTAFCLALVATEASLLVRYFTRFTEEGFCALISLIFIYDAMGKMLNLIRAYPIQRPGSSAYGCFCQYPGTGGNTSEWTSAKLKDTEDILSVPGLVNASFLPPPECIRQGGHPLGPSCHTVPDIAFFSLLLFFTSFLCAIALKHIKNSRFFPSVVRKVLGDFSSVLAILLGCGLDTFLGLATPKLLVPTEFKPTLSGRGWLVSPFGANPWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQGAGFHLDLFCVAVLMLFTSALGLPWYVSATVISLAHIDSLRRESKACIPGEAPNFLGIREQRLTGLVVFVLTGVSIFLAPVLKFIPMPVLYGIFLYMGVAALSSIQFVKRVQLLLMPRKHQPDMLLLRHVPLSRVHLFTAIQLACLGLLWVVKSTPAAIVFPLMLLGLVAIRKALEWVFSPQELLWLDELMPEEEETIPENRSEPEHLFSGNDSEDSELMYQPKAPEINISVN" } }, { "url": "https://www.uniprot.org/uniprot/A0A494BA31#A0A494BBC3-1", "isoform_ac": "A0A494BBC3-1", "locus": { "end_pos": 36528187, "strand": "-", "start_pos": 36541249, "chromosome": "18", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000236126", "id": "ENSMUST00000236126", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000158410", "id": "ENSMUSP00000158410", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A494BBC3-1|A0A494BA31_MOUSE Computationally mapped isoform of Anion exchange protein OS=Mus musculus OX=10090 GN=Slc4a9 PE=3 SV=1 CANONICAL=A0A494BA31-1", "length": 918, "sequence": "MKLPGQGDFESSDAHENAHSEEPDSGLGPGPGLNGPSGIDIGESQVSKDPLLFIQLNELLGWPQALEWRETGRWLLFEEKLDMGAGRWSAPHVPTLELPSLQKLRSLLAEGIVLLDCQAQSLLELVEQVVSGESLSPELRGQLQALLLQRPQHHIQTMGIRPCRESNAFRKASRDEDAPLKHQNPLRQKLPAGAEAAAVLAGELGFLEQPLGAFVRLRNPIVLEPLTEMILPSRFFCLLLGPPTLGRSYHEMGRAAAVLLSDPQFQWSVRRASHLPDLLAALDAFLQEVTALPPGRWDRTARIPPPKYLPSQHKRFPSKLQEVTSLSRQSAALAEDKHHHGPHTPIPELQRTGRLFGGLIQDVRRKACWYTSDFLDALHPQCFSAVFYIYLATVTNAITFGGLLGDATEGAQGVLESFLGTAVAGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVTAFCLALVATEASLLVRYFTRFTEEGFCALISLIFIYDAMGKMLNLIRAYPIQRPGSSAYGCFCQYPGTGGNTSEWTSAKLKDTEDILSVPGLVNASFLPPPECIRQGGHPLGPSCHTVPDIAFFSLLLFFTSFLCAIALKHIKNSRFFPSVVRKVLGDFSSVLAILLGCGLDTFLGLATPKLLVPTEFKPTLSGRGWLVSPFGANPWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLFTSALGLPWEQRLTGLVVFVLTGVSIFLAPVLKFIPMPVLYGIFLYMGVAALSSIQFVKRVQLLLMPRKHQPDMLLLRHVPLSRVHLFTAIQLACLGLLWVVKSTPAAIVFPLMLLGLVAIRKALEWVFSPQELLWLDELMPEEEETIPENRSEPEHLFSGNDSEDSELMYQPKAPEINISVN" } }, { "url": "https://www.uniprot.org/uniprot/A0A494BA31#E9PUP3-1", "isoform_ac": "E9PUP3-1", "locus": { "end_pos": 36528187, "strand": "-", "start_pos": 36541249, "chromosome": "18", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000115694", "id": "ENSMUST00000115694", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000111358", "id": "ENSMUSP00000111358", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9PUP3-1|A0A494BA31_MOUSE Computationally mapped isoform of Anion exchange protein OS=Mus musculus OX=10090 GN=Slc4a9 PE=3 SV=1 CANONICAL=A0A494BA31-1", "length": 929, "sequence": "MKLPGQGDFESSDAHENAHSEEPDSGLGPGPGLNGPSGIDIGESQVSKDPLLFIQLNELLGWPQALEWRETGRWLLFEEKLDMGAGRWSAPHVPTLELPSLQKLRSLLAEGIVLLDCQAQSLLELVEQVVSGESLSPELRGQLQALLLQRPQHHIQTMGIRPCRESNAFRKASRDEDAPLKHQNPLRQKLPAGAEAAAVLAGELGFLEQPLGAFVRLRNPIVLEPLTEMILPSRFFCLLLGPPTLGRSYHEMGRAAAVLLSDPQFQWSVRRASHLPDLLAALDAFLQEVTALPPGRWDRTARIPPPKYLPSQHKRFPSKLQEVTSLSRQSAALAEDKHHHGPHTPIPELQRTGRLFGGLIQDVRRKACWYTSDFLDALHPQCFSAVFYIYLATVTNAITFGGLLGDATEGAQGVLESFLGTAVAGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVTAFCLALVATEASLLVRYFTRFTEEGFCALISLIFIYDAMGKMLNLIRAYPIQRPGSSAYGCFCQYPGTGGNTSEWTSAKLKDTEDILSVPGLVNASFLPPPECIRQGGHPLGPSCHTVPDIAFFSLLLFFTSFLCAIALKHIKNSRFFPSVVRKVLGDFSSVLAILLGCGLDTFLGLATPKLLVPTEFKPTLSGRGWLVSPFGANPWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLFTSALGLPWYVSATVISLAHIDSLRRESKACIPGEAPNFLGIREQRLTGLVVFVLTGVSIFLAPVLKFVKRVQLLLMPRKHQPDMLLLRHVPLSRVHLFTAIQLACLGLLWVVKSTPAAIVFPLMLLGLVAIRKALEWVFSPQELLWLDELMPEEEETIPENRSEPEHLFSGNDSEDSELMYQPKAPEINISVN" } }, { "url": "https://www.uniprot.org/uniprot/A0A494BA31#Q8BUG8-1", "isoform_ac": "Q8BUG8-1", "locus": { "end_pos": 36528187, "strand": "-", "start_pos": 36541249, "chromosome": "18", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000235181", "id": "ENSMUST00000235181", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000157460", "id": "ENSMUSP00000157460", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q8BUG8-1|A0A494BA31_MOUSE Computationally mapped isoform of Anion exchange protein OS=Mus musculus OX=10090 GN=Slc4a9 PE=3 SV=1 CANONICAL=A0A494BA31-1", "length": 880, "sequence": "MKLPGQGDFESSDAHENAHSEEPDSGLGPGPGLNGPSGIDIGESQVSKDPLLFIQLNELLGWPQALEWRETGRWLLFEEKLDMGAGRWSAPHVPTLELPSLQKLRSLLAEGIVLLDCQAQSLLELVEQVVSGESLSPELRGQLQALLLQRPQHHIQTMGIRPCRESNAFRKASRDEDAPLKHQNPLRQKLPAGAEAAAVLAGELGFLEQPLGAFVRLRNPIVLEPLTEMILPSRFFCLLLGPPTLGRSYHEMGRAAAVLLSDPQFQWSVRRASHLPDLLAALDAFLQEVTALPPGRWDRTARIPPPKYLPSQHKRFPSKLQEVTSLSRQSAALAEDKHHHGPHTPIPELQRTGSVSQLCSTFTWPQSQTPSLLGVFWEMPLKVPRDYSLDYLPFRLWVGIWVTAFCLALVATEASLLVRYFTRFTEEGFCALISLIFIYDAMGKMLNLIRAYPIQRPGSSAYGCFCQYPGTGGNTSEWTSAKLKDTEDILSVPGLVNASFLPPPECIRQGGHPLGPSCHTVPDIAFFSLLLFFTSFLCAIALKHIKNSRFFPSVVRKVLGDFSSVLAILLGCGLDTFLGLATPKLLVPTEFKPTLSGRGWLVSPFGANPWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLFTSALGLPWYVSATVISLAHIDSLRRESKACIPGEAPNFLGIREQRLTGLVVFVLTGVSIFLAPVLKFIPMPVLYGIFLYMGVAALSSIQFVKRVQLLLMPRKHQPDMLLLRHVPLSRVHLFTAIQLACLGLLWVVKSTPAAIVFPLMLLGLVAIRKALEWVFSPQELLWLDELMPEEEETIPENRSEPEHLFSGNDSEDSELMYQPKAPEINISVN" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:240215", "resource": "KEGG Pathway", "id": "mmu:240215", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258473.1", "annotation": "Both Ae2 and Ae4 anion exchangers are functionally expressed in submandibular acinar cells; however, only Ae4 expression appears to be important for cAMP-dependent regulation of fluid secretion", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258473.1", "id": "NP_001258473.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258473.1", "annotation": "The AE4 promoter is identified as a direct target of Foxi1.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258473.1", "id": "NP_001258473.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q8K4V2-1", "protein_name": "Anion exchange protein 4", "sequence": { "length": 953, "sequence": "MKLPGQEDFEGSDAHENVCSEQLDGDLGPGSGLDGPSDIDNGKAQGCKDPLLFIQLNELLGWPQALEWRETGRWLLFEEKLDIGAGRWSAPHVPTLALPSLQKLRGLLAEGIVLLDCPARSLLELVEQVVRVESLSPELRGQLQALLLQRPQHHIQTTGIRPCRRSNAFRKASRDEDTLLKHQNPLRQKLPPGAEAAAVLAGELGFLEQPLAAFVRLQNPVVLEPLTEVVLPSRFFCLLLGPSTLGRSYHETGRAAAVLLSDPQFQWSVRRASNLHDLLAALDAFLQEVTALPPGRWDRTARIPPPKCLPSQHKRFPSKLQEVTSLSRQSAALAENKHHHGPHTPIPELQRTGRLFGGLVQDVRRKACWYPSDFLDALHPQCFSAVLYIYLATVTNAITFGGLLGDATEGAQGVLESFLGTAVAGATFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVATFCLALVATEASLLVRYFTRFTEEGFCALISLIFIYDAVGKMLNLIRAYPIQRPGSPAYSCFCQYPGTGGNASEFDSTMFKDTEDVLNVHPGLVNASFLPPSECIRQGGYPRGPSCHTVPDIAFFSLLLFFTSFLCAIALKHVKNSRLFPSVVRKVFSDFSSVLAILLGCGLDAFLGLATPKLLVPTEFKPTLPGRGWLVSPFGANPWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLFTSALGLPWYVSATVISLAHMDSLRRESKACVPGEDPNFLGIREQRLTGLVVFILTGVSIFLAPVLKFIPMPVLYGIFLYMGVAALSSMQFMKRVQLLLMPRKHQPDVLLLRHVPLIRVHLFTAIQLACLGLLWVIKSTPAAIVFPLMLLGLVAVRKALEWIFSPQELLWLDELMPEEEKTIPENRPEPEHLFSGNDSENSELMYQPKAPEINISVN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/23732", "id": "23732", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Slc4a9", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q96Q91-1", "protein_name": "Anion exchange protein 4", "sequence": { "length": 983, "sequence": "MEMKLPGQEGFEASSAPRNIPSGELDSNPDPGTGPSPDGPSDTESKELGVPKDPLLFIQLNELLGWPQALEWRETGSSSASLLLDMGEMPSITLSTHLHHRWVLFEEKLEVAAGRWSAPHVPTLALPSLQKLRSLLAEGLVLLDCPAQSLLELVEQVTRVESLSPELRGQLQALLLQRPQHYNQTTGTRPCWGSTHPRKASDNEEAPLREQCQNPLRQKLPPGAEAGTVLAGELGFLAQPLGAFVRLRNPVVLGSLTEVSLPSRFFCLLLGPCMLGKGYHEMGRAAAVLLSDPQFQWSVRRASNLHDLLAALDAFLEEVTVLPPGRWDPTARIPPPKCLPSQHKRLPSQQREIRGPAVPRLTSAEDRHRHGPHAHSPELQRTGRLFGGLIQDVRRKVPWYPSDFLDALHLQCFSAVLYIYLATVTNAITFGGLLGDATDGAQGVLESFLGTAVAGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVATFCLVLVATEASVLVRYFTRFTEEGFCALISLIFIYDAVGKMLNLTHTYPIQKPGSSAYGCLCQYPGPGGNESQWIRTRPKDRDDIVSMDLGLINASLLPPPECTRQGGHPRGPGCHTVPDIAFFSLLLFLTSFFFAMALKCVKTSRFFPSVVRKGLSDFSSVLAILLGCGLDAFLGLATPKLMVPREFKPTLPGRGWLVSPFGANPWWWSVAAALPALLLSILIFMDQQITAVILNRMEYRLQKGAGFHLDLFCVAVLMLLTSALGLPWYVSATVISLAHMDSLRRESRACAPGERPNFLGIREQRLTGLVVFILTGASIFLAPVLKFIPMPVLYGIFLYMGVAALSSIQFTNRVKLLLMPAKHQPDLLLLRHVPLTRVHLFTAIQLACLGLLWIIKSTPAAIIFPLMLLGLVGVRKALERVFSPQELLWLDELMPEEERSIPEKGLEPEHSFSGSDSEDSELMYQPKAPEINISVN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/23732", "id": "23732", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "SLC4A9", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258473.1", "ac": "NP_001258473.1", "name": "anion exchange protein 4 isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "id": "A0A494BA31", "database": "UniProtKB" } ], "name": "transmembrane transporter activity", "id": "GO:0022857" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008510", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "id": "A0A494BA31", "database": "UniProtKB" } ], "name": "sodium:bicarbonate symporter activity", "id": "GO:0008510" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005452", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "id": "A0A494BA31", "database": "UniProtKB" } ], "name": "inorganic anion exchanger activity", "id": "GO:0005452" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015301", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "id": "A0A494BA31", "database": "UniProtKB" } ], "name": "anion:anion antiporter activity", "id": "GO:0015301" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "id": "A0A494BA31", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "pmid": "17409310", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "id": "A0A494BA31", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "pmid": "14592810", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "id": "A0A494BA31", "database": "UniProtKB" } ], "name": "apical part of cell", "id": "GO:0045177" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "id": "A0A494BA31", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "id": "A0A494BA31", "database": "UniProtKB" } ], "name": "basolateral plasma membrane", "id": "GO:0016323" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "id": "A0A494BA31", "database": "UniProtKB" } ], "name": "transmembrane transport", "id": "GO:0055085" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015701", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "id": "A0A494BA31", "database": "UniProtKB" } ], "name": "bicarbonate transport", "id": "GO:0015701" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051453", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "id": "A0A494BA31", "database": "UniProtKB" } ], "name": "regulation of intracellular pH", "id": "GO:0051453" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050801", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "id": "A0A494BA31", "database": "UniProtKB" } ], "name": "ion homeostasis", "id": "GO:0050801" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006820", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "id": "A0A494BA31", "database": "UniProtKB" } ], "name": "anion transport", "id": "GO:0006820" } ], "total": 5, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A494BA31", "type": "synonym", "resource": "RefSeq", "name": "AE; AE4; D630003B07; D630024F24Rik" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A494BA31", "type": "synonym", "resource": "RefSeq", "name": "Slc4a9" }, { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "type": "recommended", "resource": "UniProtKB", "name": "Slc4a9" } ], "pro_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/gene/240215", "id": "240215", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003020", "id": "IPR003020", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003024", "id": "IPR003024", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011531", "id": "IPR011531", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013769", "id": "IPR013769", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016152", "id": "IPR016152", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:240215", "id": "mmu:240215", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2443384", "id": "2443384", "database": "MGI" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11453", "id": "PTHR11453", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF00955", "id": "PF00955", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF07565", "id": "PF07565", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258473.1", "id": "NP_001258473.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "id": "A0A494BA31", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 104989.0, "chemical_mass": 104989.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31", "name": "Slc4a9", "locus": { "end_pos": 36541293, "strand": "+", "start_pos": 36528157, "chromosome": "18", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000024485", "id": "ENSMUSG00000024485", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A494BA31#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Anion exchange protein" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A494BA31", "type": "synonym", "resource": "RefSeq", "name": "anion exchange protein 4 isoform 1" } ] }