{ "uniprot_canonical_ac": "A0A338P791-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A338P791-1|A0A338P791_MOUSE Isoform 1 of Brachyury 2 OS=Mus musculus OX=10090 GN=T2 PE=4 SV=1 CANONICAL=A0A338P791-1", "length": 393, "sequence": "MAQILRDHFKTPKKHRGCHTQVEDKEKAAQQTLPEQSQPEAWSASPPKASTRFPSRSNAYLIIGLQNELTKCGILKNMSDDEDFWKLVQEEALGVGTKEKLQKIKLKLMNPRPWPPAASRRRETEMLVSSDQDSGARQGTQDHPGREQEVVEDGPEKERIKQGPHQPGLDPPKHRGDTASLLARLTEWRKRCQQHGAAQRLHRGPEESKTMCKTRTDSQSKMYLSRLYRMYSTSLANMEFSRKLLERDGRFADMDAEHRARSLLDYMVPRERTQADVPPRERTQADVPPRELEEEDSPTPEQQPQAGPALRFLKCQSPESPQRRPHLKTGRHQVTLCGTSKLSEHERGTLAPARRTTDPRPTAPLTLAHVIQTHPVVEAKTASRYWVNNVDEE" }, "uniprot_id": "A0A338P791_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A338P791", "id": "A0A338P791", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17954925", "type": [ "PubMed" ], "id": "17954925" } ], "title": "Tint maps to mouse chromosome 6 and may interact with a notochordal enhancer of Brachyury.", "journal": "Genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155304.1", "id": "NP_001155304.1", "database": "RefSeq" } ], "authors": "Wu JI, Centilli MA, Vasquez G, Young S, Scolnick J, Durfee LA, Spearow JL, Schwantz SD, Rennebeck G, Artzt K", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7589801", "type": [ "PubMed" ], "id": "7589801" } ], "title": "Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice.", "journal": "Developmental biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155304.1", "id": "NP_001155304.1", "database": "RefSeq" } ], "authors": "Rennebeck GM, Lader E, Chen Q, Bohm RA, Cai ZS, Faust C, Magnuson T, Pease LR, Artzt K", "date": "1995" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9799264", "type": [ "PubMed" ], "id": "9799264" } ], "title": "Mouse Brachyury the Second (T2) is a gene next to classical T and a candidate gene for tct.", "journal": "Genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155304.1", "id": "NP_001155304.1", "database": "RefSeq" } ], "authors": "Rennebeck G, Lader E, Fujimoto A, Lei EP, Artzt K", "date": "1998" } ], "uniprot_ac": "A0A338P791", "site_annotation": [ { "end_pos": 79, "annotation": "n_glycosylation_sequon", "start_pos": 77 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A338P791#A0A338P677-1", "isoform_ac": "A0A338P677-1", "locus": { "end_pos": 8413060, "strand": "-", "start_pos": 8422152, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000169635", "id": "ENSMUST00000169635", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000155866", "id": "ENSMUSP00000155866", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A338P677-1|A0A338P791_MOUSE Computationally mapped isoform of Brachyury 2 OS=Mus musculus OX=10090 GN=T2 PE=4 SV=1 CANONICAL=A0A338P791-1", "length": 183, "sequence": "MCKTRTDSQSKMYLSRLYRMYSTSLANMEFSRKLLERDGRFADMDAEHRARSLLDYMVPRERTQADVPPRERTQADVPPRELEEEDSPTPEQQPQAGPALRFLKCQSPESPQRRPHLKTGRHQVTLCGTSKLSEHERGTLAPARRTTDPRPTAPLTLAHVIQTHPVVEAKTASRYWVNNVDEE" } }, { "url": "https://www.uniprot.org/uniprot/A0A338P791#A0A338P791-1", "isoform_ac": "A0A338P791-1", "locus": { "end_pos": 8372396, "strand": "-", "start_pos": 8422152, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000163578", "id": "ENSMUST00000163578", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000156321", "id": "ENSMUSP00000156321", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A338P791-1|A0A338P791_MOUSE Isoform 1 of Brachyury 2 OS=Mus musculus OX=10090 GN=T2 PE=4 SV=1 CANONICAL=A0A338P791-1", "length": 393, "sequence": "MAQILRDHFKTPKKHRGCHTQVEDKEKAAQQTLPEQSQPEAWSASPPKASTRFPSRSNAYLIIGLQNELTKCGILKNMSDDEDFWKLVQEEALGVGTKEKLQKIKLKLMNPRPWPPAASRRRETEMLVSSDQDSGARQGTQDHPGREQEVVEDGPEKERIKQGPHQPGLDPPKHRGDTASLLARLTEWRKRCQQHGAAQRLHRGPEESKTMCKTRTDSQSKMYLSRLYRMYSTSLANMEFSRKLLERDGRFADMDAEHRARSLLDYMVPRERTQADVPPRERTQADVPPRELEEEDSPTPEQQPQAGPALRFLKCQSPESPQRRPHLKTGRHQVTLCGTSKLSEHERGTLAPARRTTDPRPTAPLTLAHVIQTHPVVEAKTASRYWVNNVDEE" } }, { "url": "https://www.uniprot.org/uniprot/A0A338P791#A0A3Q4EGG8-1", "isoform_ac": "A0A3Q4EGG8-1", "locus": { "end_pos": 8372396, "strand": "-", "start_pos": 8422152, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000234809", "id": "ENSMUST00000234809", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000157191", "id": "ENSMUSP00000157191", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A3Q4EGG8-1|A0A338P791_MOUSE Computationally mapped isoform of Brachyury 2 OS=Mus musculus OX=10090 GN=T2 PE=4 SV=1 CANONICAL=A0A338P791-1", "length": 297, "sequence": "MAQILRDHFKTPKKHRGCHTQVEDKEKAAQQTLPEQSQPEAWSASPPKASTRFPSRSNAYLIIGLQNELTKCGILKNMSDDEDFWKLVQEEALGVGTKEKLQKIKLKLMNPRPWPPAASRRRETEMLVSSDQDSGARQGTQDHPGREQEVVEDGPEKERIKQGPHQPGLDPPKHRGDTASLLARLTEWRKRCQQHGAAQRLHRGPEESKTMCKTRTDSQSKMYLSRLYRMYSTSLANMEFSRKSKLSEHERGTLAPARRTTDPRPTAPLTLAHVIQTHPVVEAKTASRYWVNNVDEE" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:21331", "resource": "KEGG Pathway", "id": "mmu:21331", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155304.1", "annotation": "Tint interacts with brachyury 2 but not with brachyury T1; T2 may be part of the T1 regulatory region through direct or indirect participation of tint GeneRIF: An unlinked modifier of Brachyury (T) called tint, interacts with T2 but not with T1. Highly conserved genomic sequences between mice and humans map to the distal end of T2. T2 may embed the long sought mammalian notochord enhancer of Brachyury.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155304.1", "id": "NP_001155304.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "F1LXU5-1", "protein_name": "Brachyury 2", "sequence": { "length": 377, "sequence": "MSQILRDHLITPKKQRARHTQVDDKEKAAQQILPEQPEAWPASPPKASTRFPPRSDAYLIVGLQNELTRCGILKNMSDYEDFWKLVREEALGVETEEKLQKIKLKLMNPRPWRSAASRRRDTRMLVTTHQDNGTQGHPGRAQEAVEDGLEKERKNQGRHQPGLDPLKHPRDTATLLDRLTEWRKRCQQWETAWRSYRGPEESKIMCKTKTDSQSETYLSRLYQMYFTSLANMEFSRRLLERDGRFAEMDAQHRARSLLDYMVPRGHTQADVPPREPGEEDSPGPGQQPRAGPALRFLKCQSPGSPQRSPHLKTGRHQVTLCGMSKLSEHKRGKLAPAGVTPDPRATAPLTLAHVIQTHPVVEAKTASRYWVNYVDDE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/86977", "id": "86977", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "T2", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155304.1", "ac": "NP_001155304.1", "name": "brachyury 2", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014028", "pmid": "7589801", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A338P791", "id": "A0A338P791", "database": "UniProtKB" } ], "name": "notochord formation", "id": "GO:0014028" } ], "total": 1, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A338P791", "type": "synonym", "resource": "RefSeq", "name": "T2" }, { "url": "https://www.uniprot.org/uniprot/A0A338P791", "type": "recommended", "resource": "UniProtKB", "name": "T2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A338P791", "type": "synonym", "resource": "RefSeq", "name": "brachyury2" } ], "pro_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/gene/21331", "id": "21331", "database": "GeneID" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:21331", "id": "mmu:21331", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:104658", "id": "104658", "database": "MGI" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155304.1", "id": "NP_001155304.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A0A338P791", "id": "A0A338P791", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 44863.0, "chemical_mass": 44863.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A338P791", "name": "T2", "locus": { "end_pos": 8423513, "strand": "+", "start_pos": 8355992, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000058159", "id": "ENSMUSG00000058159", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A338P791#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Brachyury 2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A338P791", "type": "synonym", "resource": "RefSeq", "name": "brachyury 2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A338P791", "type": "synonym", "resource": "RefSeq", "name": "brachyury the second" } ] }