{ "uniprot_canonical_ac": "A0A1B0GUS4-1", "ptm_annotation": [], "sequence": { "header": "sp|A0A1B0GUS4-1|UB2L5_HUMAN Isoform 1 of Ubiquitin-conjugating enzyme E2 L5 OS=Homo sapiens OX=9606 GN=UBE2L5 PE=2 SV=1 CANONICAL=A0A1B0GUS4-1", "length": 154, "sequence": "MAASRRLMKELEEIRKCGMENFRNIQVDEANLLTWQGLIVPDNPPYNKGAFRIEINFPAEYPFKPPRITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYSNDRKKFCKNAEEFTKKYGEKRPVD" }, "uniprot_id": "UB2L5_HUMAN", "enzyme_annotation": [ { "ec": "2.3.2.23", "activity": "" }, { "ec": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine." } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Human", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4", "id": "A0A1B0GUS4", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "publication": [], "uniprot_ac": "A0A1B0GUS4", "site_annotation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4#A0A1B0GUS4-1", "isoform_ac": "A0A1B0GUS4-1", "locus": { "end_pos": 30427991, "strand": "-", "start_pos": 30428452, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000638137", "id": "ENST00000638137", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000490931", "id": "ENSP00000490931", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0A1B0GUS4-1|UB2L5_HUMAN Isoform 1 of Ubiquitin-conjugating enzyme E2 L5 OS=Homo sapiens OX=9606 GN=UBE2L5 PE=2 SV=1 CANONICAL=A0A1B0GUS4-1", "length": 154, "sequence": "MAASRRLMKELEEIRKCGMENFRNIQVDEANLLTWQGLIVPDNPPYNKGAFRIEINFPAEYPFKPPRITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYSNDRKKFCKNAEEFTKKYGEKRPVD" } } ], "pathway": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4#function", "annotation": "Catalyzes the covalent attachment of ubiquitin to other proteins.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4#function", "id": "A0A1B0GUS4", "database": "UniProtKB" } ] } ], "orthologs": [], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4", "id": "A0A1B0GUS4", "database": "UniProtKB" } ], "name": "ubiquitin protein ligase binding", "id": "GO:0031625" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061631", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4", "id": "A0A1B0GUS4", "database": "UniProtKB" } ], "name": "ubiquitin conjugating enzyme activity", "id": "GO:0061631" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4", "id": "A0A1B0GUS4", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016874", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4", "id": "A0A1B0GUS4", "database": "UniProtKB" } ], "name": "ligase activity", "id": "GO:0016874" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4", "id": "A0A1B0GUS4", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4", "id": "A0A1B0GUS4", "database": "UniProtKB" } ], "name": "ubiquitin ligase complex", "id": "GO:0000151" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070979", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4", "id": "A0A1B0GUS4", "database": "UniProtKB" } ], "name": "protein K11-linked ubiquitination", "id": "GO:0070979" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4", "id": "A0A1B0GUS4", "database": "UniProtKB" } ], "name": "protein polyubiquitination", "id": "GO:0000209" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4", "id": "A0A1B0GUS4", "database": "UniProtKB" } ], "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4", "type": "recommended", "resource": "UniProtKB", "name": "UBE2L5" } ], "pro_annotation": [], "crossref": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A1B0GUS4", "id": "A0A1B0GUS4", "database": "BioMuta" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00195", "id": "cd00195", "database": "CDD" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=UBE2L5", "id": "UBE2L5", "database": "GeneCards" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=13477", "id": "13477", "database": "HGNC" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000608", "id": "IPR000608", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016135", "id": "IPR016135", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR023313", "id": "IPR023313", "database": "InterPro" }, { "url": "https://www.nextprot.org/entry/NX_A0A1B0GUS4", "id": "NX_A0A1B0GUS4", "database": "neXtProt" }, { "url": "https://omabrowser.org/oma/group/HAKIWIS/", "id": "HAKIWIS", "database": "OMA" }, { "url": "http://pfam.xfam.org/family/PF00179", "id": "PF00179", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A0A1B0GUS4", "id": "PR_A0A1B0GUS4", "database": "PRO" }, { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4", "id": "A0A1B0GUS4", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 17875.0, "chemical_mass": 17875.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4", "name": "UBE2L5", "locus": { "end_pos": 30428616, "strand": "+", "start_pos": 30422488, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSG00000236444", "id": "ENSG00000236444", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "2.3.2.23" }, { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Ubiquitin-conjugating enzyme E2 L5" }, { "url": "https://www.uniprot.org/uniprot/A0A1B0GUS4#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Ubiquitin-protein ligase L5" } ] }