{ "uniprot_canonical_ac": "A0A1B0GSF4-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A1B0GSF4-1|A0A1B0GSF4_MOUSE Isoform 1 of Olfactory receptor OS=Mus musculus OX=10090 GN=Olfr65 PE=3 SV=2 CANONICAL=A0A1B0GSF4-1", "length": 315, "sequence": "MPSMWLNISSSPFLLTGFPGLEKAHHLISLPLLMAYISILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLSVLWLNHREIGHGACFSQAYFIHTLSIVESGVLLAMAYDRFIAIRNPLRYTTILTDTKVIKIGIGVVMRAGLSIMPIIIRLHWFPYCRSHVLSHAFCLHQDVIKLACADITFNRLYPVVVVFAMVLLDFLIIFFSYVLILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKNVPHVVHITMSYVYFLFPPFMNPVIYSIKTKQIQSGLLRLFSLPCSKT" }, "uniprot_id": "A0A1B0GSF4_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GSF4", "id": "A0A1B0GSF4", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10220430", "type": [ "PubMed" ], "id": "10220430" } ], "title": "Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038644.2", "id": "NP_038644.2", "database": "RefSeq" } ], "authors": "Bulger M, van Doorninck JH, Saitoh N, Telling A, Farrell C, Bender MA, Felsenfeld G, Axel R, Groudine M", "date": "1999" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11121057", "type": [ "PubMed" ], "id": "11121057" } ], "title": "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038644.2", "id": "NP_038644.2", "database": "RefSeq" } ], "authors": "Bulger M, Bender MA, van Doorninck JH, Wertman B, Farrell CM, Felsenfeld G, Groudine M, Hardison R", "date": "2000" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17350283", "type": [ "PubMed" ], "id": "17350283" } ], "title": "Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse.", "journal": "Molecular and cellular neurosciences", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038644.2", "id": "NP_038644.2", "database": "RefSeq" } ], "authors": "Hirota J, Omura M, Mombaerts P", "date": "2007" } ], "uniprot_ac": "A0A1B0GSF4", "site_annotation": [ { "end_pos": 45, "annotation": "n_glycosylation_sequon", "start_pos": 43 }, { "end_pos": 9, "annotation": "n_glycosylation_sequon", "start_pos": 7 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GSF4#A0A1B0GSF4-1", "isoform_ac": "A0A1B0GSF4-1", "locus": { "end_pos": 103906441, "strand": "-", "start_pos": 103907385, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000209528", "id": "ENSMUST00000209528", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000147914", "id": "ENSMUSP00000147914", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1B0GSF4-1|A0A1B0GSF4_MOUSE Isoform 1 of Olfactory receptor OS=Mus musculus OX=10090 GN=Olfr65 PE=3 SV=2 CANONICAL=A0A1B0GSF4-1", "length": 315, "sequence": "MPSMWLNISSSPFLLTGFPGLEKAHHLISLPLLMAYISILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLSVLWLNHREIGHGACFSQAYFIHTLSIVESGVLLAMAYDRFIAIRNPLRYTTILTDTKVIKIGIGVVMRAGLSIMPIIIRLHWFPYCRSHVLSHAFCLHQDVIKLACADITFNRLYPVVVVFAMVLLDFLIIFFSYVLILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKNVPHVVHITMSYVYFLFPPFMNPVIYSIKTKQIQSGLLRLFSLPCSKT" } }, { "url": "https://www.uniprot.org/uniprot/A0A1B0GSF4#E9PYY9-1", "isoform_ac": "E9PYY9-1", "locus": { "end_pos": 103906450, "strand": "-", "start_pos": 103907385, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000106864", "id": "ENSMUST00000106864", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000102477", "id": "ENSMUSP00000102477", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9PYY9-1|A0A1B0GSF4_MOUSE Computationally mapped isoform of Olfactory receptor OS=Mus musculus OX=10090 GN=Olfr65 PE=3 SV=2 CANONICAL=A0A1B0GSF4-1", "length": 312, "sequence": "MWLNISSSPFLLTGFPGLEKAHHLISLPLLMAYISILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLSVLWLNHREIGHGACFSQAYFIHTLSIVESGVLLAMAYDRFIAIRNPLRYTTILTDTKVIKIGIGVVMRAGLSIMPIIIRLHWFPYCRSHVLSHAFCLHQDVIKLACADITFNRLYPVVVVFAMVLLDFLIIFFSYVLILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKNVPHVVHITMSYVYFLFPPFMNPVIYSIKTKQIQSGLLRLFSLPCSKT" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18365", "resource": "KEGG Pathway", "id": "mmu:18365", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-381753", "resource": "Reactome", "id": "R-MMU-381753", "name": "Olfactory Signaling Pathway" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "D3ZTS9-1", "protein_name": "Olfactory receptor", "sequence": { "length": 315, "sequence": "MPTMWLNISSSPFLLTGFPGLEKAHHLISLPLLMAYISILLGNGTLLFLIKDDHNLHEPMYYFLGMLAATDLGVTLTTMPTVLGVLWLNHREIGHGACFSQAYLIHTLSIVESGVLLAMAYDRFIAIRNPLRYTTILTDTRVIKIGIGVVMRAGLSIMPIIIRLYWFPYCRSHVLSHAFCLHQDVIKLACADISFNRLYPVVVVFAMVLLDFLVIFFSYILILKTVMGIASTDERAKALNTCVSHICCILVFYVTVVGLTFIHRFGKHVPHVVHITMSYIYFLFPPFMNPVIYSIKTKQIQSGLLRLFSLPWSKT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/66459", "id": "66459", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Olr132", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9H340-1", "protein_name": "Olfactory receptor 51B6", "sequence": { "length": 312, "sequence": "MGLNKSASTFQLTGFPGMEKAHHWIFIPLLAAYISILLGNGTLLFLIRNDHNLHEPMYYFLAMLAATDLGVTLTTMPTVLGVLWLDHREIGHGACFSQAYFIHTLSVMESGVLLAMAYDCFITIRSPLRYTSILTNTQVMKIGVRVLTRAGLSIMPIVVRLHWFPYCRSHVLSHAFCLHQDVIKLACADITFNRLYPVVVLFAMVLLDFLIIFFSYILILKTVMGIGSGGERAKALNTCVSHICCILVFYVTVVCLTFIHRFGKHVPHVVHITMSYIHFLFPPFMNPFIYSIKTKQIQSGILRLFSLPHSRA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/66459", "id": "66459", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "OR51B6", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038644.2", "ac": "NP_038644.2", "name": "olfactory receptor 65", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]." }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "pmid": "14611657", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GSF4", "id": "A0A1B0GSF4", "database": "UniProtKB" } ], "name": "olfactory receptor activity", "id": "GO:0004984" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GSF4", "id": "A0A1B0GSF4", "database": "UniProtKB" } ], "name": "G protein-coupled receptor activity", "id": "GO:0004930" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GSF4", "id": "A0A1B0GSF4", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "14611657", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GSF4", "id": "A0A1B0GSF4", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "pmid": "14611657", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GSF4", "id": "A0A1B0GSF4", "database": "UniProtKB" } ], "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007608", "pmid": "14611657", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GSF4", "id": "A0A1B0GSF4", "database": "UniProtKB" } ], "name": "sensory perception of smell", "id": "GO:0007608" } ], "total": 2, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A1B0GSF4", "type": "synonym", "resource": "RefSeq", "name": "5'beta3; 5'[b]3; MOR1; MOR1-1; MOR1-2; Olfr64; ORL670" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A1B0GSF4", "type": "synonym", "resource": "RefSeq", "name": "Olfr65" }, { "url": "https://www.uniprot.org/uniprot/A0A1B0GSF4", "type": "recommended", "resource": "UniProtKB", "name": "Olfr65" } ], "pro_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/gene/18365", "id": "18365", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "id": "IPR000276", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "id": "IPR000725", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "id": "IPR017452", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18365", "id": "mmu:18365", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:1341910", "id": "1341910", "database": "MGI" }, { "url": "http://www.orthodb.org/?query=877122at2759", "id": "877122at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF13853", "id": "PF13853", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-381753", "id": "R-MMU-381753", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038644.2", "id": "NP_038644.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A0A1B0GSF4", "id": "A0A1B0GSF4", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 35532.0, "chemical_mass": 35532.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GSF4", "name": "Olfr65", "locus": { "end_pos": 103908650, "strand": "+", "start_pos": 103903487, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000110259", "id": "ENSMUSG00000110259", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A1B0GSF4", "type": "synonym", "resource": "RefSeq", "name": "GA_x6K02T2PBJ9-6634906-6633983" }, { "url": "https://www.uniprot.org/uniprot/A0A1B0GSF4#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Olfactory receptor" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A1B0GSF4", "type": "synonym", "resource": "RefSeq", "name": "olfactory receptor 65" } ] }