{ "uniprot_canonical_ac": "A0A0U1RPR8-1", "ptm_annotation": [], "sequence": { "header": "sp|A0A0U1RPR8-1|GUC2D_MOUSE Isoform 1 of Guanylate cyclase D OS=Mus musculus OX=10090 GN=Gucy2d PE=2 SV=1 CANONICAL=A0A0U1RPR8-1", "length": 1117, "sequence": "MAGLQQGCHFEGQNWTAPHWKTCLPCQGPWRLTVSHLKTVSSISVLSVVFWSVLLWADSLSLLAWARETFTLGVLGPWDCDPIFAQALPSIATQLAVDQVNQDASLLPGSQLDFKVLPTGCDTPHALATFVAHKNIVAAFVGPVNPGFCSAAALLAQGWGKSLFSWACEAPEGGGDLVPTLPSAADVLLSVMRHFGWARWAIVSSHQDIWVTTAQQLATAFRTHGLPIGLVTSLGPGEKGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTTLLHCAWEEGLTDGRLVFLPYDTLLFALPYGNRSYLVLDDHGPLQEAYDAVLTVSLESSPESHAFTATEMSGGATANLEPEQVSPLFGTIYDAVILLAHALNRSETHGAGLSGAHLGDHVRALDVAGFSQRIRTDGKGRRLAQYVILDTDGEGSQLVPTHILDTSTWQVQPLGKPIHFPGGSPPAHDASCWFDPNTLCIRGVQPLGSLLTLTIACVLALVGGFLAYFIRLGLQQLRLLRGPHRILLTSQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPRSVTQGSARSLPAFLEHTNVALYQGEWVWLKKFEAGVAPDLRPSSLSFLRKLREMRHENVTAFLGLFVGPGVSAMVLEHCARGSLEDLLQNENLRLDWTFKASLLLDLIRGLRYLHHRRFPHGRLKSRNCVVDTRFVLKITDHGYAEFLESHCSSRPQPAPEELLWTAPELLRGPGKATFKGDVFSLAIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQFKSINQGKKTSVVDSMLRMLEKYSESLEDLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTLFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANLALDILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSQSTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKVGFCRPLPTPLSIKPGDPWQDRINQEIRTGFAKARQGLAEPRKSGEAGPGP" }, "uniprot_id": "GUC2D_MOUSE", "enzyme_annotation": [ { "ec": "4.6.1.2", "activity": "" }, { "ec": "4.6.1.2", "activity": "GTP = 3',5'-cyclic GMP + diphosphate." } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14993224", "type": [ "PubMed" ], "id": "14993224" } ], "title": "Guanylyl cyclase-activating proteins (GCAPs) are Ca2+/Mg2+ sensors: implications for photoreceptor guanylyl cyclase (RetGC) regulation in mammalian photoreceptors.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "id": "NP_001124165.1", "database": "RefSeq" } ], "authors": "Peshenko IV, Dizhoor AM", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17702944", "type": [ "PubMed" ], "id": "17702944" } ], "title": "Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse.", "journal": "Science", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "authors": "Luo M., Zhong C., Hu J., Ding C., Walz A., Chi Q., Matsunami H., Mombaerts P.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17724338", "type": [ "PubMed" ], "id": "17724338" } ], "title": "Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "authors": "Garbers D.L., Reed R.R., Biel M., Michalakis S., Leinders-Zufall T., Munger S.D., Zufall F., Cockerham R.E.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20637621", "type": [ "PubMed" ], "id": "20637621" } ], "title": "An olfactory subsystem that detects carbon disulfide and mediates food-related social learning.", "journal": "Curr. Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "authors": "Schmid A., Biel M., Wandernoth P., Wennemuth G., Kelliher K.R., Leinders-Zufall T., Munger S.D., Zufall F., Cockerham R.E., McDougall L.M.", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22623665", "type": [ "PubMed" ], "id": "22623665" } ], "title": "Retinal guanylyl cyclase isozyme 1 is the preferential in vivo target for constitutively active GCAP1 mutants causing congenital degeneration of photoreceptors.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "id": "NP_001124165.1", "database": "RefSeq" } ], "authors": "Olshevskaya EV, Peshenko IV, Savchenko AB, Dizhoor AM", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27703005", "type": [ "PubMed" ], "id": "27703005" } ], "title": "The R838S Mutation in Retinal Guanylyl Cyclase 1 (RetGC1) Alters Calcium Sensitivity of cGMP Synthesis in the Retina and Causes Blindness in Transgenic Mice.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "id": "NP_001124165.1", "database": "RefSeq" } ], "authors": "Dizhoor AM, Olshevskaya EV, Peshenko IV", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27881908", "type": [ "PubMed" ], "id": "27881908" } ], "title": "Functional study of two biochemically unusual mutations in GUCY2D Leber congenital amaurosis expressed via adenoassociated virus vector in mouse retinas.", "journal": "Molecular vision", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "id": "NP_001124165.1", "database": "RefSeq" } ], "authors": "Boye SL, Olshevskaya EV, Peshenko IV, McCullough KT, Boye SE, Dizhoor AM", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8838319", "type": [ "PubMed" ], "id": "8838319" } ], "title": "Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina.", "journal": "Genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "id": "NP_001124165.1", "database": "RefSeq" } ], "authors": "Yang RB, Fulle HJ, Garbers DL", "date": "1996" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9096404", "type": [ "PubMed" ], "id": "9096404" } ], "title": "A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "authors": "Beavo J.A., Garbers D.L., Houslay M.D., Zhao A.Z., Fuelle H.J., Juilfs D.M.", "date": "1997" } ], "uniprot_ac": "A0A0U1RPR8", "site_annotation": [ { "end_pos": 16, "annotation": "n_glycosylation_sequon", "start_pos": 14 }, { "end_pos": 306, "annotation": "n_glycosylation_sequon", "start_pos": 304 }, { "end_pos": 376, "annotation": "n_glycosylation_sequon", "start_pos": 374 }, { "end_pos": 613, "annotation": "n_glycosylation_sequon", "start_pos": 611 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8#A0A0U1RPB5-1", "isoform_ac": "A0A0U1RPB5-1", "locus": { "end_pos": 98467694, "strand": "-", "start_pos": 98474743, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000205350", "id": "ENSMUST00000205350", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000145913", "id": "ENSMUSP00000145913", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0U1RPB5-1|GUC2D_MOUSE Computationally mapped isoform of Guanylate cyclase D OS=Mus musculus OX=10090 GN=Gucy2d PE=2 SV=1 CANONICAL=A0A0U1RPR8-1", "length": 178, "sequence": "PIEVVGFLNDLYTLFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANLALDILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSQSTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKVGFCRPLPTPLSIKPG" } }, { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8#A0A0U1RPR8-1", "isoform_ac": "A0A0U1RPR8-1", "locus": { "end_pos": 98440509, "strand": "-", "start_pos": 98477289, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000206435", "id": "ENSMUST00000206435", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000146093", "id": "ENSMUSP00000146093", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A0A0U1RPR8-1|GUC2D_MOUSE Isoform 1 of Guanylate cyclase D OS=Mus musculus OX=10090 GN=Gucy2d PE=2 SV=1 CANONICAL=A0A0U1RPR8-1", "length": 1117, "sequence": "MAGLQQGCHFEGQNWTAPHWKTCLPCQGPWRLTVSHLKTVSSISVLSVVFWSVLLWADSLSLLAWARETFTLGVLGPWDCDPIFAQALPSIATQLAVDQVNQDASLLPGSQLDFKVLPTGCDTPHALATFVAHKNIVAAFVGPVNPGFCSAAALLAQGWGKSLFSWACEAPEGGGDLVPTLPSAADVLLSVMRHFGWARWAIVSSHQDIWVTTAQQLATAFRTHGLPIGLVTSLGPGEKGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTTLLHCAWEEGLTDGRLVFLPYDTLLFALPYGNRSYLVLDDHGPLQEAYDAVLTVSLESSPESHAFTATEMSGGATANLEPEQVSPLFGTIYDAVILLAHALNRSETHGAGLSGAHLGDHVRALDVAGFSQRIRTDGKGRRLAQYVILDTDGEGSQLVPTHILDTSTWQVQPLGKPIHFPGGSPPAHDASCWFDPNTLCIRGVQPLGSLLTLTIACVLALVGGFLAYFIRLGLQQLRLLRGPHRILLTSQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPRSVTQGSARSLPAFLEHTNVALYQGEWVWLKKFEAGVAPDLRPSSLSFLRKLREMRHENVTAFLGLFVGPGVSAMVLEHCARGSLEDLLQNENLRLDWTFKASLLLDLIRGLRYLHHRRFPHGRLKSRNCVVDTRFVLKITDHGYAEFLESHCSSRPQPAPEELLWTAPELLRGPGKATFKGDVFSLAIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQFKSINQGKKTSVVDSMLRMLEKYSESLEDLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTLFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANLALDILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSQSTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKVGFCRPLPTPLSIKPGDPWQDRINQEIRTGFAKARQGLAEPRKSGEAGPGP" } }, { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8#F6VFS9-1", "isoform_ac": "F6VFS9-1", "locus": { "end_pos": 98443421, "strand": "-", "start_pos": 98477289, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000098274", "id": "ENSMUST00000098274", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000095875", "id": "ENSMUSP00000095875", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6VFS9-1|GUC2D_MOUSE Computationally mapped isoform of Guanylate cyclase D OS=Mus musculus OX=10090 GN=Gucy2d PE=2 SV=1 CANONICAL=A0A0U1RPR8-1", "length": 1116, "sequence": "SGLQQGCHFEGQNWTAPHWKTCLPCQGPWRLTVSHLKTVSSISVLSVVFWSVLLWADSLSLLAWARETFTLGVLGPWDCDPIFAQALPSIATQLAVDQVNQDASLLPGSQLDFKVLPTGCDTPHALATFVAHKNIVAAFVGPVNPGFCSAAALLAQGWGKSLFSWACEAPEGGGDLVPTLPSAADVLLSVMRHFGWARWAIVSSHQDIWVTTAQQLATAFRTHGLPIGLVTSLGPGEKGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTTLLHCAWEEGLTDGRLVFLPYDTLLFALPYGNRSYLVLDDHGPLQEAYDAVLTVSLESSPESHAFTATEMSGGATANLEPEQVSPLFGTIYDAVILLAHALNRSETHGAGLSGAHLGDHVRALDVAGFSQRIRTDGKGRRLAQYVILDTDGEGSQLVPTHILDTSTWQVQPLGKPIHFPGGSPPAHDASCWFDPNTLCIRGVQPLGSLLTLTIACVLALVGGFLAYFIRLGLQQLRLLRGPHRILLTSQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPRSVTQGSARSLPAFLEHTNVALYQGEWVWLKKFEAGVAPDLRPSSLSFLRKLREMRHENVTAFLGLFVGPGVSAMVLEHCARGSLEDLLQNENLRLDWTFKASLLLDLIRGLRYLHHRRFPHGRLKSRNCVVDTRFVLKITDHGYAEFLESHCSSRPQPAPEELLWTAPELLRGPGKATFKGDVFSLAIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQFKSINQGKKTSVVDSMLRMLEKYSESLEDLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTLFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANLALDILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSQSTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKVGFCRPLPTPLSIKPGDPWQDRINQEIRTGFAKARQGLAEPRKSGEAGPGP" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14918", "resource": "KEGG Pathway", "id": "mmu:14918", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8#function", "annotation": "Functions as an olfactory receptor activated by urine odorants, uroguanylin and guanylin and as well by the volatile semiochemicals carbon disulfide (CS2) and carbon dioxide (CO2) (PubMed:17724338, PubMed:17702944, PubMed:20637621). Has guanylate cyclase activity upon binding of the ligand (By similarity). Activation of GUCY2D neurons leads to the cGMP-dependent activation of the CNGA3 channels, membrane depolarization and an increase in action potential frequency (PubMed:17724338, PubMed:20637621). Signaling pathways activated by GUCY2D may trigger social behaviors such as acquisition of food preference (PubMed:20637621).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8#function", "id": "A0A0U1RPR8", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "annotation": "Mg(2+) binding to GCAPs is critical for setting the actual dynamic range of RetGC regulation by GCAPs at physiological levels of free Ca(2+)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "id": "NP_001124165.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "annotation": "The S248W mutation contributes to Leber congenital amaurosis 1 by hampering the expression, processing, and/or cellular transport of GUCY2D, rather than its enzymatic properties. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "id": "NP_001124165.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "annotation": "This mouse model provides the first direct biochemical and physiological in vivo evidence for the Arg(838) substitutions in RetGC1 being the culprit behind the pathogenesis of the CORD6 congenital blindness.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "id": "NP_001124165.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P51839-1", "protein_name": "Guanylate cyclase 2D", "sequence": { "length": 1110, "sequence": "MAGLQQGCHPEGQDWTAPHWKTCRPCQGPRGLTVRHLRTVSSISVFSVVFWGVLLWADSLSLPAWARETFTLGVLGPWDCDPIFAQALPSMATQLAVDRVNQDASLLLGSQLDFKILPTGCDTPHALATFVAHRNTVAAFIGPVNPGYCPAAALLAQGWGKSLFSWACGAPEGGGALVPTLPSMADVLLSVMRHFGWARLAIVSSHQDIWVTTAQQLATAFRAHGLPIGLITSLGPGEKGATEVCKQLHSVHGLKIVVLCMHSALLGGLEQTVLLRCARKEGLTDGRLVFLPYDTLLFALPYRNRSYLVLDDDGPLQEAYDAVLTISLDTSPESHAFTATKMRGGTAANLGPEQVSPLFGTIYDAVILLAHALNHSEAHGTGLSGAHLGNHIRALDVAGFSQRIRIDGKGRRLPQYVILDTNGEGSQLVPTHILDVSTQQVQPLGTAVHFPGGSPPARDASCWFDPNTLCIRGVQPLGSLLTLTITCVLALVGGFLAYFIRLGLQQLRLLRGPHRILLTPQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPQSVIQGSTRSVPAFLEHTNVALYQGEWVWLKKFEAGTAPDLRPSSLSLLRKMREMRHENVTAFLGLFVGPEVSAMVLEHCARGSLEDLLRNEDLRLDWTFKASLLLDLIRGLRYLHHRHFPHGRLKSRNCVVDTRFVLKITDHGYAEFLESHCSFRPQPAPEELLWTAPELLRGPRRPWGPGKATFKGDVFSLGIILQEVLTRDPPYCSWGLSAEEIIRKVASPPPLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPSLDQIYTQFKSINQGKKTSVADSMLRMLEKYSQSLEGLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTMFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEIANMALEILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSRNTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLTGKTGFCRSLPTPLSIQPGDPWQDHINQEIRTGFAKLARVG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/71540", "id": "71540", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0U1RPR8/", "id": "A0A0U1RPR8", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Gucy2d", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124165.1", "ac": "NP_001124165.1", "name": "guanylate cyclase D precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "pmid": "17724338", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "olfactory receptor activity", "id": "GO:0004984" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005549", "pmid": "17724338", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "odorant binding", "id": "GO:0005549" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001653", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "peptide receptor activity", "id": "GO:0001653" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004383", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "guanylate cyclase activity", "id": "GO:0004383" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "protein kinase activity", "id": "GO:0004672" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016941", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "natriuretic peptide receptor activity", "id": "GO:0016941" } ], "total": 7, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097730", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "non-motile cilium", "id": "GO:0097730" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060170", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "ciliary membrane", "id": "GO:0060170" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042048", "pmid": "20637621", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", "id": "A0A0U1RPR8", "database": "UniProtKB" } ], "name": "olfactory behavior", "id": "GO:0042048" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8", 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"ENSMUSG00000074003", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "4.6.1.2" }, { "url": "https://www.uniprot.org/uniprot/A0A0U1RPR8#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Guanylate cyclase D" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0U1RPR8", "type": "synonym", "resource": "RefSeq", "name": "guanylate cyclase D precursor" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0U1RPR8", "type": "synonym", "resource": "RefSeq", "name": "guanylyl cyclase 2d; guanylyl cyclase D; olfactory guanylyl cyclase GC-D; guanylate cyclase D" } ] }