{ "uniprot_canonical_ac": "A0A0J9YV76-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0J9YV76-1|A0A0J9YV76_MOUSE Isoform 1 of 2'-5' oligoadenylate synthetase 1E OS=Mus musculus OX=10090 GN=Oas1e PE=3 SV=1 CANONICAL=A0A0J9YV76-1", "length": 386, "sequence": "MARELFRTPIWRLDNFIEDQLLPDTTFLTELRADIDSISAFLKERCFQGATHPMRVARVVMGGSYDEHNALKGRSEANMVVFFNDLTSFEDQLKWQQVFIEEIRKHLLQLQQEKPCKLKFEVQSSEEPNTRSLTFKLCSPERQQEVEFDVQPAYDALYEGGYCKSFESINYNKVYAQLIHECTTLEKEGEFSICFTDLHQSFLRYRAPKLWNLIRLVKHWYQLCKEKLRGPLPPQYALELLTVYVWEFGVQDSFGLHAAQCFRTVLELVTKYKCLLIYWTWFYDFRPEISDYLHGQIKKARPLILDPADPTRNVAGSDLQAWDLLAKEAQTWIHSNFFRNCDMSLVNGWEVSLPTVFSGSQAVMDREERKLDFHLSTCWEVLSNSG" }, "uniprot_id": "A0A0J9YV76_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12080145", "type": [ "PubMed" ], "id": "12080145" } ], "title": "Positional cloning of the murine flavivirus resistance gene.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334379.1", "id": "NP_001334379.1", "database": "RefSeq" } ], "authors": "Perelygin AA, Scherbik SV, Zhulin IB, Stockman BM, Li Y, Brinton MA", "date": "2002" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12396720", "type": [ "PubMed" ], "id": "12396720" } ], "title": "Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family.", "journal": "Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334379.1", "id": "NP_001334379.1", "database": "RefSeq" } ], "authors": "Kakuta S, Shibata S, Iwakura Y", "date": "2002" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14559211", "type": [ "PubMed" ], "id": "14559211" } ], "title": "Structural and functional genomics and evolutionary relationships in the cluster of genes encoding murine 2',5'-oligoadenylate synthetases.", "journal": "Genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334379.1", "id": "NP_001334379.1", "database": "RefSeq" } ], "authors": "Mashimo T, Glaser P, Lucas M, Simon-Chazottes D, Ceccaldi PE, Montagutelli X, Despres P, Guenet JL", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17015433", "type": [ "PubMed" ], "id": "17015433" } ], "title": "Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.", "journal": "Genes & development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334379.1", "id": "NP_001334379.1", "database": "RefSeq" } ], "authors": "Evsikov AV, Graber JH, Brockman JM, Hampl A, Holbrook AE, Singh P, Eppig JJ, Solter D, Knowles BB", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21142819", "type": [ "PubMed" ], "id": "21142819" } ], "title": "The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities.", "journal": "Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334379.1", "id": "NP_001334379.1", "database": "RefSeq" } ], "authors": "Kristiansen H, Gad HH, Eskildsen-Larsen S, Despres P, Hartmann R", "date": "2011" } ], "uniprot_ac": "A0A0J9YV76", "site_annotation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76#A0A0J9YV17-1", "isoform_ac": "A0A0J9YV17-1", "locus": { "end_pos": 120791845, "strand": "+", "start_pos": 120795498, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000200786", "id": "ENSMUST00000200786", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000144442", "id": "ENSMUSP00000144442", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0J9YV17-1|A0A0J9YV76_MOUSE Computationally mapped isoform of 2'-5' oligoadenylate synthetase 1E OS=Mus musculus OX=10090 GN=Oas1e PE=3 SV=1 CANONICAL=A0A0J9YV76-1", "length": 106, "sequence": "MARELFRTPIWRLDNFIEDQLLPDTTFLTELRADIDSISAFLKERCFQGATHPMRVARVVMMKGDTASPLNPLTTTKSTPNSSMSAPPWRRRASSPSASPTFIRAS" } }, { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76#A0A0J9YV76-1", "isoform_ac": "A0A0J9YV76-1", "locus": { "end_pos": 120786614, "strand": "+", "start_pos": 120795498, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000201172", "id": "ENSMUST00000201172", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000144529", "id": "ENSMUSP00000144529", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0J9YV76-1|A0A0J9YV76_MOUSE Isoform 1 of 2'-5' oligoadenylate synthetase 1E OS=Mus musculus OX=10090 GN=Oas1e PE=3 SV=1 CANONICAL=A0A0J9YV76-1", "length": 386, "sequence": "MARELFRTPIWRLDNFIEDQLLPDTTFLTELRADIDSISAFLKERCFQGATHPMRVARVVMGGSYDEHNALKGRSEANMVVFFNDLTSFEDQLKWQQVFIEEIRKHLLQLQQEKPCKLKFEVQSSEEPNTRSLTFKLCSPERQQEVEFDVQPAYDALYEGGYCKSFESINYNKVYAQLIHECTTLEKEGEFSICFTDLHQSFLRYRAPKLWNLIRLVKHWYQLCKEKLRGPLPPQYALELLTVYVWEFGVQDSFGLHAAQCFRTVLELVTKYKCLLIYWTWFYDFRPEISDYLHGQIKKARPLILDPADPTRNVAGSDLQAWDLLAKEAQTWIHSNFFRNCDMSLVNGWEVSLPTVFSGSQAVMDREERKLDFHLSTCWEVLSNSG" } }, { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76#Q8C2W3-1", "isoform_ac": "Q8C2W3-1", "locus": { "end_pos": 120786927, "strand": "+", "start_pos": 120795498, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000100785", "id": "ENSMUST00000100785", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000098348", "id": "ENSMUSP00000098348", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q8C2W3-1|A0A0J9YV76_MOUSE Computationally mapped isoform of 2'-5' oligoadenylate synthetase 1E OS=Mus musculus OX=10090 GN=Oas1e PE=3 SV=1 CANONICAL=A0A0J9YV76-1", "length": 356, "sequence": "MARELFRTPIWRLDNFIEDQLLPDTTFLTELRADIDSISAFLKERCFQGATHPMRVARVVMGGSYDEHNALKGRSEANMVVFFNDLTSFEDQLKWQQVFIEEIRKHLLQLQQEKPCKLKFEVQSSEEPNTRSLTFKLCSPERQQEVEFDVQPAYDALYEGGYCKSFESINYNKVYAQLIHECTTLEKEGEFSICFTDLHQSFLRYRAPKLWNLIRLVKHWYQLCKEKLRGPLPPQYALELLTVYVWEFGVQDSFGLHAAQCFRTVLELVTKYKCLLIYWTWFYDFRPEISDYLHGQIKKARPLILDPADPTRNVAGSDLQAWDLLAKEAQTWIHSNFFRNCDMSLVNGWEVSPEKQ" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:231699", "resource": "KEGG Pathway", "id": "mmu:231699", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q8VI95-1", "protein_name": "Inactive 2'-5'-oligoadenylate synthase 1D", "sequence": { "length": 361, "sequence": "MARELFRTPIWRLDKFIEDQLLPDTTFLTELRADIDSISAFLMERCFQGAAHPVRVSRVVMGGCYNEYTVLKGRSEANMVVFLINLTSFEDQFNGQVVFIEEIWRHLLQLQQEKLCKLKFEVQSPKEPNSRFLSFKLSCPERQHELEFDVQPAYDALYEVRHFKPFDSSNYNKVYAQLTHECTTLEKEGEFSICFTDLHQSFLRYRAPKLWNLIRLVKHWYQLCKEKLRGPLPPQYALELLTVYVWEYGIHENPGLHTAQCFRTVLELVTKYKRLRIYWTWCYDFQHEISDYLQGQIKKARPLILDPADPTRNVAGSDLQAWDLLAKEAQIWIDSTFFTNHDMSIVEAWEVMPERQECVFL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/110815", "id": "110815", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Oas1d", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q924S2-1", "protein_name": "Inactive 2'-5' oligoadenylate synthetase 1C", "sequence": { "length": 362, "sequence": "MENGLCSIQARELDEFICDYLFPDTTFLTELRADIDSISAFLKERCFQGAAHPVRVSRVVMGGSYDEHTALKGKSEAKMVLFFNNLTSFEEQLKRRGEFVEEIQKHLCQLQQEKPFKVKFEVQSSEEPNSRSLSFKLSSPELQQEVEFDVQPAYDVLYELRNNTYAEPQFYNKVYAQLIHECTTLEKEGDFSICFTDLHQNFMRYRAPKLWNLIRLVKHWYQLCKEKLREPLPPQYALELLTVYVWEHSNKNQEKVTTAKNFRTFLELVAYYKNLRIYWTWYYDFRHQEVCAYLCRQLKKARPLILDPADPTRNVAGSDLQAWDLLAKEAQTWMQSSCFRNCDMSFVPTWDLSPERQECAFQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/110815", "id": "110815", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Oas1c", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334379.1", "ac": "NP_001334379.1", "name": "2'-5' oligoadenylate synthetase 1E isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003725", "pmid": "12396720", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "double-stranded RNA binding", "id": "GO:0003725" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016779", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "nucleotidyltransferase activity", "id": "GO:0016779" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "defense response to virus", "id": "GO:0051607" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045071", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "negative regulation of viral genome replication", "id": "GO:0045071" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060700", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "name": "regulation of ribonuclease activity", "id": "GO:0060700" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0J9YV76", "type": "synonym", "resource": "RefSeq", "name": "C87484; oasl7" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0J9YV76", "type": "synonym", "resource": "RefSeq", "name": "Oas1e" }, { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "type": "recommended", "resource": "UniProtKB", "name": "Oas1e" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000066867", "id": "ENSMUSG00000066867", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05400", "id": "cd05400", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/231699", "id": "231699", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006116", "id": "IPR006116", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018952", "id": "IPR018952", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR026774", "id": "IPR026774", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR038121", "id": "IPR038121", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR043519", "id": "IPR043519", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:231699", "id": "mmu:231699", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2180856", "id": "2180856", "database": "MGI" }, { "url": "http://www.orthodb.org/?query=611234at2759", "id": "611234at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11258", "id": "PTHR11258", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF10421", "id": "PF10421", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334379.1", "id": "NP_001334379.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "id": "A0A0J9YV76", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 45299.0, "chemical_mass": 45299.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76", "name": "Oas1e", "locus": { "end_pos": 120786226, "strand": "-", "start_pos": 120795530, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000066867", "id": "ENSMUSG00000066867", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0J9YV76", "type": "synonym", "resource": "RefSeq", "name": "2'-5' oligoadenylate synthetase 1E isoform 1" }, { "url": "https://www.uniprot.org/uniprot/A0A0J9YV76#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "2'-5' oligoadenylate synthetase 1E" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0J9YV76", "type": "synonym", "resource": "RefSeq", "name": "2,5-oligoadenylate synthetase-like 7; 2'-5'olygoadenylate synthetase 1E; 2'-5' oligoadenylate synthetase-like 7" } ] }