{
    "uniprot_canonical_ac": "A0A0H2UHM7-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A0A0H2UHM7-1|A0A0H2UHM7_RAT Isoform 1 of Tubulin alpha chain  OS=Rattus norvegicus OX=10116 GN=LOC100909441 PE=3 SV=1 CANONICAL=A0A0H2UHM7-1", 
        "length": 448, 
        "sequence": "RECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLARVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGADSAEGDDEGEEY"
    }, 
    "uniprot_id": "A0A0H2UHM7_RAT", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0H2UHM7", 
                    "id": "A0A0H2UHM7", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [], 
    "uniprot_ac": "A0A0H2UHM7", 
    "site_annotation": [
        {
            "end_pos": 381, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 379
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0H2UHM7#A0A0H2UHM7-1", 
            "isoform_ac": "A0A0H2UHM7-1", 
            "locus": {
                "end_pos": 199199845, 
                "strand": "-", 
                "start_pos": 199203634, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000020932", 
                        "id": "ENSRNOT00000020932", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000020932", 
                        "id": "ENSRNOP00000020932", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0H2UHM7-1|A0A0H2UHM7_RAT Isoform 1 of Tubulin alpha chain  OS=Rattus norvegicus OX=10116 GN=LOC100909441 PE=3 SV=1 CANONICAL=A0A0H2UHM7-1", 
                "length": 448, 
                "sequence": "RECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLARVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGADSAEGDDEGEEY"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-190840", 
            "resource": "Reactome", 
            "id": "R-RNO-190840", 
            "name": "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2132295", 
            "resource": "Reactome", 
            "id": "R-RNO-2132295", 
            "name": "MHC class II antigen presentation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2467813", 
            "resource": "Reactome", 
            "id": "R-RNO-2467813", 
            "name": "Separation of Sister Chromatids"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2500257", 
            "resource": "Reactome", 
            "id": "R-RNO-2500257", 
            "name": "Resolution of Sister Chromatid Cohesion"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3371497", 
            "resource": "Reactome", 
            "id": "R-RNO-3371497", 
            "name": "HSP90 chaperone cycle for steroid hormone receptors (SHR)"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-380320", 
            "resource": "Reactome", 
            "id": "R-RNO-380320", 
            "name": "Recruitment of NuMA to mitotic centrosomes"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-437239", 
            "resource": "Reactome", 
            "id": "R-RNO-437239", 
            "name": "Recycling pathway of L1"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5610787", 
            "resource": "Reactome", 
            "id": "R-RNO-5610787", 
            "name": "Hedgehog 'off' state"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5617833", 
            "resource": "Reactome", 
            "id": "R-RNO-5617833", 
            "name": "Cilium Assembly"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5620924", 
            "resource": "Reactome", 
            "id": "R-RNO-5620924", 
            "name": "Intraflagellar transport"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5626467", 
            "resource": "Reactome", 
            "id": "R-RNO-5626467", 
            "name": "RHO GTPases activate IQGAPs"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5663220", 
            "resource": "Reactome", 
            "id": "R-RNO-5663220", 
            "name": "RHO GTPases Activate Formins"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6807878", 
            "resource": "Reactome", 
            "id": "R-RNO-6807878", 
            "name": "COPI-mediated anterograde transport"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6811434", 
            "resource": "Reactome", 
            "id": "R-RNO-6811434", 
            "name": "COPI-dependent Golgi-to-ER retrograde traffic"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6811436", 
            "resource": "Reactome", 
            "id": "R-RNO-6811436", 
            "name": "COPI-independent Golgi-to-ER retrograde traffic"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-68877", 
            "resource": "Reactome", 
            "id": "R-RNO-68877", 
            "name": "Mitotic Prometaphase"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8852276", 
            "resource": "Reactome", 
            "id": "R-RNO-8852276", 
            "name": "The role of GTSE1 in G2/M progression after G2 checkpoint"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8955332", 
            "resource": "Reactome", 
            "id": "R-RNO-8955332", 
            "name": "Carboxyterminal post-translational modifications of tubulin"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9646399", 
            "resource": "Reactome", 
            "id": "R-RNO-9646399", 
            "name": "Aggrephagy"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9648025", 
            "resource": "Reactome", 
            "id": "R-RNO-9648025", 
            "name": "EML4 and NUDC in mitotic spindle formation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9668328", 
            "resource": "Reactome", 
            "id": "R-RNO-9668328", 
            "name": "Sealing of the nuclear envelope (NE) by ESCRT-III"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983189", 
            "resource": "Reactome", 
            "id": "R-RNO-983189", 
            "name": "Kinesins"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0H2UHM7#function", 
            "annotation": "Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0H2UHM7#function", 
                    "id": "A0A0H2UHM7", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [], 
    "refseq": {}, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005200", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0H2UHM7", 
                                "id": "A0A0H2UHM7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "structural constituent of cytoskeleton", 
                        "id": "GO:0005200"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0H2UHM7", 
                                "id": "A0A0H2UHM7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "GTP binding", 
                        "id": "GO:0005525"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0H2UHM7", 
                                "id": "A0A0H2UHM7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "GTPase activity", 
                        "id": "GO:0003924"
                    }
                ], 
                "total": 3, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0H2UHM7", 
                                "id": "A0A0H2UHM7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0H2UHM7", 
                                "id": "A0A0H2UHM7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "microtubule", 
                        "id": "GO:0005874"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0H2UHM7", 
                                "id": "A0A0H2UHM7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "mitotic cell cycle", 
                        "id": "GO:0000278"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0H2UHM7", 
                                "id": "A0A0H2UHM7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "microtubule cytoskeleton organization", 
                        "id": "GO:0000226"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007017", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0H2UHM7", 
                                "id": "A0A0H2UHM7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "microtubule-based process", 
                        "id": "GO:0007017"
                    }
                ], 
                "total": 3, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0H2UHM7", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "LOC100909441"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000015544", 
            "id": "ENSRNOG00000015544", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000217", 
            "id": "IPR000217", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002452", 
            "id": "IPR002452", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003008", 
            "id": "IPR003008", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008280", 
            "id": "IPR008280", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017975", 
            "id": "IPR017975", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018316", 
            "id": "IPR018316", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023123", 
            "id": "IPR023123", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036525", 
            "id": "IPR036525", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037103", 
            "id": "IPR037103", 
            "database": "InterPro"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/ILTCHTT/", 
            "id": "ILTCHTT", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11588", 
            "id": "PTHR11588", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00091", 
            "id": "PF00091", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF03953", 
            "id": "PF03953", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-190840", 
            "id": "R-RNO-190840", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2132295", 
            "id": "R-RNO-2132295", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2467813", 
            "id": "R-RNO-2467813", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2500257", 
            "id": "R-RNO-2500257", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3371497", 
            "id": "R-RNO-3371497", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-380320", 
            "id": "R-RNO-380320", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-437239", 
            "id": "R-RNO-437239", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5610787", 
            "id": "R-RNO-5610787", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5617833", 
            "id": "R-RNO-5617833", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5620924", 
            "id": "R-RNO-5620924", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5626467", 
            "id": "R-RNO-5626467", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5663220", 
            "id": "R-RNO-5663220", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6807878", 
            "id": "R-RNO-6807878", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6811434", 
            "id": "R-RNO-6811434", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6811436", 
            "id": "R-RNO-6811436", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-68877", 
            "id": "R-RNO-68877", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8852276", 
            "id": "R-RNO-8852276", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8955332", 
            "id": "R-RNO-8955332", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9646399", 
            "id": "R-RNO-9646399", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9648025", 
            "id": "R-RNO-9648025", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9668328", 
            "id": "R-RNO-9668328", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983189", 
            "id": "R-RNO-983189", 
            "database": "Reactome"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=6503589", 
            "id": "6503589", 
            "database": "RGD"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0H2UHM7", 
            "id": "A0A0H2UHM7", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 49806.0, 
        "chemical_mass": 49806.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0H2UHM7", 
            "name": "LOC100909441", 
            "locus": {
                "end_pos": 199203637, 
                "strand": "+", 
                "start_pos": 199199845, 
                "chromosome": "2", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000015544", 
                        "id": "ENSRNOG00000015544", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0H2UHM7#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Tubulin alpha chain"
        }
    ]
}