{ "uniprot_canonical_ac": "A0A0G2QC64-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2QC64-1|A0A0G2QC64_RAT Isoform 1 of WD repeat domain 34 OS=Rattus norvegicus OX=10116 GN=Wdr34 PE=4 SV=1 CANONICAL=A0A0G2QC64-1", "length": 537, "sequence": "MAISASPRPFPRVGSARVAALAAGGAGGGERRGRPAPLQDETLGVASVPSQWRSVQGIRGEPKSCQTAGIATAEASAQARTHADAQVQTEAPEEPAAVAPVSQYDTLRLAAFLRRVEAMVVRELNNNWQSHAFDGYEVNWTEQQQTVSCLHTLGYPPAQGQGLHVTGISWNTTGSVLACAYGRLDDGDWGTLKSYVCTWNLDRQGLNPHQPSVVVEVPSAVMCLAFHPIQPSHIAGGLYSGEVLVWDMSRPEDPLLWRTGLTDDTHTDPVYQVLWLPEPRHSHRFQVLSAATDGRVLLWRGSGAGQLRLSKGFALAVQQLPRSTKLKKPPRGETEVGVTSVAFSSFDSSLFVLGTEGGFPLKCSLAAEAAALTRMPSSVPLRAPVQFTFSPHGGPVYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAQPLTSLQLSHKYLFAVRWSPVRPLVFAAASGEGDVQLFDLQKSSQKPTVSITQTQDGSPVYCLEFNSQQTQLLAAGDAKGVVKVWQLSTAFTEQGPREAEDLDQLEAEIAT" }, "uniprot_id": "A0A0G2QC64_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC64", "id": "A0A0G2QC64", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25205765", "type": [ "PubMed" ], "id": "25205765" } ], "title": "Subunit composition of the human cytoplasmic dynein-2 complex.", "journal": "Journal of cell science", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005542.2", "id": "NP_001005542.2", "database": "RefSeq" } ], "authors": "Asante D, Stevenson NL, Stephens DJ", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25830415", "type": [ "PubMed" ], "id": "25830415" } ], "title": "Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.", "journal": "Cell cycle (Georgetown, Tex.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005542.2", "id": "NP_001005542.2", "database": "RefSeq" } ], "authors": "Gholkar AA, Senese S, Lo YC, Capri J, Deardorff WJ, Dharmarajan H, Contreras E, Hodara E, Whitelegge JP, Jackson PK, Torres JZ", "date": "2015" } ], "uniprot_ac": "A0A0G2QC64", "site_annotation": [ { "end_pos": 141, "annotation": "n_glycosylation_sequon", "start_pos": 139 }, { "end_pos": 173, "annotation": "n_glycosylation_sequon", "start_pos": 171 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC64#A0A0G2QC64-1", "isoform_ac": "A0A0G2QC64-1", "locus": { "end_pos": 8599350, "strand": "+", "start_pos": 8614714, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000021132", "id": "ENSRNOT00000021132", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000021132", "id": "ENSRNOP00000021132", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2QC64-1|A0A0G2QC64_RAT Isoform 1 of WD repeat domain 34 OS=Rattus norvegicus OX=10116 GN=Wdr34 PE=4 SV=1 CANONICAL=A0A0G2QC64-1", "length": 537, "sequence": "MAISASPRPFPRVGSARVAALAAGGAGGGERRGRPAPLQDETLGVASVPSQWRSVQGIRGEPKSCQTAGIATAEASAQARTHADAQVQTEAPEEPAAVAPVSQYDTLRLAAFLRRVEAMVVRELNNNWQSHAFDGYEVNWTEQQQTVSCLHTLGYPPAQGQGLHVTGISWNTTGSVLACAYGRLDDGDWGTLKSYVCTWNLDRQGLNPHQPSVVVEVPSAVMCLAFHPIQPSHIAGGLYSGEVLVWDMSRPEDPLLWRTGLTDDTHTDPVYQVLWLPEPRHSHRFQVLSAATDGRVLLWRGSGAGQLRLSKGFALAVQQLPRSTKLKKPPRGETEVGVTSVAFSSFDSSLFVLGTEGGFPLKCSLAAEAAALTRMPSSVPLRAPVQFTFSPHGGPVYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAQPLTSLQLSHKYLFAVRWSPVRPLVFAAASGEGDVQLFDLQKSSQKPTVSITQTQDGSPVYCLEFNSQQTQLLAAGDAKGVVKVWQLSTAFTEQGPREAEDLDQLEAEIAT" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:296618", "resource": "KEGG Pathway", "id": "rno:296618", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5620924", "resource": "Reactome", "id": "R-RNO-5620924", "name": "Intraflagellar transport" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q5U4F6-1", "protein_name": "Cytoplasmic dynein 2 intermediate chain 2", "sequence": { "length": 537, "sequence": "MAMCASPRPFRRVGSAGAAALAAGGAGGAERRGRPAPLQDETLGVASVPSQWRSVQGIRGETKSCQTAGIATAESSAQARTHADAQVQTEAPEEPAAMAPVSQYDTLRLEAFLRRVEAMVIRELNNNWQSHAFDGYEVNWTEQQQTVSCLHTLVYPLAQGQGLHVTGISWNSTGSVLACAYGRLDDGDWSTLKSYVCTWNLDRQGLNPQQPSVVVEVPSAVMCLAFHPTQPSHIAGGLYSGEVLVWDMSRPEDPLLWRTGLTDDTHTDPVYQVLWLPEPRHSHRFQVLSAATDGKVLLWRGSGAGQLRLTKGFALAVQQLPRSTKLKKPPRGETEVGVTSVAFSSFDSSLFVLGTEGGFPLKCSLASEVAALTRMPSSVPLRAPVQFTFSPHGGPVYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAQPLTSLQLSHKYLFAVRWSPVRPLVFAAASGEGDVQLFDLQKSSQKPTVSITQTQDGSPVYCLEFNSQQTQLLAAGDAKGMVKVWQLSTAFTEQGPREVEDLDQLEAEITT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/14156", "id": "14156", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Dync2i2", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q96EX3-1", "protein_name": "Cytoplasmic dynein 2 intermediate chain 2", "sequence": { "length": 536, "sequence": "MATRAQPGPLSQAGSAGVAALATVGVASGPGPGRPGPLQDETLGVASVPSQWRAVQGIRWETKSCQTASIATASASAQARNHVDAQVQTEAPVPVSVQPPSQYDIPRLAAFLRRVEAMVIRELNKNWQSHAFDGFEVNWTEQQQMVSCLYTLGYPPAQAQGLHVTSISWNSTGSVVACAYGRLDHGDWSTLKSFVCAWNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQGIGVGQLQLTEGFALVMQQLPRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGTVKVWQLSTEFTEQGPREAEDLDCLAAEVAA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/14156", "id": "14156", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "DYNC2I2", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005542.2", "ac": "NP_001005542.2", "name": "WD repeat-containing protein 34", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045504", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC64", "id": "A0A0G2QC64", "database": "UniProtKB" } ], "name": "dynein heavy chain binding", "id": "GO:0045504" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045503", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC64", "id": "A0A0G2QC64", "database": "UniProtKB" } ], "name": "dynein light chain binding", "id": "GO:0045503" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097014", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC64", "id": "A0A0G2QC64", "database": "UniProtKB" } ], "name": "ciliary plasm", "id": "GO:0097014" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC64", "id": "A0A0G2QC64", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC64", "id": "A0A0G2QC64", "database": "UniProtKB" } ], "name": "centriole", "id": "GO:0005814" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC64", "id": "A0A0G2QC64", "database": "UniProtKB" } ], "name": "axoneme", "id": "GO:0005930" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC64", "id": "A0A0G2QC64", "database": "UniProtKB" } ], "name": "ciliary basal body", "id": "GO:0036064" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005868", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC64", "id": "A0A0G2QC64", "database": "UniProtKB" } ], "name": "cytoplasmic dynein complex", "id": "GO:0005868" } ], "total": 6, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007018", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC64", "id": "A0A0G2QC64", "database": "UniProtKB" } ], "name": "microtubule-based movement", "id": "GO:0007018" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042073", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC64", "id": "A0A0G2QC64", "database": "UniProtKB" } ], "name": "intraciliary transport", "id": "GO:0042073" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC64", "id": "A0A0G2QC64", "database": "UniProtKB" } ], "name": "cilium assembly", "id": "GO:0060271" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2QC64", "type": "synonym", "resource": "RefSeq", "name": "Dync2i2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2QC64", "type": "synonym", "resource": "RefSeq", "name": "Wdr34" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2QC64", "type": "recommended", "resource": "UniProtKB", "name": "Wdr34" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000015636", "id": "ENSRNOG00000015636", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/296618", "id": "296618", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "id": "IPR001680", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "id": "IPR015943", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017986", "id": "IPR017986", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "id": "IPR036322", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:296618", "id": "rno:296618", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/WSCTGSV/", "id": "WSCTGSV", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1453532at2759", "id": "1453532at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00400", "id": "PF00400", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5620924", "id": "R-RNO-5620924", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005542.2", "id": "NP_001005542.2", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1359465", "id": "1359465", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2QC64", "id": "A0A0G2QC64", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [ { "id": "MONDO:0014287", "url": "https://monarchinitiative.org/disease/MONDO:0014287", "resource": "MONDO", "name": "SRTD11", "description": "" }, { "id": "MONDO:0014287", "url": "https://monarchinitiative.org/disease/MONDO:0014287", "resource": "MONDO", "name": "short-rib thoracic dysplasia 11 with or without polydactyly; SRTD11", "description": "" }, { "id": "DOID:0110095", "url": "http://disease-ontology.org/term/DOID:0110095", "resource": "Disease Ontology", "name": "SRTD11", "description": "" } ], "recommended_name": { "id": "DOID:0110095", "url": "http://disease-ontology.org/term/DOID:0110095", "resource": "Disease Ontology", "name": "short-rib thoracic dysplasia 11 with or without polydactyly", "description": "An asphyxiating thoracic dystrophy that has_material_basis_in homozygous or compound heterozygous mutation in the WDR34 gene on chromosome 9q34." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/0110095#disease-associations", "id": "0110095", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [], "mass": { "monoisotopic_mass": 57896.0, "chemical_mass": 57896.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2QC64", "name": "Wdr34", "locus": { "end_pos": 8599148, "strand": "-", "start_pos": 8615532, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000015636", "id": "ENSRNOG00000015636", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2QC64", "type": "synonym", "resource": "RefSeq", "name": "WD repeat domain 34" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2QC64#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "WD repeat domain 34" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2QC64", "type": "synonym", "resource": "RefSeq", "name": "WD repeat-containing protein 34" } ] }