{ "uniprot_canonical_ac": "A0A0G2KB60-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2KB60-1|A0A0G2KB60_RAT Isoform 1 of Non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Rps6kc1 PE=1 SV=1 CANONICAL=A0A0G2KB60-1", "length": 1045, "sequence": "MTSPWGHSADLARFYTVTEPQRHPRGYTIYKVTARVVSRRNPEDVQEIIVWRRYSDFKKLHRELWQIHRNAFRHSELFPPFAKGTVFGRFDKTVIEERRQCAEDLLQFSANIPALYNSKQLQDFFKGGIISDGSELIGPAEAYPDSLANTFSECGTEGFSSDSDLLSLTVDADSLAEVDDGMASRQGSPSRAFGLSVSADSSAVGAVASDIEPSKAEDRESRSLFPSSLKPRLGRRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAESICSLRVTAQLDTGPQPPGALSSRPPWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSECSRNRKTIIPRCVPNMVCLHTYIISEESVFLVLQHAEGGKLWSYISKFLNRSSRESLDIKEARPPMPPRVRLQQPSASPQGSYSVESRGSDTGSMLKVLPLKTSLTPSSQDDSNQEDDGQDSSPKWPDSGSSSEEECTAGYLTLCNEYGQEKLDLTSLNEESVMQPEGENADSQAVRSFPASLTADSASPSTQLKFFPGDEGLEAVCSPRTSDSLRRSKNSPMEFFRIDSKDSTSELLGLDSGEKLHSLKPEPLKALFTLEDGDSPSQSFDAGKSQGESEAQDSISRGSDDSVPVISFKEAASEDVCSAEEGRPDLLVNLPGELQPTKETSAVDPTKFSQASIGRLEAPDVLCLRLSSEQCHDLGQEGPEELSHPTEFRPGGVTPERSAQADLGVLFTATVDHSSSQDQFLFSSLHSESDRLGQVEGAVTSQDLQESLFHIASPCSGAKEDSAHTDTATSEEVLLFTEPSKEGDSEAKVRSVGAGGAEKEVHQIFEDLDQRLAVSARLFIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDGGHIQLTYFSRWSEVEDLCDSDAIARMYCAPEVGAVTEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPDCVSEEARSLIQQLLQFNPMERLGAGVAGVEDIKSHPFFTPVDWAELTR" }, "uniprot_id": "A0A0G2KB60_RAT", "enzyme_annotation": [ { "ec": "2.7.11.1", "activity": "" }, { "ec": "2.7.11.1", "activity": "ATP + a protein = ADP + a phosphoprotein." } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB60", "id": "A0A0G2KB60", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB60", "id": "A0A0G2KB60", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" } ], "uniprot_ac": "A0A0G2KB60", "site_annotation": [ { "end_pos": 422, "annotation": "n_glycosylation_sequon", "start_pos": 420 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB60#A0A0G2KB60-1", "isoform_ac": "A0A0G2KB60-1", "locus": { "end_pos": 109339472, "strand": "+", "start_pos": 109483778, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000087305", "id": "ENSRNOT00000087305", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075665", "id": "ENSRNOP00000075665", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KB60-1|A0A0G2KB60_RAT Isoform 1 of Non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Rps6kc1 PE=1 SV=1 CANONICAL=A0A0G2KB60-1", "length": 1045, "sequence": "MTSPWGHSADLARFYTVTEPQRHPRGYTIYKVTARVVSRRNPEDVQEIIVWRRYSDFKKLHRELWQIHRNAFRHSELFPPFAKGTVFGRFDKTVIEERRQCAEDLLQFSANIPALYNSKQLQDFFKGGIISDGSELIGPAEAYPDSLANTFSECGTEGFSSDSDLLSLTVDADSLAEVDDGMASRQGSPSRAFGLSVSADSSAVGAVASDIEPSKAEDRESRSLFPSSLKPRLGRRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAESICSLRVTAQLDTGPQPPGALSSRPPWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSECSRNRKTIIPRCVPNMVCLHTYIISEESVFLVLQHAEGGKLWSYISKFLNRSSRESLDIKEARPPMPPRVRLQQPSASPQGSYSVESRGSDTGSMLKVLPLKTSLTPSSQDDSNQEDDGQDSSPKWPDSGSSSEEECTAGYLTLCNEYGQEKLDLTSLNEESVMQPEGENADSQAVRSFPASLTADSASPSTQLKFFPGDEGLEAVCSPRTSDSLRRSKNSPMEFFRIDSKDSTSELLGLDSGEKLHSLKPEPLKALFTLEDGDSPSQSFDAGKSQGESEAQDSISRGSDDSVPVISFKEAASEDVCSAEEGRPDLLVNLPGELQPTKETSAVDPTKFSQASIGRLEAPDVLCLRLSSEQCHDLGQEGPEELSHPTEFRPGGVTPERSAQADLGVLFTATVDHSSSQDQFLFSSLHSESDRLGQVEGAVTSQDLQESLFHIASPCSGAKEDSAHTDTATSEEVLLFTEPSKEGDSEAKVRSVGAGGAEKEVHQIFEDLDQRLAVSARLFIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDGGHIQLTYFSRWSEVEDLCDSDAIARMYCAPEVGAVTEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPDCVSEEARSLIQQLLQFNPMERLGAGVAGVEDIKSHPFFTPVDWAELTR" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KB60#D3Z991-1", "isoform_ac": "D3Z991-1", "locus": { "end_pos": 109339472, "strand": "+", "start_pos": 109483778, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000067017", "id": "ENSRNOT00000067017", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000062125", "id": "ENSRNOP00000062125", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3Z991-1|A0A0G2KB60_RAT Computationally mapped isoform of Non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Rps6kc1 PE=1 SV=1 CANONICAL=A0A0G2KB60-1", "length": 1004, "sequence": "MTSPWGHSADLARFYTVTEPQRHPRGYTIYKVTARVVSRRNPEDVQEIIVWRRYSDFKKLHRELWQIHRNAFRHSELFPPFAKGTVFGRFDKTVIEERRQCAEDLLQFSANIPALYNSKQLQDFFKGGIISDGSELIGPAEAYPDSLANTFSECGTEGFSSDSDLLSLTVDADSLAEVDDGMASRQGSPSRAFGLSVSADSSAVGAVASDIEPSKAEDRESRSLFPSSLKPRLGRRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGALSSRPPWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSECSRNRKTIIPRCVPNMVCLHTYIISEESVFLVLQHAEGGKLWSYISKFLNRSSRESLDIKEARPPMPPRVRLQQPSASPQGSYSVESRGSDTGSMLKVLPLKTSLTPSSQDDSNQEDDGQDSSPKWPDSGSSSEEECTAGYLTLCNEYGQEKLDLTSLNEESVMQPEGENADSQAVRSFPASLTADSASPSTQLKFFPGDEGLEAVCSPRTSDSLRRSKNSPMEFFRIDSKDSTSELLGLDSGEKLHSLKPEPLKALFTLEDGDSPSQSFDAGKSQGESEAQDSISRGSDDSVPVISFKEAASEDVCSAEEGRPDLLVNLPGELQPTKETSAVDPTKFSQASIGRLEAPDVLCLRLSSEQCHDLGQEGPEELSHPTEFRPGGVTPERSAQADLGVLFTATVDHSSSQDQFLFSSLHSESDRLGQVEGAVTSQDLQESLFHIASPCSGAKEDSAHTDTATSEEVLLFTEPSKEGDSEAKVRSVGAGGAEKEVHQIFEDLDQRLAVSARLFIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDGGHIQLTYFSRWSEVEDLCDSDAIARMYCAPEVGAVTEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPDCVSEEARSLIQQLLQFNPMERLGAGVAGVEDIKSHPFFTPVDWAELTR" } } ], "pathway": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q8BLK9-1", "protein_name": "Ribosomal protein S6 kinase delta-1", "sequence": { "length": 1056, "sequence": "MTSPWGHSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWRRYSDFKKLHRELWQIHRNAFRHSELFPPFAKGTVFGRFDKTVIEERRQCAEDLLQFSANIPALYNSRQLQDFFKGGVISDGSELIGPAEAYPDSPANAFPECGTEGFSSDSDLLSLTVDADSLAEVDDGMASRQGSPSRTFGLSLSTDSSAVGAVASDSEPSRVEDRESRSLFPSSLKPRLGRRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAESICSLRAAPQLHTGPQPPGSLSSRPPWSLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSECSRNRKTIIPRCVPNMVCLHTYIISEESVFLVLQRAEGGKLWSYISKFLNRSSQESLDIKEGRPSMPPRVCLQQPSASPQGGSSFESRGSDTGSMLKALPLKTSLTPSSQDDSNQEDDGQPSSPKWLDSGSSSEDECTAGYLTLCNEYGQEKMDLVSLSEESVMQPEGDKADTQAVSSPASLATGSVSPSTHLRVFSGGEDLEAVSSPPTSESLSRSKNSPMEFFRIDSKDSTSELLGLDFGEKLHSLKPEPLKALFTLEDGDSPSQSLDPGESKRESEAQDSVSRGSDDSVPVISFKEAAAEAISGAEEGRPDLLVNLPGELQPTKEASAMDPKFSQASAGRLDSKLLEAPDVLCLRLSSEQCHGLGPEGPEELSDPTEFCPGGVIPEHDAQADPGVLFEAAVDHRSSPDQFLFSSLRSESDRLGQVEVVVTAQALQESLFHISSPCSGANKEHSAYADTATSEEVLLFTEPTKEEANSLFQRGSEAQERGVGAGEADKEIHQIFEDLDKRLAASSRFFIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDGGHIQLTYFSRWSEVEDSCDSDAVARMYCAPEVGAVTEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPGCVSEEARSLIQQLLQFNPMERLGAGVAGVEDIKSHPFFTPVDWAELTR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/8244", "id": "8244", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Rps6kc1", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q96S38-1", "protein_name": "Ribosomal protein S6 kinase delta-1", "sequence": { "length": 1066, "sequence": "MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDDGMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSSQDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGNGVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEFFRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTISRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGIIENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAAVDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/8244", "id": "8244", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "RPS6KC1", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006250521.1", "ac": "XP_006250521.1", "name": "ribosomal protein S6 kinase delta-1 isoform X1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB60", "id": "A0A0G2KB60", "database": "UniProtKB" } ], "name": "protein kinase activity", "id": "GO:0004672" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB60", "id": "A0A0G2KB60", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB60", "id": "A0A0G2KB60", "database": "UniProtKB" } ], "name": "phosphatidylinositol binding", "id": "GO:0035091" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB60", "id": "A0A0G2KB60", "database": "UniProtKB" } ], "name": "early endosome", "id": "GO:0005769" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB60", "id": "A0A0G2KB60", "database": "UniProtKB" } ], "name": "postsynaptic density", "id": "GO:0014069" } ], "total": 2, "name": "Cellular Component" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KB60", "type": "synonym", "resource": "RefSeq", "name": "Rps6kc1" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KB60", "type": "recommended", "resource": "UniProtKB", "name": "Rps6kc1" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000003767", "id": "ENSRNOG00000003767", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05576", "id": "cd05576", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07287", "id": "cd07287", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/289342", "id": "289342", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "id": "IPR000719", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "id": "IPR001683", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007330", "id": "IPR007330", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "id": "IPR011009", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035053", "id": "IPR035053", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036181", "id": "IPR036181", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "id": "IPR036871", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR042132", "id": "IPR042132", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/DCSSDGP/", "id": "DCSSDGP", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=255297at2759", "id": "255297at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00069", "id": "PF00069", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00787", "id": "PF00787", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF04212", "id": "PF04212", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006250521.1", "id": "XP_006250521.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306578", "id": "1306578", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KB60", "id": "A0A0G2KB60", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 114891.0, "chemical_mass": 114891.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB60", "name": "Rps6kc1", "locus": { "end_pos": 109338762, "strand": "-", "start_pos": 109483891, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000003767", "id": "ENSRNOG00000003767", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB60#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "2.7.11.1" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KB60#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Non-specific serine/threonine protein kinase" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KB60", "type": "synonym", "resource": "RefSeq", "name": "ribosomal protein S6 kinase delta-1 isoform X1" } ] }