{ "uniprot_canonical_ac": "A0A0G2KB38-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2KB38-1|A0A0G2KB38_RAT Isoform 1 of Speckle type BTB/POZ protein-like OS=Rattus norvegicus OX=10116 GN=Spopl PE=3 SV=1 CANONICAL=A0A0G2KB38-1", "length": 424, "sequence": "MSREPTPPLPGDMSTSPVAESWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSSGPNDKMKWCLRVNPKGLDEESRDYLSLYLLLVSCPKSEVRAKFKFSLLNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEHLQHCLQKRWKHCTALPKELAPPLHCKWCCRQVSVVQDSVNVSGHTNTNTLKVPECRLAEDLGNLWENTRFTDCCFFVRGKEFKAHKSVLAARSPVFNAMFEHEMEECTKNRVEINDLDPEVFKEMMRFVYTGKAPNLDKMADNLLAAADKYALERLKVMCEEALCSNLSVENVADTLVLADLHSAEQLKAQAIDFINRCSVLRQLGCKDGKNWNNNQATDIMETSGWKSMIQSRPHLVAEAFRALASSQCPQFGIPRKRLKQS" }, "uniprot_id": "A0A0G2KB38_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB38", "id": "A0A0G2KB38", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A0G2KB38", "site_annotation": [ { "end_pos": 203, "annotation": "n_glycosylation_sequon", "start_pos": 201 }, { "end_pos": 330, "annotation": "n_glycosylation_sequon", "start_pos": 328 }, { "end_pos": 42, "annotation": "n_glycosylation_sequon", "start_pos": 40 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB38#A0A0G2KB38-1", "isoform_ac": "A0A0G2KB38-1", "locus": { "end_pos": 401631, "strand": "+", "start_pos": 431867, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000081816", "id": "ENSRNOT00000081816", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075640", "id": "ENSRNOP00000075640", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KB38-1|A0A0G2KB38_RAT Isoform 1 of Speckle type BTB/POZ protein-like OS=Rattus norvegicus OX=10116 GN=Spopl PE=3 SV=1 CANONICAL=A0A0G2KB38-1", "length": 424, "sequence": "MSREPTPPLPGDMSTSPVAESWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSSGPNDKMKWCLRVNPKGLDEESRDYLSLYLLLVSCPKSEVRAKFKFSLLNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEHLQHCLQKRWKHCTALPKELAPPLHCKWCCRQVSVVQDSVNVSGHTNTNTLKVPECRLAEDLGNLWENTRFTDCCFFVRGKEFKAHKSVLAARSPVFNAMFEHEMEECTKNRVEINDLDPEVFKEMMRFVYTGKAPNLDKMADNLLAAADKYALERLKVMCEEALCSNLSVENVADTLVLADLHSAEQLKAQAIDFINRCSVLRQLGCKDGKNWNNNQATDIMETSGWKSMIQSRPHLVAEAFRALASSQCPQFGIPRKRLKQS" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KB38#B2RZC7-1", "isoform_ac": "B2RZC7-1", "locus": { "end_pos": 401631, "strand": "+", "start_pos": 431867, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000033653", "id": "ENSRNOT00000033653", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000035106", "id": "ENSRNOP00000035106", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|B2RZC7-1|A0A0G2KB38_RAT Computationally mapped isoform of Speckle type BTB/POZ protein-like OS=Rattus norvegicus OX=10116 GN=Spopl PE=3 SV=1 CANONICAL=A0A0G2KB38-1", "length": 392, "sequence": "MSREPTPPLPGDMSTSPVAESWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSSGPNDKMKWCLRVNPKGLDEESRDYLSLYLLLVSCPKSEVRAKFKFSLLNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNVSGHTNTNTLKVPECRLAEDLGNLWENTRFTDCCFFVRGKEFKAHKSVLAARSPVFNAMFEHEMEECTKNRVEINDLDPEVFKEMMRFVYTGKAPNLDKMADNLLAAADKYALERLKVMCEEALCSNLSVENVADTLVLADLHSAEQLKAQAIDFINRCSVLRQLGCKDGKNWNNNQATDIMETSGWKSMIQSRPHLVAEAFRALASSQCPQFGIPRKRLKQS" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5632684", "resource": "Reactome", "id": "R-RNO-5632684", "name": "Hedgehog 'on' state" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q2M2N2-1", "protein_name": "Speckle-type POZ protein-like", "sequence": { "length": 392, "sequence": "MSREPTPPLPGDMSTSPVAESWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSSGPNDKMKWCLRVNPKGLDDESKDYLSLYLLLVSCPKSEVRAKFKFSLLNDKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNVSGHTSTNTLKVPECRLAEDLGNLWENTRFTDCCFFVRGKEFKAHKSVLAARSPVFNAMFEHEMEECTKNRVEINDLDPEVFKEMMRFVYTGKAPNLDKMADNLLAAADKYALERLKVMCEEALCSNLSVENVADTLVLADLHSAEQLKAQAIDFINRCSVLRQLGCKDGKNWNNNQATDIMETSGWKSMIQSHPHLVAEAFRALASSQCPQFGIPRKRLKQS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/78016", "id": "78016", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2KB38/", "id": "A0A0G2KB38", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Spopl", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q6IQ16-1", "protein_name": "Speckle-type POZ protein-like", "sequence": { "length": 392, "sequence": "MSREPTPPLPGDMSTGPIAESWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSSGPSDKMKWCLRVNPKGLDDESKDYLSLYLLLVSCPKSEVRAKFKFSLLNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGHTNTNTLKVPECRLAEDLGNLWENTRFTDCSFFVRGQEFKAHKSVLAARSPVFNAMFEHEMEESKKNRVEINDLDPEVFKEMMRFIYTGRAPNLDKMADNLLAAADKYALERLKVMCEEALCSNLSVENVADTLVLADLHSAEQLKAQAIDFINRCSVLRQLGCKDGKNWNSNQATDIMETSGWKSMIQSHPHLVAEAFRALASAQCPQFGIPRKRLKQS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/78016", "id": "78016", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2KB38/", "id": "A0A0G2KB38", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "SPOPL", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017447114.1", "ac": "XP_017447114.1", "name": "speckle-type POZ protein-like isoform X1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB38", "id": "A0A0G2KB38", "database": "UniProtKB" } ], "name": "ubiquitin protein ligase binding", "id": "GO:0031625" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB38", "id": "A0A0G2KB38", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB38", "id": "A0A0G2KB38", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB38", "id": "A0A0G2KB38", "database": "UniProtKB" } ], "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030162", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB38", "id": "A0A0G2KB38", "database": "UniProtKB" } ], "name": "regulation of proteolysis", "id": "GO:0030162" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB38", "id": "A0A0G2KB38", "database": "UniProtKB" } ], "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB38", "id": "A0A0G2KB38", "database": "UniProtKB" } ], "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031397", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB38", "id": "A0A0G2KB38", "database": "UniProtKB" } ], "name": "negative regulation of protein ubiquitination", "id": "GO:0031397" } ], "total": 4, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KB38", "type": "synonym", "resource": "RefSeq", "name": "RGD1305847" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KB38", "type": "synonym", "resource": "RefSeq", "name": "Spopl" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KB38", "type": "recommended", "resource": "UniProtKB", "name": "Spopl" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000005070", "id": "ENSRNOG00000005070", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/296532", "id": "296532", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "id": "IPR000210", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002083", "id": "IPR002083", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008974", "id": "IPR008974", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "id": "IPR011333", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/RFTDCCF/", "id": "RFTDCCF", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=864323at2759", "id": "864323at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00651", "id": "PF00651", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00917", "id": "PF00917", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5632684", "id": "R-RNO-5632684", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017447114.1", "id": "XP_017447114.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305847", "id": "1305847", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KB38", "id": "A0A0G2KB38", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 48619.0, "chemical_mass": 48619.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB38", "name": "Spopl", "locus": { "end_pos": 401429, "strand": "-", "start_pos": 471634, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000005070", "id": "ENSRNOG00000005070", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB38#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Speckle type BTB/POZ protein-like" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KB38", "type": "synonym", "resource": "RefSeq", "name": "speckle-type POZ protein-like isoform X1" } ] }