{ "uniprot_canonical_ac": "A0A0G2KAX2-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2KAX2-1|A0A0G2KAX2_RAT Isoform 1 of Microtubule-associated protein 11 OS=Rattus norvegicus OX=10116 GN=RGD1305455 PE=4 SV=1 CANONICAL=A0A0G2KAX2-1", "length": 580, "sequence": "MESQCDYSMYFPAVPLPPRAELAGDPGRYRALPRRNHLYLGETVRFLLVLRCRGSAGPGVGGGTGLASRGAWTELATALAALASVSAGGVLPGCGSAGDQDADPPGGGDPGGGGLFRSCSPLLTHGPGPATSGGATTLPMEEPIVSTDEVIFPLTVSLDRLPPGTPKAKIVVTVWKREVEAPEVRDQGYLRLLQTRSPGETFRGEQSAFKAQVSTLLTLLPPPVLKCRQFTVAGKHLTVLKVLNSSSQEEISIWDIRILPNFNASYLPVMPDGSVLLVDNVCHQSGEVSMGSFCRLPGTSGYFPCPLSALEEHNFLFQLRGGEQPPPGAKEGLEVPLIAVVQWSTPKLPFTQSIYTHYRLPSVRLDRPCFVMTASCESPVRTYERFTVTYTLLNNLQDFLAVRLVWTPEHAQAGKQLCEEERRAMQAALDSIVCHTPLNNLGFSRKGSALTFSVAFQALRTGLFELSQHMKLKLQFTASVSHPPPEARPLSRKSSPSSPAVRDLVERHQASLGRSQSFSHQQPSRSHLMRSGSVMERRAITPPVASPVGRPLYLPPDKAVLSLDKIAKRECKVLVVEPVK" }, "uniprot_id": "A0A0G2KAX2_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAX2", "id": "A0A0G2KAX2", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A0G2KAX2", "site_annotation": [ { "end_pos": 246, "annotation": "n_glycosylation_sequon", "start_pos": 244 }, { "end_pos": 265, "annotation": "n_glycosylation_sequon", "start_pos": 263 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAX2#A0A0G2KAX2-1", "isoform_ac": "A0A0G2KAX2-1", "locus": { "end_pos": 19578482, "strand": "+", "start_pos": 19582026, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000085853", "id": "ENSRNOT00000085853", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075560", "id": "ENSRNOP00000075560", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KAX2-1|A0A0G2KAX2_RAT Isoform 1 of Microtubule-associated protein 11 OS=Rattus norvegicus OX=10116 GN=RGD1305455 PE=4 SV=1 CANONICAL=A0A0G2KAX2-1", "length": 580, "sequence": "MESQCDYSMYFPAVPLPPRAELAGDPGRYRALPRRNHLYLGETVRFLLVLRCRGSAGPGVGGGTGLASRGAWTELATALAALASVSAGGVLPGCGSAGDQDADPPGGGDPGGGGLFRSCSPLLTHGPGPATSGGATTLPMEEPIVSTDEVIFPLTVSLDRLPPGTPKAKIVVTVWKREVEAPEVRDQGYLRLLQTRSPGETFRGEQSAFKAQVSTLLTLLPPPVLKCRQFTVAGKHLTVLKVLNSSSQEEISIWDIRILPNFNASYLPVMPDGSVLLVDNVCHQSGEVSMGSFCRLPGTSGYFPCPLSALEEHNFLFQLRGGEQPPPGAKEGLEVPLIAVVQWSTPKLPFTQSIYTHYRLPSVRLDRPCFVMTASCESPVRTYERFTVTYTLLNNLQDFLAVRLVWTPEHAQAGKQLCEEERRAMQAALDSIVCHTPLNNLGFSRKGSALTFSVAFQALRTGLFELSQHMKLKLQFTASVSHPPPEARPLSRKSSPSSPAVRDLVERHQASLGRSQSFSHQQPSRSHLMRSGSVMERRAITPPVASPVGRPLYLPPDKAVLSLDKIAKRECKVLVVEPVK" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAX2#Q5BK00-1", "isoform_ac": "Q5BK00-1", "locus": { "end_pos": 19581266, "strand": "+", "start_pos": 19582026, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000060020", "id": "ENSRNOT00000060020", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000056771", "id": "ENSRNOP00000056771", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q5BK00-1|A0A0G2KAX2_RAT Computationally mapped isoform of Microtubule-associated protein 11 OS=Rattus norvegicus OX=10116 GN=RGD1305455 PE=4 SV=1 CANONICAL=A0A0G2KAX2-1", "length": 169, "sequence": "MESQCDYSMYFPAVPLPPRAELAGDPGRYRALPRRNHLYLGETVRFLLVLRCRGSAGPGVGGGTGLASRGAWTELATALAALASVSAGGVLPGCGSAGDQDADPPGGGDPGGGGLFRSCSPLLTHGPGPATSGGATTLPMEEPIVSTDEVIFPLTVSLDRLPPGTPKAK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:288545", "resource": "KEGG Pathway", "id": "rno:288545", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q3UTZ3-1", "protein_name": "Microtubule-associated protein 11", "sequence": { "length": 580, "sequence": "MESQCDYSMYFPAVPLPPRAELTGDPGRYRALPRRNHLYLGETVRFLLVLRCRGSVGAGVGGGAGLASRGAWTELATSLAALASVSAGGALPGCGSAGDQDADPPGGGDPGGGGLFRGCSPLLTHGQGPATSGGATTLPVEEPIVSTDEVIFPLTVSLDRLPPGTPKAKIVVTVWKREVEAPEVRDQGYLRLLQTRSPGETFRGEQSAFKAQVSTLLTLLPPPVLKCRQFTVAGKHLTVLKVLNSSSQEEISIWDIRILPNFNASYLPVMPDGSVLLVDNVCHQSGEVSMGSFCRLPGTSGYFPCPLSALEEHNFLFQLRGGEQPPPGAKEGLEVPLIAVVQWSTPKLPFTQSIYTHYRLPSVRLDRPCFVMTASCESPVRTYERFTVTYTLLNNLQDFLAVRLVWTPEHAQAGKQLCEEERRAMQAALDSIVCHTPLNNLGFSRKGSALTFSVAFQALRTGLFELSQHMKLKLQFTASVSHPPPEARPLSRKSSPSSPAVRDLVERHQASLGRSQSFSHQQPSRSHLMRSGSVMERRAITPPVASPVGRPLYLPPDKAVLSLDKIAKRECKVLVVEPVK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/10106", "id": "10106", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "MAP11", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q8WVR3-1", "protein_name": "Microtubule-associated protein 11", "sequence": { "length": 580, "sequence": "MESQCDYSMYFPAVPLPPRAELAGDPGRYRALPRRNHLYLGETVRFLLVLRCRGGAGSGTGGGPGLGSRGAWAELATALAALASVSAGGGMPGGGGAGDQDSEPPGGGDPGGGGLFRGCSPLLTHGPGPATSGGATTLPVEEPIVSTDEVIFPLTVSLDRLPPGTPKAKIVVTVWKREIEAPEVRDQGYLRLLQTRSPGETFRGEQSAFKAQVSTLLTLLPPPVLRCRQFTVAGKHLTVLKVLNSSSQEEISIWDIRILPNFNASYLPVMPDGSVLLVDNVCHQSGEVSMGSFCRLPGTSGCFPCPLNALEEHNFLFQLRGGEQPPPGAKEGLEVPLIAVVQWSTPKLPFTQSIYTHYRLPSVRLDRPCFVMTASCKSPVRTYERFTVTYTLLNNLQDFLAVRLVWTPEHAQAGKQLCEEERRAMQAALDSVVCHTPLNNLGFSRKGSALTFSVAFQALRTGLFELSQHMKLKLQFTASVSHPPPEARPLSRKSSPSSPAVRDLVERHQASLGRSQSFSHQQPSRSHLMRSGSVMERRAITPPVASPVGRPLYLPPDKAVLSLDKIAKRECKVLVVEPVK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/10106", "id": "10106", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "MAP11", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020140.2", "ac": "NP_001020140.2", "name": "uncharacterized protein C7orf43 homolog", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043014", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAX2", "id": "A0A0G2KAX2", "database": "UniProtKB" } ], "name": "alpha-tubulin binding", "id": "GO:0043014" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAX2", "id": "A0A0G2KAX2", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAX2", "id": "A0A0G2KAX2", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAX2", "id": "A0A0G2KAX2", "database": "UniProtKB" } ], "name": "midbody", "id": "GO:0030496" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAX2", "id": "A0A0G2KAX2", "database": "UniProtKB" } ], "name": "centriolar satellite", "id": "GO:0034451" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAX2", "id": "A0A0G2KAX2", "database": "UniProtKB" } ], "name": "mitotic spindle", "id": "GO:0072686" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042127", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAX2", "id": "A0A0G2KAX2", "database": "UniProtKB" } ], "name": "regulation of cell population proliferation", "id": "GO:0042127" } ], "total": 1, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KAX2", "type": "synonym", "resource": "RefSeq", "name": "Map11; RGD1305455" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAX2", "type": "synonym", "resource": "UniProtKB", "name": "Map11" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAX2", "type": "recommended", "resource": "UniProtKB", "name": "RGD1305455" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KAX2", "type": "synonym", "resource": "RefSeq", "name": "Trappc14" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000039214", "id": "ENSRNOG00000039214", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/288545", "id": "288545", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR031626", "id": "IPR031626", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:288545", "id": "rno:288545", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/TASCKSP/", "id": "TASCKSP", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=536210at2759", "id": "536210at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16096", "id": "PTHR16096", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF15806", "id": "PF15806", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020140.2", "id": "NP_001020140.2", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305455", "id": "1305455", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAX2", "id": "A0A0G2KAX2", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [ { "id": "MONDO:0009617", "url": "https://monarchinitiative.org/disease/MONDO:0009617", "resource": "MONDO", "name": "microcephaly 1, primary, autosomal recessive", "description": "" }, { "id": "MONDO:0009617", "url": "https://monarchinitiative.org/disease/MONDO:0009617", "resource": "MONDO", "name": "premature chromosome condensation with microcephaly and mental retardation", "description": "" }, { "id": "MONDO:0009617", "url": "https://monarchinitiative.org/disease/MONDO:0009617", "resource": "MONDO", "name": "autosomal recessive primary microcephaly caused by mutation in MCPH1", "description": "" }, { "id": "MONDO:0009617", "url": "https://monarchinitiative.org/disease/MONDO:0009617", "resource": "MONDO", "name": "MCPH1 autosomal recessive primary microcephaly", "description": "" }, { "id": "MONDO:0009617", "url": "https://monarchinitiative.org/disease/MONDO:0009617", "resource": "MONDO", "name": "premature chromosome condensation syndrome", "description": "" }, { "id": "MONDO:0009617", "url": "https://monarchinitiative.org/disease/MONDO:0009617", "resource": "MONDO", "name": "PCC syndrome", "description": "" }, { "id": "MONDO:0009617", "url": "https://monarchinitiative.org/disease/MONDO:0009617", "resource": "MONDO", "name": "microcephaly 1, primary, autosomal recessive; MCPH1", "description": "" }, { "id": "MONDO:0009617", "url": "https://monarchinitiative.org/disease/MONDO:0009617", "resource": "MONDO", "name": "MCPH1", "description": "" }, { "id": "DOID:0070296", "url": "http://disease-ontology.org/term/DOID:0070296", "resource": "Disease Ontology", "name": "MCPH", "description": "" } ], "recommended_name": { "id": "DOID:0070296", "url": "http://disease-ontology.org/term/DOID:0070296", "resource": "Disease Ontology", "name": "primary autosomal recessive microcephaly", "description": "A primary microcephaly characterized by microcephaly present at birth, where the brain is small but has normal architecture, and nonprogressive mental retardation that has_material_basis_in an autosomal recessive mutation." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/0070296#disease-associations", "id": "0070296", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [], "mass": { "monoisotopic_mass": 62821.0, "chemical_mass": 62821.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAX2", "name": "RGD1305455", "locus": { "end_pos": 19573893, "strand": "-", "start_pos": 19582208, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000039214", "id": "ENSRNOG00000039214", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAX2#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Microtubule-associated protein 11" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KAX2", "type": "synonym", "resource": "RefSeq", "name": "microtubule associated protein 11" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KAX2", "type": "synonym", "resource": "RefSeq", "name": "uncharacterized protein C7orf43 homolog" } ] }