{ "uniprot_canonical_ac": "A0A0G2KAU4-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2KAU4-1|A0A0G2KAU4_RAT Isoform 1 of RAS guanyl-releasing protein 3 OS=Rattus norvegicus OX=10116 GN=Rasgrp3 PE=3 SV=1 CANONICAL=A0A0G2KAU4-1", "length": 691, "sequence": "MGSNGLGKAATLDELLSTCIEMFDDNGELNDSYLPRIMLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWITKFPAEFNLDLGLIRMTEEFREVASQLGYEKHSNLMDISSIPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMNYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPESLPGSPALPPVQDEVFEFPGVTARHRDLDSRDITLVTGSSRKISVRVQRATTSQATQTEPVWSEAVWGDSGSHTFPKMKSKLHDKAAKDKGFAKWENEKPTLHAGVDVVDRGTAFEPDQDDEQDEAQQGVEDG" }, "uniprot_id": "A0A0G2KAU4_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A0G2KAU4", "site_annotation": [ { "end_pos": 32, "annotation": "n_glycosylation_sequon", "start_pos": 30 }, { "end_pos": 347, "annotation": "n_glycosylation_sequon", "start_pos": 345 }, { "end_pos": 63, "annotation": "n_glycosylation_sequon", "start_pos": 61 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4#A0A0G2KAU4-1", "isoform_ac": "A0A0G2KAU4-1", "locus": { "end_pos": 21074806, "strand": "+", "start_pos": 21109640, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000079819", "id": "ENSRNOT00000079819", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075529", "id": "ENSRNOP00000075529", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KAU4-1|A0A0G2KAU4_RAT Isoform 1 of RAS guanyl-releasing protein 3 OS=Rattus norvegicus OX=10116 GN=Rasgrp3 PE=3 SV=1 CANONICAL=A0A0G2KAU4-1", "length": 691, "sequence": "MGSNGLGKAATLDELLSTCIEMFDDNGELNDSYLPRIMLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWITKFPAEFNLDLGLIRMTEEFREVASQLGYEKHSNLMDISSIPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMNYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPESLPGSPALPPVQDEVFEFPGVTARHRDLDSRDITLVTGSSRKISVRVQRATTSQATQTEPVWSEAVWGDSGSHTFPKMKSKLHDKAAKDKGFAKWENEKPTLHAGVDVVDRGTAFEPDQDDEQDEAQQGVEDG" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4#D3ZZN2-1", "isoform_ac": "D3ZZN2-1", "locus": { "end_pos": 21074806, "strand": "+", "start_pos": 21109640, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000051239", "id": "ENSRNOT00000051239", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000051116", "id": "ENSRNOP00000051116", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZZN2-1|A0A0G2KAU4_RAT Computationally mapped isoform of RAS guanyl-releasing protein 3 OS=Rattus norvegicus OX=10116 GN=Rasgrp3 PE=3 SV=1 CANONICAL=A0A0G2KAU4-1", "length": 603, "sequence": "MGSNGLGKAATLDELLSTCIEMFDDNGELNDSYLPRIMLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWITKFPAEFNLDLGLIRMTEEFREVASQLGYEKHSNLMDISSIPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVELWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPESLPGSPALPPVQDEVFEFPGVTARHRDLDSRDITLVTGSSRKISVRVQRATTSQATQTEPVWSEAVWGDSGSHTFPKMKSKLHDKAAKDKGFAKWENEKPTLHAGVDVVDRGTAFEPDQDDEQDEAQQGVEDG" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169092", "resource": "Reactome", "id": "R-RNO-1169092", "name": "Activation of RAS in B cells" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5673001", "resource": "Reactome", "id": "R-RNO-5673001", "name": "RAF/MAP kinase cascade" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q6NZH9-1", "protein_name": "RAS, guanyl-releasing protein 3", "sequence": { "length": 691, "sequence": "MGSNGLGKAATLDELLSTCIEMFDDNGDLNDSYLPRIVLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGHEKHISLMDISSVPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMNYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPGSLPGSPALPPVQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKISVRLQRATTSQATQTEPVWSEAVWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPTVQAGVDVVDRGTAFEPDQDDGQDEAKQGGEDG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/15019", "id": "15019", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Rasgrp3", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q8IV61-1", "protein_name": "Ras guanyl-releasing protein 3", "sequence": { "length": 690, "sequence": "MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRVHAGVDVVDRGTEFELDQDEGEETRQDGEDG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/15019", "id": "15019", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "RASGRP3", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006239819.1", "ac": "XP_006239819.1", "name": "ras guanyl-releasing protein 3 isoform X1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "GTPase activator activity", "id": "GO:0005096" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "calcium ion binding", "id": "GO:0005509" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "kinase binding", "id": "GO:0019900" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005088", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "Ras guanyl-nucleotide exchange factor activity", "id": "GO:0005088" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017016", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "Ras GTPase binding", "id": "GO:0017016" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "perinuclear region of cytoplasm", "id": "GO:0048471" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032045", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "guanyl-nucleotide exchange factor complex", "id": "GO:0032045" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043087", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "regulation of GTPase activity", "id": "GO:0043087" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "name": "Ras protein signal transduction", "id": "GO:0007265" } ], "total": 2, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KAU4", "type": "synonym", "resource": "RefSeq", "name": "Rasgrp3" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "type": "recommended", "resource": "UniProtKB", "name": "Rasgrp3" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000032703", "id": "ENSRNOG00000032703", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00029", "id": "cd00029", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "id": "cd00051", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00155", "id": "cd00155", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06224", "id": "cd06224", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/313874", "id": "313874", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000651", "id": "IPR000651", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001895", "id": "IPR001895", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "id": "IPR002048", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002219", "id": "IPR002219", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008937", "id": "IPR008937", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "id": "IPR011992", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "id": "IPR018247", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR020454", "id": "IPR020454", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR023578", "id": "IPR023578", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029645", "id": "IPR029645", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036964", "id": "IPR036964", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/DQDEADM/", "id": "DQDEADM", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=355412at2759", "id": "355412at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113", "id": "PTHR23113", "database": "PANTHER" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113:SF178", "id": "PTHR23113:SF178", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF00130", "id": "PF00130", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00617", "id": "PF00617", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF13202", "id": "PF13202", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169092", "id": "R-RNO-1169092", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5673001", "id": "R-RNO-5673001", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006239819.1", "id": "XP_006239819.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1304612", "id": "1304612", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "id": "A0A0G2KAU4", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [ { "id": "DOID:10763", "url": "http://disease-ontology.org/term/DOID:10763", "resource": "Disease Ontology", "name": "HTN", "description": "" }, { "id": "DOID:10763", "url": "http://disease-ontology.org/term/DOID:10763", "resource": "Disease Ontology", "name": "High blood pressure", "description": "" }, { "id": "DOID:10763", "url": "http://disease-ontology.org/term/DOID:10763", "resource": "Disease Ontology", "name": "hyperpiesia", "description": "" }, { "id": "DOID:10763", "url": "http://disease-ontology.org/term/DOID:10763", "resource": "Disease Ontology", "name": "vascular hypertensive disorder", "description": "" } ], "recommended_name": { "id": "DOID:10763", "url": "http://disease-ontology.org/term/DOID:10763", "resource": "Disease Ontology", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/10763#disease-associations", "id": "10763", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [], "mass": { "monoisotopic_mass": 78529.0, "chemical_mass": 78529.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4", "name": "Rasgrp3", "locus": { "end_pos": 21072634, "strand": "-", "start_pos": 21135880, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000032703", "id": "ENSRNOG00000032703", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAU4#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "RAS guanyl-releasing protein 3" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KAU4", "type": "synonym", "resource": "RefSeq", "name": "ras guanyl-releasing protein 3 isoform X1" } ] }