{ "uniprot_canonical_ac": "A0A0G2KAM8-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2KAM8-1|A0A0G2KAM8_RAT Isoform 1 of DDB1 and CUL4-associated factor 1 OS=Rattus norvegicus OX=10116 GN=Dcaf1 PE=1 SV=1 CANONICAL=A0A0G2KAM8-1", "length": 1460, "sequence": "MSELIEKETEEYRKGDPDPFDDRHPGRADPECMLGHLLRILFKNDDFMNALVNAYVMTSREPPLNTAACRLLLDIMPGLETAVVFQEKEGIVENLFKWAREADQPLRTYSTGLLGGAMENQDIAANYRDENSQLVAIVLRRLRELQLQEVALRQDNKRPSPRKLSSEPLLPLDEEAVDMDYGDMAVDVVDGEQEASRDMEISFRLDSSHKTSSRVNSATKPEEGGLKKNKSAKHGDRENFRKAKQKLGFSSSDPDRVFVELSNSSWSEMSPWVIGTNYTLYPMTPAIEQRLILQYLTPLGEYQELLPIFMQLGSRELMMFYIDLKQTNDVLLTFEALKHLASLLLHNKFATEFVAHGGVQKLLEIPRPSMAATGVSMCLYYLSYNQDAMERVCMHPHNVLSDVVNYTLWLMECSHASGCCHATMFFSICFSFRAVLELFDRYDGLRRLVNLISTLEILNLEDQGALLSDDEIFASRQTGKHTCMALRKYFEAHLAIKLEQVKQSLQRTEGGILVHPQPPYKACSYTHEQIVEMMEFLIEYGPAQLYWEPAEVFLKLSCVQLLLQLISIACNWKTYYARNDTVRFALDVLAILTVVPKIQLQLAESVDVLDEAGSTVSTVGISIILGVAEGEFFIHDAEIQKSALQIIINCVCGPDNRISSIGKFISGTPRRKLSQTPKSSEHTLAKMWNVVQSNNGIKVLLSLLSIKMPITDADQIRALACKALVGLSRSSTVRQIISKLPLFSSCQIQQLMKEPVLQDKRSDHVKFCKYAAELIERVSGKPLLIGTDVSLARLQKADVVAQSRISFPEKELLLLIRNHLISKGLGETATVLTREADLPMTAASHSSAFTPVTAAASPVSLPRTPRIANGIASRLGSHAAVGASAPSAPPAHPPPRPPQGSLALPGPSYAGNSPLIGRISFIRERPSPCNGRKIRVLRQKSDHGAYSQSPAIKKQLDRHLPSPPTLDSIITEYLREQHARCKNPVATCPPFSLFTPHQCPEPKQRRQAPINFTSRLNRRASFPKYGGVDGGCFDRHLIFSRFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVLNDGVLWDVRSAQAIHKFDKFNMNISGVFHPNGLEVIINTEIWDLRTFHLLHTVPALDQCRVVFNHTGTVMYGAMLQADDEDDLLEERMKSPFGSSFRTFNATDYKPIATIDVKRNIFDLCTDTKDCYLAVIENQGSMDALNMDTVCRLYEVGRQRLAEDEDEEEDQEEEEQEEEDDEDDDDDTDDLDELDTDQLLEAELEEDDNNENAGEDGDNDFSPSDEELANLLEEGEEGEDEDSDADEEVELILGDRLCTYSMMGQ" }, "uniprot_id": "A0A0G2KAM8_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "id": "A0A0G2KAM8", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "id": "A0A0G2KAM8", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" } ], "uniprot_ac": "A0A0G2KAM8", "site_annotation": [ { "end_pos": 1013, "annotation": "n_glycosylation_sequon", "start_pos": 1011 }, { "end_pos": 1225, "annotation": "n_glycosylation_sequon", "start_pos": 1223 }, { "end_pos": 1266, "annotation": "n_glycosylation_sequon", "start_pos": 1264 }, { "end_pos": 1302, "annotation": "n_glycosylation_sequon", "start_pos": 1300 }, { "end_pos": 231, "annotation": "n_glycosylation_sequon", "start_pos": 229 }, { "end_pos": 265, "annotation": "n_glycosylation_sequon", "start_pos": 263 }, { "end_pos": 279, "annotation": "n_glycosylation_sequon", "start_pos": 277 }, { "end_pos": 407, "annotation": "n_glycosylation_sequon", "start_pos": 405 }, { "end_pos": 581, "annotation": "n_glycosylation_sequon", "start_pos": 579 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8#A0A0G2KAM8-1", "isoform_ac": "A0A0G2KAM8-1", "locus": { "end_pos": 115546902, "strand": "-", "start_pos": 115611256, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000079801", "id": "ENSRNOT00000079801", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075456", "id": "ENSRNOP00000075456", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KAM8-1|A0A0G2KAM8_RAT Isoform 1 of DDB1 and CUL4-associated factor 1 OS=Rattus norvegicus OX=10116 GN=Dcaf1 PE=1 SV=1 CANONICAL=A0A0G2KAM8-1", "length": 1460, "sequence": "MSELIEKETEEYRKGDPDPFDDRHPGRADPECMLGHLLRILFKNDDFMNALVNAYVMTSREPPLNTAACRLLLDIMPGLETAVVFQEKEGIVENLFKWAREADQPLRTYSTGLLGGAMENQDIAANYRDENSQLVAIVLRRLRELQLQEVALRQDNKRPSPRKLSSEPLLPLDEEAVDMDYGDMAVDVVDGEQEASRDMEISFRLDSSHKTSSRVNSATKPEEGGLKKNKSAKHGDRENFRKAKQKLGFSSSDPDRVFVELSNSSWSEMSPWVIGTNYTLYPMTPAIEQRLILQYLTPLGEYQELLPIFMQLGSRELMMFYIDLKQTNDVLLTFEALKHLASLLLHNKFATEFVAHGGVQKLLEIPRPSMAATGVSMCLYYLSYNQDAMERVCMHPHNVLSDVVNYTLWLMECSHASGCCHATMFFSICFSFRAVLELFDRYDGLRRLVNLISTLEILNLEDQGALLSDDEIFASRQTGKHTCMALRKYFEAHLAIKLEQVKQSLQRTEGGILVHPQPPYKACSYTHEQIVEMMEFLIEYGPAQLYWEPAEVFLKLSCVQLLLQLISIACNWKTYYARNDTVRFALDVLAILTVVPKIQLQLAESVDVLDEAGSTVSTVGISIILGVAEGEFFIHDAEIQKSALQIIINCVCGPDNRISSIGKFISGTPRRKLSQTPKSSEHTLAKMWNVVQSNNGIKVLLSLLSIKMPITDADQIRALACKALVGLSRSSTVRQIISKLPLFSSCQIQQLMKEPVLQDKRSDHVKFCKYAAELIERVSGKPLLIGTDVSLARLQKADVVAQSRISFPEKELLLLIRNHLISKGLGETATVLTREADLPMTAASHSSAFTPVTAAASPVSLPRTPRIANGIASRLGSHAAVGASAPSAPPAHPPPRPPQGSLALPGPSYAGNSPLIGRISFIRERPSPCNGRKIRVLRQKSDHGAYSQSPAIKKQLDRHLPSPPTLDSIITEYLREQHARCKNPVATCPPFSLFTPHQCPEPKQRRQAPINFTSRLNRRASFPKYGGVDGGCFDRHLIFSRFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVLNDGVLWDVRSAQAIHKFDKFNMNISGVFHPNGLEVIINTEIWDLRTFHLLHTVPALDQCRVVFNHTGTVMYGAMLQADDEDDLLEERMKSPFGSSFRTFNATDYKPIATIDVKRNIFDLCTDTKDCYLAVIENQGSMDALNMDTVCRLYEVGRQRLAEDEDEEEDQEEEEQEEEDDEDDDDDTDDLDELDTDQLLEAELEEDDNNENAGEDGDNDFSPSDEELANLLEEGEEGEDEDSDADEEVELILGDRLCTYSMMGQ" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8#D3ZKB7-1", "isoform_ac": "D3ZKB7-1", "locus": { "end_pos": 115546893, "strand": "-", "start_pos": 115614286, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000018932", "id": "ENSRNOT00000018932", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000018932", "id": "ENSRNOP00000018932", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZKB7-1|A0A0G2KAM8_RAT Computationally mapped isoform of DDB1 and CUL4-associated factor 1 OS=Rattus norvegicus OX=10116 GN=Dcaf1 PE=1 SV=2 CANONICAL=A0A0G2KAM8-1", "length": 1385, "sequence": "LARMSELIEKETEEYRKGDPDPFDDRHPGRADPECMLGHLLRILFKNDDFMNALVNAYVMTSREPPLNTAACRLLLDIMPGLETAVVFQEKEGIVENLFKWAREADQPLRTYSTGLLGGAMENQDIAANYRDENSQLVAIVLRRLRELQLQEVALRQDNKRPSPRKLSSEPLLPLDEEAVDMDYGDMAVDVVDGEQEASRDMEISFRLDSSHKTSSRVNSATKPEEGGLKKNKSAKHGDRENFRKAKQKLGFSSSDPDRVFVELSNSSWSEMSPWVIGTNYTLYPMTPAIEQRLILQYLTPLGEYQELLPIFMQLGSRELMMFYIDLKQTNDVLLTFEALKHLASLLLHNKFATEFVAHGGVQKLLEIPRPSMAATGVSMCLYYLSYNQDAMERVCMHPHNVLSDVVNYTLWLMECSHASGCCHATMFFSICFSFRAVLELFDRYDGLRRLVNLISTLEILNLEDQGALLSDDEIFASRQTGKHTCMALRKYFEAHLAIKLEQVKQSLQRTEGGILVHPQPPYKACSYTHEQIVEMMEFLIEYGPAQLYWEPAEVFLKLSCVQLLLQLISIACNWKTYYARNDTVRFALDVLAILTVVPKIQLQLAESVDVLDEAGSTVSTVGISIILGVAEGEFFIHDAEIQKSALQIIINCVCGPDNRISSIGKFISGTPRRKLSQTPKSSEHTLAKMWNVVQSNNGIKVLLSLLSIKMPITDADQIRALACKALVGLSRSSTVRQIISKLPLFSSCQIQQLMKEPVLQDKRSDHVKFCKYAAELIERVSGKPLLIGTDVSLARLQKADVVAQSRISFPEKELLLLIRNHLISKGLGETATVLTREADLPMTAASHSSAFTPVTAAASPVSLPRTPRIANGIASRLGSHAAVGASAPSAPPAHPPPRPPQGSLALPGPSYAGNSPLIGRISFIRERPSPCNGRKIRVLRQKSDHGAYSQSPAIKKQLDRHLPSPPTLDSIITEYLREQHARCKNPVATCPPFSLFTPHQCPEPKQRRQAPINFTSRLNRRASFPKYGGVDGGCFDRHLIFSRFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVLNDGVLWDVRSAQAIHKFDKFNMNISGVFHPNGLEVIINTEIWDLRTFHLLHTVPALDQCRVVFNHTGTVMYGAMLQADDEDDLLEERMKSPFGSSFRTFNATDYKPIATIDVKRNIFDLCTDTKDCYLAVIENQGSMDALNMDTVCRLYEVGRQRLAEDEDEEEDQQTARTTLIWKMTSSYL" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "resource": "Reactome", "id": "R-RNO-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "function": [], "orthologs": [], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030331", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "id": "A0A0G2KAM8", "database": "UniProtKB" } ], "name": "estrogen receptor binding", "id": "GO:0030331" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990244", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "id": "A0A0G2KAM8", "database": "UniProtKB" } ], "name": "histone kinase activity (H2A-T120 specific)", "id": "GO:1990244" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "id": "A0A0G2KAM8", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "id": "A0A0G2KAM8", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "id": "A0A0G2KAM8", "database": "UniProtKB" } ], "name": "fibrillar center", "id": "GO:0001650" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008180", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "id": "A0A0G2KAM8", "database": "UniProtKB" } ], "name": "COP9 signalosome", "id": "GO:0008180" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080008", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "id": "A0A0G2KAM8", "database": "UniProtKB" } ], "name": "Cul4-RING E3 ubiquitin ligase complex", "id": "GO:0080008" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "id": "A0A0G2KAM8", "database": "UniProtKB" } ], "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "id": "A0A0G2KAM8", "database": "UniProtKB" } ], "name": "protein ubiquitination", "id": "GO:0016567" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030183", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "id": "A0A0G2KAM8", "database": "UniProtKB" } ], "name": "B cell differentiation", "id": "GO:0030183" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033151", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "id": "A0A0G2KAM8", "database": "UniProtKB" } ], "name": "V(D)J recombination", "id": "GO:0033151" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035212", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "id": "A0A0G2KAM8", "database": "UniProtKB" } ], "name": "cell competition in a multicellular organism", "id": "GO:0035212" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990245", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "id": "A0A0G2KAM8", "database": "UniProtKB" } ], "name": "histone H2A-T120 phosphorylation", "id": "GO:1990245" } ], "total": 6, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "type": "recommended", "resource": "UniProtKB", "name": "Dcaf1" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000013841", "id": "ENSRNOG00000013841", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006594", "id": "IPR006594", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "id": "IPR015943", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "id": "IPR016024", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR033270", "id": "IPR033270", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "id": "IPR036322", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/VWESVCS/", "id": "VWESVCS", "database": "OMA" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13129", "id": "PTHR13129", "database": "PANTHER" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983168", "id": "R-RNO-983168", "database": "Reactome" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305176", "id": "1305176", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "id": "A0A0G2KAM8", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 163863.0, "chemical_mass": 163863.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8", "name": "Dcaf1", "locus": { "end_pos": 115615282, "strand": "+", "start_pos": 115546712, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000013841", "id": "ENSRNOG00000013841", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAM8#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "DDB1 and CUL4-associated factor 1" } ] }