{ "uniprot_canonical_ac": "A0A0G2KAE6-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2KAE6-1|A0A0G2KAE6_RAT Isoform 1 of Mitoguardin 2 OS=Rattus norvegicus OX=10116 GN=Miga2 PE=1 SV=1 CANONICAL=A0A0G2KAE6-1", "length": 593, "sequence": "MAFRRTEGMSMIQALAMTVAEIPVFLYTTFGQSAFSQLRLTPGLRKVLFATALGTVALALAAHQLKRRRRKKKQVGPEMGSEQLGTFPMPILMARKVPSVKKGCSSRRVQSPSSKSNDTLSGISSIEPSKHSGSSHSLASMVMVNSSSPTAACSGSWETRGMEESVPTMDGSAESLYVQGMELFEEALQKWEQALSVGQRGDGGSTPTPGDSLQNPDTSSEALSEPESQRREFAEKLESLLHRAYHLQEEFGSTLPSDNMLLDLERTLMLPLTEGSLCLRADDEDSLTSEDSFFSATELFESLQIGEYPLPLSRPAAAYEEALQLVKEGKVPCRTLRTELLGCYSDQDFLAKLHCVRQAFEGLLEERNNQVFFGEVGRQMVTGLMTKAEKSPKGFLESYEEMLNYALRPETWATTRLELEGRGVACMSFFDIVLDFILMDAFEDLENPPSSVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKPQLSEVCAFFKHQIVQYLRDMFDLDNVRYTSVPALAEDILQLSRRRSEILLGYLGAPVASSTGLNGPLPRENGPLDELQ" }, "uniprot_id": "A0A0G2KAE6_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6", "id": "A0A0G2KAE6", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6", "id": "A0A0G2KAE6", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" } ], "uniprot_ac": "A0A0G2KAE6", "site_annotation": [ { "end_pos": 119, "annotation": "n_glycosylation_sequon", "start_pos": 117 }, { "end_pos": 147, "annotation": "n_glycosylation_sequon", "start_pos": 145 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6#A0A0G2KAE6-1", "isoform_ac": "A0A0G2KAE6-1", "locus": { "end_pos": 8933071, "strand": "-", "start_pos": 8949746, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000088509", "id": "ENSRNOT00000088509", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075370", "id": "ENSRNOP00000075370", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KAE6-1|A0A0G2KAE6_RAT Isoform 1 of Mitoguardin 2 OS=Rattus norvegicus OX=10116 GN=Miga2 PE=1 SV=1 CANONICAL=A0A0G2KAE6-1", "length": 593, "sequence": "MAFRRTEGMSMIQALAMTVAEIPVFLYTTFGQSAFSQLRLTPGLRKVLFATALGTVALALAAHQLKRRRRKKKQVGPEMGSEQLGTFPMPILMARKVPSVKKGCSSRRVQSPSSKSNDTLSGISSIEPSKHSGSSHSLASMVMVNSSSPTAACSGSWETRGMEESVPTMDGSAESLYVQGMELFEEALQKWEQALSVGQRGDGGSTPTPGDSLQNPDTSSEALSEPESQRREFAEKLESLLHRAYHLQEEFGSTLPSDNMLLDLERTLMLPLTEGSLCLRADDEDSLTSEDSFFSATELFESLQIGEYPLPLSRPAAAYEEALQLVKEGKVPCRTLRTELLGCYSDQDFLAKLHCVRQAFEGLLEERNNQVFFGEVGRQMVTGLMTKAEKSPKGFLESYEEMLNYALRPETWATTRLELEGRGVACMSFFDIVLDFILMDAFEDLENPPSSVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKPQLSEVCAFFKHQIVQYLRDMFDLDNVRYTSVPALAEDILQLSRRRSEILLGYLGAPVASSTGLNGPLPRENGPLDELQ" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6#D3Z899-1", "isoform_ac": "D3Z899-1", "locus": { "end_pos": 8933071, "strand": "-", "start_pos": 8949746, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000065300", "id": "ENSRNOT00000065300", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000062428", "id": "ENSRNOP00000062428", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3Z899-1|A0A0G2KAE6_RAT Computationally mapped isoform of Mitoguardin 2 OS=Rattus norvegicus OX=10116 GN=Miga2 PE=1 SV=1 CANONICAL=A0A0G2KAE6-1", "length": 554, "sequence": "MAFRRTEGMSMIQALAMTVAEIPVFLYTTFGQSAFSQLRLTPGLRKVLFATALGTVALALAAHQLKRRRRKKKQVGPEMGSEQLGTFPMPILMARKVPSVKKGCSSRRVQSPSSKSNDTLSGISSIEPSKHSGSSHSLASMVMVNSSSPTAACSGSWETRGMEESVPTMDGSAESLYVQGMELFEEALQKWEQALSVGQRGDGGSTPTPGDSLQNPDTSSEALSEPESQRREFAEKLESLLHRAYHLQEEFGSTLPSDNMLLDLERTLMLPLTEGSLCLRADDEDSLTSEDSFFSATELFESLQIGEYPLPLSRPAAAYEEALQLVKEGKVPCRTLRTELLGCYSDQDFLAKLHCVRQAFEGLLEERNNQVFFGEVGRQMVTGLMTKAEKSPKGFLESYEEMLNYALRPETWATTRLELEGRGVACMSFFDIVLDFILMDAFEDLENPPSSVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMHQIVQYLRDMFDLDNVRYTSVPALAEDILQLSRRRSEILLGYLGAPVASSTGLNGPLPRENGPLDELQ" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1483166", "resource": "Reactome", "id": "R-RNO-1483166", "name": "Synthesis of PA" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q7L4E1-1", "protein_name": "Mitoguardin 2", "sequence": { "length": 593, "sequence": "MAFRRAEGTSMIQALAMTVAEIPVFLYTTFGQSAFSQLRLTPGLRKVLFATALGTVALALAAHQLKRRRRRKKQVGPEMGGEQLGTVPLPILLARKVPSVKKGYSSRRVQSPSSKSNDTLSGISSIEPSKHSGSSHSVASMMAVNSSSPTAACSGLWDARGMEESLTTSDGNAESLYMQGMELFEEALQKWEQALSVGQRGDSGSTPMPRDGLRNPETASEPLSEPESQRKEFAEKLESLLHRAYHLQEEFGSTFPADSMLLDLERTLMLPLTEGSLRLRADDEDSLTSEDSFFSATELFESLQTGDYPIPLSRPAAAYEEALQLVKEGRVPCRTLRTELLGCYSDQDFLAKLHCVRQAFEGLLEDKSNQLFFGKVGRQMVTGLMTKAEKSPKGFLESYEEMLSYALRPETWATTRLELEGRGVVCMSFFDIVLDFILMDAFEDLENPPASVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKPQLAEVCAFFKHQIVQYLRDMFDLDNVRYTSLPALADDILQLSRRRSEILLGYLGVPAASSAGVNGALPRENGPLGELQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/13125", "id": "13125", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2KAE6/", "id": "A0A0G2KAE6", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "MIGA2", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8BK03-1", "protein_name": "Mitoguardin 2", "sequence": { "length": 593, "sequence": "MAFRRTEGMSMIQALAMTVAEIPVFLYTTFGQSAFSQLRLTPGLRKVLFATALGTVALALAAHQLKRRRRKKKQVGPEMGGEQLGTVPMPILMARKVPSVKKGCSSRRVQSPSSKSNDTLSGISSIEPSKHSGSSHSLASMVVVNSSSPTAACSGSWEARGMEESVPTTDGSAESLYVQGMELFEEALQKWEQALSVGQRGDGGSTPTPGDSLQNPDTASEALSEPESQRREFAEKLESLLHRAYHLQEEFGSTFPSDSMLLDLERTLMLPLTEGSLRLRADDEDSLTSEDSFFSATEIFESLQIGEYPLPLSRPAAAYEEALQLVKEGRVPCRTLRTELLGCYSDQDFLAKLHCVRQAFEGLLEERSNQIFFGEVGRQMVTGLMTKAEKSPKGFLESYEEMLSYALRPETWATTRLELEGRGVACMSFFDIVLDFILMDAFEDLENPPSSVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKPQLSEVCAFFKHQIVQYLRDMFDLDNVRYTSVPALAEDILQLSRRRSEILLGYLGAPVASSIGLNGPLPRENGPLEELQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/13125", "id": "13125", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2KAE6/", "id": "A0A0G2KAE6", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Miga2", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006233843.1", "ac": "XP_006233843.1", "name": "mitoguardin-2 isoform X1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6", "id": "A0A0G2KAE6", "database": "UniProtKB" } ], "name": "protein homodimerization activity", "id": "GO:0042803" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6", "id": "A0A0G2KAE6", "database": "UniProtKB" } ], "name": "protein heterodimerization activity", "id": "GO:0046982" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6", "id": "A0A0G2KAE6", "database": "UniProtKB" } ], "name": "mitochondrion", "id": "GO:0005739" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005887", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6", "id": "A0A0G2KAE6", "database": "UniProtKB" } ], "name": "integral component of plasma membrane", "id": "GO:0005887" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060348", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6", "id": "A0A0G2KAE6", "database": "UniProtKB" } ], "name": "bone development", "id": "GO:0060348" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008053", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6", "id": "A0A0G2KAE6", "database": "UniProtKB" } ], "name": "mitochondrial fusion", "id": "GO:0008053" } ], "total": 2, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KAE6", "type": "synonym", "resource": "RefSeq", "name": "Miga2" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6", "type": "recommended", "resource": "UniProtKB", "name": "Miga2" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6", "type": "synonym", "resource": "UniProtKB", "name": "RGD1310887_predicted" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KAE6", "type": "synonym", "resource": "RefSeq", "name": "RGD1310887" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6", "type": "synonym", "resource": "UniProtKB", "name": "rCG_45483" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000017513", "id": "ENSRNOG00000017513", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/296623", "id": "296623", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019392", "id": "IPR019392", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/YDICLDF/", "id": "YDICLDF", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=341855at2759", "id": "341855at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21508", "id": "PTHR21508", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF10265", "id": "PF10265", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1483166", "id": "R-RNO-1483166", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006233843.1", "id": "XP_006233843.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310887", "id": "1310887", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6", "id": "A0A0G2KAE6", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 65660.0, "chemical_mass": 65660.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6", "name": "Miga2", "locus": { "end_pos": 8951189, "strand": "+", "start_pos": 8928534, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000017513", "id": "ENSRNOG00000017513", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Mitoguardin 2" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAE6#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Similar to CG12125-PA (Predicted), isoform CRA_a" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KAE6", "type": "synonym", "resource": "RefSeq", "name": "mitoguardin-2 isoform X1" } ] }