{ "uniprot_canonical_ac": "A0A0G2KA91-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2KA91-1|A0A0G2KA91_RAT Isoform 1 of Mesoderm induction early response protein 1 OS=Rattus norvegicus OX=10116 GN=Mier1 PE=1 SV=1 CANONICAL=A0A0G2KA91-1", "length": 661, "sequence": "MVATLRLGLGSPFPSGSAVPGLQLPPQQLRNVCRASWRPQSLAQEAAARLAGRSRLRRRAEAEGRVEGWWSWRKLGRRFGGGGRPRPLPGCESPGCRRMDGASPGGGGSSGGGGSGGGYGVVARFSQCLAEFRTWLRTNWLRFNADKTDVMLPSVESSSPGGSAASEDHEFDPSADMLVHDFDDERTLEEEEMMEGETNFSSEIEDLAREGDMPIDELLSLYGYGSTVQLPEEEEEEEEEEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVTSQDAQEIIRPRRCKYFDTNSEIEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGVCRYKENEKVYENDDQLLWDPEYLPEDKVIVFLKDASRRTGDEKGVEAIPEGSHIKDNEQALYELVKCSFDTEEALRRLRFNVKAAREELSVWTEEECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKSERYDFFAQQTRFGKKKYNLHPGVTDYMDRLLDESESAASSRAPSPPPTASNSSTSQSEKEDGTLSNSNQNGVSSNGPGEILNKEEVKVEGLHVNGPTGGNKKPLLTDVDTNGYEENNLATDPKLAHMTARNENDFDEKNERPAKRRRINSSGKESPGSSEFFQEAVSHGKFEEHENTND" }, "uniprot_id": "A0A0G2KA91_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91", "id": "A0A0G2KA91", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91", "id": "A0A0G2KA91", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" } ], "uniprot_ac": "A0A0G2KA91", "site_annotation": [ { "end_pos": 201, "annotation": "n_glycosylation_sequon", "start_pos": 199 }, { "end_pos": 535, "annotation": "n_glycosylation_sequon", "start_pos": 533 }, { "end_pos": 633, "annotation": "n_glycosylation_sequon", "start_pos": 631 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91#A0A0G2KA91-1", "isoform_ac": "A0A0G2KA91-1", "locus": { "end_pos": 122642081, "strand": "-", "start_pos": 122690715, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000086765", "id": "ENSRNOT00000086765", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075308", "id": "ENSRNOP00000075308", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KA91-1|A0A0G2KA91_RAT Isoform 1 of Mesoderm induction early response protein 1 OS=Rattus norvegicus OX=10116 GN=Mier1 PE=1 SV=1 CANONICAL=A0A0G2KA91-1", "length": 661, "sequence": "MVATLRLGLGSPFPSGSAVPGLQLPPQQLRNVCRASWRPQSLAQEAAARLAGRSRLRRRAEAEGRVEGWWSWRKLGRRFGGGGRPRPLPGCESPGCRRMDGASPGGGGSSGGGGSGGGYGVVARFSQCLAEFRTWLRTNWLRFNADKTDVMLPSVESSSPGGSAASEDHEFDPSADMLVHDFDDERTLEEEEMMEGETNFSSEIEDLAREGDMPIDELLSLYGYGSTVQLPEEEEEEEEEEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVTSQDAQEIIRPRRCKYFDTNSEIEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGVCRYKENEKVYENDDQLLWDPEYLPEDKVIVFLKDASRRTGDEKGVEAIPEGSHIKDNEQALYELVKCSFDTEEALRRLRFNVKAAREELSVWTEEECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKSERYDFFAQQTRFGKKKYNLHPGVTDYMDRLLDESESAASSRAPSPPPTASNSSTSQSEKEDGTLSNSNQNGVSSNGPGEILNKEEVKVEGLHVNGPTGGNKKPLLTDVDTNGYEENNLATDPKLAHMTARNENDFDEKNERPAKRRRINSSGKESPGSSEFFQEAVSHGKFEEHENTND" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91#E9PT68-1", "isoform_ac": "E9PT68-1", "locus": { "end_pos": 122647387, "strand": "-", "start_pos": 122690715, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000066041", "id": "ENSRNOT00000066041", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000063001", "id": "ENSRNOP00000063001", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9PT68-1|A0A0G2KA91_RAT Computationally mapped isoform of Mesoderm induction early response protein 1 OS=Rattus norvegicus OX=10116 GN=Mier1 PE=1 SV=1 CANONICAL=A0A0G2KA91-1", "length": 512, "sequence": "MAEPSVESSSPGGSAASEDHEFDPSADMLVHDFDDERTLEEEEMMEGETNFSSEIEDLAREGDMPIDELLSLYGYGSTVQLPEEEEEEEEEEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVTSQDAQEIIRPRRCKYFDTNSEIEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGVCRYKENEKVYENDDQLLWDPEYLPEDKVIVFLKDASRRTGDEKGVEAIPEGSHIKDNEQALYELVKCSFDTEEALRRLRFNVKAAREELSVWTEEECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKSERYDFFAQQTRFGKKKYNLHPGVTDYMDRLLDESESAASSRAPSPPPTASNSSTSQSEKEDGTLSNSNQNGVSSNGPGEILNKEEVKVEGLHVNGPTGGNKKPLLTDVDTNGYEENNLATDPKLAHMTARNENDFDEKNERPAKRRRINSSGKESPGSSEFFQEAVSHGKFEEHENTND" } } ], "pathway": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q5UAK0-3", "protein_name": "Mesoderm induction early response protein 1", "sequence": { "length": 511, "sequence": "MAEPSVESSSPGGSATSEDHEFDPSADMLVHDFDDERTLEEEEMMEGETNFSSEIEDLAREGDMPIHELLSLYGYDSTVRLPEEEEEEEEEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVTSQDAQEIIRPRRCKYFDTNSEIEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGVCRYKENEKVYENDDQLLWDPECLPEEKVVVFLKDASRRTGDEKGVEAIPEGSHIKDNEQALYELVKCSFDTEEALRRLRFNVKAAREELSVWTEEECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKSERYDFFAQQTRFGKKKYNLHPGVTDYMDRLLDESESAASSRAPSPPPTASNSSNSQSEKEDGAVSSRNQNGVSSNGPGEILNKEEVKVEGLHVNGPTGGNKKPLLTDMDTNGYEANNLTTDPKLAHMTARNENDFDEKNERPAKRRRINSSGKESPGSSEFFQEAVSHGKFEEHENTND" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/136176", "id": "136176", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Mier1", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q8N108-11", "protein_name": "Mesoderm induction early response protein 1", "sequence": { "length": 512, "sequence": "MAEPSVESSSPGGSATSDDHEFDPSADMLVHDFDDERTLEEEEMMEGETNFSSEIEDLAREGDMPIHELLSLYGYGSTVRLPEEDEEEEEEEEEGEDDEDADNDDNSGCSGENKEENIKDSSGQEDETQSSNDDPSQSVASQDAQEIIRPRRCKYFDTNSEVEEESEEDEDYIPSEDWKKEIMVGSMFQAEIPVGICRYKENEKVYENDDQLLWDPEYLPEDKVIIFLKDASRRTGDEKGVEAIPEGSHIKDNEQALYELVKCNFDTEEALRRLRFNVKAAREELSVWTEEECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKSERYDFFAQQTRFGKKKYNLHPGVTDYMDRLLDESESAASSRAPSPPPTASNSSNSQSEKEDGTVSTANQNGVSSNGPGEILNKEEVKVEGLHINGPTGGNKKPLHADMDTNGYETDNLTTDPKLAHMTARNENDFDEKSERPAKRRRVNSNGKESPGSSEFFQEAVSHGKFEELENTDD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/136176", "id": "136176", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "MIER1", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006238541.1", "ac": "XP_006238541.1", "name": "mesoderm induction early response protein 1 isoform X3", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91", "id": "A0A0G2KA91", "database": "UniProtKB" } ], "name": "transcription corepressor activity", "id": "GO:0003714" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001103", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91", "id": "A0A0G2KA91", "database": "UniProtKB" } ], "name": "RNA polymerase II repressing transcription factor binding", "id": "GO:0001103" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004407", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91", "id": "A0A0G2KA91", "database": "UniProtKB" } ], "name": "histone deacetylase activity", "id": "GO:0004407" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91", "id": "A0A0G2KA91", "database": "UniProtKB" } ], "name": "histone deacetylase binding", "id": "GO:0042826" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91", "id": "A0A0G2KA91", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91", "id": "A0A0G2KA91", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017053", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91", "id": "A0A0G2KA91", "database": "UniProtKB" } ], "name": "transcription repressor complex", "id": "GO:0017053" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91", "id": "A0A0G2KA91", "database": "UniProtKB" } ], "name": "protein-containing complex", "id": "GO:0032991" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91", "id": "A0A0G2KA91", "database": "UniProtKB" } ], "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031937", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91", "id": "A0A0G2KA91", "database": "UniProtKB" } ], "name": "positive regulation of chromatin silencing", "id": "GO:0031937" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016575", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91", "id": "A0A0G2KA91", "database": "UniProtKB" } ], "name": "histone deacetylation", "id": "GO:0016575" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KA91", "type": "synonym", "resource": "RefSeq", "name": "Mier1" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91", "type": "recommended", "resource": "UniProtKB", "name": "Mier1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KA91", "type": "synonym", "resource": "RefSeq", "name": "RGD1562337" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000007175", "id": "ENSRNOG00000007175", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/313418", "id": "313418", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000949", "id": "IPR000949", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001005", "id": "IPR001005", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "id": "IPR009057", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017884", "id": "IPR017884", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR031169", "id": "IPR031169", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR040138", "id": "IPR040138", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/CRRMDGA/", "id": "CRRMDGA", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1062529at2759", "id": "1062529at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10865", "id": "PTHR10865", "database": "PANTHER" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10865:SF24", "id": "PTHR10865:SF24", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF00249", "id": "PF00249", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF01448", "id": "PF01448", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006238541.1", "id": "XP_006238541.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1562337", "id": "1562337", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91", "id": "A0A0G2KA91", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 73890.0, "chemical_mass": 73890.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91", "name": "Mier1", "locus": { "end_pos": 122693635, "strand": "+", "start_pos": 122641885, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000007175", "id": "ENSRNOG00000007175", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KA91#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Mesoderm induction early response protein 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KA91", "type": "synonym", "resource": "RefSeq", "name": "mesoderm induction early response protein 1 isoform X3" } ] }