{ "uniprot_canonical_ac": "A0A0G2K950-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2K950-1|A0A0G2K950_RAT Isoform 1 of 3'-phosphoadenosine-5'-phosphosulfate synthase OS=Rattus norvegicus OX=10116 GN=Papss2 PE=1 SV=1 CANONICAL=A0A0G2K950-1", "length": 619, "sequence": "MSEIKKQKTDQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNKNLGFSAGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSNYEKPETPECVLKTNLSSVSDCVQQVVELLQEQSIVPHTTIKGIHELFVPENKIDQIRAELETLPSLPITKLDLQWVQILSEGWATPLKGFMREKEYLQTLHFDTLLDGVILRDGVINMSIPIVLPVSGDDKARLEGCSKFALMYEGRRVALLQDPEFYEHRKEERCSRVWGTASAKHPHIKMVMEGGDWLVGGDLQVLERIRWNDGLDQYRLTPLELKQKCKDMDADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGILDPKSTIVAIFPSPMLYAGPTEVQWHCRCRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKIKKAMDFYDPARHDEFDFISGTRMRKLAREGEDPPDGFMAPKAWKVLTDYYRSLEKIN" }, "uniprot_id": "A0A0G2K950_RAT", "enzyme_annotation": [ { "ec": "2.7.1.25", "activity": "" }, { "ec": "2.7.1.25", "activity": "ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate." }, { "ec": "2.7.7.4", "activity": "" }, { "ec": "2.7.7.4", "activity": "ATP + sulfate = diphosphate + adenylyl sulfate." } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K950", "id": "A0A0G2K950", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K950", "id": "A0A0G2K950", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" } ], "uniprot_ac": "A0A0G2K950", "site_annotation": [ { "end_pos": 196, "annotation": "n_glycosylation_sequon", "start_pos": 194 }, { "end_pos": 299, "annotation": "n_glycosylation_sequon", "start_pos": 297 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K950#A0A0G2K950-1", "isoform_ac": "A0A0G2K950-1", "locus": { "end_pos": 251145398, "strand": "-", "start_pos": 251229102, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000083555", "id": "ENSRNOT00000083555", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074860", "id": "ENSRNOP00000074860", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K950-1|A0A0G2K950_RAT Isoform 1 of 3'-phosphoadenosine-5'-phosphosulfate synthase OS=Rattus norvegicus OX=10116 GN=Papss2 PE=1 SV=1 CANONICAL=A0A0G2K950-1", "length": 619, "sequence": "MSEIKKQKTDQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNKNLGFSAGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSNYEKPETPECVLKTNLSSVSDCVQQVVELLQEQSIVPHTTIKGIHELFVPENKIDQIRAELETLPSLPITKLDLQWVQILSEGWATPLKGFMREKEYLQTLHFDTLLDGVILRDGVINMSIPIVLPVSGDDKARLEGCSKFALMYEGRRVALLQDPEFYEHRKEERCSRVWGTASAKHPHIKMVMEGGDWLVGGDLQVLERIRWNDGLDQYRLTPLELKQKCKDMDADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGILDPKSTIVAIFPSPMLYAGPTEVQWHCRCRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKIKKAMDFYDPARHDEFDFISGTRMRKLAREGEDPPDGFMAPKAWKVLTDYYRSLEKIN" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K950#B5DFH4-1", "isoform_ac": "B5DFH4-1", "locus": { "end_pos": 251145398, "strand": "-", "start_pos": 251229102, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000014979", "id": "ENSRNOT00000014979", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000014979", "id": "ENSRNOP00000014979", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|B5DFH4-1|A0A0G2K950_RAT Computationally mapped isoform of 3'-phosphoadenosine-5'-phosphosulfate synthase OS=Rattus norvegicus OX=10116 GN=Papss2 PE=1 SV=1 CANONICAL=A0A0G2K950-1", "length": 614, "sequence": "MSEIKKQKTDQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNKNLGFSAGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSNYEKPETPECVLKTNLSSVSDCVQQVVELLQEQSIVPHTTIKGIHELFVPENKIDQIRAELETLPSLPITKLDLQWVQILSEGWATPLKGFMREKEYLQTLHFDTLLDDGVINMSIPIVLPVSGDDKARLEGCSKFALMYEGRRVALLQDPEFYEHRKEERCSRVWGTASAKHPHIKMVMEGGDWLVGGDLQVLERIRWNDGLDQYRLTPLELKQKCKDMDADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGILDPKSTIVAIFPSPMLYAGPTEVQWHCRCRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKIKKAMDFYDPARHDEFDFISGTRMRKLAREGEDPPDGFMAPKAWKVLTDYYRSLEKIN" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-174362", "resource": "Reactome", "id": "R-RNO-174362", "name": "Transport and synthesis of PAPS" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "O88428-1", "protein_name": "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2", "sequence": { "length": 621, "sequence": "MSANFKMNHKRDQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNKNLGFSAGDREENIRRIAEVARLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPECVLKTNLSSVSDCVQQVVELLQEQNIVPHTTIKGIHELFVPENKVDQIRAEAETLPSLPITKLDLQWVQILSEGWATPLKGFMREKEYLQTLHFDTLLDGVVPRDGVINMSIPIVLPVSADDKARLEGCSKFALMYEGRRVALLQDPEFYEHRKEERCSRVWGTATAKHPHIKMVMESGDWLVGGDLQVLERIRWDDGLDQYRLTPLELKQKCKDMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLEWRMKQHAAVLEERVLDPKSTIVAIFPSPMLYAGPTEVQWHCRCRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKIKKAMDFYDPARHEEFDFISGTRMRKLAREGEDPPDGFMAPKAWKVLTDYYRSLEKTN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/55840", "id": "55840", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2K950/", "id": "A0A0G2K950", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Papss2", "tax_id": 10090 }, { "uniprot_canonical_ac": "O95340-1", "protein_name": "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2", "sequence": { "length": 614, "sequence": "MSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNRNLGFSPGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPERVLKTNLSTVSDCVHQVVELLQEQNIVPYTIIKDIHELFVPENKLDHVRAEAETLPSLSITKLDLQWVQVLSEGWATPLKGFMREKEYLQVMHFDTLLDDGVINMSIPIVLPVSAEDKTRLEGCSKFVLAHGGRRVAILRDAEFYEHRKEERCSRVWGTTCTKHPHIKMVMESGDWLVGGDLQVLEKIRWNDGLDQYRLTPLELKQKCKEMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGVLDPKSTIVAIFPSPMLYAGPTEVQWHCRSRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKAKKAMDFYDPARHNEFDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYRSLEKN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/55840", "id": "55840", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "PAPSS2", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006231336.1", "ac": "XP_006231336.1", "name": "bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K950", "id": "A0A0G2K950", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004020", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K950", "id": "A0A0G2K950", "database": "UniProtKB" } ], "name": "adenylylsulfate kinase activity", "id": "GO:0004020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004781", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K950", "id": "A0A0G2K950", "database": "UniProtKB" } ], "name": "sulfate adenylyltransferase (ATP) activity", "id": "GO:0004781" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050428", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K950", "id": "A0A0G2K950", "database": "UniProtKB" } ], "name": "3'-phosphoadenosine 5'-phosphosulfate biosynthetic process", "id": "GO:0050428" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K950", "id": "A0A0G2K950", "database": "UniProtKB" } ], "name": "blood coagulation", "id": "GO:0007596" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060348", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K950", "id": "A0A0G2K950", "database": "UniProtKB" } ], "name": "bone development", "id": "GO:0060348" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000103", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K950", "id": "A0A0G2K950", "database": "UniProtKB" } ], "name": "sulfate assimilation", "id": "GO:0000103" } ], "total": 4, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2K950", "type": "synonym", "resource": "RefSeq", "name": "Papss2" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K950", "type": "recommended", "resource": "UniProtKB", "name": "Papss2" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000011068", "id": "ENSRNOG00000011068", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00517", "id": "cd00517", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02027", "id": "cd02027", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/294103", "id": "294103", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002650", "id": "IPR002650", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002891", "id": "IPR002891", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014729", "id": "IPR014729", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015947", "id": "IPR015947", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR024951", "id": "IPR024951", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR025980", "id": "IPR025980", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "id": "IPR027417", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/TVNECIQ/", "id": "TVNECIQ", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=528280at2759", "id": "528280at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF01747", "id": "PF01747", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF14306", "id": "PF14306", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-174362", "id": "R-RNO-174362", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006231336.1", "id": "XP_006231336.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307012", "id": "1307012", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K950", "id": "A0A0G2K950", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [ { "id": "MONDO:0013019", "url": "https://monarchinitiative.org/disease/MONDO:0013019", "resource": "MONDO", "name": "SEMD, Pakistani type", "description": "" }, { "id": "MONDO:0013019", "url": "https://monarchinitiative.org/disease/MONDO:0013019", "resource": "MONDO", "name": "BCYM4", "description": "" }, { "id": "MONDO:0013019", "url": "https://monarchinitiative.org/disease/MONDO:0013019", "resource": "MONDO", "name": "brachyolmia type 4 with mild epiphyseal and metaphyseal changes", "description": "" }, { "id": "MONDO:0013019", "url": "https://monarchinitiative.org/disease/MONDO:0013019", "resource": "MONDO", "name": "spondyloepimetaphyseal dysplasia Pakistani type", "description": "" }, { "id": "MONDO:0013019", "url": "https://monarchinitiative.org/disease/MONDO:0013019", "resource": "MONDO", "name": "spondylodysplasia and premature pubarche", "description": "" }, { "id": "MONDO:0013019", "url": "https://monarchinitiative.org/disease/MONDO:0013019", "resource": "MONDO", "name": "brachyolmia type 4 with mild epiphyseal and metaphyseal changes; BCYM4", "description": "" }, { "id": "DOID:0050812", "url": "http://disease-ontology.org/term/DOID:0050812", "resource": "Disease Ontology", "name": "spondyloepimetaphyseal dysplasia Pakistani type", "description": "" } ], "recommended_name": { "id": "DOID:0050812", "url": "http://disease-ontology.org/term/DOID:0050812", "resource": "Disease Ontology", "name": "spondyloepimetaphyseal dysplasia, Pakistani type", "description": "A spondyloepimetaphyseal dysplasia that is characterized by short stature, short and bowed lower limbs, mild brachydactyly, kyphoscoliosis, abnormal gait, enlarged knee joints, precocious osteoarthropathy, and normal intelligence." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/0050812#disease-associations", "id": "0050812", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [], "mass": { "monoisotopic_mass": 69950.0, "chemical_mass": 69950.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K950", "name": "Papss2", "locus": { "end_pos": 251230715, "strand": "+", "start_pos": 251145253, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000011068", "id": "ENSRNOG00000011068", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K950#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "2.7.1.25" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K950#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "2.7.7.4" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K950#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "3'-phosphoadenosine-5'-phosphosulfate synthase" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K950#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "APS kinase" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K950#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "ATP-sulfurylase" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K950#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Adenosine-5'-phosphosulfate 3'-phosphotransferase" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K950#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Adenylyl-sulfate kinase" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K950#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Adenylylsulfate 3'-phosphotransferase" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K950#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Sulfate adenylyltransferase" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2K950", "type": "synonym", "resource": "RefSeq", "name": "bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1" } ] }