{ "uniprot_canonical_ac": "A0A0G2K8F2-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2K8F2-1|A0A0G2K8F2_RAT Isoform 1 of Regulatory factor X4 OS=Rattus norvegicus OX=10116 GN=Rfx4 PE=4 SV=1 CANONICAL=A0A0G2K8F2-1", "length": 672, "sequence": "LEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGAAWVSETGKREVTKQTVAYSPRSKLGTLLPDFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHMLPVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLCQASRTVIHSADITFQMLEDWRNVDLSSITKQTLYTMEDSRDEHRRLIIQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSLKKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEAQEEIILTEGTPPTPHPGPSFSPAKSATSVEVATSPPLPSSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRSTHVPSSSVTHRIPVYSHREEHGYTGSYNYGSYGNQHPHPLQNQYPALPHDTAISGPLHYSPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPTANACYTSPSVHSTRYGNSSDMYTPLTTRRNSEYEHMQHFPGFAYINGEASTGWAK" }, "uniprot_id": "A0A0G2K8F2_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A0G2K8F2", "site_annotation": [ { "end_pos": 31, "annotation": "n_glycosylation_sequon", "start_pos": 29 }, { "end_pos": 636, "annotation": "n_glycosylation_sequon", "start_pos": 634 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2#A0A0G2K3G6-1", "isoform_ac": "A0A0G2K3G6-1", "locus": { "end_pos": 25832521, "strand": "-", "start_pos": 25907846, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000084955", "id": "ENSRNOT00000084955", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072631", "id": "ENSRNOP00000072631", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K3G6-1|A0A0G2K8F2_RAT Computationally mapped isoform of Regulatory factor X4 OS=Rattus norvegicus OX=10116 GN=Rfx4 PE=4 SV=1 CANONICAL=A0A0G2K8F2-1", "length": 641, "sequence": "MNWAAFGGPEFFIPGDMQMETSCPLGRDLTEWYHYYGIAVKESSQYYDVMYSKKGAAWVSETGKREVTKQTVAYSPRSKLGTLLPDFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHMLPVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLCQASRTVIHSADITFQMLEDWRNVDLSSITKQTLYTMEDSRDEHRRLIIQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSLKKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEAQEEIILTEGTPPTPPGPSFSPAKSATSVEVATSPPLPSSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRSTHVPSSSVTHRIPVYSHREEHGYTGSYNYGSYGNQHPHPLQNQYPALPHDTAISGPLHYSPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPTANACYTSPSVHSTRYGNSSDMYTPLTTRRNSEYEHMQHFPGFAYINGEASTGWAK" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2#A0A0G2K8F2-1", "isoform_ac": "A0A0G2K8F2-1", "locus": { "end_pos": 25808419, "strand": "-", "start_pos": 25907846, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000091571", "id": "ENSRNOT00000091571", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074585", "id": "ENSRNOP00000074585", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K8F2-1|A0A0G2K8F2_RAT Isoform 1 of Regulatory factor X4 OS=Rattus norvegicus OX=10116 GN=Rfx4 PE=4 SV=1 CANONICAL=A0A0G2K8F2-1", "length": 672, "sequence": "LEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGAAWVSETGKREVTKQTVAYSPRSKLGTLLPDFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHMLPVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLCQASRTVIHSADITFQMLEDWRNVDLSSITKQTLYTMEDSRDEHRRLIIQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSLKKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEAQEEIILTEGTPPTPHPGPSFSPAKSATSVEVATSPPLPSSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRSTHVPSSSVTHRIPVYSHREEHGYTGSYNYGSYGNQHPHPLQNQYPALPHDTAISGPLHYSPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPTANACYTSPSVHSTRYGNSSDMYTPLTTRRNSEYEHMQHFPGFAYINGEASTGWAK" } } ], "pathway": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q7TNK1-1", "protein_name": "Transcription factor RFX4", "sequence": { "length": 735, "sequence": "MHCGLLEEPDMDSTESWIERCLNESENKRYSSHTSLGNVSNDENEEKENNRASKPHSTPATLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGAAWVSETGKREVTKQTVAYSPRSKLGTLLPDFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHMLPVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLCQASRTVIHSADITFQMLEDWRNVDLSSITKQTLYTMEDSRDEHRRLIIQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSLKKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEAQEEIILTEATPPTPSPGPSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTAGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRSTHMPSSSVTHRIPVYSHREEHGYTGSYNYGSYGNQHPHPLQNQYPALPHDTAISGPLHYSPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPTANACYTSPSVHSTRYGNSSDMYTPLTTRRNSEYEHMQHFPGFAYINGEASTGWAK" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K8F2/", "id": "A0A0G2K8F2", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Rfx4", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity", "id": "GO:0003700" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "name": "chromatin binding", "id": "GO:0003682" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021696", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "name": "cerebellar cortex morphogenesis", "id": "GO:0021696" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021516", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "name": "dorsal spinal cord development", "id": "GO:0021516" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021914", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "name": "negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning", "id": "GO:0021914" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030900", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "name": "forebrain development", "id": "GO:0030900" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "name": "cilium assembly", "id": "GO:0060271" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021537", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "name": "telencephalon development", "id": "GO:0021537" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030901", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "name": "midbrain development", "id": "GO:0030901" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070613", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "name": "regulation of protein processing", "id": "GO:0070613" } ], "total": 10, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "type": "recommended", "resource": "UniProtKB", "name": "Rfx4" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000051536", "id": "ENSRNOG00000051536", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003150", "id": "IPR003150", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "id": "IPR036388", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "id": "IPR036390", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR039779", "id": "IPR039779", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/AHRMPVY/", "id": "AHRMPVY", "database": "OMA" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12619", "id": "PTHR12619", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF02257", "id": "PF02257", "database": "Pfam" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1562092", "id": "1562092", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "id": "A0A0G2K8F2", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 76148.0, "chemical_mass": 76148.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2", "name": "Rfx4", "locus": { "end_pos": 25907849, "strand": "+", "start_pos": 25808419, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000051536", "id": "ENSRNOG00000051536", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K8F2#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Regulatory factor X4" } ] }