{ "uniprot_canonical_ac": "A0A0G2K726-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2K726-1|A0A0G2K726_RAT Isoform 1 of Dolichyl-phosphate-mannose--protein mannosyltransferase OS=Rattus norvegicus OX=10116 GN=Tmtc4 PE=1 SV=1 CANONICAL=A0A0G2K726-1", "length": 799, "sequence": "MRSQLVLLAGTNGWGKLYWSPGFCPCTCIPSKLCTIAGTGISNQHNAGAGGWRPAVFKMAELDADLDHIIPSVLPPFWAKLVVGFVSLLCFARSYDGDFVFDDSEAIVNNKDLQSDTPLADLWHHDFWGSRLSSNTSHKSYRPLTVLTFRVNYYLSGGFHPVGFHVVNILLHGGISILMLDVFSVLFGGLQYSSKGRRVHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCRAFKETGNKEGTHSSTFWVLLSIFLGAVAMLCKEQGVTVLGLNAVFDILVIGRLDILVAVRKVLRKDKSLESTGMLKNGGLLFRMALLTIGGSTMLYIRWKIMGTGPPAFTEVDNPASFADSVLVRAINYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSVGDWRVIALAALWLCLIGLIFQALCSEDSCKRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSAGYCMLLTFGFGTLSRHTKKKKPVAAIILGILLINALRCVIRSGEWRSEDRLFRSALSVCPLNAKVHYNIGKNLADQGNQTAAIKYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEEAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVMKPEHSLAWNNMVILLDNTGNLAQAEAVGREALQLIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNVASYHGNLAVLYHRWGHLDSAKKHYEISLQLDPVAVGTKENYSLLRRKLEQMQKKDV" }, "uniprot_id": "A0A0G2K726_RAT", "enzyme_annotation": [ { "ec": "2.4.1.109", "activity": "" }, { "ec": "2.4.1.109", "activity": "Dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein." } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K726", "id": "A0A0G2K726", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A0G2K726", "site_annotation": [ { "end_pos": 137, "annotation": "n_glycosylation_sequon", "start_pos": 135 }, { "end_pos": 557, "annotation": "n_glycosylation_sequon", "start_pos": 555 }, { "end_pos": 669, "annotation": "n_glycosylation_sequon", "start_pos": 667 }, { "end_pos": 785, "annotation": "n_glycosylation_sequon", "start_pos": 783 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K726#A0A0G2K726-1", "isoform_ac": "A0A0G2K726-1", "locus": { "end_pos": 109339811, "strand": "+", "start_pos": 109394871, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000078424", "id": "ENSRNOT00000078424", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000074035", "id": "ENSRNOP00000074035", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K726-1|A0A0G2K726_RAT Isoform 1 of Dolichyl-phosphate-mannose--protein mannosyltransferase OS=Rattus norvegicus OX=10116 GN=Tmtc4 PE=1 SV=1 CANONICAL=A0A0G2K726-1", "length": 799, "sequence": "MRSQLVLLAGTNGWGKLYWSPGFCPCTCIPSKLCTIAGTGISNQHNAGAGGWRPAVFKMAELDADLDHIIPSVLPPFWAKLVVGFVSLLCFARSYDGDFVFDDSEAIVNNKDLQSDTPLADLWHHDFWGSRLSSNTSHKSYRPLTVLTFRVNYYLSGGFHPVGFHVVNILLHGGISILMLDVFSVLFGGLQYSSKGRRVHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCRAFKETGNKEGTHSSTFWVLLSIFLGAVAMLCKEQGVTVLGLNAVFDILVIGRLDILVAVRKVLRKDKSLESTGMLKNGGLLFRMALLTIGGSTMLYIRWKIMGTGPPAFTEVDNPASFADSVLVRAINYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSVGDWRVIALAALWLCLIGLIFQALCSEDSCKRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSAGYCMLLTFGFGTLSRHTKKKKPVAAIILGILLINALRCVIRSGEWRSEDRLFRSALSVCPLNAKVHYNIGKNLADQGNQTAAIKYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEEAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVMKPEHSLAWNNMVILLDNTGNLAQAEAVGREALQLIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNVASYHGNLAVLYHRWGHLDSAKKHYEISLQLDPVAVGTKENYSLLRRKLEQMQKKDV" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K726#F1MAQ6-1", "isoform_ac": "F1MAQ6-1", "locus": { "end_pos": 109339811, "strand": "+", "start_pos": 109389973, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000019602", "id": "ENSRNOT00000019602", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000019602", "id": "ENSRNOP00000019602", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F1MAQ6-1|A0A0G2K726_RAT Computationally mapped isoform of Dolichyl-phosphate-mannose--protein mannosyltransferase OS=Rattus norvegicus OX=10116 GN=Tmtc4 PE=1 SV=1 CANONICAL=A0A0G2K726-1", "length": 741, "sequence": "MAELDADLDHIIPSVLPPFWAKLVVGFVSLLCFARSYDGDFVFDDSEAIVNNKDLQSDTPLADLWHHDFWGSRLSSNTSHKSYRPLTVLTFRVNYYLSGGFHPVGFHVVNILLHGGISILMLDVFSVLFGGLQYSSKGRRVHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCRAFKETGNKEGTHSSTFWVLLSIFLGAVAMLCKEQGVTVLGLNAVFDILVIGRLDILVAVRKVLRKDKSLESTGMLKNGGLLFRMALLTIGGSTMLYIRWKIMGTGPPAFTEVDNPASFADSVLVRAINYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSVGDWRVIALAALWLCLIGLIFQALCSEDSCKRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSAGYCMLLTFGFGTLSRHTKKKKPVAAIILGILLINALRCVIRSGEWRSEDRLFRSALSVCPLNAKVHYNIGKNLADQGNQTAAIKYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEEAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVMKPEHSLAWNNMVILLDNTGNLAQAEAVGREALQLIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNVASYHGNLAVLYHRWGHLDSAKKHYEISLQLDPVAVGTKENYSLLRRKLEQMQKKDV" } } ], "pathway": [], "function": [], "orthologs": [], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004169", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K726", "id": "A0A0G2K726", "database": "UniProtKB" } ], "name": "dolichyl-phosphate-mannose-protein mannosyltransferase activity", "id": "GO:0004169" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051117", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K726", "id": "A0A0G2K726", "database": "UniProtKB" } ], "name": "ATPase binding", "id": "GO:0051117" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000030", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K726", "id": "A0A0G2K726", "database": "UniProtKB" } ], "name": "mannosyltransferase activity", "id": "GO:0000030" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K726", "id": "A0A0G2K726", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K726", "id": "A0A0G2K726", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K726", "id": "A0A0G2K726", "database": "UniProtKB" } ], "name": "sensory perception of sound", "id": "GO:0007605" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030968", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K726", "id": "A0A0G2K726", "database": "UniProtKB" } ], "name": "endoplasmic reticulum unfolded protein response", "id": "GO:0030968" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035269", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K726", "id": "A0A0G2K726", "database": "UniProtKB" } ], "name": "protein O-linked mannosylation", "id": "GO:0035269" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032470", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K726", "id": "A0A0G2K726", "database": "UniProtKB" } ], "name": "positive regulation of endoplasmic reticulum calcium ion concentration", "id": "GO:0032470" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905584", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K726", "id": "A0A0G2K726", "database": "UniProtKB" } ], "name": "outer hair cell apoptotic process", "id": "GO:1905584" } ], "total": 5, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K726", "type": "recommended", "resource": "UniProtKB", "name": "Tmtc4" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000014310", "id": "ENSRNOG00000014310", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "id": "IPR011990", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013026", "id": "IPR013026", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013618", "id": "IPR013618", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "id": "IPR019734", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/KAWANIL/", "id": "KAWANIL", "database": "OMA" }, { "url": "http://pfam.xfam.org/family/PF08409", "id": "PF08409", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF13181", "id": "PF13181", "database": "Pfam" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1560183", "id": "1560183", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K726", "id": "A0A0G2K726", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 89206.0, "chemical_mass": 89206.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K726", "name": "Tmtc4", "locus": { "end_pos": 109339564, "strand": "-", "start_pos": 109394927, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000014310", "id": "ENSRNOG00000014310", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K726#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "2.4.1.109" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K726#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Dolichyl-phosphate-mannose--protein mannosyltransferase" } ] }