{ "uniprot_canonical_ac": "A0A0G2K654-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2K654-1|A0A0G2K654_RAT Isoform 1 of H1.2 linker histone, cluster member OS=Rattus norvegicus OX=10116 GN=Hist1h1c PE=1 SV=1 CANONICAL=A0A0G2K654-1", "length": 212, "sequence": "MSETAPAAPAAAPPAEKAPAKKKAAKKPAGMRRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGILVQTKGTGASGSFKLNKKAASGEAKPKAKKAAAAKAKKPAGAAKKPKKATGAATPKKAAKKTPKKAKKPAAAAVTKKVAKSPKKAKVTKAKKVKSASKAVKPKAAKPKVAKAKKVAAKKK" }, "uniprot_id": "A0A0G2K654_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A0G2K654", "site_annotation": [ { "end_pos": 78, "annotation": "n_glycosylation_sequon", "start_pos": 76 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654#A0A0G2K654-1", "isoform_ac": "A0A0G2K654-1", "locus": { "end_pos": 43639752, "strand": "+", "start_pos": 43640387, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000087731", "id": "ENSRNOT00000087731", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000073681", "id": "ENSRNOP00000073681", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K654-1|A0A0G2K654_RAT Isoform 1 of H1.2 linker histone, cluster member OS=Rattus norvegicus OX=10116 GN=Hist1h1c PE=1 SV=1 CANONICAL=A0A0G2K654-1", "length": 212, "sequence": "MSETAPAAPAAAPPAEKAPAKKKAAKKPAGMRRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGILVQTKGTGASGSFKLNKKAASGEAKPKAKKAAAAKAKKPAGAAKKPKKATGAATPKKAAKKTPKKAKKPAAAAVTKKVAKSPKKAKVTKAKKVKSASKAVKPKAAKPKVAKAKKVAAKKK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:684681", "resource": "KEGG Pathway", "id": "rno:684681", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "P15864-1", "protein_name": "Histone H1.2", "sequence": { "length": 212, "sequence": "MSEAAPAAPAAAPPAEKAPAKKKAAKKPAGVRRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGILVQTKGTGASGSFKLNKKAASGEAKPQAKKAGAAKAKKPAGAAKKPKKATGAATPKKAAKKTPKKAKKPAAAAVTKKVAKSPKKAKVTKPKKVKSASKAVKPKAAKPKVAKAKKVAAKKK" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K654/", "id": "A0A0G2K654", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "H1-2", "tax_id": 10090 }, { "uniprot_canonical_ac": "P16403-1", "protein_name": "Histone H1.2", "sequence": { "length": 213, "sequence": "MSETAPAAPAAAPPAEKAPVKKKAAKKAGGTPRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKVKKAGGTKPKKPVGAAKKPKKAAGGATPKKSAKKTPKKAKKPAAATVTKKVAKSPKKAKVAKPKKAAKSAAKAVKPKAAKPKVVKPKKAAPKKK" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2K654/", "id": "A0A0G2K654", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "H1-2", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001071565.2", "ac": "XP_001071565.2", "name": "histone H1.2", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "double-stranded DNA binding", "id": "GO:0003690" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031492", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "nucleosomal DNA binding", "id": "GO:0031492" }, { "url": 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], "name": "regulation of transcription, DNA-templated", "id": "GO:0006355" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030261", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "chromosome condensation", "id": "GO:0030261" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031936", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "negative regulation of chromatin silencing", "id": "GO:0031936" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045910", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "negative regulation of DNA recombination", "id": "GO:0045910" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016584", "pmid": "", "evidence": [ { "url": 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"pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "histone H3-K4 trimethylation", "id": "GO:0080182" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098532", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "id": "A0A0G2K654", "database": "UniProtKB" } ], "name": "histone H3-K27 trimethylation", "id": "GO:0098532" } ], "total": 10, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "type": "synonym", "resource": "UniProtKB", "name": "H1f2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2K654", "type": "synonym", "resource": "RefSeq", "name": "Hist1h1c" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "type": "recommended", "resource": "UniProtKB", "name": "Hist1h1c" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "type": "synonym", "resource": "UniProtKB", "name": "LOC684681" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "type": "synonym", "resource": "UniProtKB", "name": "rCG_45246" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000054978", "id": "ENSRNOG00000054978", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00073", "id": "cd00073", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/684681", "id": "684681", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A0A0G2K654*", "id": "A0A0G2K654", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005818", "id": "IPR005818", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005819", "id": "IPR005819", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "id": "IPR036388", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "id": "IPR036390", "database": 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[ { "url": "https://www.uniprot.org/uniprot/A0A0G2K654#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "H1.2 linker histone, cluster member" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K654#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "RCG45246" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2K654", "type": "synonym", "resource": "RefSeq", "name": "histone H1.2" } ] }